MIF4G domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBM9_LEIDO

TriTrypDb:

LdBPK_365310.1 , LdCL_360060300 , LDHU3_36.7090

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XBM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBM9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.437
CLV_C14_Caspase3-7	233	237	PF00656	0.694
CLV_C14_Caspase3-7	48	52	PF00656	0.579
CLV_C14_Caspase3-7	556	560	PF00656	0.526
CLV_C14_Caspase3-7	59	63	PF00656	0.637
CLV_NRD_NRD_1	216	218	PF00675	0.499
CLV_NRD_NRD_1	350	352	PF00675	0.472
CLV_NRD_NRD_1	38	40	PF00675	0.733
CLV_NRD_NRD_1	424	426	PF00675	0.657
CLV_NRD_NRD_1	585	587	PF00675	0.494
CLV_NRD_NRD_1	74	76	PF00675	0.692
CLV_PCSK_FUR_1	72	76	PF00082	0.751
CLV_PCSK_KEX2_1	112	114	PF00082	0.659
CLV_PCSK_KEX2_1	350	352	PF00082	0.472
CLV_PCSK_KEX2_1	38	40	PF00082	0.769
CLV_PCSK_KEX2_1	424	426	PF00082	0.656
CLV_PCSK_KEX2_1	563	565	PF00082	0.520
CLV_PCSK_KEX2_1	585	587	PF00082	0.479
CLV_PCSK_KEX2_1	74	76	PF00082	0.685
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.695
CLV_PCSK_PC1ET2_1	563	565	PF00082	0.520
CLV_PCSK_PC7_1	70	76	PF00082	0.740
CLV_PCSK_SKI1_1	109	113	PF00082	0.705
CLV_PCSK_SKI1_1	116	120	PF00082	0.659
CLV_PCSK_SKI1_1	151	155	PF00082	0.486
CLV_PCSK_SKI1_1	26	30	PF00082	0.759
CLV_PCSK_SKI1_1	273	277	PF00082	0.481
CLV_PCSK_SKI1_1	306	310	PF00082	0.520
CLV_PCSK_SKI1_1	476	480	PF00082	0.548
CLV_PCSK_SKI1_1	485	489	PF00082	0.512
CLV_PCSK_SKI1_1	512	516	PF00082	0.504
CLV_PCSK_SKI1_1	585	589	PF00082	0.516
DEG_APCC_DBOX_1	272	280	PF00400	0.498
DEG_APCC_DBOX_1	584	592	PF00400	0.496
DEG_Nend_UBRbox_2	1	3	PF02207	0.775
DEG_SCF_FBW7_1	514	519	PF00400	0.391
DEG_SCF_FBW7_2	324	331	PF00400	0.521
DOC_CKS1_1	325	330	PF01111	0.518
DOC_CYCLIN_RxL_1	473	483	PF00134	0.585
DOC_CYCLIN_RxL_1	583	594	PF00134	0.490
DOC_MAPK_gen_1	166	174	PF00069	0.541
DOC_MAPK_gen_1	277	284	PF00069	0.470
DOC_MAPK_MEF2A_6	166	174	PF00069	0.541
DOC_PP1_RVXF_1	466	473	PF00149	0.505
DOC_PP1_RVXF_1	584	591	PF00149	0.493
DOC_PP2B_LxvP_1	248	251	PF13499	0.587
DOC_PP2B_LxvP_1	357	360	PF13499	0.412
DOC_PP4_MxPP_1	200	203	PF00568	0.487
DOC_USP7_MATH_1	15	19	PF00917	0.685
DOC_USP7_MATH_1	326	330	PF00917	0.732
DOC_USP7_MATH_1	4	8	PF00917	0.798
DOC_USP7_MATH_1	404	408	PF00917	0.818
DOC_USP7_UBL2_3	112	116	PF12436	0.660
DOC_USP7_UBL2_3	344	348	PF12436	0.455
DOC_WW_Pin1_4	100	105	PF00397	0.711
DOC_WW_Pin1_4	195	200	PF00397	0.572
DOC_WW_Pin1_4	268	273	PF00397	0.513
DOC_WW_Pin1_4	324	329	PF00397	0.530
DOC_WW_Pin1_4	512	517	PF00397	0.409
DOC_WW_Pin1_4	536	541	PF00397	0.532
LIG_14-3-3_CanoR_1	128	132	PF00244	0.572
