LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7XBN8_LEIDO
TriTrypDb:
LdBPK_364800.1 * , LdCL_360055100 , LDHU3_36.6460
Length:
322

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XBN8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBN8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 135 139 PF00656 0.431
CLV_C14_Caspase3-7 242 246 PF00656 0.508
CLV_C14_Caspase3-7 27 31 PF00656 0.718
CLV_NRD_NRD_1 152 154 PF00675 0.558
CLV_NRD_NRD_1 16 18 PF00675 0.563
CLV_NRD_NRD_1 92 94 PF00675 0.551
CLV_PCSK_KEX2_1 92 94 PF00082 0.551
CLV_PCSK_SKI1_1 130 134 PF00082 0.412
CLV_PCSK_SKI1_1 210 214 PF00082 0.425
CLV_PCSK_SKI1_1 224 228 PF00082 0.371
DEG_APCC_DBOX_1 91 99 PF00400 0.528
DEG_MDM2_SWIB_1 306 313 PF02201 0.363
DOC_ANK_TNKS_1 133 140 PF00023 0.432
DOC_MAPK_gen_1 120 129 PF00069 0.412
DOC_MAPK_gen_1 89 98 PF00069 0.559
DOC_PP1_RVXF_1 59 65 PF00149 0.515
DOC_USP7_MATH_1 140 144 PF00917 0.590
DOC_USP7_MATH_1 186 190 PF00917 0.611
DOC_USP7_MATH_1 259 263 PF00917 0.654
DOC_USP7_MATH_1 269 273 PF00917 0.511
DOC_WW_Pin1_4 182 187 PF00397 0.602
DOC_WW_Pin1_4 4 9 PF00397 0.636
DOC_WW_Pin1_4 43 48 PF00397 0.587
LIG_14-3-3_CanoR_1 210 217 PF00244 0.569
LIG_14-3-3_CanoR_1 219 224 PF00244 0.400
LIG_14-3-3_CanoR_1 278 283 PF00244 0.414
LIG_Actin_WH2_1 120 136 PF00022 0.423
LIG_Actin_WH2_2 121 136 PF00022 0.470
LIG_Actin_WH2_2 209 226 PF00022 0.359
LIG_APCC_ABBA_1 121 126 PF00400 0.381
LIG_APCC_ABBAyCdc20_2 120 126 PF00400 0.361
LIG_BIR_II_1 1 5 PF00653 0.576
LIG_BRCT_BRCA1_1 103 107 PF00533 0.435
LIG_FHA_1 160 166 PF00498 0.546
LIG_FHA_1 211 217 PF00498 0.363
LIG_FHA_1 289 295 PF00498 0.472
LIG_FHA_1 315 321 PF00498 0.363
LIG_FHA_1 73 79 PF00498 0.451
LIG_FHA_2 14 20 PF00498 0.628
LIG_FHA_2 220 226 PF00498 0.448
LIG_FHA_2 25 31 PF00498 0.568
LIG_FHA_2 266 272 PF00498 0.364
LIG_GBD_Chelix_1 294 302 PF00786 0.445
LIG_LIR_Gen_1 104 115 PF02991 0.497
LIG_LIR_Gen_1 162 171 PF02991 0.437
LIG_LIR_Gen_1 268 276 PF02991 0.415
LIG_LIR_Gen_1 280 290 PF02991 0.402
LIG_LIR_Gen_1 304 313 PF02991 0.361
LIG_LIR_LC3C_4 125 129 PF02991 0.462
LIG_LIR_Nem_3 104 110 PF02991 0.443
LIG_LIR_Nem_3 155 161 PF02991 0.474
LIG_LIR_Nem_3 162 167 PF02991 0.457
LIG_LIR_Nem_3 194 200 PF02991 0.363
LIG_LIR_Nem_3 268 273 PF02991 0.426
LIG_LIR_Nem_3 280 285 PF02991 0.508
LIG_LIR_Nem_3 304 309 PF02991 0.374
LIG_Pex14_2 306 310 PF04695 0.357
LIG_SH2_CRK 282 286 PF00017 0.445
LIG_SH2_STAT5 221 224 PF00017 0.449
LIG_SH3_3 143 149 PF00018 0.542
LIG_SH3_3 17 23 PF00018 0.618
LIG_SH3_3 253 259 PF00018 0.550
LIG_TRAF2_1 206 209 PF00917 0.437
LIG_TRAF2_1 57 60 PF00917 0.440
LIG_TRAF2_1 79 82 PF00917 0.440
LIG_TYR_ITSM 278 285 PF00017 0.430
LIG_WRC_WIRS_1 107 112 PF05994 0.337
MOD_CDK_SPxK_1 43 49 PF00069 0.602
MOD_CK1_1 315 321 PF00069 0.523
MOD_CK1_1 33 39 PF00069 0.643
MOD_CK1_1 72 78 PF00069 0.480
MOD_CK2_1 181 187 PF00069 0.569
MOD_CK2_1 265 271 PF00069 0.407
MOD_CK2_1 33 39 PF00069 0.747
MOD_CK2_1 54 60 PF00069 0.506
MOD_Cter_Amidation 90 93 PF01082 0.498
MOD_GlcNHglycan 1 4 PF01048 0.657
MOD_GlcNHglycan 103 106 PF01048 0.528
MOD_GlcNHglycan 142 145 PF01048 0.634
MOD_GlcNHglycan 177 180 PF01048 0.588
MOD_GlcNHglycan 192 196 PF01048 0.369
MOD_GlcNHglycan 317 320 PF01048 0.569
MOD_GlcNHglycan 32 35 PF01048 0.639
MOD_GlcNHglycan 9 12 PF01048 0.652
MOD_GSK3_1 182 189 PF00069 0.722
MOD_GSK3_1 246 253 PF00069 0.660
MOD_GSK3_1 265 272 PF00069 0.410
MOD_GSK3_1 280 287 PF00069 0.547
MOD_GSK3_1 314 321 PF00069 0.437
MOD_N-GLC_1 245 250 PF02516 0.552
MOD_N-GLC_1 30 35 PF02516 0.665
MOD_NEK2_1 13 18 PF00069 0.607
MOD_NEK2_1 301 306 PF00069 0.452
MOD_NEK2_2 106 111 PF00069 0.331
MOD_PKA_2 152 158 PF00069 0.586
MOD_PKA_2 236 242 PF00069 0.451
MOD_PKA_2 277 283 PF00069 0.564
MOD_PKA_2 69 75 PF00069 0.453
MOD_Plk_1 191 197 PF00069 0.491
MOD_Plk_2-3 271 277 PF00069 0.359
MOD_ProDKin_1 182 188 PF00069 0.596
MOD_ProDKin_1 4 10 PF00069 0.632
MOD_ProDKin_1 43 49 PF00069 0.585
MOD_SUMO_rev_2 143 149 PF00179 0.492
MOD_SUMO_rev_2 26 33 PF00179 0.605
TRG_DiLeu_BaEn_1 58 63 PF01217 0.527
TRG_DiLeu_BaEn_4 58 64 PF01217 0.495
TRG_DiLeu_BaLyEn_6 207 212 PF01217 0.436
TRG_DiLeu_BaLyEn_6 97 102 PF01217 0.532
TRG_DiLeu_LyEn_5 58 63 PF01217 0.501
TRG_ENDOCYTIC_2 197 200 PF00928 0.427
TRG_ENDOCYTIC_2 220 223 PF00928 0.545
TRG_ENDOCYTIC_2 282 285 PF00928 0.542
TRG_ER_diArg_1 120 123 PF00400 0.372
TRG_ER_diArg_1 252 255 PF00400 0.572
TRG_Pf-PMV_PEXEL_1 210 215 PF00026 0.444

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7P6 Leptomonas seymouri 38% 100%
A4HPX5 Leishmania braziliensis 64% 100%
A4IDN6 Leishmania infantum 99% 100%
E9ATP1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4Q0V7 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS