Nin one binding (NOB1) Zn-ribbon like, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nin one binding (NOB1) Zn-ribbon like, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBT5_LEIDO

TriTrypDb:

LdBPK_365290.1 , LdCL_360060100 , LDHU3_36.7070

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0030684	preribosome	3	1
GO:0030688	preribosome, small subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S7XBT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBT5

Function

Biological processes
Term	Name	Level	Count
GO:0000469	cleavage involved in rRNA processing	7	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0022613	ribonucleoprotein complex biogenesis	4	11
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0042274	ribosomal small subunit biogenesis	5	11
GO:0043170	macromolecule metabolic process	3	12
GO:0044085	cellular component biogenesis	3	11
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	11
GO:0090304	nucleic acid metabolic process	4	12
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	12
GO:0090501	RNA phosphodiester bond hydrolysis	6	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0030490	maturation of SSU-rRNA	9	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	12
GO:0004519	endonuclease activity	5	12
GO:0004521	RNA endonuclease activity	5	12
GO:0004540	RNA nuclease activity	4	12
GO:0005488	binding	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.642
CLV_C14_Caspase3-7	76	80	PF00656	0.386
CLV_NRD_NRD_1	323	325	PF00675	0.301
CLV_NRD_NRD_1	341	343	PF00675	0.301
CLV_NRD_NRD_1	438	440	PF00675	0.630
CLV_PCSK_KEX2_1	323	325	PF00082	0.301
CLV_PCSK_KEX2_1	343	345	PF00082	0.118
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.382
CLV_PCSK_SKI1_1	57	61	PF00082	0.383
CLV_PCSK_SKI1_1	8	12	PF00082	0.563
CLV_PCSK_SKI1_1	97	101	PF00082	0.258
DEG_APCC_DBOX_1	96	104	PF00400	0.286
DOC_CDC14_PxL_1	403	411	PF14671	0.596
DOC_CKS1_1	236	241	PF01111	0.496
DOC_CKS1_1	82	87	PF01111	0.421
DOC_CYCLIN_RxL_1	362	373	PF00134	0.463
DOC_CYCLIN_RxL_1	51	63	PF00134	0.437
DOC_CYCLIN_yCln2_LP_2	154	160	PF00134	0.482
DOC_MAPK_gen_1	335	341	PF00069	0.353
DOC_PP2B_LxvP_1	276	279	PF13499	0.398
DOC_USP7_MATH_1	419	423	PF00917	0.629
DOC_USP7_UBL2_3	408	412	PF12436	0.656
DOC_WW_Pin1_4	110	115	PF00397	0.370
DOC_WW_Pin1_4	235	240	PF00397	0.509
DOC_WW_Pin1_4	81	86	PF00397	0.421
LIG_14-3-3_CanoR_1	23	27	PF00244	0.657
LIG_14-3-3_CanoR_1	297	305	PF00244	0.306
LIG_14-3-3_CanoR_1	342	352	PF00244	0.361
LIG_14-3-3_CanoR_1	380	387	PF00244	0.522
LIG_14-3-3_CanoR_1	418	424	PF00244	0.536
LIG_BIR_II_1	1	5	PF00653	0.559
LIG_Clathr_ClatBox_1	59	63	PF01394	0.336
LIG_FHA_1	281	287	PF00498	0.531
LIG_FHA_1	301	307	PF00498	0.118
LIG_FHA_1	45	51	PF00498	0.659
LIG_FHA_1	82	88	PF00498	0.319
LIG_FHA_2	106	112	PF00498	0.419
LIG_FHA_2	216	222	PF00498	0.791
LIG_FHA_2	400	406	PF00498	0.666
