Mitochondrial chaperone BCS1, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial chaperone BCS1, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBS4_LEIDO

TriTrypDb:

LdBPK_365640.1 , LdCL_360063800 , LDHU3_36.7510

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	10
GO:0016020	membrane	2	10
GO:0019866	organelle inner membrane	4	10
GO:0031090	organelle membrane	3	10
GO:0031966	mitochondrial membrane	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S7XBS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBS4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0016887	ATP hydrolysis activity	7	11
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	129	131	PF00675	0.396
CLV_NRD_NRD_1	172	174	PF00675	0.325
CLV_NRD_NRD_1	209	211	PF00675	0.386
CLV_NRD_NRD_1	261	263	PF00675	0.519
CLV_NRD_NRD_1	365	367	PF00675	0.420
CLV_PCSK_FUR_1	170	174	PF00082	0.337
CLV_PCSK_KEX2_1	128	130	PF00082	0.397
CLV_PCSK_KEX2_1	172	174	PF00082	0.316
CLV_PCSK_KEX2_1	209	211	PF00082	0.382
CLV_PCSK_KEX2_1	261	263	PF00082	0.519
CLV_PCSK_KEX2_1	365	367	PF00082	0.420
CLV_PCSK_SKI1_1	192	196	PF00082	0.383
CLV_PCSK_SKI1_1	262	266	PF00082	0.369
CLV_PCSK_SKI1_1	282	286	PF00082	0.401
CLV_PCSK_SKI1_1	339	343	PF00082	0.450
CLV_PCSK_SKI1_1	413	417	PF00082	0.436
CLV_PCSK_SKI1_1	44	48	PF00082	0.393
DEG_APCC_DBOX_1	171	179	PF00400	0.337
DEG_MDM2_SWIB_1	90	97	PF02201	0.423
DEG_Nend_Nbox_1	1	3	PF02207	0.236
DEG_SPOP_SBC_1	15	19	PF00917	0.407
DEG_SPOP_SBC_1	284	288	PF00917	0.677
DOC_CKS1_1	274	279	PF01111	0.592
DOC_CYCLIN_RxL_1	34	47	PF00134	0.423
DOC_CYCLIN_yCln2_LP_2	233	239	PF00134	0.360
DOC_MAPK_DCC_7	39	48	PF00069	0.337
DOC_MAPK_gen_1	113	123	PF00069	0.360
DOC_MAPK_gen_1	170	180	PF00069	0.305
DOC_MAPK_gen_1	261	267	PF00069	0.513
DOC_MAPK_gen_1	34	43	PF00069	0.368
DOC_MAPK_gen_1	359	369	PF00069	0.416
DOC_MAPK_MEF2A_6	116	125	PF00069	0.318
DOC_MAPK_MEF2A_6	149	156	PF00069	0.320
DOC_PP1_RVXF_1	363	370	PF00149	0.441
DOC_PP2B_LxvP_1	178	181	PF13499	0.418
DOC_PP2B_LxvP_1	204	207	PF13499	0.410
DOC_PP2B_LxvP_1	233	236	PF13499	0.360
DOC_PP2B_LxvP_1	399	402	PF13499	0.543
DOC_USP7_MATH_1	260	264	PF00917	0.504
DOC_USP7_MATH_1	284	288	PF00917	0.658
DOC_USP7_MATH_1	298	302	PF00917	0.694
DOC_USP7_MATH_1	402	406	PF00917	0.691
DOC_WW_Pin1_4	273	278	PF00397	0.584
DOC_WW_Pin1_4	301	306	PF00397	0.699
DOC_WW_Pin1_4	388	393	PF00397	0.528
DOC_WW_Pin1_4	415	420	PF00397	0.456
DOC_WW_Pin1_4	56	61	PF00397	0.368
LIG_14-3-3_CanoR_1	149	153	PF00244	0.333
LIG_14-3-3_CanoR_1	16	25	PF00244	0.418
LIG_14-3-3_CanoR_1	172	181	PF00244	0.311
LIG_14-3-3_CanoR_1	318	324	PF00244	0.594
LIG_14-3-3_CanoR_1	413	422	PF00244	0.527
LIG_14-3-3_CanoR_1	76	80	PF00244	0.332
LIG_14-3-3_CanoR_1	89	95	PF00244	0.390
LIG_Actin_WH2_2	73	91	PF00022	0.411
LIG_BRCT_BRCA1_1	18	22	PF00533	0.384
LIG_FHA_1	10	16	PF00498	0.315
LIG_FHA_1	149	155	PF00498	0.337
LIG_FHA_1	175	181	PF00498	0.412
LIG_FHA_1	182	188	PF00498	0.408
LIG_FHA_1	221	227	PF00498	0.357
LIG_FHA_1	254	260	PF00498	0.543
LIG_FHA_1	290	296	PF00498	0.659
LIG_FHA_1	346	352	PF00498	0.480
LIG_FHA_2	184	190	PF00498	0.383
LIG_FHA_2	274	280	PF00498	0.463
LIG_FHA_2	342	348	PF00498	0.386
LIG_FHA_2	45	51	PF00498	0.396
LIG_FHA_2	9	15	PF00498	0.365
LIG_FHA_2	96	102	PF00498	0.423
LIG_LIR_Gen_1	19	29	PF02991	0.368
LIG_LIR_Gen_1	199	207	PF02991	0.387
LIG_LIR_Gen_1	92	100	PF02991	0.388
LIG_LIR_Nem_3	19	25	PF02991	0.368
LIG_LIR_Nem_3	199	204	PF02991	0.382
LIG_LIR_Nem_3	428	434	PF02991	0.570
LIG_LIR_Nem_3	92	97	PF02991	0.379
LIG_NRBOX	322	328	PF00104	0.420
LIG_PCNA_yPIPBox_3	424	437	PF02747	0.461
LIG_Pex14_1	208	212	PF04695	0.363
LIG_Pex14_2	90	94	PF04695	0.370
LIG_REV1ctd_RIR_1	123	134	PF16727	0.337
LIG_SH2_CRK	201	205	PF00017	0.414
LIG_SH2_CRK	431	435	PF00017	0.510
LIG_SH2_SRC	179	182	PF00017	0.501
LIG_SH2_STAP1	309	313	PF00017	0.719
LIG_SH2_STAT5	155	158	PF00017	0.318
LIG_SH2_STAT5	179	182	PF00017	0.461
LIG_SH2_STAT5	212	215	PF00017	0.301
LIG_SH2_STAT5	96	99	PF00017	0.415
LIG_SH3_3	302	308	PF00018	0.743
LIG_SUMO_SIM_anti_2	263	269	PF11976	0.368
LIG_SUMO_SIM_par_1	11	19	PF11976	0.332
LIG_SUMO_SIM_par_1	238	245	PF11976	0.329
LIG_SUMO_SIM_par_1	248	258	PF11976	0.415
LIG_SUMO_SIM_par_1	263	269	PF11976	0.276
LIG_SUMO_SIM_par_1	339	345	PF11976	0.384
LIG_SUMO_SIM_par_1	44	51	PF11976	0.318
LIG_TRAF2_1	18	21	PF00917	0.332
LIG_UBA3_1	193	198	PF00899	0.502
LIG_UBA3_1	266	275	PF00899	0.551
MOD_CK1_1	241	247	PF00069	0.346
MOD_CK1_1	254	260	PF00069	0.413
MOD_CK1_1	283	289	PF00069	0.635
MOD_CK1_1	301	307	PF00069	0.639
MOD_CK1_1	319	325	PF00069	0.328
MOD_CK1_1	391	397	PF00069	0.566
MOD_CK1_1	433	439	PF00069	0.629
MOD_CK1_1	61	67	PF00069	0.450
MOD_CK2_1	15	21	PF00069	0.287
MOD_CK2_1	183	189	PF00069	0.393
MOD_CK2_1	273	279	PF00069	0.589
MOD_CK2_1	331	337	PF00069	0.522
MOD_CK2_1	391	397	PF00069	0.571
MOD_CK2_1	404	410	PF00069	0.608
MOD_CK2_1	8	14	PF00069	0.363
MOD_CK2_1	95	101	PF00069	0.423
MOD_GlcNHglycan	282	285	PF01048	0.679
MOD_GlcNHglycan	287	290	PF01048	0.677
MOD_GlcNHglycan	299	303	PF01048	0.576
MOD_GlcNHglycan	318	321	PF01048	0.416
MOD_GlcNHglycan	323	326	PF01048	0.418
MOD_GlcNHglycan	393	396	PF01048	0.557
MOD_GlcNHglycan	402	405	PF01048	0.450
MOD_GlcNHglycan	406	409	PF01048	0.696
MOD_GlcNHglycan	69	72	PF01048	0.404
MOD_GSK3_1	217	224	PF00069	0.303
MOD_GSK3_1	251	258	PF00069	0.559
MOD_GSK3_1	280	287	PF00069	0.675
MOD_GSK3_1	297	304	PF00069	0.657
MOD_GSK3_1	341	348	PF00069	0.397
MOD_GSK3_1	400	407	PF00069	0.587
MOD_GSK3_1	411	418	PF00069	0.595
MOD_GSK3_1	435	442	PF00069	0.606
MOD_GSK3_1	5	12	PF00069	0.383
MOD_N-GLC_1	345	350	PF02516	0.490
MOD_NEK2_1	121	126	PF00069	0.391
MOD_NEK2_1	197	202	PF00069	0.405
MOD_NEK2_1	253	258	PF00069	0.432
