Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBQ9_LEIDO

TriTrypDb:

LdBPK_365020.1 , LdCL_360057400 , LDHU3_36.6740

Length:

926

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XBQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBQ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	565	569	PF00656	0.657
CLV_C14_Caspase3-7	89	93	PF00656	0.585
CLV_NRD_NRD_1	141	143	PF00675	0.528
CLV_NRD_NRD_1	149	151	PF00675	0.493
CLV_NRD_NRD_1	199	201	PF00675	0.457
CLV_NRD_NRD_1	234	236	PF00675	0.570
CLV_NRD_NRD_1	320	322	PF00675	0.551
CLV_NRD_NRD_1	394	396	PF00675	0.561
CLV_NRD_NRD_1	452	454	PF00675	0.562
CLV_NRD_NRD_1	531	533	PF00675	0.665
CLV_NRD_NRD_1	549	551	PF00675	0.695
CLV_NRD_NRD_1	580	582	PF00675	0.654
CLV_NRD_NRD_1	606	608	PF00675	0.523
CLV_NRD_NRD_1	614	616	PF00675	0.519
CLV_NRD_NRD_1	672	674	PF00675	0.517
CLV_NRD_NRD_1	714	716	PF00675	0.703
CLV_NRD_NRD_1	728	730	PF00675	0.554
CLV_NRD_NRD_1	754	756	PF00675	0.624
CLV_NRD_NRD_1	886	888	PF00675	0.705
CLV_NRD_NRD_1	909	911	PF00675	0.562
CLV_PCSK_FUR_1	547	551	PF00082	0.652
CLV_PCSK_FUR_1	884	888	PF00082	0.616
CLV_PCSK_KEX2_1	140	142	PF00082	0.526
CLV_PCSK_KEX2_1	148	150	PF00082	0.472
CLV_PCSK_KEX2_1	234	236	PF00082	0.512
CLV_PCSK_KEX2_1	320	322	PF00082	0.548
CLV_PCSK_KEX2_1	394	396	PF00082	0.502
CLV_PCSK_KEX2_1	403	405	PF00082	0.501
CLV_PCSK_KEX2_1	451	453	PF00082	0.558
CLV_PCSK_KEX2_1	488	490	PF00082	0.600
CLV_PCSK_KEX2_1	547	549	PF00082	0.647
CLV_PCSK_KEX2_1	614	616	PF00082	0.683
CLV_PCSK_KEX2_1	714	716	PF00082	0.703
CLV_PCSK_KEX2_1	728	730	PF00082	0.777
CLV_PCSK_KEX2_1	754	756	PF00082	0.680
CLV_PCSK_KEX2_1	883	885	PF00082	0.696
CLV_PCSK_KEX2_1	886	888	PF00082	0.673
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.604
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.566
CLV_PCSK_PC1ET2_1	883	885	PF00082	0.714
CLV_PCSK_PC7_1	144	150	PF00082	0.544
CLV_PCSK_SKI1_1	124	128	PF00082	0.578
CLV_PCSK_SKI1_1	157	161	PF00082	0.567
CLV_PCSK_SKI1_1	395	399	PF00082	0.547
CLV_PCSK_SKI1_1	453	457	PF00082	0.549
CLV_PCSK_SKI1_1	473	477	PF00082	0.429
CLV_PCSK_SKI1_1	488	492	PF00082	0.661
CLV_PCSK_SKI1_1	50	54	PF00082	0.441
CLV_PCSK_SKI1_1	586	590	PF00082	0.581
CLV_Separin_Metazoa	679	683	PF03568	0.583
DEG_APCC_DBOX_1	824	832	PF00400	0.634
DEG_Nend_Nbox_1	1	3	PF02207	0.650
DEG_SPOP_SBC_1	290	294	PF00917	0.581
DEG_SPOP_SBC_1	33	37	PF00917	0.566
DOC_CYCLIN_RxL_1	581	594	PF00134	0.561
DOC_CYCLIN_yCln2_LP_2	510	516	PF00134	0.648
DOC_MAPK_gen_1	883	893	PF00069	0.679
DOC_MAPK_HePTP_8	299	311	PF00069	0.549
DOC_MAPK_MEF2A_6	302	311	PF00069	0.554
DOC_PP1_RVXF_1	887	894	PF00149	0.720
DOC_PP2B_LxvP_1	106	109	PF13499	0.518
DOC_PP2B_LxvP_1	510	513	PF13499	0.652
DOC_PP4_FxxP_1	766	769	PF00568	0.685
DOC_PP4_FxxP_1	913	916	PF00568	0.577
DOC_USP7_MATH_1	109	113	PF00917	0.663
DOC_USP7_MATH_1	212	216	PF00917	0.578
DOC_USP7_MATH_1	223	227	PF00917	0.632
DOC_USP7_MATH_1	250	254	PF00917	0.516
DOC_USP7_MATH_1	26	30	PF00917	0.712
DOC_USP7_MATH_1	33	37	PF00917	0.669
DOC_USP7_MATH_1	455	459	PF00917	0.601
DOC_USP7_MATH_1	567	571	PF00917	0.709
DOC_USP7_MATH_1	722	726	PF00917	0.641
DOC_USP7_MATH_1	757	761	PF00917	0.671
DOC_USP7_MATH_1	772	776	PF00917	0.708
DOC_USP7_MATH_1	788	792	PF00917	0.688
DOC_USP7_MATH_1	846	850	PF00917	0.724
DOC_USP7_MATH_1	866	870	PF00917	0.662
DOC_USP7_UBL2_3	201	205	PF12436	0.482
DOC_USP7_UBL2_3	428	432	PF12436	0.593
DOC_USP7_UBL2_3	533	537	PF12436	0.684
DOC_WW_Pin1_4	116	121	PF00397	0.551
DOC_WW_Pin1_4	466	471	PF00397	0.595
DOC_WW_Pin1_4	524	529	PF00397	0.677
DOC_WW_Pin1_4	554	559	PF00397	0.676
DOC_WW_Pin1_4	702	707	PF00397	0.698
DOC_WW_Pin1_4	718	723	PF00397	0.668
DOC_WW_Pin1_4	82	87	PF00397	0.534
DOC_WW_Pin1_4	830	835	PF00397	0.710
DOC_WW_Pin1_4	852	857	PF00397	0.616
DOC_WW_Pin1_4	864	869	PF00397	0.642
DOC_WW_Pin1_4	897	902	PF00397	0.637
DOC_WW_Pin1_4	99	104	PF00397	0.534
LIG_14-3-3_CanoR_1	320	328	PF00244	0.590
LIG_14-3-3_CanoR_1	410	417	PF00244	0.597
LIG_14-3-3_CanoR_1	548	554	PF00244	0.653
LIG_14-3-3_CanoR_1	586	591	PF00244	0.591
LIG_14-3-3_CanoR_1	631	640	PF00244	0.671
LIG_14-3-3_CanoR_1	700	707	PF00244	0.645
LIG_14-3-3_CanoR_1	74	78	PF00244	0.618
LIG_14-3-3_CanoR_1	859	868	PF00244	0.608
LIG_14-3-3_CanoR_1	877	883	PF00244	0.750
LIG_14-3-3_CanoR_1	886	892	PF00244	0.668
LIG_14-3-3_CanoR_1	908	914	PF00244	0.654
LIG_APCC_ABBAyCdc20_2	395	401	PF00400	0.539
LIG_BIR_III_2	305	309	PF00653	0.472
LIG_BRCT_BRCA1_1	75	79	PF00533	0.569
LIG_BRCT_BRCA1_1	889	893	PF00533	0.688
LIG_Clathr_ClatBox_1	180	184	PF01394	0.439
LIG_eIF4E_1	823	829	PF01652	0.635
LIG_FHA_1	165	171	PF00498	0.633
LIG_FHA_1	291	297	PF00498	0.477
LIG_FHA_1	349	355	PF00498	0.601
LIG_FHA_1	470	476	PF00498	0.505
LIG_FHA_1	681	687	PF00498	0.639
LIG_FHA_1	699	705	PF00498	0.631
LIG_FHA_1	7	13	PF00498	0.783
LIG_FHA_1	734	740	PF00498	0.528
LIG_FHA_1	796	802	PF00498	0.766
LIG_FHA_1	877	883	PF00498	0.680
