Probable eukaryotic initiation factor 4A

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-dependent DEAD/H RNA helicase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBG9_LEIDO

TriTrypDb:

LdBPK_364620.1 , LdCL_360053300 , LDHU3_36.6240

Length:

964

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XBG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBG9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003676	nucleic acid binding	3	8
GO:0003724	RNA helicase activity	3	8
GO:0003743	translation initiation factor activity	4	8
GO:0003824	catalytic activity	1	8
GO:0004386	helicase activity	2	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0008135	translation factor activity, RNA binding	3	8
GO:0008186	ATP-dependent activity, acting on RNA	2	8
GO:0016787	hydrolase activity	2	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0045182	translation regulator activity	1	8
GO:0090079	translation regulator activity, nucleic acid binding	2	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140098	catalytic activity, acting on RNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8
GO:0140657	ATP-dependent activity	1	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	590	594	PF00656	0.595
CLV_C14_Caspase3-7	887	891	PF00656	0.511
CLV_NRD_NRD_1	119	121	PF00675	0.638
CLV_NRD_NRD_1	12	14	PF00675	0.569
CLV_NRD_NRD_1	27	29	PF00675	0.645
CLV_NRD_NRD_1	35	37	PF00675	0.622
CLV_NRD_NRD_1	412	414	PF00675	0.298
CLV_NRD_NRD_1	550	552	PF00675	0.683
CLV_NRD_NRD_1	632	634	PF00675	0.602
CLV_NRD_NRD_1	637	639	PF00675	0.605
CLV_NRD_NRD_1	718	720	PF00675	0.298
CLV_NRD_NRD_1	816	818	PF00675	0.463
CLV_NRD_NRD_1	824	826	PF00675	0.510
CLV_NRD_NRD_1	911	913	PF00675	0.613
CLV_PCSK_FUR_1	328	332	PF00082	0.281
CLV_PCSK_KEX2_1	119	121	PF00082	0.662
CLV_PCSK_KEX2_1	249	251	PF00082	0.767
CLV_PCSK_KEX2_1	29	31	PF00082	0.599
CLV_PCSK_KEX2_1	327	329	PF00082	0.258
CLV_PCSK_KEX2_1	330	332	PF00082	0.253
CLV_PCSK_KEX2_1	35	37	PF00082	0.618
CLV_PCSK_KEX2_1	412	414	PF00082	0.298
CLV_PCSK_KEX2_1	515	517	PF00082	0.679
CLV_PCSK_KEX2_1	632	634	PF00082	0.602
CLV_PCSK_KEX2_1	718	720	PF00082	0.298
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.604
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.767
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.576
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.261
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.250
