Snare region anchored in the vesicle membrane C-terminus family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Golgi SNAP receptor complex member 1, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBH8_LEIDO

TriTrypDb:

LdBPK_364220.1 , LdCL_360049300 , LDHU3_36.5650

Length:

276

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	12
GO:0005801	cis-Golgi network	5	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0098588	bounding membrane of organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005794	Golgi apparatus	5	1
GO:0005797	Golgi medial cisterna	5	1
GO:0031201	SNARE complex	3	1
GO:0031984	organelle subcompartment	2	1
GO:0031985	Golgi cisterna	4	1
GO:0032991	protein-containing complex	1	1
GO:0098791	Golgi apparatus subcompartment	3	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

A0A3S7XBH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBH8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0016192	vesicle-mediated transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0048193	Golgi vesicle transport	5	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0048284	organelle fusion	5	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1

Molecular functions
Term	Name	Level	Count
GO:0005484	SNAP receptor activity	3	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.325
CLV_NRD_NRD_1	157	159	PF00675	0.293
CLV_NRD_NRD_1	175	177	PF00675	0.367
CLV_NRD_NRD_1	248	250	PF00675	0.255
CLV_NRD_NRD_1	255	257	PF00675	0.324
CLV_NRD_NRD_1	29	31	PF00675	0.356
CLV_PCSK_FUR_1	253	257	PF00082	0.322
CLV_PCSK_KEX2_1	148	150	PF00082	0.331
CLV_PCSK_KEX2_1	174	176	PF00082	0.470
CLV_PCSK_KEX2_1	248	250	PF00082	0.249
CLV_PCSK_KEX2_1	253	255	PF00082	0.243
CLV_PCSK_PC7_1	249	255	PF00082	0.198
CLV_PCSK_SKI1_1	138	142	PF00082	0.400
CLV_PCSK_SKI1_1	150	154	PF00082	0.326
DEG_Nend_UBRbox_3	1	3	PF02207	0.556
DEG_SPOP_SBC_1	48	52	PF00917	0.563
DEG_SPOP_SBC_1	56	60	PF00917	0.710
DEG_SPOP_SBC_1	67	71	PF00917	0.651
DOC_MAPK_gen_1	253	261	PF00069	0.403
DOC_MAPK_gen_1	30	37	PF00069	0.590
DOC_MAPK_MEF2A_6	185	192	PF00069	0.528
DOC_MAPK_RevD_3	241	256	PF00069	0.482
DOC_USP7_MATH_1	47	51	PF00917	0.653
DOC_USP7_MATH_1	67	71	PF00917	0.668
DOC_WW_Pin1_4	60	65	PF00397	0.717
DOC_WW_Pin1_4	77	82	PF00397	0.724
LIG_14-3-3_CanoR_1	132	140	PF00244	0.588
LIG_14-3-3_CanoR_1	19	25	PF00244	0.585
LIG_APCC_ABBA_1	35	40	PF00400	0.592
LIG_BIR_III_4	183	187	PF00653	0.547
LIG_BRCT_BRCA1_1	266	270	PF00533	0.381
LIG_FHA_1	19	25	PF00498	0.593
LIG_FHA_1	61	67	PF00498	0.767
LIG_LIR_Gen_1	224	234	PF02991	0.413
LIG_LIR_Gen_1	267	276	PF02991	0.334
LIG_LIR_Gen_1	86	96	PF02991	0.559
LIG_LIR_Nem_3	224	229	PF02991	0.469
LIG_LIR_Nem_3	267	273	PF02991	0.334
LIG_LIR_Nem_3	86	92	PF02991	0.663
LIG_PDZ_Class_2	271	276	PF00595	0.293
LIG_Pex14_2	270	274	PF04695	0.327
LIG_Rb_pABgroove_1	32	40	PF01858	0.522
LIG_SH2_NCK_1	162	166	PF00017	0.533
LIG_SH2_STAP1	162	166	PF00017	0.533
LIG_SH3_3	61	67	PF00018	0.723
LIG_SUMO_SIM_anti_2	257	263	PF11976	0.304
LIG_SUMO_SIM_par_1	257	263	PF11976	0.285
LIG_SUMO_SIM_par_1	33	41	PF11976	0.532
MOD_CK1_1	60	66	PF00069	0.665
MOD_CK1_1	69	75	PF00069	0.647
MOD_CK1_1	76	82	PF00069	0.592
MOD_CK1_1	85	91	PF00069	0.648
MOD_GlcNHglycan	127	130	PF01048	0.357
MOD_GlcNHglycan	45	48	PF01048	0.378
MOD_GlcNHglycan	76	79	PF01048	0.501
MOD_GSK3_1	260	267	PF00069	0.381
MOD_GSK3_1	43	50	PF00069	0.563
MOD_GSK3_1	56	63	PF00069	0.663
MOD_GSK3_1	69	76	PF00069	0.627
MOD_NEK2_1	110	115	PF00069	0.525
MOD_NEK2_1	164	169	PF00069	0.619
MOD_NEK2_1	73	78	PF00069	0.724
MOD_NEK2_2	49	54	PF00069	0.583
MOD_PIKK_1	91	97	PF00454	0.577
MOD_PKA_2	131	137	PF00069	0.584
MOD_PKA_2	18	24	PF00069	0.593
MOD_PKB_1	148	156	PF00069	0.510
MOD_Plk_1	110	116	PF00069	0.594
MOD_Plk_4	110	116	PF00069	0.493
MOD_Plk_4	260	266	PF00069	0.374
MOD_Plk_4	69	75	PF00069	0.644
MOD_ProDKin_1	60	66	PF00069	0.717
MOD_ProDKin_1	77	83	PF00069	0.722
MOD_SUMO_rev_2	39	44	PF00179	0.557
TRG_DiLeu_BaEn_2	237	243	PF01217	0.469
TRG_ER_diArg_1	148	150	PF00400	0.572
TRG_ER_diArg_1	155	158	PF00400	0.537
TRG_ER_diArg_1	174	176	PF00400	0.647
TRG_ER_diArg_1	218	221	PF00400	0.461
TRG_ER_diArg_1	247	249	PF00400	0.451
TRG_ER_diArg_1	252	255	PF00400	0.442
TRG_NES_CRM1_1	27	41	PF08389	0.594
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.373
TRG_Pf-PMV_PEXEL_1	149	154	PF00026	0.343
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDH6	Leptomonas seymouri	67%	99%
A0A0S4IYJ5	Bodo saltans	30%	100%
A0A1X0P3F0	Trypanosomatidae	37%	100%
A0A3R7MXC4	Trypanosoma rangeli	32%	100%
A4HPS0	Leishmania braziliensis	79%	100%
A4ICZ3	Leishmania infantum	100%	100%
D0A8N3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ATI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O08522	Cricetulus griseus	25%	100%
O88630	Mus musculus	25%	100%
O95249	Homo sapiens	25%	100%
P38736	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q2TBU3	Bos taurus	25%	100%
Q4Q113	Leishmania major	96%	100%
Q5RBL6	Pongo abelii	25%	100%
Q62931	Rattus norvegicus	25%	100%
Q95ZW1	Caenorhabditis elegans	21%	100%
Q9VE50	Drosophila melanogaster	26%	100%
V5BMF0	Trypanosoma cruzi	34%	100%