LIG_FHA_2	29	35	PF00498	0.721
LIG_FHA_2	442	448	PF00498	0.536
LIG_FHA_2	630	636	PF00498	0.574
LIG_FHA_2	738	744	PF00498	0.637
LIG_FHA_2	87	93	PF00498	0.635
LIG_FHA_2	9	15	PF00498	0.637
LIG_HCF-1_HBM_1	594	597	PF13415	0.480
LIG_Integrin_RGD_1	813	815	PF01839	0.579
LIG_IRF3_LxIS_1	307	312	PF10401	0.567
LIG_LIR_Apic_2	912	916	PF02991	0.624
LIG_LIR_Gen_1	827	837	PF02991	0.655
LIG_LIR_Gen_1	85	94	PF02991	0.509
LIG_LIR_Nem_3	827	832	PF02991	0.656
LIG_LIR_Nem_3	85	90	PF02991	0.506
LIG_MYND_1	466	470	PF01753	0.502
LIG_NRBOX	295	301	PF00104	0.584
LIG_Pex14_2	388	392	PF04695	0.481
LIG_PTB_Apo_2	505	512	PF02174	0.619
LIG_PTB_Phospho_1	505	511	PF10480	0.618
LIG_RPA_C_Fungi	441	453	PF08784	0.515
LIG_SH2_CRK	823	827	PF00017	0.639
LIG_SH2_NCK_1	511	515	PF00017	0.650
LIG_SH2_NCK_1	823	827	PF00017	0.591
LIG_SH2_SRC	399	402	PF00017	0.539
LIG_SH2_SRC	511	514	PF00017	0.651
LIG_SH2_STAP1	171	175	PF00017	0.566
LIG_SH2_STAP1	326	330	PF00017	0.580
LIG_SH2_STAT3	474	477	PF00017	0.544
LIG_SH2_STAT3	597	600	PF00017	0.481
LIG_SH2_STAT5	10	13	PF00017	0.604
LIG_SH2_STAT5	474	477	PF00017	0.493
LIG_SH3_1	460	466	PF00018	0.548
LIG_SH3_3	20	26	PF00018	0.547
LIG_SH3_3	225	231	PF00018	0.492
LIG_SH3_3	301	307	PF00018	0.546
LIG_SH3_3	357	363	PF00018	0.720
LIG_SH3_3	411	417	PF00018	0.479
LIG_SH3_3	460	466	PF00018	0.570
LIG_SH3_3	681	687	PF00018	0.743
LIG_SH3_3	716	722	PF00018	0.769
LIG_SH3_3	72	78	PF00018	0.589
LIG_SH3_3	761	767	PF00018	0.689
LIG_SH3_3	791	797	PF00018	0.600
LIG_SUMO_SIM_par_1	307	312	PF11976	0.543
LIG_SUMO_SIM_par_1	586	591	PF11976	0.546
LIG_TRAF2_1	182	185	PF00917	0.411
LIG_TRAF2_1	413	416	PF00917	0.620
LIG_TRAF2_1	619	622	PF00917	0.539
MOD_CDC14_SPxK_1	102	105	PF00782	0.553
MOD_CDC14_SPxK_1	705	708	PF00782	0.589
MOD_CDK_SPK_2	554	559	PF00069	0.658
MOD_CDK_SPxK_1	702	708	PF00069	0.616
MOD_CDK_SPxK_1	99	105	PF00069	0.557
MOD_CDK_SPxxK_3	466	473	PF00069	0.575
MOD_CDK_SPxxK_3	852	859	PF00069	0.618
MOD_CK1_1	116	122	PF00069	0.761
MOD_CK1_1	274	280	PF00069	0.567
MOD_CK1_1	312	318	PF00069	0.642
MOD_CK1_1	344	350	PF00069	0.611
MOD_CK1_1	441	447	PF00069	0.586
MOD_CK1_1	469	475	PF00069	0.604
MOD_CK1_1	496	502	PF00069	0.687
MOD_CK1_1	5	11	PF00069	0.622
MOD_CK1_1	552	558	PF00069	0.736
MOD_CK1_1	691	697	PF00069	0.671
MOD_CK1_1	698	704	PF00069	0.685
MOD_CK1_1	804	810	PF00069	0.689
MOD_CK1_1	827	833	PF00069	0.672
MOD_CK1_1	838	844	PF00069	0.688
MOD_CK2_1	26	32	PF00069	0.728
MOD_CK2_1	289	295	PF00069	0.500
MOD_CK2_1	441	447	PF00069	0.550
MOD_CK2_1	455	461	PF00069	0.655
MOD_CK2_1	567	573	PF00069	0.677
MOD_CK2_1	718	724	PF00069	0.726
MOD_CK2_1	737	743	PF00069	0.639
MOD_CK2_1	8	14	PF00069	0.686
MOD_CK2_1	889	895	PF00069	0.755
MOD_Cter_Amidation	318	321	PF01082	0.517
MOD_Cter_Amidation	908	911	PF01082	0.580
MOD_GlcNHglycan	111	114	PF01048	0.751
MOD_GlcNHglycan	120	123	PF01048	0.521
MOD_GlcNHglycan	273	276	PF01048	0.569
MOD_GlcNHglycan	314	317	PF01048	0.622
MOD_GlcNHglycan	346	349	PF01048	0.688
MOD_GlcNHglycan	374	377	PF01048	0.498
MOD_GlcNHglycan	420	423	PF01048	0.683
MOD_GlcNHglycan	440	443	PF01048	0.367
MOD_GlcNHglycan	457	460	PF01048	0.653
MOD_GlcNHglycan	495	498	PF01048	0.722
MOD_GlcNHglycan	568	572	PF01048	0.644
MOD_GlcNHglycan	641	644	PF01048	0.731
MOD_GlcNHglycan	660	663	PF01048	0.514
MOD_GlcNHglycan	690	693	PF01048	0.683
MOD_GlcNHglycan	837	840	PF01048	0.684
MOD_GlcNHglycan	843	846	PF01048	0.727
MOD_GlcNHglycan	848	851	PF01048	0.770
MOD_GlcNHglycan	868	871	PF01048	0.737
MOD_GlcNHglycan	922	925	PF01048	0.700
MOD_GSK3_1	109	116	PF00069	0.721
MOD_GSK3_1	2	9	PF00069	0.748
MOD_GSK3_1	212	219	PF00069	0.557
MOD_GSK3_1	28	35	PF00069	0.724
MOD_GSK3_1	307	314	PF00069	0.644
MOD_GSK3_1	344	351	PF00069	0.695
MOD_GSK3_1	368	375	PF00069	0.552
MOD_GSK3_1	489	496	PF00069	0.604
MOD_GSK3_1	522	529	PF00069	0.753
MOD_GSK3_1	548	555	PF00069	0.792
MOD_GSK3_1	691	698	PF00069	0.655
MOD_GSK3_1	718	725	PF00069	0.648
MOD_GSK3_1	733	740	PF00069	0.617
MOD_GSK3_1	801	808	PF00069	0.768
MOD_GSK3_1	82	89	PF00069	0.594
MOD_GSK3_1	860	867	PF00069	0.713
MOD_LATS_1	524	530	PF00433	0.659
MOD_LATS_1	584	590	PF00433	0.573
MOD_N-GLC_1	164	169	PF02516	0.598
MOD_N-GLC_1	300	305	PF02516	0.573
MOD_N-GLC_1	342	347	PF02516	0.667
MOD_N-GLC_1	537	542	PF02516	0.606
MOD_N-GLC_1	694	699	PF02516	0.625
MOD_N-GLC_1	887	892	PF02516	0.667
MOD_NEK2_1	309	314	PF00069	0.633
MOD_NEK2_1	409	414	PF00069	0.584
MOD_NEK2_1	438	443	PF00069	0.608
MOD_NEK2_1	680	685	PF00069	0.690
MOD_NEK2_1	73	78	PF00069	0.575
MOD_NEK2_1	871	876	PF00069	0.734
MOD_NEK2_1	878	883	PF00069	0.659
MOD_PIKK_1	213	219	PF00454	0.563
MOD_PIKK_1	223	229	PF00454	0.540
MOD_PIKK_1	26	32	PF00454	0.789
MOD_PIKK_1	489	495	PF00454	0.641
MOD_PIKK_1	526	532	PF00454	0.672
MOD_PIKK_1	758	764	PF00454	0.658
MOD_PK_1	887	893	PF00069	0.619
MOD_PKA_1	488	494	PF00069	0.633
MOD_PKA_1	548	554	PF00069	0.701
MOD_PKA_2	319	325	PF00069	0.601
MOD_PKA_2	409	415	PF00069	0.605
