Amino acid transporter, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amino acid transporter, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBM8_LEIDO

TriTrypDb:

LdBPK_364700.1 , LdCL_360054100 , LDHU3_36.6320

Length:

789

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7XBM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBM8

Function

Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	1
GO:0006810	transport	3	1
GO:0006865	amino acid transport	5	1
GO:0009987	cellular process	1	1
GO:0015849	organic acid transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:1903825	organic acid transmembrane transport	3	1
GO:1905039	carboxylic acid transmembrane transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005342	organic acid transmembrane transporter activity	3	1
GO:0015171	amino acid transmembrane transporter activity	5	1
GO:0015179	L-amino acid transmembrane transporter activity	6	1
GO:0022857	transmembrane transporter activity	2	1
GO:0046943	carboxylic acid transmembrane transporter activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.800
CLV_C14_Caspase3-7	309	313	PF00656	0.330
CLV_C14_Caspase3-7	730	734	PF00656	0.637
CLV_NRD_NRD_1	128	130	PF00675	0.472
CLV_NRD_NRD_1	220	222	PF00675	0.560
CLV_NRD_NRD_1	268	270	PF00675	0.363
CLV_NRD_NRD_1	271	273	PF00675	0.348
CLV_NRD_NRD_1	418	420	PF00675	0.336
CLV_NRD_NRD_1	496	498	PF00675	0.346
CLV_NRD_NRD_1	532	534	PF00675	0.314
CLV_NRD_NRD_1	611	613	PF00675	0.363
CLV_NRD_NRD_1	7	9	PF00675	0.451
CLV_PCSK_FUR_1	266	270	PF00082	0.408
CLV_PCSK_KEX2_1	219	221	PF00082	0.562
CLV_PCSK_KEX2_1	266	268	PF00082	0.420
CLV_PCSK_KEX2_1	271	273	PF00082	0.386
CLV_PCSK_KEX2_1	367	369	PF00082	0.591
CLV_PCSK_KEX2_1	418	420	PF00082	0.336
CLV_PCSK_KEX2_1	496	498	PF00082	0.346
CLV_PCSK_KEX2_1	532	534	PF00082	0.314
CLV_PCSK_KEX2_1	611	613	PF00082	0.363
CLV_PCSK_KEX2_1	7	9	PF00082	0.451
CLV_PCSK_PC1ET2_1	367	369	PF00082	0.563
CLV_PCSK_PC7_1	216	222	PF00082	0.593
CLV_PCSK_PC7_1	262	268	PF00082	0.479
CLV_PCSK_SKI1_1	272	276	PF00082	0.346
CLV_PCSK_SKI1_1	8	12	PF00082	0.423
DEG_APCC_DBOX_1	495	503	PF00400	0.546
DEG_APCC_DBOX_1	746	754	PF00400	0.693
DEG_Nend_UBRbox_3	1	3	PF02207	0.783
DEG_SCF_FBW7_2	580	585	PF00400	0.562
DEG_SPOP_SBC_1	159	163	PF00917	0.783
DOC_CYCLIN_RxL_1	5	14	PF00134	0.620
DOC_CYCLIN_yCln2_LP_2	66	72	PF00134	0.411
DOC_MAPK_gen_1	749	759	PF00069	0.602
DOC_MAPK_MEF2A_6	477	484	PF00069	0.389
DOC_PP2B_LxvP_1	37	40	PF13499	0.623
DOC_PP2B_LxvP_1	66	69	PF13499	0.411
DOC_PP4_FxxP_1	245	248	PF00568	0.726
DOC_USP7_MATH_1	153	157	PF00917	0.744
DOC_USP7_MATH_1	228	232	PF00917	0.728
DOC_USP7_MATH_1	241	245	PF00917	0.680
DOC_USP7_MATH_1	248	252	PF00917	0.573
DOC_USP7_MATH_1	303	307	PF00917	0.346
DOC_USP7_MATH_1	510	514	PF00917	0.539
DOC_USP7_MATH_1	520	524	PF00917	0.558
DOC_USP7_MATH_1	534	538	PF00917	0.418
