SET domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBL2_LEIDO

TriTrypDb:

LdBPK_364520.1 , LdCL_360052400 , LDHU3_36.6140

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XBL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBL2

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018026	peptidyl-lysine monomethylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	268	270	PF00675	0.252
CLV_NRD_NRD_1	389	391	PF00675	0.455
CLV_NRD_NRD_1	395	397	PF00675	0.327
CLV_NRD_NRD_1	448	450	PF00675	0.381
CLV_NRD_NRD_1	519	521	PF00675	0.381
CLV_PCSK_KEX2_1	389	391	PF00082	0.423
CLV_PCSK_KEX2_1	395	397	PF00082	0.331
CLV_PCSK_KEX2_1	448	450	PF00082	0.381
CLV_PCSK_KEX2_1	519	521	PF00082	0.389
CLV_PCSK_PC7_1	515	521	PF00082	0.318
CLV_PCSK_SKI1_1	195	199	PF00082	0.340
CLV_PCSK_SKI1_1	27	31	PF00082	0.361
CLV_PCSK_SKI1_1	270	274	PF00082	0.344
CLV_PCSK_SKI1_1	310	314	PF00082	0.424
CLV_PCSK_SKI1_1	374	378	PF00082	0.603
CLV_PCSK_SKI1_1	448	452	PF00082	0.367
CLV_PCSK_SKI1_1	489	493	PF00082	0.405
DOC_CKS1_1	434	439	PF01111	0.538
DOC_MAPK_gen_1	27	36	PF00069	0.334
DOC_MAPK_gen_1	395	405	PF00069	0.384
DOC_MAPK_MEF2A_6	489	496	PF00069	0.338
DOC_PP2B_LxvP_1	158	161	PF13499	0.449
DOC_PP4_FxxP_1	35	38	PF00568	0.322
DOC_PP4_FxxP_1	42	45	PF00568	0.315
DOC_SPAK_OSR1_1	300	304	PF12202	0.294
DOC_USP7_MATH_1	460	464	PF00917	0.396
DOC_USP7_MATH_1	482	486	PF00917	0.331
DOC_USP7_MATH_1	5	9	PF00917	0.520
DOC_USP7_MATH_1	69	73	PF00917	0.449
DOC_USP7_UBL2_3	27	31	PF12436	0.433
DOC_WW_Pin1_4	114	119	PF00397	0.439
DOC_WW_Pin1_4	18	23	PF00397	0.368
DOC_WW_Pin1_4	338	343	PF00397	0.461
DOC_WW_Pin1_4	433	438	PF00397	0.544
DOC_WW_Pin1_4	72	77	PF00397	0.425
DOC_WW_Pin1_4	81	86	PF00397	0.425
DOC_WW_Pin1_4	90	95	PF00397	0.339
LIG_14-3-3_CanoR_1	195	203	PF00244	0.524
LIG_14-3-3_CanoR_1	269	278	PF00244	0.512
LIG_14-3-3_CanoR_1	319	325	PF00244	0.297
LIG_14-3-3_CanoR_1	357	364	PF00244	0.412
LIG_14-3-3_CanoR_1	415	421	PF00244	0.438
LIG_14-3-3_CanoR_1	433	437	PF00244	0.493
LIG_14-3-3_CanoR_1	471	479	PF00244	0.514
LIG_APCC_ABBA_1	217	222	PF00400	0.449
LIG_APCC_ABBA_1	34	39	PF00400	0.327
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_BRCT_BRCA1_1	11	15	PF00533	0.455
LIG_BRCT_BRCA1_1	224	228	PF00533	0.484
LIG_deltaCOP1_diTrp_1	208	217	PF00928	0.469
LIG_FHA_1	144	150	PF00498	0.543
LIG_FHA_1	165	171	PF00498	0.475
LIG_FHA_1	172	178	PF00498	0.436
LIG_FHA_1	278	284	PF00498	0.511
