Cyclin N-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cyclin 12, L-type

Species:

Leishmania donovani

UniProt:

A0A3S7XBU2_LEIDO

TriTrypDb:

LdBPK_365890.1 , LdCL_360066300 , LDHU3_36.7800

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XBU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBU2

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	12
GO:0006357	regulation of transcription by RNA polymerase II	7	12
GO:0009889	regulation of biosynthetic process	4	12
GO:0010468	regulation of gene expression	5	12
GO:0010556	regulation of macromolecule biosynthetic process	5	12
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	12
GO:0019222	regulation of metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12
GO:0031326	regulation of cellular biosynthetic process	5	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051252	regulation of RNA metabolic process	5	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0080090	regulation of primary metabolic process	4	12
GO:1903506	regulation of nucleic acid-templated transcription	7	12
GO:2001141	regulation of RNA biosynthetic process	6	12
GO:0000365	mRNA trans splicing, via spliceosome	9	1
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045291	mRNA trans splicing, SL addition	10	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	5	12
GO:0019207	kinase regulator activity	3	12
GO:0019887	protein kinase regulator activity	4	12
GO:0030234	enzyme regulator activity	2	12
GO:0098772	molecular function regulator activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.468
CLV_NRD_NRD_1	297	299	PF00675	0.418
CLV_NRD_NRD_1	456	458	PF00675	0.619
CLV_NRD_NRD_1	469	471	PF00675	0.589
CLV_NRD_NRD_1	479	481	PF00675	0.614
CLV_NRD_NRD_1	490	492	PF00675	0.696
CLV_NRD_NRD_1	493	495	PF00675	0.679
CLV_PCSK_FUR_1	295	299	PF00082	0.412
CLV_PCSK_FUR_1	488	492	PF00082	0.709
CLV_PCSK_KEX2_1	180	182	PF00082	0.422
CLV_PCSK_KEX2_1	297	299	PF00082	0.549
CLV_PCSK_KEX2_1	455	457	PF00082	0.635
CLV_PCSK_KEX2_1	469	471	PF00082	0.682
CLV_PCSK_KEX2_1	475	477	PF00082	0.734
CLV_PCSK_KEX2_1	479	481	PF00082	0.679
CLV_PCSK_KEX2_1	488	490	PF00082	0.771
CLV_PCSK_KEX2_1	72	74	PF00082	0.535
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.686
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.535
CLV_PCSK_PC7_1	176	182	PF00082	0.384
CLV_PCSK_SKI1_1	226	230	PF00082	0.429
CLV_PCSK_SKI1_1	297	301	PF00082	0.495
CLV_PCSK_SKI1_1	335	339	PF00082	0.514
CLV_PCSK_SKI1_1	355	359	PF00082	0.601
DEG_APCC_DBOX_1	119	127	PF00400	0.601
DEG_APCC_DBOX_1	72	80	PF00400	0.553
DEG_SPOP_SBC_1	414	418	PF00917	0.746
DOC_CYCLIN_yCln2_LP_2	129	135	PF00134	0.500
DOC_CYCLIN_yCln2_LP_2	300	306	PF00134	0.404
DOC_MAPK_DCC_7	120	129	PF00069	0.589