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.679
CLV_PCSK_SKI1_1	307	311	PF00082	0.216
CLV_PCSK_SKI1_1	353	357	PF00082	0.273
CLV_PCSK_SKI1_1	536	540	PF00082	0.687
CLV_PCSK_SKI1_1	552	556	PF00082	0.532
CLV_PCSK_SKI1_1	6	10	PF00082	0.591
CLV_PCSK_SKI1_1	614	618	PF00082	0.461
CLV_PCSK_SKI1_1	719	723	PF00082	0.298
CLV_PCSK_SKI1_1	74	78	PF00082	0.591
CLV_PCSK_SKI1_1	912	916	PF00082	0.534
CLV_PCSK_SKI1_1	921	925	PF00082	0.560
DEG_APCC_DBOX_1	740	748	PF00400	0.498
DEG_SCF_FBW7_1	545	550	PF00400	0.633
DEG_SCF_FBW7_2	214	219	PF00400	0.469
DEG_SCF_SKP2-CKS1_1	542	549	PF00560	0.630
DEG_SPOP_SBC_1	529	533	PF00917	0.612
DEG_SPOP_SBC_1	99	103	PF00917	0.656
DOC_CKS1_1	388	393	PF01111	0.456
DOC_CYCLIN_RxL_1	204	215	PF00134	0.426
DOC_CYCLIN_RxL_1	339	349	PF00134	0.465
DOC_MAPK_DCC_7	595	605	PF00069	0.664
DOC_MAPK_gen_1	327	338	PF00069	0.458
DOC_MAPK_gen_1	412	419	PF00069	0.498
DOC_MAPK_gen_1	718	729	PF00069	0.481
DOC_MAPK_gen_1	749	757	PF00069	0.498
DOC_MAPK_gen_1	894	902	PF00069	0.471
DOC_MAPK_gen_1	943	951	PF00069	0.563
DOC_MAPK_HePTP_8	649	661	PF00069	0.463
DOC_MAPK_MEF2A_6	138	145	PF00069	0.618
DOC_MAPK_MEF2A_6	357	364	PF00069	0.471
DOC_MAPK_MEF2A_6	652	661	PF00069	0.460
DOC_MAPK_MEF2A_6	722	731	PF00069	0.498
DOC_MAPK_MEF2A_6	751	759	PF00069	0.498
DOC_PP1_RVXF_1	205	212	PF00149	0.475
DOC_PP1_RVXF_1	270	277	PF00149	0.498
DOC_PP1_RVXF_1	704	711	PF00149	0.498
DOC_PP1_RVXF_1	741	747	PF00149	0.498
DOC_PP1_RVXF_1	846	852	PF00149	0.424
DOC_PP2B_LxvP_1	151	154	PF13499	0.728
DOC_PP2B_PxIxI_1	383	389	PF00149	0.498
DOC_PP4_FxxP_1	211	214	PF00568	0.428
DOC_PP4_FxxP_1	276	279	PF00568	0.456
DOC_USP7_MATH_1	100	104	PF00917	0.615
DOC_USP7_MATH_1	105	109	PF00917	0.635
DOC_USP7_MATH_1	517	521	PF00917	0.664
DOC_USP7_MATH_1	527	531	PF00917	0.541
DOC_USP7_MATH_1	547	551	PF00917	0.655
DOC_USP7_MATH_1	554	558	PF00917	0.670
DOC_USP7_MATH_1	63	67	PF00917	0.620
DOC_USP7_MATH_1	637	641	PF00917	0.602
DOC_USP7_MATH_1	687	691	PF00917	0.448
DOC_USP7_MATH_1	83	87	PF00917	0.453
DOC_USP7_MATH_1	93	97	PF00917	0.606
DOC_USP7_UBL2_3	14	18	PF12436	0.585
DOC_USP7_UBL2_3	489	493	PF12436	0.728
DOC_USP7_UBL2_3	5	9	PF12436	0.586
DOC_USP7_UBL2_3	511	515	PF12436	0.622
DOC_USP7_UBL2_3	536	540	PF12436	0.724
DOC_USP7_UBL2_3	555	559	PF12436	0.633
DOC_USP7_UBL2_3	745	749	PF12436	0.498
DOC_USP7_UBL2_3	858	862	PF12436	0.465
DOC_WW_Pin1_4	212	217	PF00397	0.430
DOC_WW_Pin1_4	294	299	PF00397	0.527
DOC_WW_Pin1_4	336	341	PF00397	0.498
