Vacuolar sorting protein 9 (VPS9) domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar sorting protein 9 (VPS9) domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBS1_LEIDO

TriTrypDb:

LdBPK_364890.1 , LdCL_360056000 , LDHU3_36.6570

Length:

931

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0030139	endocytic vesicle	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XBS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBS1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0016192	vesicle-mediated transport	4	7
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7

Molecular functions
Term	Name	Level	Count
GO:0005085	guanyl-nucleotide exchange factor activity	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0030695	GTPase regulator activity	4	7
GO:0060589	nucleoside-triphosphatase regulator activity	3	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7
GO:0140678	molecular function inhibitor activity	2	7
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0031267	small GTPase binding	5	1
GO:0051020	GTPase binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.654
CLV_C14_Caspase3-7	5	9	PF00656	0.678
CLV_C14_Caspase3-7	816	820	PF00656	0.767
CLV_NRD_NRD_1	428	430	PF00675	0.633
CLV_NRD_NRD_1	490	492	PF00675	0.515
CLV_NRD_NRD_1	529	531	PF00675	0.544
CLV_NRD_NRD_1	603	605	PF00675	0.411
CLV_PCSK_FUR_1	601	605	PF00082	0.383
CLV_PCSK_KEX2_1	162	164	PF00082	0.489
CLV_PCSK_KEX2_1	428	430	PF00082	0.633
CLV_PCSK_KEX2_1	490	492	PF00082	0.515
CLV_PCSK_KEX2_1	529	531	PF00082	0.544
CLV_PCSK_KEX2_1	603	605	PF00082	0.411
CLV_PCSK_KEX2_1	607	609	PF00082	0.411
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.489
CLV_PCSK_PC1ET2_1	607	609	PF00082	0.436
CLV_PCSK_PC7_1	603	609	PF00082	0.436
CLV_PCSK_SKI1_1	122	126	PF00082	0.483
CLV_PCSK_SKI1_1	224	228	PF00082	0.449
CLV_PCSK_SKI1_1	349	353	PF00082	0.614
CLV_PCSK_SKI1_1	511	515	PF00082	0.467
CLV_PCSK_SKI1_1	604	608	PF00082	0.389
CLV_PCSK_SKI1_1	718	722	PF00082	0.704
CLV_PCSK_SKI1_1	743	747	PF00082	0.608
CLV_PCSK_SKI1_1	898	902	PF00082	0.501
CLV_PCSK_SKI1_1	924	928	PF00082	0.567
DEG_APCC_DBOX_1	223	231	PF00400	0.537
DEG_APCC_DBOX_1	498	506	PF00400	0.407
DEG_SCF_FBW7_1	242	248	PF00400	0.563
DEG_SCF_FBW7_1	489	496	PF00400	0.553
DOC_CDC14_PxL_1	251	259	PF14671	0.671
DOC_CKS1_1	242	247	PF01111	0.614
DOC_CYCLIN_RxL_1	534	543	PF00134	0.548
DOC_CYCLIN_RxL_1	894	903	PF00134	0.530
DOC_MAPK_gen_1	36	44	PF00069	0.513
DOC_MAPK_gen_1	894	902	PF00069	0.556
DOC_MAPK_MEF2A_6	587	596	PF00069	0.372
DOC_PP1_RVXF_1	643	650	PF00149	0.513
DOC_PP2B_LxvP_1	279	282	PF13499	0.809
DOC_PP2B_LxvP_1	42	45	PF13499	0.422
DOC_PP2B_LxvP_1	844	847	PF13499	0.792
DOC_PP2B_LxvP_1	882	885	PF13499	0.653
DOC_PP4_FxxP_1	575	578	PF00568	0.411
DOC_PP4_FxxP_1	659	662	PF00568	0.513
DOC_USP7_MATH_1	181	185	PF00917	0.676