DOC_USP7_MATH_1	539	543	PF00917	0.521
DOC_USP7_MATH_1	6	10	PF00917	0.714
DOC_USP7_MATH_1	626	630	PF00917	0.546
DOC_USP7_MATH_1	680	684	PF00917	0.416
DOC_USP7_MATH_1	718	722	PF00917	0.649
DOC_USP7_MATH_1	727	731	PF00917	0.689
DOC_USP7_MATH_1	739	743	PF00917	0.480
DOC_WW_Pin1_4	542	547	PF00397	0.491
DOC_WW_Pin1_4	568	573	PF00397	0.546
DOC_WW_Pin1_4	576	581	PF00397	0.604
DOC_WW_Pin1_4	588	593	PF00397	0.449
DOC_WW_Pin1_4	652	657	PF00397	0.535
DOC_WW_Pin1_4	711	716	PF00397	0.606
LIG_14-3-3_CanoR_1	107	116	PF00244	0.578
LIG_14-3-3_CanoR_1	16	23	PF00244	0.701
LIG_14-3-3_CanoR_1	160	165	PF00244	0.832
LIG_14-3-3_CanoR_1	271	281	PF00244	0.546
LIG_14-3-3_CanoR_1	34	38	PF00244	0.712
LIG_14-3-3_CanoR_1	362	371	PF00244	0.346
LIG_14-3-3_CanoR_1	386	390	PF00244	0.405
LIG_14-3-3_CanoR_1	501	505	PF00244	0.546
LIG_14-3-3_CanoR_1	611	620	PF00244	0.542
LIG_14-3-3_CanoR_1	635	639	PF00244	0.466
LIG_14-3-3_CanoR_1	7	11	PF00244	0.719
LIG_BIR_III_4	103	107	PF00653	0.596
LIG_BIR_III_4	627	631	PF00653	0.563
LIG_BRCT_BRCA1_1	316	320	PF00533	0.429
LIG_BRCT_BRCA1_1	715	719	PF00533	0.659
LIG_deltaCOP1_diTrp_1	339	349	PF00928	0.546
LIG_EH1_1	353	361	PF00400	0.404
LIG_eIF4E_1	466	472	PF01652	0.339
LIG_FHA_1	109	115	PF00498	0.557
LIG_FHA_1	322	328	PF00498	0.338
LIG_FHA_1	395	401	PF00498	0.389
LIG_FHA_1	439	445	PF00498	0.436
LIG_FHA_1	44	50	PF00498	0.669
LIG_FHA_1	526	532	PF00498	0.528
LIG_FHA_1	536	542	PF00498	0.566
LIG_FHA_1	568	574	PF00498	0.539
LIG_FHA_1	644	650	PF00498	0.526
LIG_FHA_1	657	663	PF00498	0.533
LIG_FHA_1	672	678	PF00498	0.411
LIG_FHA_1	696	702	PF00498	0.299
LIG_FHA_2	135	141	PF00498	0.702
LIG_FHA_2	179	185	PF00498	0.795
LIG_FHA_2	307	313	PF00498	0.309
LIG_FHA_2	506	512	PF00498	0.513
LIG_GBD_Chelix_1	49	57	PF00786	0.336
LIG_LIR_Apic_2	244	248	PF02991	0.731
LIG_LIR_Apic_2	403	409	PF02991	0.411
LIG_LIR_Apic_2	779	785	PF02991	0.461
LIG_LIR_Gen_1	340	350	PF02991	0.546
LIG_LIR_Gen_1	351	361	PF02991	0.411
LIG_LIR_Gen_1	381	392	PF02991	0.319
LIG_LIR_Gen_1	581	592	PF02991	0.619
LIG_LIR_Gen_1	618	628	PF02991	0.504
LIG_LIR_Gen_1	667	678	PF02991	0.389
LIG_LIR_Gen_1	694	704	PF02991	0.411
LIG_LIR_Gen_1	775	786	PF02991	0.551
LIG_LIR_Gen_1	88	98	PF02991	0.406
LIG_LIR_Nem_3	284	290	PF02991	0.431
LIG_LIR_Nem_3	317	323	PF02991	0.416
LIG_LIR_Nem_3	340	346	PF02991	0.546
LIG_LIR_Nem_3	351	357	PF02991	0.411
LIG_LIR_Nem_3	370	374	PF02991	0.243
LIG_LIR_Nem_3	378	382	PF02991	0.304
LIG_LIR_Nem_3	581	587	PF02991	0.619
LIG_LIR_Nem_3	618	624	PF02991	0.504
LIG_LIR_Nem_3	667	673	PF02991	0.389
LIG_LIR_Nem_3	694	699	PF02991	0.411
LIG_LIR_Nem_3	746	751	PF02991	0.623
LIG_LIR_Nem_3	775	781	PF02991	0.525
LIG_LIR_Nem_3	88	93	PF02991	0.477
LIG_LIR_Nem_3	94	99	PF02991	0.520
LIG_LYPXL_yS_3	371	374	PF13949	0.346
LIG_MLH1_MIPbox_1	316	320	PF16413	0.402
LIG_NRBOX	755	761	PF00104	0.436
