Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBP3_LEIDO

TriTrypDb:

LdBPK_365050.1 , LdCL_360057700 , LDHU3_36.6770

Length:

509

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0000974	Prp19 complex	2	1
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A0A3S7XBP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBP3

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	11
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	11
GO:0000398	mRNA splicing, via spliceosome	8	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.516
CLV_NRD_NRD_1	453	455	PF00675	0.554
CLV_NRD_NRD_1	57	59	PF00675	0.491
CLV_PCSK_KEX2_1	133	135	PF00082	0.520
CLV_PCSK_KEX2_1	453	455	PF00082	0.536
CLV_PCSK_KEX2_1	56	58	PF00082	0.621
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.520
CLV_PCSK_SKI1_1	152	156	PF00082	0.500
CLV_PCSK_SKI1_1	177	181	PF00082	0.397
CLV_PCSK_SKI1_1	264	268	PF00082	0.319
CLV_PCSK_SKI1_1	402	406	PF00082	0.576
CLV_PCSK_SKI1_1	430	434	PF00082	0.356
CLV_PCSK_SKI1_1	492	496	PF00082	0.224
CLV_PCSK_SKI1_1	500	504	PF00082	0.217
CLV_Separin_Metazoa	261	265	PF03568	0.397
DEG_Nend_UBRbox_3	1	3	PF02207	0.539
DEG_SPOP_SBC_1	78	82	PF00917	0.542
DOC_CYCLIN_RxL_1	352	363	PF00134	0.519
DOC_MAPK_gen_1	150	157	PF00069	0.597
DOC_MAPK_gen_1	175	183	PF00069	0.397
DOC_MAPK_gen_1	352	362	PF00069	0.417
DOC_PP1_RVXF_1	356	363	PF00149	0.519
DOC_PP2B_LxvP_1	26	29	PF13499	0.581
DOC_USP7_MATH_1	121	125	PF00917	0.664
DOC_USP7_MATH_1	202	206	PF00917	0.442
DOC_USP7_MATH_1	230	234	PF00917	0.519
DOC_USP7_MATH_1	278	282	PF00917	0.466
DOC_USP7_MATH_1	368	372	PF00917	0.528
DOC_USP7_MATH_1	403	407	PF00917	0.647
DOC_USP7_MATH_1	434	438	PF00917	0.339
DOC_USP7_MATH_1	49	53	PF00917	0.671
DOC_USP7_MATH_1	79	83	PF00917	0.686
DOC_WW_Pin1_4	168	173	PF00397	0.544
DOC_WW_Pin1_4	237	242	PF00397	0.417
DOC_WW_Pin1_4	425	430	PF00397	0.335
LIG_14-3-3_CanoR_1	232	237	PF00244	0.442
LIG_14-3-3_CanoR_1	421	429	PF00244	0.268
LIG_14-3-3_CanoR_1	44	51	PF00244	0.723
LIG_BRCT_BRCA1_1	331	335	PF00533	0.519
LIG_BRCT_BRCA1_1	383	387	PF00533	0.506
LIG_EVH1_2	36	40	PF00568	0.510
LIG_FHA_1	215	221	PF00498	0.355
LIG_FHA_1	291	297	PF00498	0.435
LIG_FHA_1	310	316	PF00498	0.356
LIG_FHA_1	391	397	PF00498	0.533
LIG_FHA_1	466	472	PF00498	0.374
LIG_FHA_1	483	489	PF00498	0.417
LIG_FHA_1	73	79	PF00498	0.707
LIG_FHA_2	111	117	PF00498	0.582
LIG_FHA_2	190	196	PF00498	0.507
LIG_FHA_2	2	8	PF00498	0.669
LIG_FHA_2	90	96	PF00498	0.737
LIG_LIR_Apic_2	446	450	PF02991	0.425
LIG_LIR_Gen_1	203	212	PF02991	0.519
LIG_LIR_Gen_1	332	342	PF02991	0.519
LIG_LIR_LC3C_4	153	157	PF02991	0.594
LIG_LIR_LC3C_4	317	320	PF02991	0.484
LIG_LIR_Nem_3	203	209	PF02991	0.519
LIG_LIR_Nem_3	332	338	PF02991	0.519
LIG_PCNA_yPIPBox_3	253	267	PF02747	0.519
LIG_Pex14_1	63	67	PF04695	0.621
LIG_Pex14_2	335	339	PF04695	0.519
LIG_REV1ctd_RIR_1	264	274	PF16727	0.519
LIG_RPA_C_Fungi	53	65	PF08784	0.510
LIG_SH2_CRK	170	174	PF00017	0.545
LIG_SH2_NCK_1	170	174	PF00017	0.561
LIG_SH2_STAP1	418	422	PF00017	0.456
LIG_SH2_STAP1	445	449	PF00017	0.391
