Mitochondrial_N(5)-glutamine_methyltransferase_MT Q1_putative/GeneDB:LmjF.36.4490

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBK9_LEIDO

TriTrypDb:

LdBPK_364710.1 , LdCL_360054200 , LDHU3_36.6340

Length:

514

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XBK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBK9

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0032259	methylation	2	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0043414	macromolecule methylation	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	11
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0008276	protein methyltransferase activity	3	4
GO:0140096	catalytic activity, acting on a protein	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.721
CLV_C14_Caspase3-7	390	394	PF00656	0.549
CLV_NRD_NRD_1	229	231	PF00675	0.459
CLV_NRD_NRD_1	29	31	PF00675	0.644
CLV_NRD_NRD_1	290	292	PF00675	0.449
CLV_NRD_NRD_1	460	462	PF00675	0.486
CLV_NRD_NRD_1	80	82	PF00675	0.774
CLV_PCSK_FUR_1	458	462	PF00082	0.526
CLV_PCSK_KEX2_1	229	231	PF00082	0.444
CLV_PCSK_KEX2_1	233	235	PF00082	0.421
CLV_PCSK_KEX2_1	29	31	PF00082	0.677
CLV_PCSK_KEX2_1	290	292	PF00082	0.449
CLV_PCSK_KEX2_1	460	462	PF00082	0.489
CLV_PCSK_KEX2_1	80	82	PF00082	0.617
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.531
CLV_PCSK_PC7_1	229	235	PF00082	0.502
CLV_PCSK_SKI1_1	175	179	PF00082	0.457
CLV_PCSK_SKI1_1	230	234	PF00082	0.419
CLV_PCSK_SKI1_1	291	295	PF00082	0.626
CLV_PCSK_SKI1_1	427	431	PF00082	0.422
CLV_PCSK_SKI1_1	453	457	PF00082	0.462
CLV_PCSK_SKI1_1	506	510	PF00082	0.439
CLV_PCSK_SKI1_1	67	71	PF00082	0.548
DEG_APCC_DBOX_1	233	241	PF00400	0.541
DEG_SCF_TRCP1_1	60	66	PF00400	0.628
DOC_ANK_TNKS_1	124	131	PF00023	0.724
DOC_CYCLIN_RxL_1	172	179	PF00134	0.565
DOC_CYCLIN_RxL_1	229	241	PF00134	0.520
DOC_CYCLIN_yCln2_LP_2	242	248	PF00134	0.369
DOC_MAPK_gen_1	436	444	PF00069	0.508
DOC_MAPK_gen_1	488	497	PF00069	0.522
DOC_MAPK_MEF2A_6	466	475	PF00069	0.482
DOC_MAPK_MEF2A_6	490	499	PF00069	0.480
DOC_PP2B_LxvP_1	40	43	PF13499	0.711
DOC_PP2B_PxIxI_1	468	474	PF00149	0.496
DOC_USP7_MATH_1	136	140	PF00917	0.724
DOC_USP7_MATH_1	358	362	PF00917	0.517
DOC_USP7_MATH_1	376	380	PF00917	0.542
DOC_USP7_MATH_1	47	51	PF00917	0.693
DOC_USP7_MATH_1	510	514	PF00917	0.361
DOC_WW_Pin1_4	168	173	PF00397	0.552
DOC_WW_Pin1_4	295	300	PF00397	0.667
DOC_WW_Pin1_4	349	354	PF00397	0.525
LIG_14-3-3_CanoR_1	29	35	PF00244	0.684
LIG_14-3-3_CanoR_1	290	299	PF00244	0.613
LIG_14-3-3_CanoR_1	355	363	PF00244	0.520
LIG_14-3-3_CanoR_1	46	52	PF00244	0.617