MOD_PKA_2	488	494	PF00069	0.633
MOD_PKA_2	531	537	PF00069	0.759
MOD_PKA_2	548	554	PF00069	0.692
MOD_PKA_2	699	705	PF00069	0.726
MOD_PKA_2	73	79	PF00069	0.621
MOD_PKA_2	824	830	PF00069	0.634
MOD_PKA_2	876	882	PF00069	0.633
MOD_PKA_2	909	915	PF00069	0.565
MOD_PKB_1	547	555	PF00069	0.655
MOD_PKB_1	629	637	PF00069	0.627
MOD_PKB_1	715	723	PF00069	0.592
MOD_PKB_1	887	895	PF00069	0.621
MOD_Plk_1	207	213	PF00069	0.510
MOD_Plk_1	300	306	PF00069	0.563
MOD_Plk_1	5	11	PF00069	0.716
MOD_Plk_1	624	630	PF00069	0.658
MOD_Plk_1	887	893	PF00069	0.741
MOD_Plk_2-3	28	34	PF00069	0.540
MOD_Plk_4	216	222	PF00069	0.591
MOD_Plk_4	824	830	PF00069	0.652
MOD_Plk_4	889	895	PF00069	0.610
MOD_ProDKin_1	116	122	PF00069	0.549
MOD_ProDKin_1	466	472	PF00069	0.594
MOD_ProDKin_1	524	530	PF00069	0.676
MOD_ProDKin_1	554	560	PF00069	0.676
MOD_ProDKin_1	702	708	PF00069	0.699
MOD_ProDKin_1	718	724	PF00069	0.668
MOD_ProDKin_1	82	88	PF00069	0.534
MOD_ProDKin_1	830	836	PF00069	0.708
MOD_ProDKin_1	852	858	PF00069	0.621
MOD_ProDKin_1	864	870	PF00069	0.641
MOD_ProDKin_1	897	903	PF00069	0.638
MOD_ProDKin_1	99	105	PF00069	0.535
MOD_SUMO_for_1	402	405	PF00179	0.499
MOD_SUMO_rev_2	197	207	PF00179	0.476
MOD_SUMO_rev_2	529	539	PF00179	0.680
MOD_SUMO_rev_2	613	620	PF00179	0.581
TRG_DiLeu_BaEn_1	295	300	PF01217	0.578
TRG_DiLeu_BaEn_1	676	681	PF01217	0.567
TRG_DiLeu_BaLyEn_6	183	188	PF01217	0.434
TRG_ENDOCYTIC_2	190	193	PF00928	0.513
TRG_ENDOCYTIC_2	399	402	PF00928	0.463
TRG_ENDOCYTIC_2	42	45	PF00928	0.577
TRG_ER_diArg_1	139	142	PF00400	0.572
TRG_ER_diArg_1	148	150	PF00400	0.527
TRG_ER_diArg_1	334	337	PF00400	0.533
TRG_ER_diArg_1	393	395	PF00400	0.565
TRG_ER_diArg_1	451	453	PF00400	0.615
TRG_ER_diArg_1	547	550	PF00400	0.650
TRG_ER_diArg_1	628	631	PF00400	0.599
TRG_ER_diArg_1	713	715	PF00400	0.693
TRG_ER_diArg_1	884	887	PF00400	0.656
TRG_ER_diArg_1	907	910	PF00400	0.758
TRG_NES_CRM1_1	173	185	PF08389	0.508
TRG_NLS_MonoExtC_3	882	887	PF00514	0.673
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	586	591	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	744	748	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6T1	Leptomonas seymouri	43%	97%
A4HPZ6	Leishmania braziliensis	69%	99%
A4IDQ7	Leishmania infantum	100%	100%
D0A4F0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ATR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q0T4	Leishmania major	88%	100%
V5BQ47	Trypanosoma cruzi	27%	100%