Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBS9_LEIDO

TriTrypDb:

LdBPK_365450.1 , LdCL_360061700 , LDHU3_36.7270

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 0
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005788	endoplasmic reticulum lumen	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7XBS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBS9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	7
GO:0006511	ubiquitin-dependent protein catabolic process	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0007165	signal transduction	2	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009057	macromolecule catabolic process	4	7
GO:0009987	cellular process	1	7
GO:0010033	response to organic substance	3	7
GO:0010243	response to organonitrogen compound	4	7
GO:0010498	proteasomal protein catabolic process	5	7
GO:0019538	protein metabolic process	3	7
GO:0019941	modification-dependent protein catabolic process	6	7
GO:0030163	protein catabolic process	4	7
GO:0030433	ubiquitin-dependent ERAD pathway	6	7
GO:0030968	endoplasmic reticulum unfolded protein response	3	7
GO:0033554	cellular response to stress	3	7
GO:0034976	response to endoplasmic reticulum stress	4	7
GO:0036503	ERAD pathway	5	7
GO:0042221	response to chemical	2	7
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043632	modification-dependent macromolecule catabolic process	5	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044248	cellular catabolic process	3	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0044265	obsolete cellular macromolecule catabolic process	4	7
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	7
GO:0050896	response to stimulus	1	7
GO:0051603	proteolysis involved in protein catabolic process	5	7
GO:0051716	cellular response to stimulus	2	7
GO:0065007	biological regulation	1	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901565	organonitrogen compound catabolic process	4	7
GO:1901575	organic substance catabolic process	3	7
GO:1901698	response to nitrogen compound	3	7
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0015031	protein transport	4	1
GO:0030970	retrograde protein transport, ER to cytosol	5	1
GO:0032527	protein exit from endoplasmic reticulum	5	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:1903513	endoplasmic reticulum to cytosol transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.485
CLV_NRD_NRD_1	107	109	PF00675	0.391
CLV_NRD_NRD_1	147	149	PF00675	0.517
CLV_NRD_NRD_1	182	184	PF00675	0.503
CLV_NRD_NRD_1	84	86	PF00675	0.616
CLV_PCSK_KEX2_1	107	109	PF00082	0.391
CLV_PCSK_KEX2_1	146	148	PF00082	0.565
CLV_PCSK_KEX2_1	182	184	PF00082	0.503
CLV_PCSK_KEX2_1	83	85	PF00082	0.612
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.580
CLV_PCSK_PC7_1	142	148	PF00082	0.462
CLV_PCSK_SKI1_1	213	217	PF00082	0.423
DEG_APCC_DBOX_1	212	220	PF00400	0.414
DOC_CDC14_PxL_1	223	231	PF14671	0.336
DOC_CYCLIN_yCln2_LP_2	33	39	PF00134	0.530
