IQ calmodulin-binding motif containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBK4_LEIDO

TriTrypDb:

LdBPK_364280.1 , LdCL_360049900 , LDHU3_36.5790

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XBK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBK4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0005516	calmodulin binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.760
CLV_NRD_NRD_1	103	105	PF00675	0.349
CLV_NRD_NRD_1	140	142	PF00675	0.343
CLV_NRD_NRD_1	285	287	PF00675	0.566
CLV_NRD_NRD_1	414	416	PF00675	0.846
CLV_NRD_NRD_1	417	419	PF00675	0.803
CLV_NRD_NRD_1	463	465	PF00675	0.672
CLV_NRD_NRD_1	529	531	PF00675	0.728
CLV_NRD_NRD_1	80	82	PF00675	0.349
CLV_PCSK_KEX2_1	105	107	PF00082	0.334
CLV_PCSK_KEX2_1	184	186	PF00082	0.532
CLV_PCSK_KEX2_1	285	287	PF00082	0.566
CLV_PCSK_KEX2_1	463	465	PF00082	0.770
CLV_PCSK_KEX2_1	468	470	PF00082	0.693
CLV_PCSK_KEX2_1	529	531	PF00082	0.668
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.363
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.656
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.776
CLV_PCSK_PC7_1	464	470	PF00082	0.772
CLV_PCSK_SKI1_1	115	119	PF00082	0.398
CLV_PCSK_SKI1_1	48	52	PF00082	0.578
CLV_PCSK_SKI1_1	81	85	PF00082	0.403
DEG_COP1_1	203	210	PF00400	0.703
DEG_Nend_UBRbox_3	1	3	PF02207	0.660
DEG_SPOP_SBC_1	404	408	PF00917	0.663
DOC_CKS1_1	222	227	PF01111	0.685
DOC_CKS1_1	37	42	PF01111	0.613
DOC_CYCLIN_yCln2_LP_2	243	249	PF00134	0.591
DOC_CYCLIN_yCln2_LP_2	309	315	PF00134	0.742
DOC_MAPK_gen_1	81	87	PF00069	0.549
DOC_PP2B_LxvP_1	309	312	PF13499	0.739
DOC_PP2B_LxvP_1	385	388	PF13499	0.609
DOC_PP4_FxxP_1	214	217	PF00568	0.552
DOC_SPAK_OSR1_1	464	468	PF12202	0.770
DOC_USP7_MATH_1	159	163	PF00917	0.605
DOC_USP7_MATH_1	215	219	PF00917	0.700
DOC_USP7_MATH_1	220	224	PF00917	0.659
DOC_USP7_MATH_1	225	229	PF00917	0.600
DOC_USP7_MATH_1	250	254	PF00917	0.695
DOC_USP7_MATH_1	273	277	PF00917	0.674
DOC_USP7_MATH_1	313	317	PF00917	0.594
DOC_USP7_MATH_1	333	337	PF00917	0.504
DOC_USP7_MATH_1	355	359	PF00917	0.685
DOC_USP7_MATH_1	360	364	PF00917	0.811
DOC_USP7_MATH_1	404	408	PF00917	0.671
DOC_USP7_MATH_1	442	446	PF00917	0.826
DOC_USP7_MATH_1	451	455	PF00917	0.655
DOC_USP7_MATH_1	456	460	PF00917	0.771
DOC_USP7_MATH_1	492	496	PF00917	0.753
DOC_USP7_MATH_2	373	379	PF00917	0.814
DOC_WW_Pin1_4	221	226	PF00397	0.703
DOC_WW_Pin1_4	242	247	PF00397	0.809
DOC_WW_Pin1_4	314	319	PF00397	0.733
DOC_WW_Pin1_4	347	352	PF00397	0.762
DOC_WW_Pin1_4	36	41	PF00397	0.692
LIG_14-3-3_CanoR_1	111	115	PF00244	0.570
LIG_14-3-3_CanoR_1	235	244	PF00244	0.591
LIG_14-3-3_CanoR_1	295	299	PF00244	0.612
LIG_14-3-3_CanoR_1	33	38	PF00244	0.559
LIG_14-3-3_CanoR_1	455	465	PF00244	0.699
LIG_14-3-3_CanoR_1	491	498	PF00244	0.530
LIG_Actin_WH2_2	166	181	PF00022	0.600
LIG_CaM_IQ_9	128	144	PF13499	0.546
LIG_CaM_IQ_9	68	84	PF13499	0.546
LIG_CaM_IQ_9	91	107	PF13499	0.411
LIG_FHA_1	202	208	PF00498	0.601
LIG_FHA_1	367	373	PF00498	0.650
LIG_FHA_1	432	438	PF00498	0.650
LIG_FHA_1	66	72	PF00498	0.547
LIG_FHA_1	9	15	PF00498	0.640
LIG_FHA_2	120	126	PF00498	0.512
LIG_FHA_2	169	175	PF00498	0.538
LIG_FHA_2	228	234	PF00498	0.700
LIG_LIR_Gen_1	122	131	PF02991	0.512
LIG_LIR_Gen_1	21	31	PF02991	0.502
LIG_LIR_Gen_1	32	42	PF02991	0.511
LIG_LIR_Nem_3	122	127	PF02991	0.511
LIG_LIR_Nem_3	209	214	PF02991	0.511
LIG_LIR_Nem_3	21	26	PF02991	0.510
LIG_LIR_Nem_3	319	324	PF02991	0.604
LIG_LIR_Nem_3	32	38	PF02991	0.514
LIG_LIR_Nem_3	73	78	PF02991	0.585
LIG_MYND_1	347	351	PF01753	0.760
LIG_Pex14_2	461	465	PF04695	0.666
LIG_SH2_CRK	321	325	PF00017	0.609
LIG_SH2_CRK	35	39	PF00017	0.593
LIG_SH2_GRB2like	153	156	PF00017	0.488
LIG_SH2_NCK_1	35	39	PF00017	0.593
LIG_SH2_SRC	153	156	PF00017	0.534
LIG_SH2_STAP1	148	152	PF00017	0.530
LIG_SH2_STAT3	147	150	PF00017	0.544
LIG_SH2_STAT5	119	122	PF00017	0.495
LIG_SH2_STAT5	153	156	PF00017	0.502
LIG_SH3_3	207	213	PF00018	0.653
LIG_SH3_3	243	249	PF00018	0.799
LIG_SH3_3	348	354	PF00018	0.718
LIG_SH3_3	385	391	PF00018	0.703
LIG_SUMO_SIM_par_1	61	66	PF11976	0.541
LIG_WRC_WIRS_1	458	463	PF05994	0.667
MOD_CDC14_SPxK_1	319	322	PF00782	0.737
MOD_CDK_SPxK_1	316	322	PF00069	0.735
MOD_CK1_1	140	146	PF00069	0.544
MOD_CK1_1	203	209	PF00069	0.598
MOD_CK1_1	242	248	PF00069	0.655
MOD_CK1_1	316	322	PF00069	0.700
MOD_CK1_1	336	342	PF00069	0.501
MOD_CK1_1	36	42	PF00069	0.690
MOD_CK1_1	407	413	PF00069	0.726
MOD_CK1_1	445	451	PF00069	0.785
MOD_CK2_1	15	21	PF00069	0.623
MOD_CK2_1	168	174	PF00069	0.535
MOD_CK2_1	227	233	PF00069	0.698
MOD_CK2_1	250	256	PF00069	0.777
MOD_CK2_1	49	55	PF00069	0.532
MOD_CK2_1	496	502	PF00069	0.650
MOD_Cter_Amidation	413	416	PF01082	0.735
MOD_GlcNHglycan	179	182	PF01048	0.433
MOD_GlcNHglycan	252	255	PF01048	0.748
MOD_GlcNHglycan	275	278	PF01048	0.571
MOD_GlcNHglycan	335	338	PF01048	0.805
MOD_GlcNHglycan	341	344	PF01048	0.724
MOD_GlcNHglycan	377	380	PF01048	0.693
MOD_GlcNHglycan	444	447	PF01048	0.776
MOD_GlcNHglycan	494	497	PF01048	0.753
MOD_GlcNHglycan	498	501	PF01048	0.647
MOD_GlcNHglycan	51	54	PF01048	0.501
MOD_GlcNHglycan	526	529	PF01048	0.770
MOD_GSK3_1	115	122	PF00069	0.439
MOD_GSK3_1	216	223	PF00069	0.686
MOD_GSK3_1	235	242	PF00069	0.537
MOD_GSK3_1	29	36	PF00069	0.572
MOD_GSK3_1	307	314	PF00069	0.705
MOD_GSK3_1	327	334	PF00069	0.828
MOD_GSK3_1	335	342	PF00069	0.637
MOD_GSK3_1	394	401	PF00069	0.738
MOD_GSK3_1	403	410	PF00069	0.758
MOD_GSK3_1	445	452	PF00069	0.727
MOD_GSK3_1	487	494	PF00069	0.748
MOD_N-GLC_1	220	225	PF02516	0.686
MOD_N-GLC_1	33	38	PF02516	0.527
MOD_N-GLC_1	361	366	PF02516	0.754
MOD_N-GLC_1	487	492	PF02516	0.706
MOD_NEK2_1	126	131	PF00069	0.411
MOD_NEK2_1	15	20	PF00069	0.660
MOD_NEK2_1	201	206	PF00069	0.699
MOD_NEK2_1	398	403	PF00069	0.811
MOD_NEK2_1	524	529	PF00069	0.769
MOD_NEK2_2	119	124	PF00069	0.514
MOD_NEK2_2	457	462	PF00069	0.775
MOD_PIKK_1	168	174	PF00454	0.592
MOD_PIKK_1	336	342	PF00454	0.704
MOD_PIKK_1	349	355	PF00454	0.776
MOD_PIKK_1	396	402	PF00454	0.786
MOD_PKA_2	110	116	PF00069	0.495
MOD_PKA_2	140	146	PF00069	0.492
MOD_PKA_2	159	165	PF00069	0.620
MOD_PKA_2	294	300	PF00069	0.598
MOD_PKA_2	408	414	PF00069	0.850
MOD_PKB_1	185	193	PF00069	0.438
MOD_Plk_1	187	193	PF00069	0.651
MOD_Plk_1	239	245	PF00069	0.593
MOD_Plk_1	307	313	PF00069	0.643
MOD_Plk_1	33	39	PF00069	0.527
MOD_Plk_1	425	431	PF00069	0.615
MOD_Plk_1	65	71	PF00069	0.418
MOD_Plk_4	115	121	PF00069	0.501
MOD_Plk_4	206	212	PF00069	0.606
MOD_Plk_4	239	245	PF00069	0.593
MOD_Plk_4	33	39	PF00069	0.580
MOD_Plk_4	42	48	PF00069	0.441
MOD_ProDKin_1	221	227	PF00069	0.704
MOD_ProDKin_1	242	248	PF00069	0.807
MOD_ProDKin_1	314	320	PF00069	0.730
MOD_ProDKin_1	347	353	PF00069	0.764
MOD_ProDKin_1	36	42	PF00069	0.690
MOD_SUMO_rev_2	176	186	PF00179	0.569
MOD_SUMO_rev_2	509	515	PF00179	0.660
TRG_DiLeu_BaEn_1	239	244	PF01217	0.595
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.378
TRG_ENDOCYTIC_2	153	156	PF00928	0.591
TRG_ENDOCYTIC_2	211	214	PF00928	0.521
TRG_ENDOCYTIC_2	23	26	PF00928	0.651
TRG_ENDOCYTIC_2	321	324	PF00928	0.610
TRG_ENDOCYTIC_2	35	38	PF00928	0.504
TRG_ER_diArg_1	104	107	PF00400	0.436
TRG_ER_diArg_1	284	286	PF00400	0.558
TRG_ER_diArg_1	463	465	PF00400	0.770
TRG_NLS_MonoCore_2	414	419	PF00514	0.811
TRG_NLS_MonoExtC_3	414	419	PF00514	0.733
TRG_NLS_MonoExtN_4	412	419	PF00514	0.657

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I2	Leptomonas seymouri	39%	100%
A4HPS6	Leishmania braziliensis	68%	100%
A4IE66	Leishmania infantum	99%	100%
E9ATJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q107	Leishmania major	88%	100%