DOC_MAPK_gen_1	118	126	PF00069	0.650
DOC_MAPK_gen_1	166	173	PF00069	0.393
DOC_MAPK_gen_1	295	302	PF00069	0.483
DOC_MAPK_gen_1	72	78	PF00069	0.547
DOC_MAPK_HePTP_8	117	129	PF00069	0.532
DOC_MAPK_MEF2A_6	120	129	PF00069	0.572
DOC_MAPK_MEF2A_6	166	175	PF00069	0.390
DOC_MAPK_MEF2A_6	226	234	PF00069	0.336
DOC_PP2B_LxvP_1	129	132	PF13499	0.503
DOC_PP2B_LxvP_1	300	303	PF13499	0.424
DOC_PP2B_LxvP_1	320	323	PF13499	0.568
DOC_PP2B_LxvP_1	58	61	PF13499	0.538
DOC_PP4_FxxP_1	428	431	PF00568	0.743
DOC_USP7_MATH_1	397	401	PF00917	0.507
DOC_USP7_MATH_1	415	419	PF00917	0.631
DOC_WW_Pin1_4	181	186	PF00397	0.563
DOC_WW_Pin1_4	220	225	PF00397	0.407
DOC_WW_Pin1_4	25	30	PF00397	0.401
DOC_WW_Pin1_4	405	410	PF00397	0.600
DOC_WW_Pin1_4	80	85	PF00397	0.551
LIG_14-3-3_CanoR_1	176	180	PF00244	0.485
LIG_14-3-3_CanoR_1	365	371	PF00244	0.645
LIG_Actin_WH2_2	11	28	PF00022	0.395
LIG_Actin_WH2_2	164	182	PF00022	0.436
LIG_BRCT_BRCA1_1	326	330	PF00533	0.508
LIG_BRCT_BRCA1_1	35	39	PF00533	0.395
LIG_CtBP_PxDLS_1	317	321	PF00389	0.433
LIG_deltaCOP1_diTrp_1	324	330	PF00928	0.409
LIG_eIF4E_1	33	39	PF01652	0.320
LIG_FHA_1	119	125	PF00498	0.583
LIG_FHA_1	18	24	PF00498	0.353
LIG_FHA_1	356	362	PF00498	0.505
LIG_FHA_1	367	373	PF00498	0.424
LIG_FHA_2	156	162	PF00498	0.424
LIG_FHA_2	217	223	PF00498	0.390
LIG_FHA_2	319	325	PF00498	0.471
LIG_FHA_2	373	379	PF00498	0.570
LIG_FHA_2	393	399	PF00498	0.558
LIG_Integrin_RGD_1	251	253	PF01839	0.590
LIG_LIR_Apic_2	108	112	PF02991	0.458
LIG_LIR_Apic_2	427	431	PF02991	0.733
LIG_LIR_Gen_1	36	46	PF02991	0.417
LIG_LIR_Nem_3	222	228	PF02991	0.434
LIG_LIR_Nem_3	341	347	PF02991	0.501
LIG_LIR_Nem_3	36	42	PF02991	0.403
LIG_LIR_Nem_3	8	13	PF02991	0.412
LIG_LYPXL_SIV_4	224	232	PF13949	0.462
LIG_Pex14_1	326	330	PF04695	0.365
LIG_SH2_CRK	225	229	PF00017	0.346
LIG_SH2_CRK	373	377	PF00017	0.584
LIG_SH2_GRB2like	231	234	PF00017	0.480
LIG_SH2_PTP2	227	230	PF00017	0.473
LIG_SH2_SRC	231	234	PF00017	0.449
LIG_SH2_STAT3	310	313	PF00017	0.461
LIG_SH2_STAT5	10	13	PF00017	0.392
LIG_SH2_STAT5	109	112	PF00017	0.469
LIG_SH2_STAT5	135	138	PF00017	0.409
LIG_SH2_STAT5	148	151	PF00017	0.325
LIG_SH2_STAT5	227	230	PF00017	0.475
LIG_SH2_STAT5	231	234	PF00017	0.485
LIG_SH2_STAT5	54	57	PF00017	0.531
LIG_SH3_1	95	101	PF00018	0.511
LIG_SH3_3	218	224	PF00018	0.325
LIG_SH3_3	406	412	PF00018	0.586
LIG_SH3_3	95	101	PF00018	0.672
LIG_TRAF2_1	433	436	PF00917	0.671
LIG_TYR_ITIM	229	234	PF00017	0.487
LIG_WRC_WIRS_1	217	222	PF05994	0.397
MOD_CDC14_SPxK_1	223	226	PF00782	0.405
MOD_CDK_SPxK_1	220	226	PF00069	0.414
MOD_CK1_1	190	196	PF00069	0.458
MOD_CK1_1	348	354	PF00069	0.619
MOD_CK1_1	400	406	PF00069	0.634
MOD_CK1_1	444	450	PF00069	0.658
MOD_CK1_1	45	51	PF00069	0.522
MOD_CK1_1	82	88	PF00069	0.663