LIG_14-3-3_CanoR_1	56	63	PF00244	0.661
LIG_14-3-3_CanoR_1	81	91	PF00244	0.767
LIG_Actin_WH2_2	14	31	PF00022	0.646
LIG_Actin_WH2_2	65	82	PF00022	0.720
LIG_APCC_ABBA_1	495	500	PF00400	0.369
LIG_BRCT_BRCA1_1	251	255	PF00533	0.491
LIG_BRCT_BRCA1_1	360	364	PF00533	0.476
LIG_CtBP_PxDLS_1	15	19	PF00389	0.648
LIG_deltaCOP1_diTrp_1	206	213	PF00928	0.388
LIG_deltaCOP1_diTrp_1	274	279	PF00928	0.375
LIG_EH1_1	479	487	PF00400	0.512
LIG_FHA_1	311	317	PF00498	0.476
LIG_FHA_1	396	402	PF00498	0.516
LIG_FHA_1	426	432	PF00498	0.524
LIG_FHA_1	46	52	PF00498	0.714
LIG_FHA_2	146	152	PF00498	0.649
LIG_FHA_2	328	334	PF00498	0.537
LIG_FHA_2	388	394	PF00498	0.567
LIG_FHA_2	420	426	PF00498	0.480
LIG_Integrin_RGD_1	125	127	PF01839	0.723
LIG_LIR_Gen_1	361	372	PF02991	0.530
LIG_LIR_Gen_1	398	407	PF02991	0.411
LIG_LIR_Gen_1	438	449	PF02991	0.466
LIG_LIR_Nem_3	184	189	PF02991	0.535
LIG_LIR_Nem_3	277	282	PF02991	0.511
LIG_LIR_Nem_3	361	367	PF02991	0.504
LIG_LIR_Nem_3	385	391	PF02991	0.514
LIG_LIR_Nem_3	398	402	PF02991	0.360
LIG_LIR_Nem_3	412	417	PF02991	0.420
LIG_LIR_Nem_3	438	444	PF02991	0.468
LIG_LIR_Nem_3	489	495	PF02991	0.407
LIG_LIR_Nem_3	90	94	PF02991	0.688
LIG_MYND_1	265	269	PF01753	0.372
LIG_Pex14_2	293	297	PF04695	0.496
LIG_PTB_Apo_2	402	409	PF02174	0.362
LIG_PTB_Phospho_1	402	408	PF10480	0.360
LIG_SH2_CRK	399	403	PF00017	0.504
LIG_SH2_CRK	91	95	PF00017	0.772
LIG_SH2_PTP2	408	411	PF00017	0.393
LIG_SH2_PTP2	414	417	PF00017	0.430
LIG_SH2_SRC	248	251	PF00017	0.378
LIG_SH2_STAP1	183	187	PF00017	0.469
LIG_SH2_STAP1	399	403	PF00017	0.504
LIG_SH2_STAT3	501	504	PF00017	0.458
LIG_SH2_STAT5	102	105	PF00017	0.645
LIG_SH2_STAT5	248	251	PF00017	0.348
LIG_SH2_STAT5	408	411	PF00017	0.414
LIG_SH2_STAT5	414	417	PF00017	0.461
LIG_SH2_STAT5	441	444	PF00017	0.374
LIG_SH2_STAT5	71	74	PF00017	0.539
LIG_SH3_3	191	197	PF00018	0.583
LIG_SH3_3	400	406	PF00018	0.364
LIG_SH3_3	412	418	PF00018	0.427
LIG_SUMO_SIM_anti_2	330	337	PF11976	0.537
LIG_SUMO_SIM_par_1	14	20	PF11976	0.542
LIG_TRAF2_1	224	227	PF00917	0.573
LIG_TRAF2_1	502	505	PF00917	0.583
LIG_UBA3_1	177	185	PF00899	0.540
MOD_CDC14_SPxK_1	302	305	PF00782	0.535
MOD_CDC14_SPxK_1	352	355	PF00782	0.525
MOD_CDK_SPK_2	168	173	PF00069	0.552
MOD_CDK_SPxK_1	299	305	PF00069	0.581
MOD_CDK_SPxK_1	349	355	PF00069	0.525
MOD_CDK_SPxxK_3	168	175	PF00069	0.405
MOD_CK1_1	107	113	PF00069	0.588
MOD_CK1_1	132	138	PF00069	0.678
MOD_CK1_1	17	23	PF00069	0.533
MOD_CK1_1	90	96	PF00069	0.771
MOD_CK2_1	145	151	PF00069	0.610
MOD_CK2_1	168	174	PF00069	0.449
MOD_CK2_1	221	227	PF00069	0.593