LIG_14-3-3_CanoR_1	217	225	PF00244	0.552
LIG_14-3-3_CanoR_1	383	389	PF00244	0.766
LIG_14-3-3_CanoR_1	425	433	PF00244	0.609
LIG_14-3-3_CanoR_1	485	490	PF00244	0.561
LIG_14-3-3_CanoR_1	569	577	PF00244	0.484
LIG_14-3-3_CanoR_1	91	96	PF00244	0.737
LIG_Actin_WH2_2	507	525	PF00022	0.599
LIG_Actin_WH2_2	574	591	PF00022	0.563
LIG_BIR_III_4	62	66	PF00653	0.650
LIG_BRCT_BRCA1_1	146	150	PF00533	0.556
LIG_BRCT_BRCA1_1	440	444	PF00533	0.554
LIG_CaM_IQ_9	336	352	PF13499	0.568
LIG_FHA_1	225	231	PF00498	0.574
LIG_FHA_1	307	313	PF00498	0.566
LIG_FHA_1	517	523	PF00498	0.482
LIG_FHA_1	578	584	PF00498	0.539
LIG_FHA_2	128	134	PF00498	0.557
LIG_FHA_2	182	188	PF00498	0.433
LIG_FHA_2	231	237	PF00498	0.528
LIG_FHA_2	369	375	PF00498	0.660
LIG_FHA_2	398	404	PF00498	0.810
LIG_FHA_2	410	416	PF00498	0.695
LIG_FHA_2	427	433	PF00498	0.438
LIG_FHA_2	447	453	PF00498	0.548
LIG_FHA_2	486	492	PF00498	0.624
LIG_FHA_2	513	519	PF00498	0.525
LIG_Integrin_RGD_1	66	68	PF01839	0.694
LIG_LIR_Gen_1	122	131	PF02991	0.486
LIG_LIR_Gen_1	180	191	PF02991	0.476
LIG_LIR_Gen_1	441	451	PF02991	0.594
LIG_LIR_Gen_1	464	470	PF02991	0.517
LIG_LIR_Gen_1	483	494	PF02991	0.516
LIG_LIR_Nem_3	122	127	PF02991	0.474
LIG_LIR_Nem_3	147	153	PF02991	0.586
LIG_LIR_Nem_3	180	186	PF02991	0.457
LIG_LIR_Nem_3	187	193	PF02991	0.380
LIG_LIR_Nem_3	441	447	PF02991	0.580
LIG_LIR_Nem_3	464	469	PF02991	0.507
LIG_LIR_Nem_3	483	489	PF02991	0.514
LIG_MYND_1	355	359	PF01753	0.452
LIG_SH2_PTP2	171	174	PF00017	0.356
LIG_SH2_STAT5	140	143	PF00017	0.457
LIG_SH2_STAT5	171	174	PF00017	0.356
LIG_SH3_3	196	202	PF00018	0.513
LIG_SH3_3	248	254	PF00018	0.710
LIG_SH3_3	255	261	PF00018	0.669
LIG_SH3_3	370	376	PF00018	0.729
LIG_SH3_3	578	584	PF00018	0.563
LIG_SUMO_SIM_anti_2	281	286	PF11976	0.467
LIG_SUMO_SIM_par_1	506	513	PF11976	0.524
LIG_TRAF2_1	376	379	PF00917	0.729
LIG_UBA3_1	189	197	PF00899	0.587
LIG_UBA3_1	341	348	PF00899	0.450
LIG_WRC_WIRS_1	156	161	PF05994	0.500
LIG_WW_3	359	363	PF00397	0.539
MOD_CDK_SPK_2	268	273	PF00069	0.513
MOD_CK1_1	155	161	PF00069	0.501
MOD_CK1_1	268	274	PF00069	0.531
MOD_CK1_1	406	412	PF00069	0.772
MOD_CK1_1	510	516	PF00069	0.578
MOD_CK1_1	539	545	PF00069	0.576
MOD_CK1_1	6	12	PF00069	0.751
MOD_CK2_1	133	139	PF00069	0.560
MOD_CK2_1	181	187	PF00069	0.472
MOD_CK2_1	268	274	PF00069	0.511
MOD_CK2_1	368	374	PF00069	0.593
MOD_CK2_1	397	403	PF00069	0.812
MOD_CK2_1	426	432	PF00069	0.578
MOD_CK2_1	446	452	PF00069	0.482
MOD_CK2_1	485	491	PF00069	0.543
MOD_Cter_Amidation	72	75	PF01082	0.622
MOD_GlcNHglycan	17	20	PF01048	0.602
MOD_GlcNHglycan	218	221	PF01048	0.559
MOD_GlcNHglycan	328	331	PF01048	0.677
