Exosome-associated_protein_4_putative/GeneDB:LmjF.36.4895

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exosome-associated protein 4, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBS2_LEIDO

TriTrypDb:

LdBPK_365120.1 , LdCL_360058400 , LDHU3_36.6840

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000176	nuclear exosome (RNase complex)	3	1
GO:0000177	cytoplasmic exosome (RNase complex)	5	1
GO:0000178	exosome (RNase complex)	4	1
GO:0005730	nucleolus	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1905354	exoribonuclease complex	3	1

Expansion

Sequence features

A0A3S7XBS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBS2

Function

Biological processes
Term	Name	Level	Count
GO:0000291	nuclear-transcribed mRNA catabolic process, exonucleolytic	8	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0016073	snRNA metabolic process	7	1
GO:0016074	sno(s)RNA metabolic process	7	1
GO:0016075	rRNA catabolic process	7	1
GO:0016180	snRNA processing	8	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031126	sno(s)RNA 3'-end processing	9	1
GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'	9	1
GO:0034470	ncRNA processing	7	1
GO:0034472	snRNA 3'-end processing	8	1
GO:0034475	U4 snRNA 3'-end processing	9	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0034660	ncRNA metabolic process	6	1
GO:0034661	ncRNA catabolic process	6	1
GO:0043144	sno(s)RNA processing	8	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043628	regulatory ncRNA 3'-end processing	8	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071025	RNA surveillance	6	1
GO:0071027	nuclear RNA surveillance	7	1
GO:0071028	nuclear mRNA surveillance	8	1
GO:0071051	polyadenylation-dependent snoRNA 3'-end processing	10	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	72	76	PF00656	0.438
CLV_NRD_NRD_1	148	150	PF00675	0.497
CLV_NRD_NRD_1	207	209	PF00675	0.499
CLV_PCSK_KEX2_1	148	150	PF00082	0.497
CLV_PCSK_KEX2_1	2	4	PF00082	0.551
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.571
DEG_Nend_UBRbox_1	1	4	PF02207	0.618
DOC_CDC14_PxL_1	96	104	PF14671	0.419
DOC_MAPK_gen_1	148	155	PF00069	0.444
DOC_MAPK_MEF2A_6	148	157	PF00069	0.645
DOC_USP7_MATH_1	165	169	PF00917	0.584
DOC_USP7_MATH_1	69	73	PF00917	0.486
DOC_WW_Pin1_4	6	11	PF00397	0.550
LIG_14-3-3_CanoR_1	66	74	PF00244	0.445
LIG_FHA_1	120	126	PF00498	0.513
LIG_FHA_1	18	24	PF00498	0.510
LIG_FHA_1	200	206	PF00498	0.647
LIG_FHA_1	35	41	PF00498	0.346
LIG_FHA_2	156	162	PF00498	0.561
LIG_LIR_Gen_1	135	145	PF02991	0.497
LIG_LIR_Nem_3	135	140	PF02991	0.510
LIG_MAD2	38	46	PF02301	0.475
LIG_MYND_3	210	214	PF01753	0.562
LIG_PCNA_yPIPBox_3	98	108	PF02747	0.378
LIG_SH2_STAT5	182	185	PF00017	0.553
LIG_SH3_3	40	46	PF00018	0.419
LIG_SUMO_SIM_par_1	153	158	PF11976	0.629
LIG_TRAF2_1	158	161	PF00917	0.515
LIG_WRC_WIRS_1	137	142	PF05994	0.574
MOD_CDK_SPK_2	6	11	PF00069	0.492
MOD_CK1_1	141	147	PF00069	0.558
MOD_CK1_1	173	179	PF00069	0.554
MOD_CK1_1	67	73	PF00069	0.455
MOD_CK2_1	155	161	PF00069	0.561
MOD_GlcNHglycan	140	143	PF01048	0.564
MOD_GlcNHglycan	172	175	PF01048	0.578
MOD_GlcNHglycan	28	31	PF01048	0.219
MOD_GlcNHglycan	75	79	PF01048	0.315
MOD_GSK3_1	161	168	PF00069	0.546
MOD_GSK3_1	64	71	PF00069	0.429
MOD_NEK2_1	68	73	PF00069	0.456
MOD_PIKK_1	192	198	PF00454	0.541
MOD_PKA_2	53	59	PF00069	0.440
MOD_Plk_1	189	195	PF00069	0.602
MOD_Plk_4	165	171	PF00069	0.607
MOD_ProDKin_1	6	12	PF00069	0.551
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.569
TRG_ENDOCYTIC_2	137	140	PF00928	0.498
TRG_ER_diArg_1	147	149	PF00400	0.489
TRG_ER_diArg_1	57	60	PF00400	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4R2	Leptomonas seymouri	80%	100%
A0A0N1ILN0	Leptomonas seymouri	28%	90%
A0A1X0P328	Trypanosomatidae	52%	97%
A0A3S7XB24	Leishmania donovani	28%	100%
A0A422NC95	Trypanosoma rangeli	50%	97%
A0RXU1	Cenarchaeum symbiosum (strain A)	30%	91%
A1RST0	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	29%	90%
A2BKC0	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	28%	87%
A3MUP1	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	26%	90%
A4HPG8	Leishmania braziliensis	23%	100%
A4HQ06	Leishmania braziliensis	90%	100%
A4ID90	Leishmania infantum	28%	100%
A4IDR7	Leishmania infantum	100%	100%
A8WQQ5	Caenorhabditis briggsae	28%	92%
A9A5C9	Nitrosopumilus maritimus (strain SCM1)	29%	91%
B1Y978	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	28%	90%
B6YSI2	Thermococcus onnurineus (strain NA1)	30%	89%
C5A2B9	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	28%	89%
D0A8W6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	95%
E9AT80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9ATS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O26779	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	25%	92%
O42872	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	91%
O59223	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	29%	89%
Q17533	Caenorhabditis elegans	28%	92%
Q28F19	Xenopus tropicalis	29%	82%
Q4JB27	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	24%	91%
Q4Q0S3	Leishmania major	98%	100%
Q4Q1B7	Leishmania major	28%	100%
Q5JIR6	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	30%	89%
Q5RKV6	Homo sapiens	33%	81%
Q6P0I8	Danio rerio	28%	82%
Q7YRA3	Bos taurus	31%	90%
Q8BTW3	Mus musculus	32%	81%
Q8TYC1	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	23%	92%
Q8U0L9	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	27%	88%
Q8ZVM9	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	27%	90%
Q921I9	Mus musculus	31%	90%
Q975G8	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	24%	91%
Q97BZ5	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	25%	89%
Q9HIP2	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	24%	89%
Q9LX74	Arabidopsis thaliana	26%	92%
Q9NPD3	Homo sapiens	31%	90%
Q9UXC2	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	25%	89%
Q9V119	Pyrococcus abyssi (strain GE5 / Orsay)	29%	89%
Q9YC03	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	26%	90%
V5AP50	Trypanosoma cruzi	49%	85%