LIG_NRBOX	80	86	PF00104	0.411
LIG_Pex14_2	484	488	PF04695	0.411
LIG_SH2_CRK	287	291	PF00017	0.376
LIG_SH2_CRK	293	297	PF00017	0.411
LIG_SH2_CRK	369	373	PF00017	0.380
LIG_SH2_CRK	379	383	PF00017	0.304
LIG_SH2_CRK	406	410	PF00017	0.546
LIG_SH2_CRK	96	100	PF00017	0.513
LIG_SH2_NCK_1	406	410	PF00017	0.546
LIG_SH2_PTP2	354	357	PF00017	0.402
LIG_SH2_SRC	369	372	PF00017	0.419
LIG_SH2_STAP1	293	297	PF00017	0.411
LIG_SH2_STAP1	584	588	PF00017	0.619
LIG_SH2_STAP1	778	782	PF00017	0.442
LIG_SH2_STAT3	119	122	PF00017	0.592
LIG_SH2_STAT3	363	366	PF00017	0.346
LIG_SH2_STAT5	127	130	PF00017	0.643
LIG_SH2_STAT5	319	322	PF00017	0.324
LIG_SH2_STAT5	354	357	PF00017	0.411
LIG_SH2_STAT5	410	413	PF00017	0.546
LIG_SH2_STAT5	421	424	PF00017	0.546
LIG_SH2_STAT5	446	449	PF00017	0.397
LIG_SH2_STAT5	73	76	PF00017	0.553
LIG_SH2_STAT5	96	99	PF00017	0.411
LIG_SH3_3	167	173	PF00018	0.763
LIG_SH3_3	426	432	PF00018	0.546
LIG_SH3_3	450	456	PF00018	0.419
LIG_SH3_3	650	656	PF00018	0.537
LIG_SH3_3	709	715	PF00018	0.513
LIG_SUMO_SIM_anti_2	659	667	PF11976	0.546
LIG_SUMO_SIM_par_1	489	495	PF11976	0.411
LIG_SUMO_SIM_par_1	503	508	PF11976	0.546
LIG_SUMO_SIM_par_1	645	650	PF11976	0.546
LIG_SUMO_SIM_par_1	82	89	PF11976	0.407
LIG_TRAF2_1	138	141	PF00917	0.740
LIG_TRAF2_1	197	200	PF00917	0.742
LIG_TRAF2_1	261	264	PF00917	0.614
LIG_TYR_ITIM	291	296	PF00017	0.411
LIG_TYR_ITIM	352	357	PF00017	0.402
LIG_UBA3_1	750	754	PF00899	0.615
LIG_WRC_WIRS_1	395	400	PF05994	0.367
LIG_WRC_WIRS_1	446	451	PF05994	0.411
LIG_WRC_WIRS_1	696	701	PF05994	0.299
LIG_WRC_WIRS_1	778	783	PF05994	0.448
LIG_WRC_WIRS_1	87	92	PF05994	0.436
MOD_CK1_1	154	160	PF00069	0.745
MOD_CK1_1	168	174	PF00069	0.771
MOD_CK1_1	202	208	PF00069	0.809
MOD_CK1_1	249	255	PF00069	0.641
MOD_CK1_1	306	312	PF00069	0.346
MOD_CK1_1	33	39	PF00069	0.694
MOD_CK1_1	378	384	PF00069	0.266
MOD_CK1_1	492	498	PF00069	0.411
MOD_CK1_1	537	543	PF00069	0.585
MOD_CK2_1	106	112	PF00069	0.586
MOD_CK2_1	134	140	PF00069	0.752
MOD_CK2_1	194	200	PF00069	0.769
MOD_CK2_1	223	229	PF00069	0.813
MOD_CK2_1	626	632	PF00069	0.564
MOD_Cter_Amidation	609	612	PF01082	0.336
MOD_GlcNHglycan	153	156	PF01048	0.537
MOD_GlcNHglycan	167	170	PF01048	0.556
MOD_GlcNHglycan	248	251	PF01048	0.453
MOD_GlcNHglycan	511	515	PF01048	0.330
MOD_GlcNHglycan	522	525	PF01048	0.305
MOD_GlcNHglycan	608	611	PF01048	0.367
MOD_GlcNHglycan	613	616	PF01048	0.333
MOD_GlcNHglycan	627	631	PF01048	0.358
MOD_GlcNHglycan	682	685	PF01048	0.619
MOD_GlcNHglycan	715	718	PF01048	0.460
MOD_GlcNHglycan	720	723	PF01048	0.451
MOD_GlcNHglycan	729	732	PF01048	0.460
MOD_GlcNHglycan	736	739	PF01048	0.422
MOD_GSK3_1	102	109	PF00069	0.578
MOD_GSK3_1	15	22	PF00069	0.684
MOD_GSK3_1	154	161	PF00069	0.762
MOD_GSK3_1	230	237	PF00069	0.815
MOD_GSK3_1	45	52	PF00069	0.606
MOD_GSK3_1	535	542	PF00069	0.566
MOD_GSK3_1	544	551	PF00069	0.523