DOC_WW_Pin1_4	387	392	PF00397	0.467
DOC_WW_Pin1_4	543	548	PF00397	0.630
LIG_14-3-3_CanoR_1	120	128	PF00244	0.601
LIG_14-3-3_CanoR_1	292	301	PF00244	0.533
LIG_14-3-3_CanoR_1	331	337	PF00244	0.498
LIG_14-3-3_CanoR_1	614	619	PF00244	0.455
LIG_14-3-3_CanoR_1	74	83	PF00244	0.602
LIG_14-3-3_CanoR_1	783	789	PF00244	0.498
LIG_14-3-3_CanoR_1	925	931	PF00244	0.545
LIG_Actin_WH2_2	731	747	PF00022	0.484
LIG_Actin_WH2_2	832	850	PF00022	0.458
LIG_AP2alpha_1	746	750	PF02296	0.498
LIG_BIR_II_1	1	5	PF00653	0.569
LIG_BRCT_BRCA1_1	427	431	PF00533	0.505
LIG_FHA_1	288	294	PF00498	0.484
LIG_FHA_1	339	345	PF00498	0.492
LIG_FHA_1	621	627	PF00498	0.512
LIG_FHA_1	75	81	PF00498	0.593
LIG_FHA_1	946	952	PF00498	0.566
LIG_FHA_2	434	440	PF00498	0.452
LIG_FHA_2	497	503	PF00498	0.612
LIG_FHA_2	583	589	PF00498	0.626
LIG_FHA_2	626	632	PF00498	0.576
LIG_FHA_2	699	705	PF00498	0.481
LIG_GBD_Chelix_1	839	847	PF00786	0.408
LIG_IRF3_LxIS_1	332	339	PF10401	0.500
LIG_LIR_Apic_2	208	214	PF02991	0.466
LIG_LIR_Apic_2	273	279	PF02991	0.456
LIG_LIR_Gen_1	428	438	PF02991	0.498
LIG_LIR_Nem_3	428	434	PF02991	0.498
LIG_LIR_Nem_3	474	480	PF02991	0.597
LIG_LIR_Nem_3	692	697	PF02991	0.498
LIG_LIR_Nem_3	815	819	PF02991	0.458
LIG_NRBOX	280	286	PF00104	0.498
LIG_NRBOX	433	439	PF00104	0.498
LIG_NRBOX	719	725	PF00104	0.498
LIG_NRBOX	75	81	PF00104	0.593
LIG_NRBOX	802	808	PF00104	0.400
LIG_PCNA_yPIPBox_3	357	368	PF02747	0.493
LIG_Pex14_2	746	750	PF04695	0.498
LIG_SH2_CRK	779	783	PF00017	0.500
LIG_SH2_NCK_1	41	45	PF00017	0.645
LIG_SH2_PTP2	416	419	PF00017	0.481
LIG_SH2_STAT5	190	193	PF00017	0.455
LIG_SH2_STAT5	405	408	PF00017	0.498
LIG_SH2_STAT5	416	419	PF00017	0.498
LIG_SH2_STAT5	618	621	PF00017	0.431
LIG_SH2_STAT5	683	686	PF00017	0.402
LIG_SH2_STAT5	694	697	PF00017	0.431
LIG_SH2_STAT5	775	778	PF00017	0.492
LIG_SH2_STAT5	788	791	PF00017	0.423
LIG_SH3_1	138	144	PF00018	0.602
LIG_SH3_3	138	144	PF00018	0.612
LIG_SH3_3	295	301	PF00018	0.442
LIG_SH3_3	601	607	PF00018	0.643
LIG_SH3_3	67	73	PF00018	0.688
LIG_SH3_4	489	496	PF00018	0.621
LIG_SUMO_SIM_anti_2	801	807	PF11976	0.415
LIG_SUMO_SIM_par_1	148	156	PF11976	0.598
LIG_SUMO_SIM_par_1	620	628	PF11976	0.509
LIG_SxIP_EBH_1	109	122	PF03271	0.503
LIG_TRAF2_1	216	219	PF00917	0.471
LIG_TRAF2_1	573	576	PF00917	0.737
LIG_TRAF2_1	65	68	PF00917	0.629
LIG_TYR_ITIM	414	419	PF00017	0.481
LIG_UBA3_1	716	722	PF00899	0.498
LIG_UBA3_1	819	826	PF00899	0.489
LIG_WRC_WIRS_1	830	835	PF05994	0.478
