Calponin homology (CH) domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBQ1_LEIDO

TriTrypDb:

LdBPK_365150.1 , LdCL_360058700 , LDHU3_36.6890

Length:

696

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0005938	cell cortex	3	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3S7XBQ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBQ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	276	280	PF00656	0.509
CLV_C14_Caspase3-7	287	291	PF00656	0.370
CLV_C14_Caspase3-7	313	317	PF00656	0.444
CLV_C14_Caspase3-7	536	540	PF00656	0.775
CLV_C14_Caspase3-7	551	555	PF00656	0.572
CLV_C14_Caspase3-7	93	97	PF00656	0.664
CLV_NRD_NRD_1	102	104	PF00675	0.669
CLV_NRD_NRD_1	112	114	PF00675	0.635
CLV_NRD_NRD_1	273	275	PF00675	0.433
CLV_NRD_NRD_1	546	548	PF00675	0.799
CLV_NRD_NRD_1	583	585	PF00675	0.701
CLV_NRD_NRD_1	658	660	PF00675	0.625
CLV_NRD_NRD_1	66	68	PF00675	0.585
CLV_PCSK_KEX2_1	112	114	PF00082	0.722
CLV_PCSK_KEX2_1	253	255	PF00082	0.530
CLV_PCSK_KEX2_1	272	274	PF00082	0.216
CLV_PCSK_KEX2_1	441	443	PF00082	0.642
CLV_PCSK_KEX2_1	545	547	PF00082	0.803
CLV_PCSK_KEX2_1	658	660	PF00082	0.625
CLV_PCSK_KEX2_1	66	68	PF00082	0.664
CLV_PCSK_KEX2_1	668	670	PF00082	0.459
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.530
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.216
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.642
CLV_PCSK_PC1ET2_1	668	670	PF00082	0.546
CLV_PCSK_PC7_1	664	670	PF00082	0.551
CLV_PCSK_SKI1_1	112	116	PF00082	0.521
CLV_PCSK_SKI1_1	14	18	PF00082	0.526
CLV_PCSK_SKI1_1	639	643	PF00082	0.614
CLV_PCSK_SKI1_1	659	663	PF00082	0.334
CLV_PCSK_SKI1_1	668	672	PF00082	0.454
CLV_PCSK_SKI1_1	90	94	PF00082	0.686
CLV_PCSK_SKI1_1	95	99	PF00082	0.575
DEG_APCC_DBOX_1	188	196	PF00400	0.671
DEG_APCC_DBOX_1	335	343	PF00400	0.685
DEG_APCC_DBOX_1	94	102	PF00400	0.650
DEG_SCF_FBW7_2	572	577	PF00400	0.663
DEG_SPOP_SBC_1	374	378	PF00917	0.658
DOC_AGCK_PIF_2	17	22	PF00069	0.548
DOC_CKS1_1	390	395	PF01111	0.622
DOC_MAPK_gen_1	24	34	PF00069	0.634
DOC_MAPK_gen_1	658	665	PF00069	0.604
DOC_MAPK_MEF2A_6	227	236	PF00069	0.530
DOC_MAPK_MEF2A_6	315	322	PF00069	0.618
DOC_MAPK_MEF2A_6	611	620	PF00069	0.653
DOC_MAPK_MEF2A_6	658	665	PF00069	0.604
DOC_PP1_RVXF_1	588	594	PF00149	0.821
DOC_PP1_RVXF_1	656	663	PF00149	0.605
DOC_PP2B_LxvP_1	249	252	PF13499	0.530
DOC_PP2B_LxvP_1	411	414	PF13499	0.599
DOC_PP2B_LxvP_1	474	477	PF13499	0.652
DOC_PP2B_PxIxI_1	317	323	PF00149	0.574
DOC_PP4_FxxP_1	390	393	PF00568	0.630
DOC_USP7_MATH_1	139	143	PF00917	0.769
DOC_USP7_MATH_1	159	163	PF00917	0.695
DOC_USP7_MATH_1	169	173	PF00917	0.664
DOC_USP7_MATH_1	225	229	PF00917	0.394
DOC_USP7_MATH_1	448	452	PF00917	0.849
DOC_USP7_MATH_1	503	507	PF00917	0.803
DOC_USP7_MATH_1	540	544	PF00917	0.779
DOC_USP7_MATH_1	97	101	PF00917	0.562
DOC_USP7_MATH_2	362	368	PF00917	0.712
DOC_USP7_UBL2_3	437	441	PF12436	0.684
DOC_WW_Pin1_4	121	126	PF00397	0.736
DOC_WW_Pin1_4	154	159	PF00397	0.734
DOC_WW_Pin1_4	238	243	PF00397	0.452
DOC_WW_Pin1_4	375	380	PF00397	0.646
DOC_WW_Pin1_4	38	43	PF00397	0.644
DOC_WW_Pin1_4	389	394	PF00397	0.690
DOC_WW_Pin1_4	450	455	PF00397	0.800
DOC_WW_Pin1_4	492	497	PF00397	0.715
DOC_WW_Pin1_4	570	575	PF00397	0.713
DOC_WW_Pin1_4	595	600	PF00397	0.694
DOC_WW_Pin1_4	631	636	PF00397	0.650
LIG_14-3-3_CanoR_1	103	108	PF00244	0.404
LIG_14-3-3_CanoR_1	119	125	PF00244	0.533
LIG_14-3-3_CanoR_1	295	304	PF00244	0.530
LIG_14-3-3_CanoR_1	306	314	PF00244	0.430
LIG_14-3-3_CanoR_1	637	642	PF00244	0.658
LIG_14-3-3_CanoR_1	85	92	PF00244	0.512
LIG_Actin_WH2_1	658	675	PF00022	0.611
LIG_Actin_WH2_2	212	229	PF00022	0.530
LIG_BIR_II_1	1	5	PF00653	0.740
LIG_BIR_III_2	539	543	PF00653	0.779
LIG_BRCT_BRCA1_1	1	5	PF00533	0.740
LIG_EH1_1	282	290	PF00400	0.452
LIG_FHA_1	427	433	PF00498	0.736
LIG_FHA_1	460	466	PF00498	0.844
LIG_FHA_1	528	534	PF00498	0.646
LIG_FHA_2	159	165	PF00498	0.688
LIG_FHA_2	186	192	PF00498	0.664
LIG_FHA_2	282	288	PF00498	0.530
LIG_FHA_2	311	317	PF00498	0.454
LIG_FHA_2	333	339	PF00498	0.686
LIG_FHA_2	39	45	PF00498	0.632
LIG_FHA_2	4	10	PF00498	0.566
LIG_FHA_2	405	411	PF00498	0.742
LIG_FHA_2	523	529	PF00498	0.854
LIG_FHA_2	571	577	PF00498	0.712
LIG_FHA_2	596	602	PF00498	0.664
LIG_FHA_2	642	648	PF00498	0.662
LIG_FHA_2	74	80	PF00498	0.654
LIG_FHA_2	91	97	PF00498	0.394
LIG_LIR_Gen_1	21	28	PF02991	0.545
LIG_LIR_Gen_1	44	53	PF02991	0.618
LIG_LIR_Nem_3	15	20	PF02991	0.609
LIG_LIR_Nem_3	21	25	PF02991	0.519
LIG_LIR_Nem_3	44	49	PF02991	0.614
LIG_LIR_Nem_3	610	616	PF02991	0.679
LIG_LIR_Nem_3	645	651	PF02991	0.613
LIG_NRBOX	231	237	PF00104	0.530
LIG_PDZ_Class_2	691	696	PF00595	0.668
LIG_REV1ctd_RIR_1	256	265	PF16727	0.530
LIG_RPA_C_Fungi	648	660	PF08784	0.597
LIG_SH2_NCK_1	275	279	PF00017	0.530
LIG_SH2_STAP1	323	327	PF00017	0.649
LIG_SH2_STAT3	105	108	PF00017	0.709
LIG_SH2_STAT5	561	564	PF00017	0.781
LIG_SH2_STAT5	648	651	PF00017	0.594
LIG_SH3_2	500	505	PF14604	0.628
LIG_SH3_3	353	359	PF00018	0.633
LIG_SH3_3	388	394	PF00018	0.692
LIG_SH3_3	419	425	PF00018	0.697
LIG_SH3_3	497	503	PF00018	0.683
LIG_SH3_3	516	522	PF00018	0.658
LIG_SH3_3	566	572	PF00018	0.663
LIG_TRAF2_1	394	397	PF00917	0.717
LIG_TRAF2_1	525	528	PF00917	0.812
LIG_TRAF2_1	548	551	PF00917	0.825
LIG_TRAF2_1	574	577	PF00917	0.791
LIG_TYR_ITIM	649	654	PF00017	0.610
LIG_UBA3_1	16	24	PF00899	0.621
LIG_UBA3_1	231	238	PF00899	0.491
LIG_UBA3_1	45	54	PF00899	0.621
LIG_WRC_WIRS_1	264	269	PF05994	0.530
LIG_WW_1	605	608	PF00397	0.692
LIG_WW_3	604	608	PF00397	0.708
MOD_CDC14_SPxK_1	495	498	PF00782	0.629
MOD_CDC14_SPxK_1	634	637	PF00782	0.618
MOD_CDK_SPxK_1	492	498	PF00069	0.752
MOD_CDK_SPxK_1	631	637	PF00069	0.646
MOD_CDK_SPxxK_3	121	128	PF00069	0.742
MOD_CDK_SPxxK_3	375	382	PF00069	0.744
MOD_CK1_1	118	124	PF00069	0.763
MOD_CK1_1	152	158	PF00069	0.836
MOD_CK1_1	170	176	PF00069	0.814
MOD_CK1_1	181	187	PF00069	0.611
MOD_CK1_1	310	316	PF00069	0.453
MOD_CK1_1	404	410	PF00069	0.790
MOD_CK1_1	475	481	PF00069	0.750
MOD_CK1_1	506	512	PF00069	0.598
MOD_CK1_1	595	601	PF00069	0.593
MOD_CK2_1	38	44	PF00069	0.644
MOD_CK2_1	380	386	PF00069	0.745
MOD_CK2_1	404	410	PF00069	0.675
MOD_CK2_1	522	528	PF00069	0.812
MOD_CK2_1	545	551	PF00069	0.793
MOD_CK2_1	570	576	PF00069	0.783
MOD_CK2_1	595	601	PF00069	0.719
MOD_CK2_1	641	647	PF00069	0.678
MOD_Cter_Amidation	543	546	PF01082	0.663
MOD_GlcNHglycan	1	4	PF01048	0.691
MOD_GlcNHglycan	161	164	PF01048	0.731
MOD_GlcNHglycan	183	186	PF01048	0.714
MOD_GlcNHglycan	227	230	PF01048	0.530
MOD_GlcNHglycan	309	312	PF01048	0.631
MOD_GlcNHglycan	403	406	PF01048	0.733
MOD_GlcNHglycan	450	453	PF01048	0.755
MOD_GlcNHglycan	474	477	PF01048	0.769
MOD_GlcNHglycan	487	490	PF01048	0.661
MOD_GlcNHglycan	542	545	PF01048	0.777
MOD_GlcNHglycan	547	550	PF01048	0.729
MOD_GlcNHglycan	644	647	PF01048	0.654
MOD_GSK3_1	148	155	PF00069	0.771
MOD_GSK3_1	159	166	PF00069	0.611
MOD_GSK3_1	181	188	PF00069	0.716
MOD_GSK3_1	238	245	PF00069	0.398
MOD_GSK3_1	263	270	PF00069	0.474
MOD_GSK3_1	296	303	PF00069	0.420
MOD_GSK3_1	373	380	PF00069	0.714
MOD_GSK3_1	450	457	PF00069	0.806
MOD_GSK3_1	481	488	PF00069	0.708
MOD_GSK3_1	492	499	PF00069	0.733
MOD_GSK3_1	522	529	PF00069	0.804