MOD_NEK2_1	285	290	PF00069	0.644
MOD_NEK2_1	321	326	PF00069	0.532
MOD_NEK2_1	341	346	PF00069	0.186
MOD_NEK2_1	380	385	PF00069	0.446
MOD_NEK2_1	90	95	PF00069	0.317
MOD_NEK2_2	174	179	PF00069	0.337
MOD_PIKK_1	16	22	PF00454	0.402
MOD_PKA_2	148	154	PF00069	0.341
MOD_PKA_2	15	21	PF00069	0.332
MOD_PKA_2	260	266	PF00069	0.523
MOD_PKA_2	75	81	PF00069	0.364
MOD_Plk_1	346	352	PF00069	0.453
MOD_Plk_1	380	386	PF00069	0.517
MOD_Plk_1	411	417	PF00069	0.662
MOD_Plk_2-3	183	189	PF00069	0.319
MOD_Plk_4	121	127	PF00069	0.408
MOD_Plk_4	174	180	PF00069	0.360
MOD_Plk_4	183	189	PF00069	0.390
MOD_Plk_4	221	227	PF00069	0.318
MOD_Plk_4	5	11	PF00069	0.422
MOD_Plk_4	51	57	PF00069	0.373
MOD_Plk_4	75	81	PF00069	0.341
MOD_Plk_4	90	96	PF00069	0.433
MOD_ProDKin_1	273	279	PF00069	0.595
MOD_ProDKin_1	301	307	PF00069	0.698
MOD_ProDKin_1	388	394	PF00069	0.532
MOD_ProDKin_1	415	421	PF00069	0.473
MOD_ProDKin_1	56	62	PF00069	0.368
MOD_SUMO_rev_2	50	55	PF00179	0.411
TRG_DiLeu_BaEn_1	337	342	PF01217	0.384
TRG_DiLeu_BaEn_3	189	195	PF01217	0.431
TRG_DiLeu_BaLyEn_6	336	341	PF01217	0.410
TRG_DiLeu_BaLyEn_6	422	427	PF01217	0.508
TRG_ENDOCYTIC_2	201	204	PF00928	0.379
TRG_ENDOCYTIC_2	431	434	PF00928	0.582
TRG_ER_diArg_1	128	130	PF00400	0.397
TRG_ER_diArg_1	170	173	PF00400	0.321
TRG_ER_diArg_1	208	210	PF00400	0.404
TRG_ER_diArg_1	260	262	PF00400	0.571
TRG_ER_diArg_1	365	368	PF00400	0.449
TRG_ER_diArg_1	437	440	PF00400	0.468
TRG_NES_CRM1_1	169	183	PF08389	0.423
TRG_NES_CRM1_1	232	245	PF08389	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFP5	Leptomonas seymouri	70%	96%
A0A0S4IXD9	Bodo saltans	32%	100%
A0A1X0NQP6	Trypanosomatidae	28%	94%
A0A1X0P1R2	Trypanosomatidae	45%	81%
A0A3Q8IUI9	Leishmania donovani	29%	100%
A0A3R7RKG3	Trypanosoma rangeli	44%	100%
A0A422MTV6	Trypanosoma rangeli	30%	94%
A4HAQ0	Leishmania braziliensis	27%	100%
A4HQ55	Leishmania braziliensis	88%	100%
A4IDV4	Leishmania infantum	100%	100%
C9ZVE3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	92%
D0A462	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	83%
E9ATX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
F4IQG2	Arabidopsis thaliana	28%	90%
P32839	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	97%
Q4Q0M1	Leishmania major	94%	99%
Q54DY9	Dictyostelium discoideum	30%	97%
Q54HY8	Dictyostelium discoideum	31%	100%
Q5E9H5	Bos taurus	28%	100%
Q7ZTL7	Xenopus laevis	28%	100%
Q7ZV60	Danio rerio	27%	100%
Q8GW96	Arabidopsis thaliana	29%	89%
Q9CZP5	Mus musculus	27%	100%
Q9FLD5	Arabidopsis thaliana	28%	86%
Q9LH83	Arabidopsis thaliana	26%	90%
Q9LJJ7	Arabidopsis thaliana	26%	89%
Q9LP11	Arabidopsis thaliana	28%	93%
Q9P6Q3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	99%
Q9Y276	Homo sapiens	27%	100%
V5BA71	Trypanosoma cruzi	30%	95%
V5BUW7	Trypanosoma cruzi	47%	80%
V5DQN5	Trypanosoma cruzi	23%	85%