DOC_USP7_MATH_1	392	396	PF00917	0.732
DOC_USP7_MATH_1	406	410	PF00917	0.720
DOC_USP7_MATH_1	471	475	PF00917	0.516
DOC_USP7_MATH_1	663	667	PF00917	0.429
DOC_USP7_MATH_1	773	777	PF00917	0.735
DOC_USP7_MATH_1	802	806	PF00917	0.720
DOC_USP7_MATH_1	813	817	PF00917	0.800
DOC_USP7_MATH_1	822	826	PF00917	0.624
DOC_USP7_UBL2_3	237	241	PF12436	0.559
DOC_WW_Pin1_4	241	246	PF00397	0.578
DOC_WW_Pin1_4	489	494	PF00397	0.511
DOC_WW_Pin1_4	574	579	PF00397	0.411
DOC_WW_Pin1_4	697	702	PF00397	0.643
DOC_WW_Pin1_4	842	847	PF00397	0.765
DOC_WW_Pin1_4	880	885	PF00397	0.744
DOC_WW_Pin1_4	889	894	PF00397	0.658
DOC_WW_Pin1_4	91	96	PF00397	0.824
LIG_14-3-3_CanoR_1	246	252	PF00244	0.667
LIG_14-3-3_CanoR_1	339	346	PF00244	0.706
LIG_14-3-3_CanoR_1	444	449	PF00244	0.507
LIG_14-3-3_CanoR_1	46	51	PF00244	0.482
LIG_14-3-3_CanoR_1	473	481	PF00244	0.601
LIG_14-3-3_CanoR_1	494	502	PF00244	0.641
LIG_14-3-3_CanoR_1	511	518	PF00244	0.320
LIG_14-3-3_CanoR_1	645	650	PF00244	0.404
LIG_BIR_II_1	1	5	PF00653	0.570
LIG_BIR_III_2	551	555	PF00653	0.478
LIG_BRCT_BRCA1_1	678	682	PF00533	0.477
LIG_BRCT_BRCA1_1	78	82	PF00533	0.667
LIG_Clathr_ClatBox_1	133	137	PF01394	0.478
LIG_Clathr_ClatBox_1	539	543	PF01394	0.622
LIG_CtBP_PxDLS_1	724	728	PF00389	0.678
LIG_DLG_GKlike_1	46	53	PF00625	0.482
LIG_FHA_1	124	130	PF00498	0.529
LIG_FHA_1	242	248	PF00498	0.658
LIG_FHA_1	304	310	PF00498	0.719
LIG_FHA_1	490	496	PF00498	0.612
LIG_FHA_1	512	518	PF00498	0.459
LIG_FHA_2	739	745	PF00498	0.707
LIG_FHA_2	785	791	PF00498	0.682
LIG_FHA_2	910	916	PF00498	0.541
LIG_LIR_Apic_2	573	578	PF02991	0.411
LIG_LIR_Apic_2	657	662	PF02991	0.513
LIG_LIR_Gen_1	130	139	PF02991	0.485
LIG_LIR_Gen_1	436	446	PF02991	0.490
LIG_LIR_Gen_1	475	482	PF02991	0.501
LIG_LIR_Gen_1	515	524	PF02991	0.487
LIG_LIR_Gen_1	907	916	PF02991	0.531
LIG_LIR_Nem_3	119	124	PF02991	0.518
LIG_LIR_Nem_3	126	131	PF02991	0.450
LIG_LIR_Nem_3	142	147	PF02991	0.472
LIG_LIR_Nem_3	426	430	PF02991	0.551
LIG_LIR_Nem_3	436	442	PF02991	0.526
LIG_LIR_Nem_3	475	481	PF02991	0.508
LIG_LIR_Nem_3	515	521	PF02991	0.482
LIG_LIR_Nem_3	907	911	PF02991	0.539
LIG_MYND_1	880	884	PF01753	0.586
LIG_PCNA_yPIPBox_3	499	513	PF02747	0.591
LIG_Pex14_2	438	442	PF04695	0.600
LIG_Pex14_2	633	637	PF04695	0.411
LIG_Pex14_2	682	686	PF04695	0.246
LIG_PTB_Apo_2	138	145	PF02174	0.648
LIG_PTB_Apo_2	649	656	PF02174	0.411
LIG_PTB_Phospho_1	649	655	PF10480	0.411
LIG_REV1ctd_RIR_1	572	577	PF16727	0.411
LIG_SH2_CRK	131	135	PF00017	0.454
LIG_SH2_CRK	427	431	PF00017	0.538
LIG_SH2_CRK	518	522	PF00017	0.478
LIG_SH2_NCK_1	331	335	PF00017	0.759
LIG_SH2_STAP1	277	281	PF00017	0.733
LIG_SH2_STAT5	327	330	PF00017	0.773
LIG_SH2_STAT5	331	334	PF00017	0.695
LIG_SH2_STAT5	461	464	PF00017	0.615
LIG_SH2_STAT5	512	515	PF00017	0.464
LIG_SH2_STAT5	58	61	PF00017	0.627
LIG_SH2_STAT5	655	658	PF00017	0.438
