Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBP8_LEIDO

TriTrypDb:

LdBPK_365460.1 , LdCL_360061800 , LDHU3_36.7280

Length:

487

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3S7XBP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBP8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.801
CLV_NRD_NRD_1	186	188	PF00675	0.675
CLV_NRD_NRD_1	294	296	PF00675	0.647
CLV_NRD_NRD_1	320	322	PF00675	0.576
CLV_NRD_NRD_1	35	37	PF00675	0.489
CLV_NRD_NRD_1	64	66	PF00675	0.567
CLV_PCSK_FUR_1	33	37	PF00082	0.485
CLV_PCSK_KEX2_1	101	103	PF00082	0.748
CLV_PCSK_KEX2_1	186	188	PF00082	0.641
CLV_PCSK_KEX2_1	294	296	PF00082	0.702
CLV_PCSK_KEX2_1	305	307	PF00082	0.626
CLV_PCSK_KEX2_1	320	322	PF00082	0.537
CLV_PCSK_KEX2_1	35	37	PF00082	0.489
CLV_PCSK_KEX2_1	64	66	PF00082	0.521
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.572
CLV_PCSK_SKI1_1	197	201	PF00082	0.597
CLV_PCSK_SKI1_1	295	299	PF00082	0.591
CLV_PCSK_SKI1_1	372	376	PF00082	0.629
DEG_APCC_DBOX_1	294	302	PF00400	0.493
DOC_CDC14_PxL_1	128	136	PF14671	0.523
DOC_CKS1_1	405	410	PF01111	0.398
DOC_CYCLIN_RxL_1	292	299	PF00134	0.388
DOC_MAPK_MEF2A_6	113	120	PF00069	0.426
DOC_PP4_FxxP_1	405	408	PF00568	0.454
DOC_USP7_MATH_1	39	43	PF00917	0.751
DOC_USP7_MATH_1	44	48	PF00917	0.752
DOC_USP7_MATH_1	51	55	PF00917	0.683
DOC_WW_Pin1_4	258	263	PF00397	0.408
DOC_WW_Pin1_4	404	409	PF00397	0.385
LIG_14-3-3_CanoR_1	217	221	PF00244	0.373
LIG_14-3-3_CanoR_1	263	268	PF00244	0.481
LIG_14-3-3_CanoR_1	321	327	PF00244	0.435
LIG_Actin_WH2_2	399	414	PF00022	0.406
LIG_BRCT_BRCA1_1	345	349	PF00533	0.440
LIG_BRCT_BRCA1_1	72	76	PF00533	0.342
LIG_BRCT_BRCA1_1	88	92	PF00533	0.502
LIG_FHA_1	120	126	PF00498	0.441
LIG_FHA_1	20	26	PF00498	0.684
LIG_FHA_1	211	217	PF00498	0.414
LIG_FHA_1	279	285	PF00498	0.523
LIG_FHA_1	361	367	PF00498	0.516
LIG_FHA_1	480	486	PF00498	0.464
LIG_FHA_2	131	137	PF00498	0.494
LIG_FHA_2	323	329	PF00498	0.450
LIG_FHA_2	352	358	PF00498	0.516
LIG_LIR_Apic_2	403	408	PF02991	0.376
LIG_LIR_Apic_2	451	455	PF02991	0.356
LIG_LIR_Gen_1	190	201	PF02991	0.395
LIG_LIR_Gen_1	313	323	PF02991	0.433
LIG_LIR_Gen_1	325	334	PF02991	0.349
LIG_LIR_Gen_1	346	356	PF02991	0.473
LIG_LIR_Nem_3	190	196	PF02991	0.355
LIG_LIR_Nem_3	236	240	PF02991	0.467
LIG_LIR_Nem_3	281	285	PF02991	0.440
LIG_LIR_Nem_3	313	318	PF02991	0.446
LIG_LIR_Nem_3	325	329	PF02991	0.306
LIG_LIR_Nem_3	335	339	PF02991	0.317
LIG_LIR_Nem_3	346	350	PF02991	0.314
LIG_LYPXL_yS_3	107	110	PF13949	0.503
LIG_NRBOX	461	467	PF00104	0.387
LIG_PDZ_Class_2	482	487	PF00595	0.483
LIG_SH2_CRK	148	152	PF00017	0.393
LIG_SH2_CRK	193	197	PF00017	0.356
LIG_SH2_CRK	230	234	PF00017	0.363
LIG_SH2_CRK	336	340	PF00017	0.358
LIG_SH2_CRK	452	456	PF00017	0.394
LIG_SH2_PTP2	83	86	PF00017	0.436
LIG_SH2_SRC	228	231	PF00017	0.433
LIG_SH2_SRC	343	346	PF00017	0.363
LIG_SH2_STAP1	148	152	PF00017	0.393
LIG_SH2_STAP1	230	234	PF00017	0.422
LIG_SH2_STAP1	326	330	PF00017	0.376
LIG_SH2_STAP1	343	347	PF00017	0.365
LIG_SH2_STAT5	228	231	PF00017	0.394
LIG_SH2_STAT5	238	241	PF00017	0.357
LIG_SH2_STAT5	83	86	PF00017	0.436
LIG_SH3_3	328	334	PF00018	0.388
LIG_SUMO_SIM_anti_2	327	333	PF11976	0.370
LIG_SUMO_SIM_par_1	114	119	PF11976	0.390
LIG_SUMO_SIM_par_1	248	254	PF11976	0.349