MOD_CK2_1	232	238	PF00069	0.476
MOD_CK2_1	354	360	PF00069	0.571
MOD_CK2_1	419	425	PF00069	0.483
MOD_CK2_1	81	87	PF00069	0.710
MOD_CMANNOS	276	279	PF00535	0.376
MOD_GlcNHglycan	138	141	PF01048	0.662
MOD_GlcNHglycan	325	328	PF01048	0.338
MOD_GlcNHglycan	356	359	PF01048	0.377
MOD_GlcNHglycan	372	375	PF01048	0.534
MOD_GlcNHglycan	378	381	PF01048	0.631
MOD_GlcNHglycan	60	63	PF01048	0.710
MOD_GlcNHglycan	84	87	PF01048	0.701
MOD_GlcNHglycan	98	101	PF01048	0.664
MOD_GSK3_1	132	139	PF00069	0.722
MOD_GSK3_1	270	277	PF00069	0.389
MOD_GSK3_1	291	298	PF00069	0.654
MOD_GSK3_1	323	330	PF00069	0.547
MOD_GSK3_1	354	361	PF00069	0.546
MOD_GSK3_1	376	383	PF00069	0.671
MOD_GSK3_1	419	426	PF00069	0.482
MOD_GSK3_1	47	54	PF00069	0.695
MOD_GSK3_1	506	513	PF00069	0.334
MOD_N-GLC_1	107	112	PF02516	0.759
MOD_N-GLC_1	136	141	PF02516	0.709
MOD_NEK2_1	486	491	PF00069	0.438
MOD_NEK2_1	51	56	PF00069	0.635
MOD_NEK2_1	63	68	PF00069	0.551
MOD_NEK2_2	387	392	PF00069	0.539
MOD_PIKK_1	249	255	PF00454	0.474
MOD_PIKK_1	30	36	PF00454	0.728
MOD_PKA_2	221	227	PF00069	0.583
MOD_PKA_2	289	295	PF00069	0.581
MOD_PKA_2	339	345	PF00069	0.581
MOD_PKA_2	354	360	PF00069	0.581
MOD_PKA_2	435	441	PF00069	0.521
MOD_PKA_2	45	51	PF00069	0.671
MOD_PKB_1	56	64	PF00069	0.652
MOD_Plk_2-3	129	135	PF00069	0.677
MOD_Plk_2-3	146	152	PF00069	0.621
MOD_Plk_2-3	221	227	PF00069	0.564
MOD_Plk_4	190	196	PF00069	0.613
MOD_Plk_4	244	250	PF00069	0.445
MOD_Plk_4	47	53	PF00069	0.692
MOD_ProDKin_1	168	174	PF00069	0.544
MOD_ProDKin_1	295	301	PF00069	0.656
MOD_ProDKin_1	349	355	PF00069	0.525
MOD_SUMO_rev_2	144	154	PF00179	0.684
TRG_DiLeu_BaLyEn_6	262	267	PF01217	0.382
TRG_ENDOCYTIC_2	183	186	PF00928	0.477
TRG_ENDOCYTIC_2	282	285	PF00928	0.540
TRG_ENDOCYTIC_2	356	359	PF00928	0.465
TRG_ENDOCYTIC_2	399	402	PF00928	0.440
TRG_ENDOCYTIC_2	414	417	PF00928	0.332
TRG_ENDOCYTIC_2	441	444	PF00928	0.374
TRG_ENDOCYTIC_2	91	94	PF00928	0.782
TRG_ER_diArg_1	21	24	PF00400	0.678
TRG_ER_diArg_1	28	30	PF00400	0.636
TRG_ER_diArg_1	457	460	PF00400	0.516
TRG_ER_diArg_1	55	58	PF00400	0.757
TRG_ER_diArg_1	79	81	PF00400	0.610
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXT0	Leptomonas seymouri	56%	100%
A0A0S4K087	Bodo saltans	47%	100%
A0A1X0P0C0	Trypanosomatidae	47%	100%
A0A3R7N4Z4	Trypanosoma rangeli	53%	100%
A4HPW6	Leishmania braziliensis	73%	97%
A4IDM8	Leishmania infantum	100%	100%
D0A4B4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9ATN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q0W5	Leishmania major	93%	100%
V5DLL0	Trypanosoma cruzi	50%	100%