MOD_CDC14_SPxK_1	339	342	PF00782	0.498
MOD_CDK_SPxK_1	336	342	PF00069	0.498
MOD_CDK_SPxK_1	387	393	PF00069	0.456
MOD_CDK_SPxK_1	543	549	PF00069	0.632
MOD_CK1_1	122	128	PF00069	0.564
MOD_CK1_1	254	260	PF00069	0.497
MOD_CK1_1	265	271	PF00069	0.451
MOD_CK1_1	464	470	PF00069	0.540
MOD_CK1_1	530	536	PF00069	0.654
MOD_CK1_1	550	556	PF00069	0.639
MOD_CK1_1	625	631	PF00069	0.567
MOD_CK1_1	86	92	PF00069	0.576
MOD_CK2_1	225	231	PF00069	0.527
MOD_CK2_1	297	303	PF00069	0.469
MOD_CK2_1	433	439	PF00069	0.481
MOD_CK2_1	496	502	PF00069	0.605
MOD_CK2_1	582	588	PF00069	0.626
MOD_CK2_1	625	631	PF00069	0.567
MOD_CK2_1	665	671	PF00069	0.494
MOD_CK2_1	825	831	PF00069	0.501
MOD_Cter_Amidation	512	515	PF01082	0.689
MOD_Cter_Amidation	823	826	PF01082	0.501
MOD_Cter_Amidation	910	913	PF01082	0.504
MOD_Cter_Amidation	961	964	PF01082	0.556
MOD_GlcNHglycan	113	116	PF01048	0.569
MOD_GlcNHglycan	125	128	PF01048	0.555
MOD_GlcNHglycan	185	188	PF01048	0.569
MOD_GlcNHglycan	227	230	PF01048	0.523
MOD_GlcNHglycan	24	27	PF01048	0.479
MOD_GlcNHglycan	253	256	PF01048	0.319
MOD_GlcNHglycan	264	267	PF01048	0.227
MOD_GlcNHglycan	269	272	PF01048	0.202
MOD_GlcNHglycan	427	430	PF01048	0.298
MOD_GlcNHglycan	466	469	PF01048	0.580
MOD_GlcNHglycan	556	559	PF01048	0.660
MOD_GlcNHglycan	620	623	PF01048	0.461
MOD_GlcNHglycan	634	638	PF01048	0.596
MOD_GlcNHglycan	671	674	PF01048	0.547
MOD_GlcNHglycan	926	929	PF01048	0.549
MOD_GlcNHglycan	93	96	PF01048	0.629
MOD_GSK3_1	107	114	PF00069	0.588
MOD_GSK3_1	119	126	PF00069	0.615
MOD_GSK3_1	283	290	PF00069	0.474
MOD_GSK3_1	297	304	PF00069	0.500
MOD_GSK3_1	332	339	PF00069	0.498
MOD_GSK3_1	530	537	PF00069	0.573
MOD_GSK3_1	543	550	PF00069	0.616
MOD_GSK3_1	582	589	PF00069	0.602
MOD_GSK3_1	59	66	PF00069	0.604
MOD_GSK3_1	614	621	PF00069	0.450
MOD_GSK3_1	633	640	PF00069	0.600
MOD_GSK3_1	665	672	PF00069	0.503
MOD_GSK3_1	758	765	PF00069	0.471
MOD_GSK3_1	825	832	PF00069	0.465
MOD_N-GLC_1	679	684	PF02516	0.441
MOD_N-GLC_2	111	113	PF02516	0.574
MOD_NEK2_1	128	133	PF00069	0.717
MOD_NEK2_1	209	214	PF00069	0.490
MOD_NEK2_1	284	289	PF00069	0.416
MOD_NEK2_1	406	411	PF00069	0.527
MOD_NEK2_1	425	430	PF00069	0.464
MOD_NEK2_1	669	674	PF00069	0.539
MOD_NEK2_1	698	703	PF00069	0.498
MOD_NEK2_1	734	739	PF00069	0.498
MOD_NEK2_1	819	824	PF00069	0.483
MOD_NEK2_1	835	840	PF00069	0.482
MOD_NEK2_1	924	929	PF00069	0.536
MOD_NEK2_2	301	306	PF00069	0.416
MOD_PIKK_1	236	242	PF00454	0.544