MOD_GSK3_1	634	641	PF00069	0.544
MOD_GSK3_1	652	659	PF00069	0.475
MOD_GSK3_1	691	698	PF00069	0.299
MOD_GSK3_1	739	746	PF00069	0.659
MOD_N-GLC_1	588	593	PF02516	0.355
MOD_NEK2_1	314	319	PF00069	0.360
MOD_NEK2_1	330	335	PF00069	0.387
MOD_NEK2_1	341	346	PF00069	0.479
MOD_NEK2_1	385	390	PF00069	0.365
MOD_NEK2_1	400	405	PF00069	0.313
MOD_NEK2_1	423	428	PF00069	0.518
MOD_NEK2_1	587	592	PF00069	0.609
MOD_NEK2_1	671	676	PF00069	0.478
MOD_NEK2_1	691	696	PF00069	0.183
MOD_NEK2_1	72	77	PF00069	0.445
MOD_NEK2_1	85	90	PF00069	0.411
MOD_NEK2_2	91	96	PF00069	0.515
MOD_PIKK_1	15	21	PF00454	0.692
MOD_PIKK_1	362	368	PF00454	0.346
MOD_PKA_1	611	617	PF00069	0.555
MOD_PKA_2	106	112	PF00069	0.586
MOD_PKA_2	15	21	PF00069	0.638
MOD_PKA_2	159	165	PF00069	0.804
MOD_PKA_2	25	31	PF00069	0.550
MOD_PKA_2	33	39	PF00069	0.715
MOD_PKA_2	385	391	PF00069	0.330
MOD_PKA_2	500	506	PF00069	0.546
MOD_PKA_2	520	526	PF00069	0.558
MOD_PKA_2	6	12	PF00069	0.732
MOD_PKA_2	611	617	PF00069	0.536
MOD_PKA_2	634	640	PF00069	0.491
MOD_PKB_1	209	217	PF00069	0.692
MOD_Plk_1	202	208	PF00069	0.841
MOD_Plk_1	510	516	PF00069	0.546
MOD_Plk_1	656	662	PF00069	0.619
MOD_Plk_2-3	199	205	PF00069	0.794
MOD_Plk_4	241	247	PF00069	0.776
MOD_Plk_4	342	348	PF00069	0.518
MOD_Plk_4	49	55	PF00069	0.558
MOD_Plk_4	500	506	PF00069	0.546
MOD_Plk_4	56	62	PF00069	0.376
MOD_Plk_4	657	663	PF00069	0.604
MOD_Plk_4	672	678	PF00069	0.295
MOD_Plk_4	691	697	PF00069	0.411
MOD_Plk_4	73	79	PF00069	0.388
MOD_Plk_4	772	778	PF00069	0.436
MOD_ProDKin_1	542	548	PF00069	0.491
MOD_ProDKin_1	568	574	PF00069	0.546
MOD_ProDKin_1	576	582	PF00069	0.604
MOD_ProDKin_1	588	594	PF00069	0.449
MOD_ProDKin_1	652	658	PF00069	0.535
MOD_ProDKin_1	711	717	PF00069	0.608
MOD_SUMO_rev_2	335	344	PF00179	0.543
MOD_SUMO_rev_2	730	737	PF00179	0.632
TRG_DiLeu_BaEn_1	667	672	PF01217	0.411
TRG_DiLeu_BaLyEn_6	746	751	PF01217	0.670
TRG_DiLeu_LyEn_5	569	574	PF01217	0.546
TRG_ENDOCYTIC_2	287	290	PF00928	0.376
TRG_ENDOCYTIC_2	293	296	PF00928	0.411
TRG_ENDOCYTIC_2	319	322	PF00928	0.411
TRG_ENDOCYTIC_2	354	357	PF00928	0.411
TRG_ENDOCYTIC_2	371	374	PF00928	0.304
TRG_ENDOCYTIC_2	379	382	PF00928	0.307
TRG_ENDOCYTIC_2	412	415	PF00928	0.546
TRG_ENDOCYTIC_2	421	424	PF00928	0.546
TRG_ENDOCYTIC_2	446	449	PF00928	0.411
TRG_ENDOCYTIC_2	584	587	PF00928	0.619
TRG_ENDOCYTIC_2	778	781	PF00928	0.495
TRG_ENDOCYTIC_2	96	99	PF00928	0.411
TRG_ER_diArg_1	208	211	PF00400	0.780
TRG_ER_diArg_1	219	221	PF00400	0.760
TRG_ER_diArg_1	265	268	PF00400	0.611
TRG_ER_diArg_1	269	272	PF00400	0.595
TRG_ER_diArg_1	418	420	PF00400	0.533
TRG_ER_diArg_1	531	533	PF00400	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDJ5	Leptomonas seymouri	55%	99%
A4HPW5	Leishmania braziliensis	69%	99%
A4IDM7	Leishmania infantum	99%	100%
E9ATN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q0W6	Leishmania major	88%	99%