LIG_FHA_1	307	313	PF00498	0.357
LIG_FHA_1	350	356	PF00498	0.422
LIG_FHA_1	452	458	PF00498	0.448
LIG_FHA_1	61	67	PF00498	0.478
LIG_FHA_1	69	75	PF00498	0.467
LIG_FHA_2	161	167	PF00498	0.467
LIG_FHA_2	258	264	PF00498	0.497
LIG_FHA_2	93	99	PF00498	0.400
LIG_LIR_Apic_2	241	247	PF02991	0.425
LIG_LIR_Apic_2	39	45	PF02991	0.320
LIG_LIR_Apic_2	431	437	PF02991	0.541
LIG_LIR_Apic_2	473	479	PF02991	0.523
LIG_LIR_Gen_1	273	283	PF02991	0.438
LIG_LIR_Gen_1	304	313	PF02991	0.304
LIG_LIR_Gen_1	463	472	PF02991	0.408
LIG_LIR_Gen_1	490	499	PF02991	0.454
LIG_LIR_Nem_3	216	220	PF02991	0.445
LIG_LIR_Nem_3	273	278	PF02991	0.442
LIG_LIR_Nem_3	287	293	PF02991	0.395
LIG_LIR_Nem_3	304	308	PF02991	0.261
LIG_LIR_Nem_3	463	468	PF02991	0.405
LIG_LIR_Nem_3	490	494	PF02991	0.459
LIG_MLH1_MIPbox_1	11	15	PF16413	0.373
LIG_MYND_1	243	247	PF01753	0.459
LIG_PDZ_Class_1	537	542	PF00595	0.455
LIG_Pex14_1	373	377	PF04695	0.489
LIG_Pex14_2	228	232	PF04695	0.421
LIG_Pex14_2	301	305	PF04695	0.276
LIG_PTB_Apo_2	250	257	PF02174	0.449
LIG_Rb_LxCxE_1	63	83	PF01857	0.529
LIG_Rb_pABgroove_1	401	409	PF01858	0.326
LIG_SH2_CRK	293	297	PF00017	0.463
LIG_SH2_CRK	469	473	PF00017	0.517
LIG_SH2_GRB2like	537	540	PF00017	0.371
LIG_SH2_NCK_1	465	469	PF00017	0.389
LIG_SH2_SRC	407	410	PF00017	0.479
LIG_SH2_SRC	465	468	PF00017	0.316
LIG_SH2_SRC	537	540	PF00017	0.343
LIG_SH2_STAP1	465	469	PF00017	0.442
LIG_SH2_STAP1	537	541	PF00017	0.367
LIG_SH2_STAT5	244	247	PF00017	0.427
LIG_SH2_STAT5	354	357	PF00017	0.516
LIG_SH2_STAT5	412	415	PF00017	0.302
LIG_SH2_STAT5	456	459	PF00017	0.373
LIG_SH3_1	79	85	PF00018	0.400
LIG_SH3_3	115	121	PF00018	0.442
LIG_SH3_3	79	85	PF00018	0.516
LIG_Sin3_3	103	110	PF02671	0.420
LIG_SUMO_SIM_anti_2	104	111	PF11976	0.529
LIG_SUMO_SIM_par_1	62	67	PF11976	0.512
LIG_TRAF2_1	439	442	PF00917	0.401
LIG_WRPW_2	119	122	PF00400	0.529
MOD_CDC14_SPxK_1	117	120	PF00782	0.449
MOD_CDK_SPxK_1	114	120	PF00069	0.449
MOD_CDK_SPxxK_3	72	79	PF00069	0.449
MOD_CK1_1	321	327	PF00069	0.383
MOD_CK1_1	349	355	PF00069	0.549
MOD_CK1_1	72	78	PF00069	0.448
MOD_CK2_1	257	263	PF00069	0.493
MOD_CK2_1	526	532	PF00069	0.351
MOD_CK2_1	64	70	PF00069	0.495
MOD_CK2_1	92	98	PF00069	0.559
MOD_CMANNOS	119	122	PF00535	0.236
MOD_Cter_Amidation	267	270	PF01082	0.236
MOD_GlcNHglycan	1	4	PF01048	0.604
MOD_GlcNHglycan	137	140	PF01048	0.362
MOD_GlcNHglycan	171	174	PF01048	0.325
MOD_GlcNHglycan	320	323	PF01048	0.435
