Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBM3_LEIDO

TriTrypDb:

LdBPK_364940.1 , LdCL_360056500 , LDHU3_36.6650

Length:

727

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	7
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:1990904	ribonucleoprotein complex	2	7

Expansion

Sequence features

A0A3S7XBM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBM3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	425	429	PF00656	0.426
CLV_C14_Caspase3-7	668	672	PF00656	0.685
CLV_NRD_NRD_1	169	171	PF00675	0.647
CLV_NRD_NRD_1	223	225	PF00675	0.421
CLV_NRD_NRD_1	273	275	PF00675	0.440
CLV_NRD_NRD_1	365	367	PF00675	0.566
CLV_NRD_NRD_1	402	404	PF00675	0.537
CLV_NRD_NRD_1	55	57	PF00675	0.449
CLV_NRD_NRD_1	611	613	PF00675	0.714
CLV_NRD_NRD_1	697	699	PF00675	0.507
CLV_NRD_NRD_1	710	712	PF00675	0.539
CLV_PCSK_FUR_1	221	225	PF00082	0.492
CLV_PCSK_FUR_1	708	712	PF00082	0.542
CLV_PCSK_KEX2_1	223	225	PF00082	0.483
CLV_PCSK_KEX2_1	273	275	PF00082	0.440
CLV_PCSK_KEX2_1	365	367	PF00082	0.566
CLV_PCSK_KEX2_1	402	404	PF00082	0.537
CLV_PCSK_KEX2_1	472	474	PF00082	0.543
CLV_PCSK_KEX2_1	545	547	PF00082	0.630
CLV_PCSK_KEX2_1	55	57	PF00082	0.552
CLV_PCSK_KEX2_1	611	613	PF00082	0.714
CLV_PCSK_KEX2_1	632	634	PF00082	0.672
CLV_PCSK_KEX2_1	683	685	PF00082	0.516
CLV_PCSK_KEX2_1	697	699	PF00082	0.507
CLV_PCSK_KEX2_1	707	709	PF00082	0.537
CLV_PCSK_KEX2_1	710	712	PF00082	0.539
CLV_PCSK_PC1ET2_1	472	474	PF00082	0.603
CLV_PCSK_PC1ET2_1	545	547	PF00082	0.630
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.552
CLV_PCSK_PC1ET2_1	632	634	PF00082	0.698
CLV_PCSK_PC1ET2_1	683	685	PF00082	0.516
CLV_PCSK_PC1ET2_1	707	709	PF00082	0.537
CLV_PCSK_SKI1_1	529	533	PF00082	0.545
CLV_PCSK_SKI1_1	535	539	PF00082	0.562
CLV_PCSK_SKI1_1	582	586	PF00082	0.751
CLV_PCSK_SKI1_1	691	695	PF00082	0.521
CLV_Separin_Metazoa	530	534	PF03568	0.562
DEG_APCC_DBOX_1	364	372	PF00400	0.541
DEG_Nend_UBRbox_2	1	3	PF02207	0.578
DEG_SPOP_SBC_1	498	502	PF00917	0.617
DOC_MAPK_gen_1	178	188	PF00069	0.541
DOC_MAPK_gen_1	221	228	PF00069	0.542
DOC_MAPK_gen_1	533	541	PF00069	0.578
DOC_MAPK_gen_1	694	703	PF00069	0.507
DOC_MAPK_MEF2A_6	181	188	PF00069	0.528
DOC_PP1_RVXF_1	523	529	PF00149	0.536
DOC_PP1_RVXF_1	697	704	PF00149	0.522
DOC_USP7_MATH_1	176	180	PF00917	0.648
DOC_USP7_MATH_1	499	503	PF00917	0.757
DOC_USP7_MATH_1	573	577	PF00917	0.676
DOC_USP7_MATH_1	659	663	PF00917	0.708
DOC_USP7_MATH_1	666	670	PF00917	0.748
DOC_USP7_MATH_1	98	102	PF00917	0.518
DOC_USP7_UBL2_3	167	171	PF12436	0.603
DOC_USP7_UBL2_3	567	571	PF12436	0.640
DOC_WW_Pin1_4	299	304	PF00397	0.383
DOC_WW_Pin1_4	558	563	PF00397	0.622
LIG_14-3-3_CanoR_1	121	126	PF00244	0.498
LIG_14-3-3_CanoR_1	143	152	PF00244	0.535
LIG_14-3-3_CanoR_1	412	422	PF00244	0.450
LIG_14-3-3_CanoR_1	56	60	PF00244	0.473
LIG_14-3-3_CanoR_1	595	605	PF00244	0.616
LIG_Actin_WH2_2	119	134	PF00022	0.549
