Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBS7_LEIDO

TriTrypDb:

LdBPK_365530.1 , LdCL_360062600 , LDHU3_36.7360

Length:

1116

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XBS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBS7

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0005488	binding	1	5
GO:0005524	ATP binding	5	5
GO:0017076	purine nucleotide binding	4	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.591
CLV_C14_Caspase3-7	614	618	PF00656	0.652
CLV_C14_Caspase3-7	855	859	PF00656	0.384
CLV_C14_Caspase3-7	866	870	PF00656	0.513
CLV_NRD_NRD_1	1058	1060	PF00675	0.488
CLV_NRD_NRD_1	15	17	PF00675	0.701
CLV_NRD_NRD_1	297	299	PF00675	0.523
CLV_NRD_NRD_1	303	305	PF00675	0.574
CLV_NRD_NRD_1	34	36	PF00675	0.621
CLV_NRD_NRD_1	470	472	PF00675	0.676

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVW3	Leptomonas seymouri	49%	78%
A4HQ44	Leishmania braziliensis	72%	100%
A4IC80	Leishmania infantum	99%	100%
E9ATW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4Q0N2	Leishmania major	92%	100%

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