LIG_SH2_STAT5	671	674	PF00017	0.411
LIG_SH3_3	108	114	PF00018	0.751
LIG_SH3_3	196	202	PF00018	0.600
LIG_SH3_3	249	255	PF00018	0.780
LIG_SH3_3	316	322	PF00018	0.809
LIG_SH3_3	848	854	PF00018	0.648
LIG_Sin3_3	637	644	PF02671	0.411
LIG_SUMO_SIM_anti_2	49	54	PF11976	0.560
LIG_SUMO_SIM_anti_2	500	507	PF11976	0.510
LIG_SUMO_SIM_anti_2	787	793	PF11976	0.675
LIG_SUMO_SIM_par_1	306	313	PF11976	0.721
LIG_TRAF2_1	666	669	PF00917	0.411
LIG_TRAF2_1	780	783	PF00917	0.662
LIG_TRAF2_2	95	100	PF00917	0.769
LIG_TYR_ITIM	129	134	PF00017	0.449
LIG_UBA3_1	207	212	PF00899	0.501
LIG_UBA3_1	29	36	PF00899	0.505
LIG_WW_3	845	849	PF00397	0.700
MOD_CDC14_SPxK_1	845	848	PF00782	0.776
MOD_CDK_SPK_2	241	246	PF00069	0.556
MOD_CDK_SPK_2	489	494	PF00069	0.557
MOD_CDK_SPK_2	574	579	PF00069	0.411
MOD_CDK_SPK_2	889	894	PF00069	0.508
MOD_CDK_SPxK_1	842	848	PF00069	0.783
MOD_CDK_SPxxK_3	574	581	PF00069	0.411
MOD_CDK_SPxxK_3	889	896	PF00069	0.493
MOD_CK1_1	142	148	PF00069	0.512
MOD_CK1_1	184	190	PF00069	0.623
MOD_CK1_1	233	239	PF00069	0.674
MOD_CK1_1	280	286	PF00069	0.707
MOD_CK1_1	3	9	PF00069	0.521
MOD_CK1_1	342	348	PF00069	0.713
MOD_CK1_1	373	379	PF00069	0.795
MOD_CK1_1	67	73	PF00069	0.762
MOD_CK1_1	827	833	PF00069	0.729
MOD_CK1_1	889	895	PF00069	0.714
MOD_CK2_1	150	156	PF00069	0.534
MOD_CK2_1	233	239	PF00069	0.587
MOD_CK2_1	28	34	PF00069	0.519
MOD_CK2_1	301	307	PF00069	0.718
MOD_CK2_1	344	350	PF00069	0.709
MOD_CK2_1	437	443	PF00069	0.540
MOD_CK2_1	522	528	PF00069	0.559
MOD_CK2_1	574	580	PF00069	0.411
MOD_CK2_1	663	669	PF00069	0.459
MOD_CK2_1	777	783	PF00069	0.846
MOD_CK2_1	853	859	PF00069	0.641
MOD_CK2_1	909	915	PF00069	0.508
MOD_GlcNHglycan	147	150	PF01048	0.606
MOD_GlcNHglycan	183	186	PF01048	0.689
MOD_GlcNHglycan	191	194	PF01048	0.696
MOD_GlcNHglycan	232	235	PF01048	0.565
MOD_GlcNHglycan	279	282	PF01048	0.749
MOD_GlcNHglycan	346	349	PF01048	0.679
MOD_GlcNHglycan	353	356	PF01048	0.642
MOD_GlcNHglycan	375	378	PF01048	0.678
MOD_GlcNHglycan	474	477	PF01048	0.502
MOD_GlcNHglycan	495	498	PF01048	0.421
MOD_GlcNHglycan	617	620	PF01048	0.408
MOD_GlcNHglycan	69	73	PF01048	0.739
MOD_GlcNHglycan	703	706	PF01048	0.700
MOD_GlcNHglycan	713	716	PF01048	0.546
MOD_GlcNHglycan	727	730	PF01048	0.737
MOD_GlcNHglycan	78	81	PF01048	0.768
MOD_GlcNHglycan	819	823	PF01048	0.752
MOD_GlcNHglycan	855	858	PF01048	0.807
MOD_GSK3_1	184	191	PF00069	0.672
MOD_GSK3_1	241	248	PF00069	0.655
MOD_GSK3_1	293	300	PF00069	0.703
MOD_GSK3_1	301	308	PF00069	0.689
MOD_GSK3_1	456	463	PF00069	0.466
MOD_GSK3_1	489	496	PF00069	0.541
MOD_GSK3_1	64	71	PF00069	0.712
MOD_GSK3_1	663	670	PF00069	0.459
MOD_GSK3_1	672	679	PF00069	0.366
MOD_GSK3_1	697	704	PF00069	0.720
MOD_GSK3_1	763	770	PF00069	0.696
MOD_GSK3_1	773	780	PF00069	0.762
MOD_GSK3_1	818	825	PF00069	0.735
MOD_GSK3_1	827	834	PF00069	0.790
MOD_GSK3_1	900	907	PF00069	0.455