LIG_APCC_ABBA_1	226	231	PF00400	0.469
LIG_BRCT_BRCA1_1	103	107	PF00533	0.486
LIG_BRCT_BRCA1_1	338	342	PF00533	0.493
LIG_BRCT_BRCA1_1	72	76	PF00533	0.538
LIG_FHA_1	120	126	PF00498	0.581
LIG_FHA_1	13	19	PF00498	0.662
LIG_FHA_1	183	189	PF00498	0.641
LIG_FHA_1	46	52	PF00498	0.392
LIG_FHA_2	206	212	PF00498	0.378
LIG_FHA_2	457	463	PF00498	0.527
LIG_FHA_2	516	522	PF00498	0.629
LIG_LIR_Apic_2	314	318	PF02991	0.437
LIG_LIR_Gen_1	432	439	PF02991	0.436
LIG_LIR_Nem_3	432	436	PF02991	0.424
LIG_Pex14_1	315	319	PF04695	0.423
LIG_PTB_Apo_2	288	295	PF02174	0.486
LIG_SH2_SRC	227	230	PF00017	0.433
LIG_SH2_STAP1	260	264	PF00017	0.406
LIG_SH2_STAT3	235	238	PF00017	0.378
LIG_SH2_STAT5	113	116	PF00017	0.501
LIG_SH2_STAT5	227	230	PF00017	0.448
LIG_SH2_STAT5	235	238	PF00017	0.354
LIG_SH2_STAT5	241	244	PF00017	0.384
LIG_SH2_STAT5	376	379	PF00017	0.604
LIG_SH2_STAT5	399	402	PF00017	0.557
LIG_SH3_1	181	187	PF00018	0.612
LIG_SH3_2	187	192	PF14604	0.465
LIG_SH3_3	15	21	PF00018	0.622
LIG_SH3_3	181	187	PF00018	0.612
LIG_SH3_3	34	40	PF00018	0.429
LIG_SH3_3	60	66	PF00018	0.488
LIG_SUMO_SIM_anti_2	122	127	PF11976	0.493
LIG_SUMO_SIM_par_1	120	127	PF11976	0.556
LIG_SUMO_SIM_par_1	210	219	PF11976	0.388
LIG_SUMO_SIM_par_1	420	425	PF11976	0.417
LIG_TRAF2_1	138	141	PF00917	0.520
LIG_WRC_WIRS_1	332	337	PF05994	0.429
MOD_CDK_SPxxK_3	558	565	PF00069	0.606
MOD_CK1_1	101	107	PF00069	0.387
MOD_CK1_1	165	171	PF00069	0.627
MOD_CK1_1	179	185	PF00069	0.731
MOD_CK1_1	252	258	PF00069	0.405
MOD_CK1_1	287	293	PF00069	0.481
MOD_CK1_1	379	385	PF00069	0.591
MOD_CK1_1	497	503	PF00069	0.845
MOD_CK1_1	506	512	PF00069	0.723
MOD_CK1_1	586	592	PF00069	0.695
MOD_CK1_1	598	604	PF00069	0.675
MOD_CK1_1	607	613	PF00069	0.588
MOD_CK1_1	615	621	PF00069	0.685
MOD_CK1_1	640	646	PF00069	0.775
MOD_CK1_1	669	675	PF00069	0.714
MOD_CK2_1	100	106	PF00069	0.328
MOD_CK2_1	456	462	PF00069	0.496
MOD_CK2_1	55	61	PF00069	0.466
MOD_Cter_Amidation	147	150	PF01082	0.672
MOD_GlcNHglycan	115	118	PF01048	0.328
MOD_GlcNHglycan	164	167	PF01048	0.731
MOD_GlcNHglycan	181	184	PF01048	0.697
MOD_GlcNHglycan	251	254	PF01048	0.401
MOD_GlcNHglycan	26	29	PF01048	0.428
MOD_GlcNHglycan	286	289	PF01048	0.482
MOD_GlcNHglycan	371	374	PF01048	0.537
MOD_GlcNHglycan	389	392	PF01048	0.585
MOD_GlcNHglycan	424	427	PF01048	0.427
MOD_GlcNHglycan	617	620	PF01048	0.669
MOD_GlcNHglycan	638	642	PF01048	0.709
MOD_GlcNHglycan	657	660	PF01048	0.565
MOD_GlcNHglycan	76	79	PF01048	0.586
MOD_GlcNHglycan	98	101	PF01048	0.328
MOD_GSK3_1	115	122	PF00069	0.462
MOD_GSK3_1	12	19	PF00069	0.565
MOD_GSK3_1	162	169	PF00069	0.710
MOD_GSK3_1	248	255	PF00069	0.370
MOD_GSK3_1	283	290	PF00069	0.437
MOD_GSK3_1	374	381	PF00069	0.545
MOD_GSK3_1	493	500	PF00069	0.679
MOD_GSK3_1	502	509	PF00069	0.678
MOD_GSK3_1	511	518	PF00069	0.594
MOD_GSK3_1	586	593	PF00069	0.705
MOD_GSK3_1	642	649	PF00069	0.654
MOD_GSK3_1	651	658	PF00069	0.607
