Endonuclease/exonuclease protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endonuclease/exonuclease protein-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7XBT9_LEIDO

TriTrypDb:

LdBPK_365500.1 , LdCL_360062200 , LDHU3_36.7320

Length:

732

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Previous1Next

Expansion

Sequence features

A0A3S7XBT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBT9

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006259	DNA metabolic process	4	10
GO:0006281	DNA repair	5	10
GO:0006284	base-excision repair	6	1
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0006950	response to stress	2	10
GO:0006974	DNA damage response	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10

Previous1 2 3Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0003824	catalytic activity	1	10
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity	4	3
GO:0004518	nuclease activity	4	10
GO:0004519	endonuclease activity	5	10
GO:0004527	exonuclease activity	5	7
GO:0004529	DNA exonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0005488	binding	1	10

Previous1 2 3Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.320
CLV_C14_Caspase3-7	437	441	PF00656	0.484
CLV_C14_Caspase3-7	705	709	PF00656	0.583
CLV_NRD_NRD_1	129	131	PF00675	0.369
CLV_NRD_NRD_1	194	196	PF00675	0.382
CLV_NRD_NRD_1	222	224	PF00675	0.344
CLV_NRD_NRD_1	482	484	PF00675	0.400
CLV_NRD_NRD_1	65	67	PF00675	0.443
CLV_NRD_NRD_1	82	84	PF00675	0.443
CLV_PCSK_FUR_1	480	484	PF00082	0.369

Previous1 2 3 4 5…25Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB73	Leptomonas seymouri	58%	98%
A0A1X0P3V4	Trypanosomatidae	37%	100%
A0A3R7M024	Trypanosoma rangeli	41%	100%
A4IDU8	Leishmania infantum	100%	100%
D0A8S3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AIY2	Leishmania braziliensis	79%	100%
E9ATW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q0N5	Leishmania major	92%	100%

Previous1Next