MOD_LATS_1	269	275	PF00433	0.599
MOD_N-GLC_1	145	150	PF02516	0.590
MOD_N-GLC_1	392	397	PF02516	0.694
MOD_N-GLC_1	522	527	PF02516	0.539
MOD_N-GLC_1	763	768	PF02516	0.723
MOD_N-GLC_1	889	894	PF02516	0.697
MOD_N-GLC_1	904	909	PF02516	0.475
MOD_N-GLC_2	299	301	PF02516	0.728
MOD_NEK2_1	20	25	PF00069	0.483
MOD_NEK2_1	230	235	PF00069	0.576
MOD_NEK2_1	247	252	PF00069	0.760
MOD_NEK2_1	305	310	PF00069	0.605
MOD_NEK2_1	351	356	PF00069	0.697
MOD_NEK2_1	370	375	PF00069	0.680
MOD_NEK2_1	59	64	PF00069	0.646
MOD_NEK2_1	676	681	PF00069	0.513
MOD_NEK2_1	900	905	PF00069	0.478
MOD_NEK2_2	406	411	PF00069	0.676
MOD_NEK2_2	713	718	PF00069	0.711
MOD_OFUCOSY	584	589	PF10250	0.513
MOD_PIKK_1	763	769	PF00454	0.705
MOD_PIKK_1	900	906	PF00454	0.529
MOD_PK_1	831	837	PF00069	0.714
MOD_PKA_2	150	156	PF00069	0.619
MOD_PKA_2	181	187	PF00069	0.606
MOD_PKA_2	245	251	PF00069	0.667
MOD_PKA_2	472	478	PF00069	0.601
MOD_PKA_2	493	499	PF00069	0.654
MOD_PKA_2	500	506	PF00069	0.496
MOD_PKA_2	64	70	PF00069	0.809
MOD_PKA_2	822	828	PF00069	0.737
MOD_PKA_2	847	853	PF00069	0.794
MOD_PKB_1	337	345	PF00069	0.692
MOD_PKB_1	643	651	PF00069	0.411
MOD_Plk_1	342	348	PF00069	0.770
MOD_Plk_1	667	673	PF00069	0.411
MOD_Plk_1	904	910	PF00069	0.530
MOD_Plk_2-3	777	783	PF00069	0.754
MOD_Plk_2-3	784	790	PF00069	0.671
MOD_Plk_2-3	909	915	PF00069	0.552
MOD_Plk_4	20	26	PF00069	0.550
MOD_Plk_4	247	253	PF00069	0.713
MOD_Plk_4	305	311	PF00069	0.709
MOD_Plk_4	500	506	PF00069	0.522
MOD_Plk_4	645	651	PF00069	0.393
MOD_Plk_4	676	682	PF00069	0.513
MOD_Plk_4	784	790	PF00069	0.738
MOD_ProDKin_1	241	247	PF00069	0.581
MOD_ProDKin_1	489	495	PF00069	0.506
MOD_ProDKin_1	574	580	PF00069	0.411
MOD_ProDKin_1	697	703	PF00069	0.644
MOD_ProDKin_1	842	848	PF00069	0.768
MOD_ProDKin_1	880	886	PF00069	0.747
MOD_ProDKin_1	889	895	PF00069	0.648
MOD_ProDKin_1	91	97	PF00069	0.826
MOD_SUMO_rev_2	233	242	PF00179	0.640
MOD_SUMO_rev_2	858	867	PF00179	0.612
TRG_DiLeu_BaEn_1	218	223	PF01217	0.396
TRG_DiLeu_BaEn_1	441	446	PF01217	0.583
TRG_DiLeu_BaEn_1	922	927	PF01217	0.546
TRG_DiLeu_BaEn_4	668	674	PF01217	0.436
TRG_ENDOCYTIC_2	131	134	PF00928	0.443
TRG_ENDOCYTIC_2	331	334	PF00928	0.761
TRG_ENDOCYTIC_2	427	430	PF00928	0.549
TRG_ENDOCYTIC_2	439	442	PF00928	0.488
TRG_ENDOCYTIC_2	478	481	PF00928	0.426
TRG_ENDOCYTIC_2	518	521	PF00928	0.540
TRG_ER_diArg_1	179	182	PF00400	0.659
TRG_ER_diArg_1	427	429	PF00400	0.608
TRG_ER_diArg_1	489	491	PF00400	0.503
TRG_ER_diArg_1	600	603	PF00400	0.383
TRG_ER_diArg_1	642	645	PF00400	0.411
TRG_ER_diArg_1	893	896	PF00400	0.660
TRG_Pf-PMV_PEXEL_1	924	929	PF00026	0.666

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7P3	Leptomonas seymouri	43%	92%
A4HPY3	Leishmania braziliensis	64%	100%
A4IDP4	Leishmania infantum	99%	100%
E9ATQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q0U8	Leishmania major	89%	100%