Asparaginase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Asparaginase

Gene product:

asparaginase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7XBI7_LEIDO

TriTrypDb:

LdBPK_364650.1 , LdCL_360053600 , LDHU3_36.6270

Length:

369

Annotations

Annotations by Jardim et al.

Amino acid metabolism, Asparaginase-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XBI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBI7

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	12
GO:0006520	amino acid metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009066	aspartate family amino acid metabolic process	5	12
GO:0009987	cellular process	1	12
GO:0019752	carboxylic acid metabolic process	5	12
GO:0043436	oxoacid metabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004067	asparaginase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	12
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.426
CLV_NRD_NRD_1	10	12	PF00675	0.705
CLV_NRD_NRD_1	215	217	PF00675	0.360
CLV_NRD_NRD_1	277	279	PF00675	0.313
CLV_NRD_NRD_1	350	352	PF00675	0.453
CLV_NRD_NRD_1	53	55	PF00675	0.520
CLV_PCSK_KEX2_1	277	279	PF00082	0.335
CLV_PCSK_KEX2_1	282	284	PF00082	0.326
CLV_PCSK_KEX2_1	52	54	PF00082	0.551
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.381

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVX8	Leptomonas seymouri	31%	94%
A0A0N1PEN4	Leptomonas seymouri	73%	98%
A0A0S4J4T5	Bodo saltans	48%	91%
A0A0S4J8X9	Bodo saltans	45%	100%
A0A0S4JTX6	Bodo saltans	36%	91%
A0A1X0P1U7	Trypanosomatidae	51%	99%
A0A3Q8IA09	Leishmania donovani	30%	100%
A0A3R7KPG5	Trypanosoma rangeli	50%	100%
A0A422N3G9	Trypanosoma rangeli	30%	82%
A1RX40	Thermofilum pendens (strain DSM 2475 / Hrk 5)	26%	82%

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