LIG_LIR_Apic_2	233	239	PF02991	0.522
LIG_LIR_Apic_2	350	355	PF02991	0.301
LIG_LIR_Gen_1	2	10	PF02991	0.573
LIG_LIR_Gen_1	299	306	PF02991	0.421
LIG_LIR_LC3C_4	303	306	PF02991	0.409
LIG_LIR_Nem_3	2	6	PF02991	0.579
LIG_LIR_Nem_3	299	305	PF02991	0.421
LIG_LIR_Nem_3	421	426	PF02991	0.523
LIG_SH2_CRK	352	356	PF00017	0.301
LIG_SH2_GRB2like	338	341	PF00017	0.421
LIG_SH2_STAT3	267	270	PF00017	0.381
LIG_SH2_STAT5	327	330	PF00017	0.301
LIG_SH2_STAT5	338	341	PF00017	0.301
LIG_SH3_3	106	112	PF00018	0.317
LIG_SH3_3	154	160	PF00018	0.469
LIG_SH3_3	47	53	PF00018	0.556
LIG_SH3_3	79	85	PF00018	0.386
LIG_SUMO_SIM_par_1	302	309	PF11976	0.456
LIG_SUMO_SIM_par_1	58	63	PF11976	0.336
LIG_TRAF2_1	226	229	PF00917	0.661
LIG_WRC_WIRS_1	400	405	PF05994	0.666
LIG_WRC_WIRS_1	52	57	PF05994	0.520
MOD_CK1_1	318	324	PF00069	0.301
MOD_CK2_1	182	188	PF00069	0.688
MOD_CK2_1	215	221	PF00069	0.790
MOD_CK2_1	399	405	PF00069	0.664
MOD_GlcNHglycan	198	201	PF01048	0.678
MOD_GlcNHglycan	207	210	PF01048	0.612
MOD_GlcNHglycan	246	249	PF01048	0.613
MOD_GlcNHglycan	317	320	PF01048	0.291
MOD_GSK3_1	205	212	PF00069	0.552
MOD_GSK3_1	296	303	PF00069	0.356
MOD_GSK3_1	343	350	PF00069	0.304
MOD_N-GLC_1	16	21	PF02516	0.621
MOD_NEK2_1	269	274	PF00069	0.357
MOD_NEK2_1	296	301	PF00069	0.322
MOD_NEK2_1	6	11	PF00069	0.657
MOD_NEK2_2	22	27	PF00069	0.733
MOD_PIKK_1	29	35	PF00454	0.698
MOD_PKA_1	343	349	PF00069	0.351
MOD_PKA_2	22	28	PF00069	0.658
MOD_PKA_2	296	302	PF00069	0.317
MOD_PKA_2	343	349	PF00069	0.313
MOD_PKA_2	361	367	PF00069	0.411
MOD_PKA_2	379	385	PF00069	0.603
MOD_PKA_2	93	99	PF00069	0.399
MOD_PKB_1	342	350	PF00069	0.421
MOD_Plk_4	105	111	PF00069	0.421
MOD_Plk_4	22	28	PF00069	0.735
MOD_Plk_4	269	275	PF00069	0.379
MOD_Plk_4	347	353	PF00069	0.301
MOD_ProDKin_1	110	116	PF00069	0.370
MOD_ProDKin_1	235	241	PF00069	0.499
MOD_ProDKin_1	81	87	PF00069	0.421
MOD_SUMO_for_1	10	13	PF00179	0.633
MOD_SUMO_rev_2	208	218	PF00179	0.760
MOD_SUMO_rev_2	331	337	PF00179	0.448
MOD_SUMO_rev_2	46	53	PF00179	0.616
TRG_ENDOCYTIC_2	338	341	PF00928	0.421
TRG_ER_diArg_1	322	324	PF00400	0.301
TRG_ER_diArg_1	341	344	PF00400	0.301
TRG_NLS_MonoExtN_4	407	414	PF00514	0.652
TRG_NLS_MonoExtN_4	431	436	PF00514	0.552
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAE9	Leptomonas seymouri	77%	98%
A0A0S4JQ15	Bodo saltans	53%	100%
A0A1X0NEQ4	Trypanosomatidae	51%	100%
A0A422N6K6	Trypanosoma rangeli	53%	100%
A4HQ22	Leishmania braziliensis	88%	100%
A4IDS9	Leishmania infantum	100%	100%
D0A8U7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9ATU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q3T042	Bos taurus	29%	100%
Q4Q0Q6	Leishmania major	95%	100%
Q4R537	Macaca fascicularis	28%	100%
Q5RBB3	Pongo abelii	29%	100%
Q6VEU1	Rattus norvegicus	29%	100%
Q8BW10	Mus musculus	30%	100%
Q9ULX3	Homo sapiens	27%	100%
Q9UTK0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
V5AXR8	Trypanosoma cruzi	55%	100%