Putative membrane protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Predicted membrane protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBP1_LEIDO

TriTrypDb:

LdBPK_364830.1 , LdCL_360055400 , LDHU3_36.6490

Length:

159

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S7XBP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBP1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	81	83	PF00082	0.340
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.340
CLV_PCSK_SKI1_1	82	86	PF00082	0.365
CLV_Separin_Metazoa	69	73	PF03568	0.348
DEG_APCC_DBOX_1	71	79	PF00400	0.436
DEG_Nend_UBRbox_1	1	4	PF02207	0.600
DOC_CDC14_PxL_1	94	102	PF14671	0.378
DOC_MAPK_gen_1	141	150	PF00069	0.658
DOC_MAPK_MEF2A_6	55	63	PF00069	0.356
DOC_WW_Pin1_4	12	17	PF00397	0.664
DOC_WW_Pin1_4	153	158	PF00397	0.711
LIG_14-3-3_CanoR_1	2	7	PF00244	0.633
LIG_APCC_ABBAyCdc20_2	81	87	PF00400	0.550
LIG_Clathr_ClatBox_1	127	131	PF01394	0.469
LIG_FHA_1	121	127	PF00498	0.329
LIG_FHA_1	66	72	PF00498	0.385
LIG_FHA_1	91	97	PF00498	0.401
LIG_FHA_2	112	118	PF00498	0.251
LIG_GBD_Chelix_1	102	110	PF00786	0.241
LIG_GBD_Chelix_1	88	96	PF00786	0.469
LIG_LIR_Apic_2	29	35	PF02991	0.371
LIG_LIR_Gen_1	149	158	PF02991	0.664
LIG_LIR_Gen_1	26	36	PF02991	0.405
LIG_LIR_Nem_3	149	154	PF02991	0.613
LIG_LIR_Nem_3	26	31	PF02991	0.350
LIG_LIR_Nem_3	39	43	PF02991	0.292
LIG_LIR_Nem_3	83	88	PF02991	0.550
LIG_NRBOX	17	23	PF00104	0.556
LIG_PALB2_WD40_1	33	41	PF16756	0.469
LIG_SH2_CRK	32	36	PF00017	0.398
LIG_SH2_PTP2	151	154	PF00017	0.664
LIG_SH2_STAT5	151	154	PF00017	0.612
LIG_SH2_STAT5	40	43	PF00017	0.430
LIG_SUMO_SIM_anti_2	123	129	PF11976	0.342
LIG_SUMO_SIM_par_1	125	131	PF11976	0.348
LIG_SUMO_SIM_par_1	20	26	PF11976	0.457
MOD_CK1_1	153	159	PF00069	0.715
MOD_CK1_1	49	55	PF00069	0.338
MOD_CK2_1	111	117	PF00069	0.251
MOD_GlcNHglycan	32	35	PF01048	0.482
MOD_GSK3_1	116	123	PF00069	0.356
MOD_GSK3_1	26	33	PF00069	0.390
MOD_NEK2_1	116	121	PF00069	0.343
MOD_NEK2_1	140	145	PF00069	0.661
MOD_NEK2_1	150	155	PF00069	0.602
MOD_NEK2_1	92	97	PF00069	0.395
MOD_NEK2_2	23	28	PF00069	0.437
MOD_PIKK_1	120	126	PF00454	0.440
MOD_PIKK_1	49	55	PF00454	0.330
MOD_PKA_2	140	146	PF00069	0.683
MOD_Plk_1	116	122	PF00069	0.356
MOD_Plk_4	23	29	PF00069	0.387
MOD_Plk_4	92	98	PF00069	0.348
MOD_ProDKin_1	12	18	PF00069	0.664
MOD_ProDKin_1	153	159	PF00069	0.715
TRG_DiLeu_BaEn_2	86	92	PF01217	0.519
TRG_ENDOCYTIC_2	151	154	PF00928	0.643
TRG_ENDOCYTIC_2	40	43	PF00928	0.348
TRG_ER_diArg_1	1	4	PF00400	0.682
TRG_NES_CRM1_1	87	99	PF08389	0.436
TRG_Pf-PMV_PEXEL_1	82	87	PF00026	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM58	Leptomonas seymouri	63%	99%
A0A0S4JJP3	Bodo saltans	28%	100%
A0A1X0P0F4	Trypanosomatidae	35%	99%
A0A3R7LEN3	Trypanosoma rangeli	36%	100%
A4IDN9	Leishmania infantum	99%	100%
D0A4C5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	99%
E9ATP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q0V4	Leishmania major	93%	100%