Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBI9_LEIDO

TriTrypDb:

LdBPK_364320.1 , LdCL_360050300 , LDHU3_36.5840

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XBI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBI9

PDB structure(s): 7ane_ax

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.573
CLV_NRD_NRD_1	2	4	PF00675	0.629
CLV_PCSK_FUR_1	121	125	PF00082	0.552
CLV_PCSK_KEX2_1	123	125	PF00082	0.508
CLV_PCSK_KEX2_1	2	4	PF00082	0.599
CLV_PCSK_KEX2_1	26	28	PF00082	0.570
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.498
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.589
CLV_PCSK_SKI1_1	124	128	PF00082	0.491
DEG_Nend_UBRbox_1	1	4	PF02207	0.591
DEG_SPOP_SBC_1	168	172	PF00917	0.535
DOC_CKS1_1	148	153	PF01111	0.570
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.503
DOC_SPAK_OSR1_1	125	129	PF12202	0.487
DOC_USP7_MATH_1	168	172	PF00917	0.557
DOC_USP7_UBL2_3	35	39	PF12436	0.553
DOC_WW_Pin1_4	132	137	PF00397	0.475
DOC_WW_Pin1_4	147	152	PF00397	0.524
DOC_WW_Pin1_4	8	13	PF00397	0.512
LIG_14-3-3_CanoR_1	5	15	PF00244	0.590
LIG_14-3-3_CanoR_1	60	64	PF00244	0.519
LIG_CSL_BTD_1	140	143	PF09270	0.515
LIG_FHA_1	2	8	PF00498	0.658
LIG_LIR_Gen_1	13	23	PF02991	0.537
LIG_LIR_Gen_1	62	69	PF02991	0.528
LIG_LIR_Gen_1	82	91	PF02991	0.534
LIG_LIR_Nem_3	13	18	PF02991	0.509
LIG_LIR_Nem_3	162	167	PF02991	0.629
LIG_LIR_Nem_3	62	66	PF02991	0.521
LIG_LIR_Nem_3	82	88	PF02991	0.527
LIG_Pex14_2	126	130	PF04695	0.482
LIG_Pex14_2	160	164	PF04695	0.627
LIG_SH3_3	106	112	PF00018	0.588
LIG_SH3_3	140	146	PF00018	0.528
LIG_SH3_3	96	102	PF00018	0.564
LIG_TYR_ITIM	61	66	PF00017	0.505
MOD_CDK_SPxK_1	8	14	PF00069	0.510
MOD_CDK_SPxxK_3	147	154	PF00069	0.567
MOD_CK1_1	155	161	PF00069	0.580
MOD_CK1_1	171	177	PF00069	0.616
MOD_CK1_1	179	185	PF00069	0.764
MOD_CK1_1	38	44	PF00069	0.588
MOD_GlcNHglycan	179	182	PF01048	0.711
MOD_GSK3_1	13	20	PF00069	0.563
MOD_GSK3_1	163	170	PF00069	0.656
MOD_GSK3_1	176	183	PF00069	0.681
MOD_NEK2_1	1	6	PF00069	0.573
MOD_NEK2_1	152	157	PF00069	0.521
MOD_NEK2_1	167	172	PF00069	0.532
MOD_NEK2_1	18	23	PF00069	0.569
MOD_NEK2_1	74	79	PF00069	0.606
MOD_PIKK_1	155	161	PF00454	0.580
MOD_PIKK_1	93	99	PF00454	0.516
MOD_PKA_2	1	7	PF00069	0.534
MOD_PKA_2	168	174	PF00069	0.679
MOD_PKA_2	59	65	PF00069	0.517
MOD_PKA_2	74	80	PF00069	0.495
MOD_ProDKin_1	132	138	PF00069	0.478
MOD_ProDKin_1	147	153	PF00069	0.526
MOD_ProDKin_1	8	14	PF00069	0.514
MOD_SUMO_rev_2	106	112	PF00179	0.538
TRG_ENDOCYTIC_2	63	66	PF00928	0.498
TRG_ER_diArg_1	1	3	PF00400	0.607
TRG_ER_diArg_1	124	126	PF00400	0.558
TRG_NLS_MonoExtN_4	121	127	PF00514	0.504
TRG_Pf-PMV_PEXEL_1	89	94	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTA3	Leptomonas seymouri	89%	100%
A0A0S4IP42	Bodo saltans	69%	100%
A0A1X0P4J4	Trypanosomatidae	72%	100%
A0A3R7L6J8	Trypanosoma rangeli	80%	100%
A4HPT0	Leishmania braziliensis	92%	100%
A4IE62	Leishmania infantum	100%	100%
D0A8P6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	100%
E9ATJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q103	Leishmania major	98%	100%