MOD_PIKK_1	63	69	PF00454	0.626
MOD_PK_1	40	46	PF00069	0.640
MOD_PKA_1	119	125	PF00069	0.649
MOD_PKA_1	307	313	PF00069	0.416
MOD_PKA_1	4	10	PF00069	0.578
MOD_PKA_1	825	831	PF00069	0.501
MOD_PKA_1	912	918	PF00069	0.542
MOD_PKA_2	119	125	PF00069	0.621
MOD_PKA_2	183	189	PF00069	0.550
MOD_PKA_2	236	242	PF00069	0.696
MOD_PKA_2	291	297	PF00069	0.469
MOD_PKA_2	517	523	PF00069	0.664
MOD_PKA_2	550	556	PF00069	0.754
MOD_PKA_2	637	643	PF00069	0.598
MOD_PKA_2	782	788	PF00069	0.498
MOD_PKA_2	871	877	PF00069	0.503
MOD_PKA_2	924	930	PF00069	0.532
MOD_PKA_2	945	951	PF00069	0.564
MOD_PKB_1	38	46	PF00069	0.576
MOD_Plk_1	461	467	PF00069	0.580
MOD_Plk_1	679	685	PF00069	0.448
MOD_Plk_2-3	433	439	PF00069	0.481
MOD_Plk_2-3	72	78	PF00069	0.571
MOD_Plk_2-3	878	884	PF00069	0.561
MOD_Plk_4	270	276	PF00069	0.498
MOD_Plk_4	332	338	PF00069	0.498
MOD_Plk_4	433	439	PF00069	0.500
MOD_Plk_4	473	479	PF00069	0.599
MOD_Plk_4	637	643	PF00069	0.598
MOD_Plk_4	679	685	PF00069	0.448
MOD_Plk_4	801	807	PF00069	0.380
MOD_Plk_4	83	89	PF00069	0.514
MOD_Plk_4	835	841	PF00069	0.446
MOD_ProDKin_1	212	218	PF00069	0.424
MOD_ProDKin_1	294	300	PF00069	0.527
MOD_ProDKin_1	336	342	PF00069	0.498
MOD_ProDKin_1	387	393	PF00069	0.467
MOD_ProDKin_1	543	549	PF00069	0.632
MOD_SUMO_rev_2	238	245	PF00179	0.592
TRG_DiLeu_BaEn_1	433	438	PF01217	0.498
TRG_ENDOCYTIC_2	41	44	PF00928	0.647
TRG_ENDOCYTIC_2	416	419	PF00928	0.481
TRG_ENDOCYTIC_2	696	699	PF00928	0.498
TRG_ER_diArg_1	27	30	PF00400	0.602
TRG_ER_diArg_1	35	38	PF00400	0.622
TRG_ER_diArg_1	412	414	PF00400	0.498
TRG_ER_diArg_1	717	719	PF00400	0.498
TRG_ER_diArg_1	741	744	PF00400	0.498
TRG_NLS_Bipartite_1	13	32	PF00514	0.566
TRG_NLS_Bipartite_1	493	515	PF00514	0.572
TRG_NLS_MonoExtC_3	326	331	PF00514	0.469
TRG_NLS_MonoExtC_3	510	515	PF00514	0.669
TRG_NLS_MonoExtN_4	117	123	PF00514	0.542
TRG_NLS_MonoExtN_4	325	331	PF00514	0.484
TRG_NLS_MonoExtN_4	511	518	PF00514	0.637
TRG_Pf-PMV_PEXEL_1	342	347	PF00026	0.256
TRG_Pf-PMV_PEXEL_1	74	78	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	766	771	PF00026	0.298
TRG_Pf-PMV_PEXEL_1	817	821	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	901	906	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ87	Leptomonas seymouri	69%	100%
A0A0S4II81	Bodo saltans	26%	100%
A4HPV7	Leishmania braziliensis	79%	100%
A4IDL9	Leishmania infantum	100%	100%
E9ATM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q0X4	Leishmania major	93%	100%