MOD_GlcNHglycan	347	351	PF01048	0.547
MOD_GlcNHglycan	381	384	PF01048	0.553
MOD_GlcNHglycan	480	483	PF01048	0.551
MOD_GlcNHglycan	484	487	PF01048	0.481
MOD_GlcNHglycan	6	10	PF01048	0.511
MOD_GlcNHglycan	70	74	PF01048	0.281
MOD_GSK3_1	1	8	PF00069	0.684
MOD_GSK3_1	160	167	PF00069	0.462
MOD_GSK3_1	218	225	PF00069	0.538
MOD_GSK3_1	273	280	PF00069	0.541
MOD_GSK3_1	338	345	PF00069	0.459
MOD_GSK3_1	428	435	PF00069	0.504
MOD_GSK3_1	456	463	PF00069	0.406
MOD_GSK3_1	478	485	PF00069	0.493
MOD_GSK3_1	526	533	PF00069	0.392
MOD_GSK3_1	60	67	PF00069	0.436
MOD_GSK3_1	68	75	PF00069	0.436
MOD_N-GLC_1	252	257	PF02516	0.225
MOD_NEK2_1	134	139	PF00069	0.580
MOD_NEK2_1	252	257	PF00069	0.505
MOD_NEK2_1	432	437	PF00069	0.500
MOD_NEK2_1	451	456	PF00069	0.381
MOD_NEK2_1	458	463	PF00069	0.342
MOD_NEK2_1	510	515	PF00069	0.518
MOD_NEK2_2	428	433	PF00069	0.567
MOD_NEK2_2	460	465	PF00069	0.387
MOD_PIKK_1	222	228	PF00454	0.538
MOD_PKA_2	318	324	PF00069	0.298
MOD_PKA_2	356	362	PF00069	0.396
MOD_PKA_2	432	438	PF00069	0.534
MOD_PKA_2	470	476	PF00069	0.531
MOD_Plk_1	164	170	PF00069	0.419
MOD_Plk_1	252	258	PF00069	0.441
MOD_Plk_1	346	352	PF00069	0.419
MOD_Plk_1	5	11	PF00069	0.454
MOD_Plk_4	10	16	PF00069	0.554
MOD_Plk_4	145	151	PF00069	0.470
MOD_Plk_4	165	171	PF00069	0.513
MOD_Plk_4	327	333	PF00069	0.432
MOD_Plk_4	451	457	PF00069	0.335
MOD_Plk_4	460	466	PF00069	0.394
MOD_Plk_4	60	66	PF00069	0.425
MOD_ProDKin_1	114	120	PF00069	0.439
MOD_ProDKin_1	18	24	PF00069	0.365
MOD_ProDKin_1	338	344	PF00069	0.460
MOD_ProDKin_1	433	439	PF00069	0.539
MOD_ProDKin_1	72	78	PF00069	0.425
MOD_ProDKin_1	81	87	PF00069	0.425
MOD_ProDKin_1	90	96	PF00069	0.339
TRG_DiLeu_BaEn_1	241	246	PF01217	0.421
TRG_DiLeu_BaEn_1	409	414	PF01217	0.433
TRG_ENDOCYTIC_2	293	296	PF00928	0.468
TRG_ENDOCYTIC_2	465	468	PF00928	0.471
TRG_ENDOCYTIC_2	469	472	PF00928	0.545
TRG_ER_diArg_1	395	397	PF00400	0.304
TRG_ER_diArg_1	448	450	PF00400	0.381
TRG_ER_diArg_1	518	520	PF00400	0.427
TRG_Pf-PMV_PEXEL_1	520	524	PF00026	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILW4	Leptomonas seymouri	64%	100%
A0A0S4J9V9	Bodo saltans	34%	100%
A0A1X0P0B9	Trypanosomatidae	39%	100%
A0A3R7KPF2	Trypanosoma rangeli	40%	100%
A4IE43	Leishmania infantum	99%	100%
D0A495	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9ATL5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q0Y3	Leishmania major	92%	100%
V5DLN2	Trypanosoma cruzi	41%	100%