MOD_GlcNHglycan	406	409	PF01048	0.809
MOD_GlcNHglycan	440	443	PF01048	0.528
MOD_GlcNHglycan	47	50	PF01048	0.613
MOD_GlcNHglycan	546	549	PF01048	0.406
MOD_GlcNHglycan	553	556	PF01048	0.469
MOD_GlcNHglycan	6	9	PF01048	0.802
MOD_GlcNHglycan	95	98	PF01048	0.702
MOD_GSK3_1	306	313	PF00069	0.555
MOD_GSK3_1	320	327	PF00069	0.671
MOD_GSK3_1	340	347	PF00069	0.371
MOD_GSK3_1	378	385	PF00069	0.799
MOD_GSK3_1	403	410	PF00069	0.658
MOD_GSK3_1	512	519	PF00069	0.502
MOD_GSK3_1	532	539	PF00069	0.499
MOD_GSK3_1	609	616	PF00069	0.666
MOD_N-GLC_1	13	18	PF02516	0.624
MOD_NEK2_1	126	131	PF00069	0.470
MOD_NEK2_1	45	50	PF00069	0.549
MOD_NEK2_1	570	575	PF00069	0.478
MOD_NEK2_1	577	582	PF00069	0.514
MOD_PIKK_1	161	167	PF00454	0.529
MOD_PIKK_1	173	179	PF00454	0.519
MOD_PIKK_1	419	425	PF00454	0.633
MOD_PIKK_1	456	462	PF00454	0.655
MOD_PIKK_1	570	576	PF00454	0.487
MOD_PK_1	454	460	PF00069	0.508
MOD_PKA_1	306	312	PF00069	0.484
MOD_PKA_2	127	133	PF00069	0.506
MOD_PKA_2	216	222	PF00069	0.554
MOD_PKA_2	32	38	PF00069	0.787
MOD_PKA_2	382	388	PF00069	0.763
MOD_PKB_1	41	49	PF00069	0.732
MOD_PKB_1	64	72	PF00069	0.656
MOD_PKB_1	91	99	PF00069	0.739
MOD_Plk_1	378	384	PF00069	0.804
MOD_Plk_2-3	133	139	PF00069	0.570
MOD_Plk_4	155	161	PF00069	0.437
MOD_Plk_4	265	271	PF00069	0.618
MOD_Plk_4	320	326	PF00069	0.670
MOD_Plk_4	446	452	PF00069	0.560
MOD_Plk_4	485	491	PF00069	0.565
MOD_Plk_4	504	510	PF00069	0.467
MOD_ProDKin_1	100	106	PF00069	0.711
MOD_ProDKin_1	195	201	PF00069	0.563
MOD_ProDKin_1	268	274	PF00069	0.511
MOD_ProDKin_1	324	330	PF00069	0.525
MOD_ProDKin_1	512	518	PF00069	0.405
MOD_ProDKin_1	536	542	PF00069	0.530
MOD_SUMO_rev_2	147	156	PF00179	0.556
MOD_SUMO_rev_2	556	565	PF00179	0.593
TRG_DiLeu_BaEn_1	265	270	PF01217	0.685
TRG_DiLeu_BaEn_2	79	85	PF01217	0.632
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.489
TRG_ENDOCYTIC_2	171	174	PF00928	0.444
TRG_ER_diArg_1	350	352	PF00400	0.505
TRG_ER_diArg_1	38	41	PF00400	0.732
TRG_ER_diArg_1	424	426	PF00400	0.644
TRG_ER_diArg_1	584	586	PF00400	0.484
TRG_ER_diArg_1	72	75	PF00400	0.705
TRG_ER_diArg_1	90	93	PF00400	0.661
TRG_NLS_MonoExtC_3	111	116	PF00514	0.545
TRG_NLS_MonoExtN_4	109	116	PF00514	0.641
TRG_Pf-PMV_PEXEL_1	350	354	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	575	579	PF00026	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHF8	Leptomonas seymouri	61%	98%
A0A0S4JKM1	Bodo saltans	29%	100%
A4HQ24	Leishmania braziliensis	71%	100%
D0A8U5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AHY2	Leishmania infantum	98%	100%
E9ATU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q0Q4	Leishmania major	88%	100%