MOD_GSK3_1	637	644	PF00069	0.513
MOD_N-GLC_1	148	153	PF02516	0.671
MOD_N-GLC_1	73	78	PF02516	0.676
MOD_NEK2_1	115	120	PF00069	0.808
MOD_NEK2_1	153	158	PF00069	0.775
MOD_NEK2_1	267	272	PF00069	0.474
MOD_NEK2_1	600	605	PF00069	0.705
MOD_NEK2_1	654	659	PF00069	0.562
MOD_NEK2_2	139	144	PF00069	0.823
MOD_PIKK_1	392	398	PF00454	0.658
MOD_PIKK_1	404	410	PF00454	0.650
MOD_PIKK_1	600	606	PF00454	0.593
MOD_PK_1	103	109	PF00069	0.630
MOD_PKA_1	103	109	PF00069	0.630
MOD_PKA_1	253	259	PF00069	0.530
MOD_PKA_1	545	551	PF00069	0.793
MOD_PKA_1	584	590	PF00069	0.629
MOD_PKA_2	118	124	PF00069	0.773
MOD_PKA_2	253	259	PF00069	0.374
MOD_PKA_2	332	338	PF00069	0.531
MOD_PKA_2	545	551	PF00069	0.705
MOD_PKA_2	60	66	PF00069	0.657
MOD_PKA_2	84	90	PF00069	0.491
MOD_PKB_1	637	645	PF00069	0.597
MOD_Plk_1	148	154	PF00069	0.839
MOD_Plk_1	170	176	PF00069	0.651
MOD_Plk_1	28	34	PF00069	0.638
MOD_Plk_1	414	420	PF00069	0.617
MOD_Plk_1	481	487	PF00069	0.831
MOD_Plk_1	506	512	PF00069	0.539
MOD_Plk_4	170	176	PF00069	0.789
MOD_Plk_4	263	269	PF00069	0.488
MOD_Plk_4	351	357	PF00069	0.601
MOD_Plk_4	79	85	PF00069	0.539
MOD_ProDKin_1	121	127	PF00069	0.738
MOD_ProDKin_1	154	160	PF00069	0.736
MOD_ProDKin_1	238	244	PF00069	0.452
MOD_ProDKin_1	375	381	PF00069	0.646
MOD_ProDKin_1	38	44	PF00069	0.644
MOD_ProDKin_1	389	395	PF00069	0.691
MOD_ProDKin_1	450	456	PF00069	0.799
MOD_ProDKin_1	492	498	PF00069	0.719
MOD_ProDKin_1	570	576	PF00069	0.712
MOD_ProDKin_1	595	601	PF00069	0.694
MOD_ProDKin_1	631	637	PF00069	0.646
MOD_SUMO_rev_2	245	252	PF00179	0.526
MOD_SUMO_rev_2	82	92	PF00179	0.641
MOD_SUMO_rev_2	96	106	PF00179	0.426
TRG_DiLeu_BaEn_2	385	391	PF01217	0.611
TRG_DiLeu_BaEn_4	131	137	PF01217	0.705
TRG_ENDOCYTIC_2	275	278	PF00928	0.532
TRG_ENDOCYTIC_2	50	53	PF00928	0.625
TRG_ENDOCYTIC_2	651	654	PF00928	0.618
TRG_ER_diArg_1	112	114	PF00400	0.586
TRG_ER_diArg_1	273	275	PF00400	0.433
TRG_ER_diArg_1	545	547	PF00400	0.803
TRG_ER_diArg_1	658	660	PF00400	0.625
TRG_ER_diArg_1	66	69	PF00400	0.527
TRG_NES_CRM1_1	224	240	PF08389	0.530
TRG_NES_CRM1_1	44	56	PF08389	0.625
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.724

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HQ09	Leishmania braziliensis	65%	100%
A4IDS0	Leishmania infantum	99%	100%
E9ATS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q0S0	Leishmania major	87%	100%