MOD_GSK3_1	70	77	PF00069	0.632
MOD_GSK3_1	96	103	PF00069	0.328
MOD_N-GLC_1	284	289	PF02516	0.438
MOD_N-GLC_1	290	295	PF02516	0.483
MOD_N-GLC_1	385	390	PF02516	0.618
MOD_N-GLC_1	502	507	PF02516	0.612
MOD_N-GLC_1	701	706	PF02516	0.529
MOD_N-GLC_2	199	201	PF02516	0.385
MOD_N-GLC_2	367	369	PF02516	0.532
MOD_NEK2_1	248	253	PF00069	0.363
MOD_NEK2_1	283	288	PF00069	0.431
MOD_NEK2_1	346	351	PF00069	0.385
MOD_NEK2_1	422	427	PF00069	0.434
MOD_NEK2_1	617	622	PF00069	0.694
MOD_NEK2_1	642	647	PF00069	0.681
MOD_NEK2_2	331	336	PF00069	0.520
MOD_PIKK_1	234	240	PF00454	0.382
MOD_PIKK_1	503	509	PF00454	0.638
MOD_PK_1	121	127	PF00069	0.328
MOD_PK_1	268	274	PF00069	0.421
MOD_PK_1	55	61	PF00069	0.567
MOD_PK_1	612	618	PF00069	0.587
MOD_PKA_1	55	61	PF00069	0.567
MOD_PKA_1	566	572	PF00069	0.703
MOD_PKA_2	177	183	PF00069	0.732
MOD_PKA_2	413	419	PF00069	0.454
MOD_PKA_2	55	61	PF00069	0.474
MOD_PKA_2	586	592	PF00069	0.598
MOD_Plk_1	119	125	PF00069	0.328
MOD_Plk_1	16	22	PF00069	0.506
MOD_Plk_1	268	274	PF00069	0.421
MOD_Plk_1	290	296	PF00069	0.471
MOD_Plk_1	337	343	PF00069	0.508
MOD_Plk_1	374	380	PF00069	0.521
MOD_Plk_1	493	499	PF00069	0.614
MOD_Plk_1	637	643	PF00069	0.657
MOD_Plk_1	69	75	PF00069	0.514
MOD_Plk_1	701	707	PF00069	0.528
MOD_Plk_2-3	515	521	PF00069	0.640
MOD_Plk_2-3	550	556	PF00069	0.699
MOD_Plk_4	290	296	PF00069	0.497
MOD_Plk_4	379	385	PF00069	0.563
MOD_Plk_4	612	618	PF00069	0.608
MOD_Plk_4	642	648	PF00069	0.587
MOD_Plk_4	70	76	PF00069	0.525
MOD_ProDKin_1	299	305	PF00069	0.383
MOD_ProDKin_1	558	564	PF00069	0.622
MOD_SUMO_for_1	516	519	PF00179	0.565
MOD_SUMO_for_1	693	696	PF00179	0.486
MOD_SUMO_rev_2	509	518	PF00179	0.610
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.531
TRG_ENDOCYTIC_2	319	322	PF00928	0.422
TRG_ER_diArg_1	142	145	PF00400	0.502
TRG_ER_diArg_1	223	225	PF00400	0.533
TRG_ER_diArg_1	272	274	PF00400	0.530
TRG_ER_diArg_1	364	366	PF00400	0.557
TRG_ER_diArg_1	401	403	PF00400	0.516
TRG_ER_diArg_1	412	415	PF00400	0.442
TRG_ER_diArg_1	448	451	PF00400	0.508
TRG_ER_diArg_1	532	535	PF00400	0.565
TRG_ER_diArg_1	611	613	PF00400	0.711
TRG_ER_diArg_1	708	711	PF00400	0.543
TRG_NES_CRM1_1	2	14	PF08389	0.590
TRG_NLS_Bipartite_1	157	174	PF00514	0.581
TRG_NLS_Bipartite_1	682	702	PF00514	0.509
TRG_NLS_MonoCore_2	629	634	PF00514	0.630
TRG_NLS_MonoExtC_3	54	60	PF00514	0.496
TRG_NLS_MonoExtC_3	564	570	PF00514	0.608
TRG_NLS_MonoExtN_4	167	174	PF00514	0.592
TRG_NLS_MonoExtN_4	562	569	PF00514	0.679
TRG_NLS_MonoExtN_4	630	635	PF00514	0.653
TRG_NLS_MonoExtN_4	697	702	PF00514	0.514
TRG_Pf-PMV_PEXEL_1	366	370	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	691	695	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9Z8	Leptomonas seymouri	75%	100%
A4HPY8	Leishmania braziliensis	74%	99%
A4IDP9	Leishmania infantum	99%	100%
E9ATQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q0U2	Leishmania major	91%	100%