DOC_CYCLIN_yCln2_LP_2	44	50	PF00134	0.522
DOC_MAPK_gen_1	180	190	PF00069	0.500
DOC_MAPK_MEF2A_6	4	13	PF00069	0.425
DOC_PP2B_LxvP_1	44	47	PF13499	0.602
DOC_PP4_FxxP_1	197	200	PF00568	0.570
DOC_USP7_MATH_1	202	206	PF00917	0.500
LIG_14-3-3_CanoR_1	107	114	PF00244	0.417
LIG_14-3-3_CanoR_1	164	170	PF00244	0.439
LIG_14-3-3_CanoR_1	193	201	PF00244	0.542
LIG_14-3-3_CanoR_1	217	226	PF00244	0.424
LIG_14-3-3_CanoR_1	4	11	PF00244	0.494
LIG_Actin_WH2_2	9	26	PF00022	0.440
LIG_BIR_III_4	160	164	PF00653	0.485
LIG_BRCT_BRCA1_1	219	223	PF00533	0.445
LIG_CtBP_PxDLS_1	30	34	PF00389	0.586
LIG_EH1_1	96	104	PF00400	0.471
LIG_FHA_1	18	24	PF00498	0.614
LIG_FHA_2	155	161	PF00498	0.411
LIG_LIR_Apic_2	195	200	PF02991	0.566
LIG_LIR_Gen_1	118	125	PF02991	0.470
LIG_LIR_Gen_1	220	229	PF02991	0.424
LIG_LIR_Nem_3	118	124	PF02991	0.415
LIG_LIR_Nem_3	160	165	PF02991	0.475
LIG_LIR_Nem_3	220	226	PF02991	0.418
LIG_LIR_Nem_3	63	69	PF02991	0.483
LIG_SH2_CRK	203	207	PF00017	0.457
LIG_SH2_PTP2	121	124	PF00017	0.496
LIG_SH2_PTP2	66	69	PF00017	0.529
LIG_SH2_STAT5	121	124	PF00017	0.500
LIG_SH2_STAT5	125	128	PF00017	0.443
LIG_SH2_STAT5	165	168	PF00017	0.337
LIG_SH2_STAT5	66	69	PF00017	0.529
LIG_TRAF2_1	232	235	PF00917	0.576
LIG_TYR_ITIM	201	206	PF00017	0.522
LIG_UBA3_1	215	222	PF00899	0.426
MOD_CK1_1	101	107	PF00069	0.475
MOD_CK1_1	51	57	PF00069	0.536
MOD_CK1_1	70	76	PF00069	0.458
MOD_CK2_1	192	198	PF00069	0.491
MOD_CK2_1	202	208	PF00069	0.483
MOD_CK2_1	230	236	PF00069	0.538
MOD_Cter_Amidation	144	147	PF01082	0.531
MOD_Cter_Amidation	180	183	PF01082	0.491
MOD_GlcNHglycan	24	27	PF01048	0.625
MOD_GlcNHglycan	53	56	PF01048	0.624
MOD_GSK3_1	202	209	PF00069	0.527
MOD_GSK3_1	218	225	PF00069	0.522
MOD_GSK3_1	230	237	PF00069	0.433
MOD_N-GLC_1	70	75	PF02516	0.458
MOD_NEK2_1	206	211	PF00069	0.429
MOD_NEK2_1	218	223	PF00069	0.338
MOD_NEK2_1	31	36	PF00069	0.619
MOD_NEK2_2	165	170	PF00069	0.406
MOD_NEK2_2	202	207	PF00069	0.530
MOD_NMyristoyl	1	7	PF02799	0.480
MOD_PIKK_1	207	213	PF00454	0.467
MOD_PK_1	222	228	PF00069	0.527
MOD_PKA_2	106	112	PF00069	0.578
MOD_PKA_2	192	198	PF00069	0.496
MOD_PKA_2	3	9	PF00069	0.575
MOD_Plk_1	234	240	PF00069	0.572
MOD_Plk_2-3	230	236	PF00069	0.567
MOD_Plk_4	120	126	PF00069	0.532
MOD_Plk_4	165	171	PF00069	0.433
MOD_Plk_4	98	104	PF00069	0.544
MOD_SUMO_rev_2	86	92	PF00179	0.466
TRG_DiLeu_BaEn_2	37	43	PF01217	0.592
TRG_DiLeu_BaLyEn_6	214	219	PF01217	0.471
TRG_ENDOCYTIC_2	121	124	PF00928	0.506
TRG_ENDOCYTIC_2	194	197	PF00928	0.578
TRG_ENDOCYTIC_2	203	206	PF00928	0.482
TRG_ENDOCYTIC_2	66	69	PF00928	0.474
TRG_ER_diArg_1	106	108	PF00400	0.378
TRG_ER_diArg_1	146	148	PF00400	0.502
TRG_ER_diArg_1	182	184	PF00400	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N4	Leptomonas seymouri	43%	100%
A0A3R7KHI0	Trypanosoma rangeli	27%	98%
A4HQ37	Leishmania braziliensis	70%	100%
A4IDU3	Leishmania infantum	99%	100%
E9ATV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q0P0	Leishmania major	87%	100%