LeishMANIAdb
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Ribosomal protein L18e/L15 family protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ribosomal protein L18e/L15 family protein
Gene product:
60S ribosomal protein L18, putative
Species:
Leishmania donovani
UniProt:
A0A3S7XBN1_LEIDO
TriTrypDb:
LdBPK_364730.1 , LdCL_130009900 , LdCL_360054400 , LDHU3_13.0620 , LDHU3_36.6360
Length:
198

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 60S ribosomal L18 RPL18

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 6
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 21
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005840 ribosome 5 12
GO:0032991 protein-containing complex 1 13
GO:0043226 organelle 2 13
GO:0043228 non-membrane-bounded organelle 3 13
GO:0043229 intracellular organelle 3 13
GO:0043232 intracellular non-membrane-bounded organelle 4 13
GO:0110165 cellular anatomical entity 1 13
GO:1990904 ribonucleoprotein complex 2 13
GO:0005730 nucleolus 5 1
GO:0005737 cytoplasm 2 3
GO:0015934 large ribosomal subunit 4 1
GO:0022625 cytosolic large ribosomal subunit 5 1
GO:0044391 ribosomal subunit 3 1
GO:0016020 membrane 2 1

Expansion

Sequence features

A0A3S7XBN1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBN1

PDB structure(s): 6az3_P

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 13
GO:0006518 peptide metabolic process 4 13
GO:0006807 nitrogen compound metabolic process 2 13
GO:0008152 metabolic process 1 13
GO:0009058 biosynthetic process 2 13
GO:0009059 macromolecule biosynthetic process 4 13
GO:0009987 cellular process 1 13
GO:0019538 protein metabolic process 3 13
GO:0034641 cellular nitrogen compound metabolic process 3 13
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 13
GO:0043043 peptide biosynthetic process 5 13
GO:0043170 macromolecule metabolic process 3 13
GO:0043603 amide metabolic process 3 13
GO:0043604 amide biosynthetic process 4 13
GO:0044237 cellular metabolic process 2 13
GO:0044238 primary metabolic process 2 13
GO:0044249 cellular biosynthetic process 3 13
GO:0044260 obsolete cellular macromolecule metabolic process 3 13
GO:0044271 cellular nitrogen compound biosynthetic process 4 13
GO:0071704 organic substance metabolic process 2 13
GO:1901564 organonitrogen compound metabolic process 3 13
GO:1901566 organonitrogen compound biosynthetic process 4 13
GO:1901576 organic substance biosynthetic process 3 13
Molecular functions
Term Name Level Count
GO:0003735 structural constituent of ribosome 2 13
GO:0005198 structural molecule activity 1 13
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0005488 binding 1 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 148 150 PF00675 0.323
CLV_NRD_NRD_1 184 186 PF00675 0.330
CLV_NRD_NRD_1 191 193 PF00675 0.522
CLV_NRD_NRD_1 72 74 PF00675 0.324
CLV_PCSK_FUR_1 182 186 PF00082 0.415
CLV_PCSK_KEX2_1 181 183 PF00082 0.338
CLV_PCSK_KEX2_1 184 186 PF00082 0.318
CLV_PCSK_KEX2_1 191 193 PF00082 0.506
CLV_PCSK_KEX2_1 38 40 PF00082 0.415
CLV_PCSK_KEX2_1 72 74 PF00082 0.323
CLV_PCSK_PC1ET2_1 181 183 PF00082 0.424
CLV_PCSK_PC1ET2_1 191 193 PF00082 0.641
CLV_PCSK_PC1ET2_1 38 40 PF00082 0.415
CLV_PCSK_PC1ET2_1 72 74 PF00082 0.355
CLV_PCSK_SKI1_1 192 196 PF00082 0.587
CLV_PCSK_SKI1_1 51 55 PF00082 0.324
CLV_PCSK_SKI1_1 74 78 PF00082 0.434
DOC_MAPK_gen_1 56 64 PF00069 0.523
DOC_MAPK_gen_1 80 88 PF00069 0.555
DOC_MAPK_gen_1 98 107 PF00069 0.517
DOC_MAPK_MEF2A_6 82 90 PF00069 0.523
DOC_MAPK_RevD_3 60 74 PF00069 0.523
DOC_USP7_MATH_1 116 120 PF00917 0.595
DOC_USP7_UBL2_3 27 31 PF12436 0.523
DOC_USP7_UBL2_3 34 38 PF12436 0.523
LIG_14-3-3_CanoR_1 111 121 PF00244 0.505
LIG_14-3-3_CanoR_1 16 21 PF00244 0.523
LIG_14-3-3_CanoR_1 185 191 PF00244 0.610
LIG_14-3-3_CanoR_1 39 47 PF00244 0.615
LIG_14-3-3_CanoR_1 59 65 PF00244 0.420
LIG_Actin_WH2_2 95 113 PF00022 0.523
LIG_BRCT_BRCA1_1 40 44 PF00533 0.595
LIG_BRCT_BRCA1_2 40 46 PF00533 0.595
LIG_CtBP_PxDLS_1 61 65 PF00389 0.523
LIG_FHA_1 141 147 PF00498 0.506
LIG_IBAR_NPY_1 23 25 PF08397 0.523
LIG_LIR_Gen_1 129 138 PF02991 0.532
LIG_LIR_Gen_1 22 33 PF02991 0.523
LIG_LIR_Gen_1 41 52 PF02991 0.523
LIG_LIR_Nem_3 129 133 PF02991 0.523
LIG_LIR_Nem_3 22 28 PF02991 0.523
LIG_LIR_Nem_3 41 47 PF02991 0.523
LIG_SH2_CRK 33 37 PF00017 0.523
LIG_SH2_CRK 49 53 PF00017 0.523
LIG_SH2_PTP2 25 28 PF00017 0.523
LIG_SH2_STAT5 144 147 PF00017 0.595
LIG_SH2_STAT5 25 28 PF00017 0.523
LIG_SUMO_SIM_anti_2 65 71 PF11976 0.663
LIG_SUMO_SIM_par_1 60 65 PF11976 0.523
LIG_TYR_ITIM 47 52 PF00017 0.595
LIG_UBA3_1 28 34 PF00899 0.523
MOD_CK1_1 9 15 PF00069 0.595
MOD_CK2_1 148 154 PF00069 0.537
MOD_Cter_Amidation 147 150 PF01082 0.323
MOD_Cter_Amidation 182 185 PF01082 0.415
MOD_GlcNHglycan 114 117 PF01048 0.305
MOD_GlcNHglycan 150 153 PF01048 0.346
MOD_GlcNHglycan 161 164 PF01048 0.370
MOD_GlcNHglycan 41 44 PF01048 0.379
MOD_GSK3_1 112 119 PF00069 0.549
MOD_GSK3_1 136 143 PF00069 0.524
MOD_GSK3_1 148 155 PF00069 0.523
MOD_NEK2_1 110 115 PF00069 0.523
MOD_NEK2_1 159 164 PF00069 0.595
MOD_NEK2_1 52 57 PF00069 0.526
MOD_NEK2_2 152 157 PF00069 0.537
MOD_NMyristoyl 1 7 PF02799 0.383
MOD_PKA_1 38 44 PF00069 0.595
MOD_PKA_2 110 116 PF00069 0.568
MOD_PKA_2 148 154 PF00069 0.537
MOD_PKA_2 183 189 PF00069 0.555
MOD_PKA_2 38 44 PF00069 0.595
MOD_Plk_2-3 126 132 PF00069 0.523
MOD_Plk_4 116 122 PF00069 0.595
MOD_Plk_4 140 146 PF00069 0.523
TRG_DiLeu_BaLyEn_6 48 53 PF01217 0.523
TRG_ENDOCYTIC_2 25 28 PF00928 0.523
TRG_ENDOCYTIC_2 33 36 PF00928 0.523
TRG_ENDOCYTIC_2 49 52 PF00928 0.523
TRG_ER_diArg_1 146 149 PF00400 0.523
TRG_ER_diArg_1 182 185 PF00400 0.554
TRG_NLS_Bipartite_1 181 195 PF00514 0.595
TRG_NLS_MonoExtC_3 180 185 PF00514 0.595
TRG_NLS_MonoExtN_4 178 185 PF00514 0.624
TRG_NLS_MonoExtN_4 188 195 PF00514 0.728