LIG_SH2_STAT5	337	340	PF00017	0.269
LIG_SH3_2	33	38	PF14604	0.616
LIG_SH3_3	30	36	PF00018	0.596
LIG_SUMO_SIM_anti_2	281	287	PF11976	0.254
LIG_SUMO_SIM_par_1	105	111	PF11976	0.676
LIG_SUMO_SIM_par_1	431	437	PF11976	0.318
LIG_TRAF2_1	16	19	PF00917	0.430
LIG_TRAF2_1	161	164	PF00917	0.609
LIG_TRAF2_1	5	8	PF00917	0.524
LIG_WW_3	35	39	PF00397	0.543
MOD_CDK_SPK_2	425	430	PF00069	0.355
MOD_CDK_SPxxK_3	168	175	PF00069	0.511
MOD_CK1_1	111	117	PF00069	0.657
MOD_CK1_1	119	125	PF00069	0.504
MOD_CK1_1	237	243	PF00069	0.284
MOD_CK1_1	314	320	PF00069	0.256
MOD_CK1_1	329	335	PF00069	0.246
MOD_CK1_1	42	48	PF00069	0.722
MOD_CK1_1	498	504	PF00069	0.269
MOD_CK2_1	1	7	PF00069	0.573
MOD_CK2_1	110	116	PF00069	0.581
MOD_CK2_1	189	195	PF00069	0.380
MOD_GlcNHglycan	113	116	PF01048	0.680
MOD_GlcNHglycan	121	124	PF01048	0.618
MOD_GlcNHglycan	126	129	PF01048	0.704
MOD_GlcNHglycan	152	155	PF01048	0.599
MOD_GlcNHglycan	244	247	PF01048	0.290
MOD_GlcNHglycan	270	273	PF01048	0.354
MOD_GlcNHglycan	286	289	PF01048	0.206
MOD_GlcNHglycan	328	331	PF01048	0.254
MOD_GlcNHglycan	342	345	PF01048	0.345
MOD_GlcNHglycan	383	386	PF01048	0.460
MOD_GlcNHglycan	405	408	PF01048	0.700
MOD_GlcNHglycan	47	50	PF01048	0.610
MOD_GlcNHglycan	487	491	PF01048	0.254
MOD_GSK3_1	111	118	PF00069	0.637
MOD_GSK3_1	119	126	PF00069	0.576
MOD_GSK3_1	230	237	PF00069	0.397
MOD_GSK3_1	244	251	PF00069	0.301
MOD_GSK3_1	386	393	PF00069	0.471
MOD_GSK3_1	39	46	PF00069	0.691
MOD_GSK3_1	398	405	PF00069	0.609
MOD_GSK3_1	416	423	PF00069	0.359
MOD_GSK3_1	467	474	PF00069	0.401
MOD_GSK3_1	482	489	PF00069	0.219
MOD_GSK3_1	67	74	PF00069	0.673
MOD_N-GLC_1	1	6	PF02516	0.473
MOD_N-GLC_1	111	116	PF02516	0.631
MOD_N-GLC_1	222	227	PF02516	0.269
MOD_N-GLC_1	389	394	PF02516	0.408
MOD_N-GLC_1	42	47	PF02516	0.625
MOD_NEK2_1	1	6	PF00069	0.600
MOD_NEK2_1	155	160	PF00069	0.541
MOD_NEK2_1	222	227	PF00069	0.281
MOD_NEK2_1	360	365	PF00069	0.314
MOD_PIKK_1	434	440	PF00454	0.328
MOD_PIKK_1	89	95	PF00454	0.744
MOD_PKA_2	348	354	PF00069	0.254
MOD_PKA_2	420	426	PF00069	0.303
MOD_PKA_2	43	49	PF00069	0.518
MOD_Plk_1	1	7	PF00069	0.470
MOD_Plk_1	248	254	PF00069	0.308
MOD_Plk_1	290	296	PF00069	0.269
MOD_Plk_1	416	422	PF00069	0.484
MOD_Plk_1	498	504	PF00069	0.288
MOD_Plk_4	105	111	PF00069	0.681
MOD_Plk_4	304	310	PF00069	0.307
MOD_Plk_4	311	317	PF00069	0.234
MOD_ProDKin_1	168	174	PF00069	0.534
MOD_ProDKin_1	237	243	PF00069	0.254
MOD_ProDKin_1	425	431	PF00069	0.338
TRG_DiLeu_BaLyEn_6	489	494	PF01217	0.288
TRG_ER_diArg_1	299	302	PF00400	0.355
TRG_ER_diArg_1	452	454	PF00400	0.531
TRG_ER_diArg_1	505	508	PF00400	0.479
TRG_ER_diArg_1	55	58	PF00400	0.582
TRG_NES_CRM1_1	18	32	PF08389	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7N2	Leptomonas seymouri	68%	99%
A0A0N1I6C2	Leptomonas seymouri	23%	100%
A0A0N1IHN2	Leptomonas seymouri	22%	98%
A0A0N1PBF5	Leptomonas seymouri	25%	74%
A0A0S4IWG1	Bodo saltans	42%	100%
A0A0S4JE21	Bodo saltans	27%	100%
A0A0S4JL38	Bodo saltans	26%	95%
A0A0S4KJ87	Bodo saltans	25%	85%
A0A1X0NQ96	Trypanosomatidae	25%	100%
A0A1X0P0F0	Trypanosomatidae	52%	100%
A0A3Q8IBR2	Leishmania donovani	22%	100%
A0A3R7KUH0	Trypanosoma rangeli	27%	100%
A0A3R7MCP0	Trypanosoma rangeli	54%	100%
A0A3R7N6M9	Trypanosoma rangeli	22%	98%
A0A3S5H5M7	Leishmania donovani	26%	75%
A0A3S7WR72	Leishmania donovani	24%	100%
A0A3S7X9Q7	Leishmania donovani	24%	100%
A4H4H1	Leishmania braziliensis	27%	77%
A4H666	Leishmania braziliensis	24%	100%
A4HBK3	Leishmania braziliensis	21%	100%
A4HPZ9	Leishmania braziliensis	86%	100%
A4HSP6	Leishmania infantum	26%	75%
A4HUJ0	Leishmania infantum	24%	100%
A4HZL2	Leishmania infantum	22%	100%
A4IDR0	Leishmania infantum	100%	100%
B8N9H4	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	24%	100%
C4JPW9	Uncinocarpus reesii (strain UAMH 1704)	23%	100%
C9ZVL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZW72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	83%
D0A4F2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
D3Z902	Rattus norvegicus	27%	71%
E9AKN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	76%
E9AN88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9ATR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9AUX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
E9B3I3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B4L5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	71%
F1MNN4	Bos taurus	27%	72%
G0SC29	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	24%	98%
O13615	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%
O14170	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	72%
O74855	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
P0CS48	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	40%	100%
P0CS49	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	40%	100%
P25382	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	99%
P49846	Drosophila melanogaster	22%	72%
Q0D0X6	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	22%	100%
Q12417	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
Q2UGU1	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	24%	100%
Q4Q0T1	Leishmania major	93%	100%
Q4QHD6	Leishmania major	24%	100%
Q4QJ76	Leishmania major	26%	75%
Q4WT34	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	38%	100%
Q58D20	Bos taurus	23%	100%
Q5A7Q3	Candida albicans (strain SC5314 / ATCC MYA-2876)	37%	100%
Q5BE22	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	38%	100%
Q5RFF8	Pongo abelii	22%	100%
Q6BU94	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	33%	100%
Q6CKE8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	38%	100%
Q6GPC6	Xenopus laevis	22%	98%
Q75BY3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	41%	100%
Q7ZXK9	Xenopus laevis	25%	100%
Q8BHJ5	Mus musculus	20%	99%
Q8K450	Mus musculus	23%	80%
Q8VBV4	Mus musculus	27%	72%
Q8VEJ4	Mus musculus	23%	100%
Q969H0	Homo sapiens	27%	72%
Q9FN19	Arabidopsis thaliana	21%	83%
Q9NVX2	Homo sapiens	22%	100%
Q9QXE7	Mus musculus	21%	97%
V5B4Z8	Trypanosoma cruzi	53%	100%
V5BP59	Trypanosoma cruzi	26%	100%