LIG_SUMO_SIM_par_1	397	403	PF11976	0.361
LIG_SUMO_SIM_par_1	407	413	PF11976	0.402
LIG_TRAF2_1	157	160	PF00917	0.434
LIG_TRAF2_1	325	328	PF00917	0.452
LIG_TYR_ITIM	191	196	PF00017	0.393
LIG_TYR_ITIM	81	86	PF00017	0.411
LIG_UBA3_1	462	468	PF00899	0.337
MOD_CDK_SPK_2	258	263	PF00069	0.425
MOD_CK1_1	180	186	PF00069	0.482
MOD_CK1_1	19	25	PF00069	0.707
MOD_CK1_1	310	316	PF00069	0.407
MOD_CK1_1	379	385	PF00069	0.447
MOD_CK2_1	137	143	PF00069	0.417
MOD_CK2_1	322	328	PF00069	0.453
MOD_CK2_1	379	385	PF00069	0.418
MOD_CK2_1	426	432	PF00069	0.442
MOD_CMANNOS	63	66	PF00535	0.421
MOD_GlcNHglycan	139	142	PF01048	0.613
MOD_GlcNHglycan	179	182	PF01048	0.599
MOD_GlcNHglycan	230	233	PF01048	0.637
MOD_GlcNHglycan	25	28	PF01048	0.535
MOD_GlcNHglycan	287	290	PF01048	0.726
MOD_GlcNHglycan	315	318	PF01048	0.533
MOD_GlcNHglycan	37	40	PF01048	0.539
MOD_GlcNHglycan	41	44	PF01048	0.505
MOD_GlcNHglycan	46	49	PF01048	0.497
MOD_GlcNHglycan	53	56	PF01048	0.433
MOD_GlcNHglycan	72	75	PF01048	0.250
MOD_GlcNHglycan	94	97	PF01048	0.717
MOD_GSK3_1	176	183	PF00069	0.478
MOD_GSK3_1	19	26	PF00069	0.712
MOD_GSK3_1	211	218	PF00069	0.427
MOD_GSK3_1	263	270	PF00069	0.423
MOD_GSK3_1	307	314	PF00069	0.386
MOD_GSK3_1	35	42	PF00069	0.665
MOD_GSK3_1	51	58	PF00069	0.624
MOD_N-GLC_1	285	290	PF02516	0.644
MOD_NEK2_1	137	142	PF00069	0.420
MOD_NEK2_1	16	21	PF00069	0.631
MOD_NEK2_1	171	176	PF00069	0.452
MOD_NEK2_1	215	220	PF00069	0.396
MOD_NEK2_1	251	256	PF00069	0.342
MOD_NEK2_1	285	290	PF00069	0.517
MOD_NEK2_1	307	312	PF00069	0.388
MOD_NEK2_1	384	389	PF00069	0.479
MOD_NEK2_1	438	443	PF00069	0.406
MOD_NEK2_1	86	91	PF00069	0.718
MOD_NEK2_1	92	97	PF00069	0.504
MOD_NEK2_2	181	186	PF00069	0.387
MOD_NEK2_2	479	484	PF00069	0.409
MOD_OFUCOSY	18	23	PF10250	0.440
MOD_PIKK_1	120	126	PF00454	0.452
MOD_PIKK_1	171	177	PF00454	0.450
MOD_PIKK_1	360	366	PF00454	0.586
MOD_PKA_1	35	41	PF00069	0.685
MOD_PKA_2	216	222	PF00069	0.371
MOD_PKA_2	35	41	PF00069	0.698
MOD_PKA_2	51	57	PF00069	0.705
MOD_PKB_1	33	41	PF00069	0.754
MOD_Plk_1	308	314	PF00069	0.394
MOD_Plk_1	384	390	PF00069	0.420
MOD_Plk_1	438	444	PF00069	0.429
MOD_Plk_4	1	7	PF00069	0.691
MOD_Plk_4	211	217	PF00069	0.456
MOD_Plk_4	86	92	PF00069	0.616
MOD_ProDKin_1	258	264	PF00069	0.409
MOD_ProDKin_1	404	410	PF00069	0.393
TRG_DiLeu_BaEn_4	327	333	PF01217	0.388
TRG_DiLeu_BaLyEn_6	452	457	PF01217	0.364
TRG_ENDOCYTIC_2	107	110	PF00928	0.503
TRG_ENDOCYTIC_2	148	151	PF00928	0.371
TRG_ENDOCYTIC_2	193	196	PF00928	0.395
TRG_ENDOCYTIC_2	220	223	PF00928	0.374
TRG_ENDOCYTIC_2	230	233	PF00928	0.365
TRG_ENDOCYTIC_2	237	240	PF00928	0.389
TRG_ENDOCYTIC_2	282	285	PF00928	0.425
TRG_ENDOCYTIC_2	326	329	PF00928	0.378
TRG_ENDOCYTIC_2	336	339	PF00928	0.354
TRG_ENDOCYTIC_2	83	86	PF00928	0.411
TRG_ER_diArg_1	101	103	PF00400	0.610
TRG_ER_diArg_1	185	187	PF00400	0.473
TRG_ER_diArg_1	32	35	PF00400	0.734
TRG_ER_diArg_1	320	322	PF00400	0.441
TRG_ER_diArg_1	63	65	PF00400	0.758
TRG_Pf-PMV_PEXEL_1	166	170	PF00026	0.740

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P492	Leptomonas seymouri	53%	100%
A4HQ38	Leishmania braziliensis	77%	100%
A4IDU4	Leishmania infantum	99%	100%
E9ATV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q0N9	Leishmania major	89%	100%