Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat/Utp21 specific WD40 associated putative domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBK1_LEIDO

TriTrypDb:

LdBPK_364420.1 , LdCL_360051300 , LDHU3_36.5980

Length:

984

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0030684	preribosome	3	11
GO:0032040	small-subunit processome	4	11
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	12
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0034388	Pwp2p-containing subcomplex of 90S preribosome	3	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3S7XBK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBK1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.404
CLV_C14_Caspase3-7	328	332	PF00656	0.441
CLV_C14_Caspase3-7	611	615	PF00656	0.557
CLV_MEL_PAP_1	939	945	PF00089	0.425
CLV_NRD_NRD_1	340	342	PF00675	0.366
CLV_NRD_NRD_1	756	758	PF00675	0.597
CLV_NRD_NRD_1	829	831	PF00675	0.425
CLV_NRD_NRD_1	917	919	PF00675	0.342
CLV_PCSK_FUR_1	338	342	PF00082	0.384
CLV_PCSK_KEX2_1	116	118	PF00082	0.385
CLV_PCSK_KEX2_1	340	342	PF00082	0.366
CLV_PCSK_KEX2_1	388	390	PF00082	0.443
CLV_PCSK_KEX2_1	755	757	PF00082	0.595
CLV_PCSK_KEX2_1	882	884	PF00082	0.339
CLV_PCSK_KEX2_1	917	919	PF00082	0.362
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.385
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.563
CLV_PCSK_PC1ET2_1	882	884	PF00082	0.339
CLV_PCSK_SKI1_1	152	156	PF00082	0.419
CLV_PCSK_SKI1_1	487	491	PF00082	0.411
CLV_PCSK_SKI1_1	906	910	PF00082	0.390
DEG_APCC_DBOX_1	283	291	PF00400	0.619
DEG_Nend_UBRbox_2	1	3	PF02207	0.460
DEG_SCF_FBW7_2	581	587	PF00400	0.386
DEG_SCF_FBW7_2	849	854	PF00400	0.374
DEG_SPOP_SBC_1	608	612	PF00917	0.557
DOC_ANK_TNKS_1	68	75	PF00023	0.353
DOC_CKS1_1	25	30	PF01111	0.501
DOC_CKS1_1	581	586	PF01111	0.316
DOC_CYCLIN_RxL_1	149	159	PF00134	0.485
DOC_CYCLIN_RxL_1	453	462	PF00134	0.483
DOC_CYCLIN_RxL_1	900	913	PF00134	0.393
DOC_CYCLIN_yClb1_LxF_4	780	785	PF00134	0.451
DOC_CYCLIN_yCln2_LP_2	800	803	PF00134	0.320
DOC_MAPK_DCC_7	667	676	PF00069	0.518
DOC_MAPK_gen_1	247	255	PF00069	0.405
DOC_MAPK_gen_1	804	810	PF00069	0.320
DOC_MAPK_gen_1	917	924	PF00069	0.339
DOC_MAPK_HePTP_8	869	881	PF00069	0.390
DOC_MAPK_JIP1_4	819	825	PF00069	0.362
DOC_MAPK_MEF2A_6	632	640	PF00069	0.395
DOC_MAPK_MEF2A_6	667	676	PF00069	0.586
DOC_MAPK_MEF2A_6	872	881	PF00069	0.390
DOC_MAPK_MEF2A_6	96	103	PF00069	0.529
DOC_MAPK_RevD_3	903	918	PF00069	0.238
DOC_PP1_RVXF_1	115	122	PF00149	0.477
DOC_PP1_RVXF_1	780	786	PF00149	0.393
DOC_PP1_RVXF_1	918	925	PF00149	0.448
DOC_PP2B_LxvP_1	800	803	PF13499	0.320
DOC_PP4_FxxP_1	304	307	PF00568	0.525
DOC_PP4_FxxP_1	633	636	PF00568	0.458
DOC_PP4_FxxP_1	810	813	PF00568	0.320
DOC_USP7_MATH_1	240	244	PF00917	0.384
DOC_USP7_MATH_1	499	503	PF00917	0.466
DOC_USP7_MATH_1	609	613	PF00917	0.502
DOC_USP7_MATH_1	702	706	PF00917	0.699
DOC_USP7_MATH_1	711	715	PF00917	0.771
DOC_WW_Pin1_4	24	29	PF00397	0.502
DOC_WW_Pin1_4	580	585	PF00397	0.460
DOC_WW_Pin1_4	590	595	PF00397	0.452
DOC_WW_Pin1_4	632	637	PF00397	0.365
DOC_WW_Pin1_4	674	679	PF00397	0.538
DOC_WW_Pin1_4	847	852	PF00397	0.341
LIG_14-3-3_CanoR_1	376	380	PF00244	0.398
LIG_14-3-3_CanoR_1	712	719	PF00244	0.769
LIG_14-3-3_CanoR_1	962	966	PF00244	0.362
LIG_Actin_WH2_2	520	538	PF00022	0.469
LIG_Actin_WH2_2	805	821	PF00022	0.320
LIG_Actin_WH2_2	947	964	PF00022	0.374
LIG_AP2alpha_2	5	7	PF02296	0.531
LIG_BRCT_BRCA1_1	242	246	PF00533	0.390
LIG_BRCT_BRCA1_1	553	557	PF00533	0.372
LIG_BRCT_BRCA1_1	638	642	PF00533	0.349
LIG_CaM_NSCaTE_8	531	538	PF13499	0.549
LIG_Clathr_ClatBox_1	301	305	PF01394	0.486
LIG_EH1_1	962	970	PF00400	0.316
LIG_eIF4E_1	149	155	PF01652	0.361
LIG_eIF4E_1	25	31	PF01652	0.373
LIG_eIF4E_1	353	359	PF01652	0.359
LIG_eIF4E_1	416	422	PF01652	0.447
LIG_FHA_1	123	129	PF00498	0.420
LIG_FHA_1	135	141	PF00498	0.394
LIG_FHA_1	159	165	PF00498	0.413
LIG_FHA_1	224	230	PF00498	0.418
LIG_FHA_1	240	246	PF00498	0.318
LIG_FHA_1	25	31	PF00498	0.450
LIG_FHA_1	308	314	PF00498	0.482
LIG_FHA_1	346	352	PF00498	0.397
LIG_FHA_1	35	41	PF00498	0.258
LIG_FHA_1	353	359	PF00498	0.375
LIG_FHA_1	512	518	PF00498	0.472
LIG_FHA_1	530	536	PF00498	0.437
LIG_FHA_1	562	568	PF00498	0.402
LIG_FHA_1	813	819	PF00498	0.320
LIG_FHA_1	911	917	PF00498	0.425
LIG_FHA_1	98	104	PF00498	0.463
LIG_FHA_2	229	235	PF00498	0.324
LIG_FHA_2	246	252	PF00498	0.218
LIG_FHA_2	575	581	PF00498	0.563
LIG_FHA_2	609	615	PF00498	0.557
LIG_FHA_2	699	705	PF00498	0.718
LIG_FHA_2	718	724	PF00498	0.702
LIG_FHA_2	786	792	PF00498	0.320
LIG_FHA_2	812	818	PF00498	0.320
LIG_FHA_2	892	898	PF00498	0.351
LIG_LIR_Apic_2	22	28	PF02991	0.393
LIG_LIR_Apic_2	807	813	PF02991	0.320
LIG_LIR_Gen_1	308	314	PF02991	0.524
LIG_LIR_Gen_1	685	694	PF02991	0.564
LIG_LIR_Gen_1	821	826	PF02991	0.362
LIG_LIR_Gen_1	866	876	PF02991	0.415
LIG_LIR_Gen_1	910	916	PF02991	0.366
LIG_LIR_Nem_3	2	7	PF02991	0.378
LIG_LIR_Nem_3	204	209	PF02991	0.308
LIG_LIR_Nem_3	308	312	PF02991	0.549
LIG_LIR_Nem_3	37	41	PF02991	0.335
LIG_LIR_Nem_3	603	608	PF02991	0.475
LIG_LIR_Nem_3	685	691	PF02991	0.574
LIG_LIR_Nem_3	866	871	PF02991	0.385
LIG_LIR_Nem_3	910	914	PF02991	0.238
LIG_LRP6_Inhibitor_1	661	667	PF00058	0.505
LIG_MAD2	8	16	PF02301	0.465
LIG_MYND_1	799	803	PF01753	0.320
LIG_MYND_3	948	952	PF01753	0.381
LIG_PCNA_yPIPBox_3	900	909	PF02747	0.421
LIG_PCNA_yPIPBox_3	920	933	PF02747	0.121
LIG_PDZ_Class_1	979	984	PF00595	0.481
LIG_Pex14_2	911	915	PF04695	0.339
LIG_PTB_Apo_2	662	669	PF02174	0.499
LIG_PTB_Phospho_1	662	668	PF10480	0.490
LIG_Rb_pABgroove_1	484	492	PF01858	0.440
LIG_RPA_C_Fungi	184	196	PF08784	0.474
LIG_SH2_CRK	25	29	PF00017	0.407
LIG_SH2_CRK	309	313	PF00017	0.520
LIG_SH2_CRK	466	470	PF00017	0.449
LIG_SH2_CRK	605	609	PF00017	0.339
LIG_SH2_CRK	668	672	PF00017	0.432
LIG_SH2_CRK	68	72	PF00017	0.362
LIG_SH2_GRB2like	149	152	PF00017	0.418
LIG_SH2_GRB2like	887	890	PF00017	0.354
LIG_SH2_NCK_1	466	470	PF00017	0.449
LIG_SH2_NCK_1	893	897	PF00017	0.413
LIG_SH2_SRC	80	83	PF00017	0.538
LIG_SH2_SRC	887	890	PF00017	0.366
LIG_SH2_STAP1	149	153	PF00017	0.408
LIG_SH2_STAP1	309	313	PF00017	0.520
LIG_SH2_STAT5	149	152	PF00017	0.406
LIG_SH2_STAT5	309	312	PF00017	0.534
LIG_SH2_STAT5	607	610	PF00017	0.320
LIG_SH2_STAT5	660	663	PF00017	0.432
LIG_SH2_STAT5	670	673	PF00017	0.499
LIG_SH2_STAT5	80	83	PF00017	0.538
LIG_SH2_STAT5	867	870	PF00017	0.339
LIG_SH2_STAT5	887	890	PF00017	0.121
LIG_SH2_STAT5	893	896	PF00017	0.317
LIG_SH3_1	796	802	PF00018	0.320
LIG_SH3_2	799	804	PF14604	0.320
LIG_SH3_3	15	21	PF00018	0.513
LIG_SH3_3	397	403	PF00018	0.509
LIG_SH3_3	672	678	PF00018	0.438
LIG_SH3_3	796	802	PF00018	0.320
LIG_SH3_3	966	972	PF00018	0.362
LIG_SUMO_SIM_anti_2	141	147	PF11976	0.453
LIG_SUMO_SIM_anti_2	98	103	PF11976	0.443
LIG_SUMO_SIM_par_1	27	34	PF11976	0.362
LIG_SUMO_SIM_par_1	513	518	PF11976	0.390
LIG_SUMO_SIM_par_1	821	828	PF11976	0.451
LIG_TRAF2_1	577	580	PF00917	0.547
LIG_TRAF2_1	701	704	PF00917	0.741
LIG_TRAF2_1	722	725	PF00917	0.688
LIG_TRAF2_1	814	817	PF00917	0.339
LIG_TRAF2_1	851	854	PF00917	0.374
LIG_TRAF2_1	950	953	PF00917	0.425
LIG_TYR_ITIM	666	671	PF00017	0.427
LIG_WRC_WIRS_1	1	6	PF05994	0.432
LIG_WRC_WIRS_1	230	235	PF05994	0.339
LIG_WRC_WIRS_1	908	913	PF05994	0.362
MOD_CDK_SPK_2	674	679	PF00069	0.498
MOD_CDK_SPxK_1	580	586	PF00069	0.316
MOD_CK1_1	176	182	PF00069	0.541
MOD_CK1_1	188	194	PF00069	0.586
MOD_CK1_1	256	262	PF00069	0.313
MOD_CK1_1	420	426	PF00069	0.348
MOD_CK1_1	451	457	PF00069	0.457
MOD_CK1_1	593	599	PF00069	0.394
MOD_CK1_1	870	876	PF00069	0.362
MOD_CK1_1	891	897	PF00069	0.424
MOD_CK1_1	910	916	PF00069	0.456
MOD_CK1_1	970	976	PF00069	0.238
MOD_CK2_1	256	262	PF00069	0.304
MOD_CK2_1	282	288	PF00069	0.530
MOD_CK2_1	499	505	PF00069	0.330
MOD_CK2_1	574	580	PF00069	0.540
MOD_CK2_1	698	704	PF00069	0.728
MOD_CK2_1	717	723	PF00069	0.691
MOD_CK2_1	811	817	PF00069	0.320
MOD_CK2_1	86	92	PF00069	0.537
MOD_CK2_1	891	897	PF00069	0.343
MOD_CMANNOS	528	531	PF00535	0.478
MOD_Cter_Amidation	386	389	PF01082	0.440
MOD_GlcNHglycan	168	171	PF01048	0.451
MOD_GlcNHglycan	179	182	PF01048	0.591
MOD_GlcNHglycan	255	258	PF01048	0.315
MOD_GlcNHglycan	316	319	PF01048	0.337
MOD_GlcNHglycan	427	430	PF01048	0.412
MOD_GlcNHglycan	445	448	PF01048	0.298
MOD_GlcNHglycan	450	453	PF01048	0.447
MOD_GlcNHglycan	472	475	PF01048	0.363
MOD_GlcNHglycan	611	614	PF01048	0.314
MOD_GlcNHglycan	713	716	PF01048	0.717
MOD_GlcNHglycan	979	982	PF01048	0.458
MOD_GSK3_1	134	141	PF00069	0.425
MOD_GSK3_1	154	161	PF00069	0.412
MOD_GSK3_1	173	180	PF00069	0.281
MOD_GSK3_1	181	188	PF00069	0.565
MOD_GSK3_1	229	236	PF00069	0.416
MOD_GSK3_1	273	280	PF00069	0.529
MOD_GSK3_1	308	315	PF00069	0.446
MOD_GSK3_1	367	374	PF00069	0.363
MOD_GSK3_1	375	382	PF00069	0.386
MOD_GSK3_1	416	423	PF00069	0.340
MOD_GSK3_1	443	450	PF00069	0.417
MOD_GSK3_1	511	518	PF00069	0.320
MOD_GSK3_1	632	639	PF00069	0.350
MOD_GSK3_1	698	705	PF00069	0.749
MOD_GSK3_1	706	713	PF00069	0.758
MOD_GSK3_1	957	964	PF00069	0.341
MOD_GSK3_1	975	982	PF00069	0.430
MOD_N-GLC_1	482	487	PF02516	0.411
MOD_N-GLC_1	706	711	PF02516	0.695
MOD_N-GLC_1	785	790	PF02516	0.362
MOD_N-GLC_1	831	836	PF02516	0.363
MOD_N-GLC_1	888	893	PF02516	0.354
MOD_N-GLC_2	270	272	PF02516	0.304
MOD_NEK2_1	108	113	PF00069	0.454
MOD_NEK2_1	173	178	PF00069	0.504
MOD_NEK2_1	201	206	PF00069	0.418
MOD_NEK2_1	253	258	PF00069	0.390
MOD_NEK2_1	273	278	PF00069	0.218
MOD_NEK2_1	31	36	PF00069	0.349
MOD_NEK2_1	312	317	PF00069	0.427
MOD_NEK2_1	357	362	PF00069	0.323
MOD_NEK2_1	367	372	PF00069	0.340
MOD_NEK2_1	443	448	PF00069	0.516
MOD_NEK2_1	545	550	PF00069	0.440
MOD_NEK2_1	55	60	PF00069	0.555
MOD_NEK2_1	638	643	PF00069	0.386
MOD_NEK2_1	648	653	PF00069	0.313
MOD_NEK2_1	785	790	PF00069	0.339
MOD_NEK2_1	86	91	PF00069	0.545
MOD_NEK2_1	975	980	PF00069	0.468
MOD_NEK2_2	867	872	PF00069	0.425
MOD_PIKK_1	379	385	PF00454	0.399
MOD_PIKK_1	745	751	PF00454	0.631
MOD_PIKK_1	812	818	PF00454	0.330
MOD_PKA_1	756	762	PF00069	0.627
MOD_PKA_2	177	183	PF00069	0.544
MOD_PKA_2	188	194	PF00069	0.679
MOD_PKA_2	367	373	PF00069	0.366
MOD_PKA_2	375	381	PF00069	0.391
MOD_PKA_2	711	717	PF00069	0.771
MOD_PKA_2	756	762	PF00069	0.567
MOD_PKA_2	818	824	PF00069	0.320
MOD_PKA_2	961	967	PF00069	0.339
MOD_Plk_1	307	313	PF00069	0.547
MOD_Plk_1	482	488	PF00069	0.405
MOD_Plk_1	500	506	PF00069	0.384
MOD_Plk_1	551	557	PF00069	0.480
MOD_Plk_1	785	791	PF00069	0.320
MOD_Plk_2-3	375	381	PF00069	0.391
MOD_Plk_4	124	130	PF00069	0.539
MOD_Plk_4	19	25	PF00069	0.378
MOD_Plk_4	240	246	PF00069	0.343
MOD_Plk_4	297	303	PF00069	0.356
MOD_Plk_4	308	314	PF00069	0.404
MOD_Plk_4	417	423	PF00069	0.357
MOD_Plk_4	511	517	PF00069	0.308
MOD_Plk_4	552	558	PF00069	0.388
MOD_Plk_4	785	791	PF00069	0.325
MOD_Plk_4	818	824	PF00069	0.320
MOD_Plk_4	907	913	PF00069	0.390
MOD_ProDKin_1	24	30	PF00069	0.493
MOD_ProDKin_1	580	586	PF00069	0.318
MOD_ProDKin_1	590	596	PF00069	0.304
MOD_ProDKin_1	632	638	PF00069	0.367
MOD_ProDKin_1	674	680	PF00069	0.544
MOD_ProDKin_1	847	853	PF00069	0.341
MOD_SUMO_rev_2	111	118	PF00179	0.464
MOD_SUMO_rev_2	437	446	PF00179	0.390
MOD_SUMO_rev_2	878	884	PF00179	0.339
TRG_DiLeu_BaEn_1	308	313	PF01217	0.535
TRG_DiLeu_BaLyEn_6	796	801	PF01217	0.320
TRG_ENDOCYTIC_2	206	209	PF00928	0.320
TRG_ENDOCYTIC_2	309	312	PF00928	0.534
TRG_ENDOCYTIC_2	466	469	PF00928	0.449
TRG_ENDOCYTIC_2	605	608	PF00928	0.339
TRG_ENDOCYTIC_2	660	663	PF00928	0.382
TRG_ENDOCYTIC_2	668	671	PF00928	0.383
TRG_ENDOCYTIC_2	68	71	PF00928	0.364
TRG_ER_diArg_1	755	757	PF00400	0.632
TRG_ER_diArg_1	916	918	PF00400	0.390
TRG_NES_CRM1_1	847	859	PF08389	0.365
TRG_Pf-PMV_PEXEL_1	487	491	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7H8	Leptomonas seymouri	84%	100%
A0A0S4IK94	Bodo saltans	51%	100%
A0A1X0P3D2	Trypanosomatidae	63%	100%
A0A3R7KJ70	Trypanosoma rangeli	64%	100%
A4HPU0	Leishmania braziliensis	91%	100%
A4IE52	Leishmania infantum	100%	100%
D0A8Q5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	89%
E9ATK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O14053	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q06078	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q4Q0Z3	Leishmania major	95%	99%
Q8NI36	Homo sapiens	24%	100%
V5BS01	Trypanosoma cruzi	63%	100%