MOD_CK2_1	138	144	PF00069	0.603
MOD_CK2_1	155	161	PF00069	0.327
MOD_CK2_1	216	222	PF00069	0.403
MOD_CK2_1	372	378	PF00069	0.545
MOD_CK2_1	392	398	PF00069	0.551
MOD_CK2_1	430	436	PF00069	0.638
MOD_CK2_1	468	474	PF00069	0.633
MOD_CK2_1	86	92	PF00069	0.749
MOD_DYRK1A_RPxSP_1	181	185	PF00069	0.462
MOD_GlcNHglycan	181	184	PF01048	0.601
MOD_GlcNHglycan	244	247	PF01048	0.679
MOD_GlcNHglycan	253	257	PF01048	0.604
MOD_GlcNHglycan	398	402	PF01048	0.577
MOD_GlcNHglycan	417	420	PF01048	0.637
MOD_GlcNHglycan	55	58	PF01048	0.677
MOD_GSK3_1	175	182	PF00069	0.566
MOD_GSK3_1	216	223	PF00069	0.458
MOD_GSK3_1	233	240	PF00069	0.522
MOD_GSK3_1	24	31	PF00069	0.409
MOD_GSK3_1	351	358	PF00069	0.454
MOD_GSK3_1	397	404	PF00069	0.591
MOD_GSK3_1	45	52	PF00069	0.524
MOD_GSK3_1	451	458	PF00069	0.693
MOD_GSK3_1	80	87	PF00069	0.613
MOD_N-GLC_1	258	263	PF02516	0.750
MOD_N-GLC_2	172	174	PF02516	0.467
MOD_NEK2_1	155	160	PF00069	0.411
MOD_NEK2_1	17	22	PF00069	0.322
MOD_NEK2_1	175	180	PF00069	0.436
MOD_NEK2_1	24	29	PF00069	0.358
MOD_NEK2_1	372	377	PF00069	0.574
MOD_NEK2_1	79	84	PF00069	0.658
MOD_PIKK_1	277	283	PF00454	0.512
MOD_PIKK_1	49	55	PF00454	0.507
MOD_PKA_1	455	461	PF00069	0.672
MOD_PKA_2	175	181	PF00069	0.516
MOD_PKA_2	33	39	PF00069	0.376
MOD_PKA_2	392	398	PF00069	0.472
MOD_PKA_2	455	461	PF00069	0.728
MOD_PKA_2	468	474	PF00069	0.564
MOD_Plk_1	318	324	PF00069	0.512
MOD_Plk_1	42	48	PF00069	0.500
MOD_Plk_2-3	237	243	PF00069	0.470
MOD_Plk_4	216	222	PF00069	0.396
MOD_Plk_4	28	34	PF00069	0.446
MOD_ProDKin_1	181	187	PF00069	0.566
MOD_ProDKin_1	220	226	PF00069	0.414
MOD_ProDKin_1	25	31	PF00069	0.393
MOD_ProDKin_1	405	411	PF00069	0.599
MOD_ProDKin_1	80	86	PF00069	0.554
MOD_SUMO_rev_2	193	202	PF00179	0.453
MOD_SUMO_rev_2	69	74	PF00179	0.535
TRG_DiLeu_BaEn_1	436	441	PF01217	0.684
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.503
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.421
TRG_ENDOCYTIC_2	197	200	PF00928	0.373
TRG_ENDOCYTIC_2	225	228	PF00928	0.337
TRG_ENDOCYTIC_2	231	234	PF00928	0.339
TRG_ENDOCYTIC_2	373	376	PF00928	0.514
TRG_ER_diArg_1	179	181	PF00400	0.430
TRG_ER_diArg_1	294	297	PF00400	0.469
TRG_ER_diArg_1	455	457	PF00400	0.647
TRG_ER_diArg_1	468	470	PF00400	0.579
TRG_ER_diArg_1	487	490	PF00400	0.714
TRG_ER_FFAT_2	52	59	PF00635	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDY9	Leptomonas seymouri	60%	100%
A0A0S4IZS7	Bodo saltans	26%	86%
A0A1X0P050	Trypanosomatidae	39%	72%
A0A422NSB3	Trypanosoma rangeli	38%	100%
A4HQ80	Leishmania braziliensis	83%	99%
A4IDX8	Leishmania infantum	100%	100%
D0A432	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	77%
E9ATZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q0J7	Leishmania major	93%	100%
V5BNQ3	Trypanosoma cruzi	41%	82%