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4JJ16 Bodo saltans 73% 100%
A0A1D8PK43 Candida albicans (strain SC5314 / ATCC MYA-2876) 47% 100%
A0A1X0P1J6 Trypanosomatidae 77% 100%
A0A422P5B7 Trypanosoma rangeli 75% 100%
A3F4S0 Taenia asiatica 48% 100%
A4H745 Leishmania braziliensis 96% 100%
A4HPW8 Leishmania braziliensis 96% 100%
A4HVI5 Leishmania infantum 100% 100%
D0A4B6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 74% 100%
D0VWQ3 Canis lupus familiaris 49% 100%
E9AP80 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
E9ATN5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
O22254 Arabidopsis thaliana 50% 100%
O45946 Caenorhabditis elegans 45% 100%
O65729 Cicer arietinum 47% 100%
P02412 Xenopus laevis 46% 100%
P09897 Xenopus laevis 46% 100%
P0CX49 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 47% 100%
P0CX50 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 47% 100%
P0DJ17 Tetrahymena thermophila 46% 100%
P12001 Rattus norvegicus 49% 100%
P24558 Salmo salar 38% 100%
P35980 Mus musculus 49% 100%
P42791 Arabidopsis thaliana 51% 100%
P50885 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 74% 100%
P69090 Oreochromis mossambicus 47% 100%
P69091 Oreochromis niloticus 47% 100%
Q07020 Homo sapiens 48% 100%
Q0PXY6 Diaphorina citri 47% 100%
Q10192 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 47% 100%
Q1HR62 Aedes aegypti 45% 100%
Q2M0G4 Drosophila pseudoobscura pseudoobscura 44% 100%
Q4DZP2 Trypanosoma cruzi (strain CL Brener) 83% 100%
Q4GXG7 Timarcha balearica 44% 100%
Q4N438 Theileria parva 45% 100%
Q4PM04 Ixodes scapularis 46% 100%
Q4QG98 Leishmania major 100% 100%
Q4R5H8 Macaca fascicularis 48% 100%
Q4UFD5 Theileria annulata 44% 100%
Q54VZ4 Dictyostelium discoideum 49% 100%
Q56FG8 Lysiphlebus testaceipes 45% 100%
Q5E973 Bos taurus 49% 100%
Q5UAS1 Bombyx mori 49% 100%
Q60P81 Caenorhabditis briggsae 43% 100%
Q6F442 Plutella xylostella 47% 100%
Q7QJM5 Anopheles gambiae 44% 100%
Q8TFH1 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 47% 100%
Q90YV0 Ictalurus punctatus 47% 100%
Q940B0 Arabidopsis thaliana 49% 100%
Q95342 Sus scrofa 49% 100%
Q962Y8 Spodoptera frugiperda 49% 100%
Q9VS34 Drosophila melanogaster 45% 100%
V5BKK2 Trypanosoma cruzi 83% 69%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS