Prolyl oligopeptidase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Esterase PHB depolymerase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBJ7_LEIDO

TriTrypDb:

LdBPK_364870.1 , LdCL_360055800 , LDHU3_36.6550

Length:

585

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005576	extracellular region	2	6
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S7XBJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBJ7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0030600	feruloyl esterase activity	5	2
GO:0052689	carboxylic ester hydrolase activity	4	2
GO:0008233	peptidase activity	3	1
GO:0008236	serine-type peptidase activity	4	1
GO:0017171	serine hydrolase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.716
CLV_C14_Caspase3-7	91	95	PF00656	0.271
CLV_NRD_NRD_1	30	32	PF00675	0.495
CLV_NRD_NRD_1	430	432	PF00675	0.724
CLV_NRD_NRD_1	515	517	PF00675	0.780
CLV_PCSK_KEX2_1	366	368	PF00082	0.634
CLV_PCSK_KEX2_1	430	432	PF00082	0.726
CLV_PCSK_KEX2_1	434	436	PF00082	0.728
CLV_PCSK_KEX2_1	453	455	PF00082	0.605
CLV_PCSK_KEX2_1	515	517	PF00082	0.742
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.612
CLV_PCSK_PC1ET2_1	434	436	PF00082	0.635
CLV_PCSK_PC1ET2_1	453	455	PF00082	0.707
CLV_PCSK_PC7_1	430	436	PF00082	0.716
CLV_PCSK_SKI1_1	23	27	PF00082	0.577
CLV_PCSK_SKI1_1	42	46	PF00082	0.320
CLV_PCSK_SKI1_1	435	439	PF00082	0.801
CLV_Separin_Metazoa	550	554	PF03568	0.424
DOC_CKS1_1	147	152	PF01111	0.323
DOC_CKS1_1	75	80	PF01111	0.412
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.457
DOC_MAPK_gen_1	121	129	PF00069	0.341
DOC_MAPK_gen_1	37	46	PF00069	0.608
DOC_MAPK_gen_1	515	522	PF00069	0.546
DOC_MAPK_JIP1_4	157	163	PF00069	0.335
DOC_MAPK_MEF2A_6	157	165	PF00069	0.372
DOC_PP1_RVXF_1	319	326	PF00149	0.343
DOC_PP1_RVXF_1	561	568	PF00149	0.377
DOC_PP2B_LxvP_1	26	29	PF13499	0.731
DOC_PP2B_LxvP_1	313	316	PF13499	0.365
DOC_PP2B_LxvP_1	52	55	PF13499	0.457
DOC_USP7_MATH_1	268	272	PF00917	0.286
DOC_USP7_MATH_1	360	364	PF00917	0.313
DOC_USP7_MATH_1	526	530	PF00917	0.485
DOC_USP7_UBL2_3	463	467	PF12436	0.533
DOC_WW_Pin1_4	146	151	PF00397	0.343
DOC_WW_Pin1_4	16	21	PF00397	0.705
DOC_WW_Pin1_4	74	79	PF00397	0.446
LIG_14-3-3_CanoR_1	121	127	PF00244	0.339
LIG_14-3-3_CanoR_1	267	273	PF00244	0.378
LIG_14-3-3_CanoR_1	301	305	PF00244	0.333
LIG_14-3-3_CanoR_1	42	47	PF00244	0.349
LIG_APCC_ABBA_1	181	186	PF00400	0.268
LIG_BIR_III_2	27	31	PF00653	0.704
LIG_BIR_III_4	177	181	PF00653	0.313
LIG_BRCT_BRCA1_1	79	83	PF00533	0.466
LIG_EH1_1	82	90	PF00400	0.451
LIG_FHA_1	177	183	PF00498	0.268
LIG_FHA_1	288	294	PF00498	0.351
LIG_FHA_1	300	306	PF00498	0.331
LIG_FHA_1	308	314	PF00498	0.231
LIG_FHA_1	568	574	PF00498	0.308
LIG_FHA_2	381	387	PF00498	0.537
LIG_FHA_2	420	426	PF00498	0.422
LIG_FHA_2	455	461	PF00498	0.493
LIG_LIR_Apic_2	146	150	PF02991	0.322
LIG_LIR_Gen_1	188	195	PF02991	0.335
LIG_LIR_Gen_1	351	360	PF02991	0.315
LIG_LIR_Gen_1	423	432	PF02991	0.490
LIG_LIR_Nem_3	128	132	PF02991	0.399
LIG_LIR_Nem_3	179	184	PF02991	0.293
LIG_LIR_Nem_3	188	193	PF02991	0.293
LIG_LIR_Nem_3	264	269	PF02991	0.357
LIG_LIR_Nem_3	351	357	PF02991	0.297
LIG_LIR_Nem_3	387	393	PF02991	0.452
LIG_LIR_Nem_3	423	429	PF02991	0.493
LIG_PCNA_yPIPBox_3	82	90	PF02747	0.407
LIG_PTB_Apo_2	353	360	PF02174	0.340
LIG_PTB_Phospho_1	353	359	PF10480	0.424
LIG_SH2_GRB2like	354	357	PF00017	0.339
LIG_SH2_GRB2like	359	362	PF00017	0.348
LIG_SH2_PTP2	354	357	PF00017	0.281
LIG_SH2_SRC	354	357	PF00017	0.281
LIG_SH2_STAT5	100	103	PF00017	0.491
LIG_SH2_STAT5	142	145	PF00017	0.343
LIG_SH2_STAT5	201	204	PF00017	0.277
LIG_SH2_STAT5	354	357	PF00017	0.339
LIG_SH2_STAT5	426	429	PF00017	0.487
LIG_SH2_STAT5	57	60	PF00017	0.497
LIG_SH2_STAT5	572	575	PF00017	0.317
LIG_SH3_1	114	120	PF00018	0.438
LIG_SH3_3	114	120	PF00018	0.398
LIG_SH3_3	138	144	PF00018	0.307
LIG_SH3_3	72	78	PF00018	0.394
LIG_SUMO_SIM_anti_2	547	553	PF11976	0.418
LIG_SUMO_SIM_anti_2	70	77	PF11976	0.481
LIG_SUMO_SIM_par_1	70	77	PF11976	0.460
LIG_TRAF2_1	374	377	PF00917	0.467
LIG_TRAF2_1	501	504	PF00917	0.486
LIG_TRFH_1	489	493	PF08558	0.545
LIG_TYR_ITIM	182	187	PF00017	0.313
LIG_UBA3_1	164	173	PF00899	0.378
LIG_UBA3_1	52	60	PF00899	0.274
LIG_WRC_WIRS_1	126	131	PF05994	0.424
LIG_WW_3	28	32	PF00397	0.721
MOD_CDK_SPxxK_3	16	23	PF00069	0.643
MOD_CK1_1	103	109	PF00069	0.449
MOD_CK1_1	12	18	PF00069	0.770
MOD_CK1_1	146	152	PF00069	0.386
MOD_CK1_1	350	356	PF00069	0.461
MOD_CK1_1	74	80	PF00069	0.412
MOD_CK2_1	371	377	PF00069	0.539
MOD_CK2_1	380	386	PF00069	0.520
MOD_CK2_1	402	408	PF00069	0.558
MOD_CK2_1	417	423	PF00069	0.387
MOD_CK2_1	454	460	PF00069	0.494
MOD_CK2_1	544	550	PF00069	0.368
MOD_Cter_Amidation	364	367	PF01082	0.570
MOD_GlcNHglycan	272	275	PF01048	0.552
MOD_GlcNHglycan	404	407	PF01048	0.702
MOD_GSK3_1	191	198	PF00069	0.275
MOD_GSK3_1	295	302	PF00069	0.454
MOD_GSK3_1	344	351	PF00069	0.394
MOD_GSK3_1	367	374	PF00069	0.517
MOD_GSK3_1	9	16	PF00069	0.744
MOD_GSK3_1	99	106	PF00069	0.450
MOD_N-GLC_1	345	350	PF02516	0.565
MOD_N-GLC_1	360	365	PF02516	0.588
MOD_N-GLC_1	397	402	PF02516	0.752
MOD_N-GLC_2	339	341	PF02516	0.561
MOD_NEK2_1	176	181	PF00069	0.293
MOD_NEK2_1	232	237	PF00069	0.378
MOD_NEK2_2	296	301	PF00069	0.350
MOD_PIKK_1	230	236	PF00454	0.268
MOD_PIKK_1	499	505	PF00454	0.554
MOD_PIKK_1	544	550	PF00454	0.356
MOD_PKA_1	31	37	PF00069	0.648
MOD_PKA_1	430	436	PF00069	0.527
MOD_PKA_2	300	306	PF00069	0.393
MOD_PKA_2	430	436	PF00069	0.525
MOD_PKB_1	415	423	PF00069	0.470
MOD_Plk_1	238	244	PF00069	0.335
MOD_Plk_1	345	351	PF00069	0.359
MOD_Plk_1	360	366	PF00069	0.412
MOD_Plk_1	9	15	PF00069	0.662
MOD_Plk_4	100	106	PF00069	0.446
MOD_Plk_4	122	128	PF00069	0.424
MOD_Plk_4	300	306	PF00069	0.331
MOD_Plk_4	324	330	PF00069	0.376
MOD_Plk_4	350	356	PF00069	0.400
MOD_Plk_4	476	482	PF00069	0.486
MOD_ProDKin_1	146	152	PF00069	0.352
MOD_ProDKin_1	16	22	PF00069	0.708
MOD_ProDKin_1	74	80	PF00069	0.444
MOD_SUMO_rev_2	374	383	PF00179	0.467
MOD_SUMO_rev_2	466	473	PF00179	0.531
TRG_DiLeu_BaEn_1	408	413	PF01217	0.444
TRG_DiLeu_BaEn_2	185	191	PF01217	0.277
TRG_ENDOCYTIC_2	184	187	PF00928	0.313
TRG_ENDOCYTIC_2	354	357	PF00928	0.305
TRG_ENDOCYTIC_2	390	393	PF00928	0.521
TRG_ENDOCYTIC_2	426	429	PF00928	0.487
TRG_ER_diArg_1	429	431	PF00400	0.472
TRG_ER_diArg_1	444	447	PF00400	0.416
TRG_ER_diArg_1	515	518	PF00400	0.532
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD17	Leptomonas seymouri	43%	100%
A4HPY1	Leishmania braziliensis	56%	100%
A4IDP2	Leishmania infantum	100%	100%
E9ATP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q0V0	Leishmania major	84%	99%