Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBG5_LEIDO

TriTrypDb:

LdBPK_364560.1 , LdCL_360052800 , LDHU3_36.6180

Length:

889

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XBG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.805
CLV_C14_Caspase3-7	740	744	PF00656	0.747
CLV_MEL_PAP_1	598	604	PF00089	0.752
CLV_MEL_PAP_1	721	727	PF00089	0.599
CLV_NRD_NRD_1	149	151	PF00675	0.819
CLV_NRD_NRD_1	458	460	PF00675	0.710
CLV_NRD_NRD_1	624	626	PF00675	0.705
CLV_NRD_NRD_1	685	687	PF00675	0.669
CLV_NRD_NRD_1	753	755	PF00675	0.697
CLV_NRD_NRD_1	758	760	PF00675	0.666
CLV_NRD_NRD_1	886	888	PF00675	0.750
CLV_PCSK_FUR_1	751	755	PF00082	0.655
CLV_PCSK_KEX2_1	149	151	PF00082	0.819
CLV_PCSK_KEX2_1	589	591	PF00082	0.725
CLV_PCSK_KEX2_1	623	625	PF00082	0.710
CLV_PCSK_KEX2_1	687	689	PF00082	0.662
CLV_PCSK_KEX2_1	750	752	PF00082	0.681
CLV_PCSK_KEX2_1	753	755	PF00082	0.664
CLV_PCSK_KEX2_1	758	760	PF00082	0.671
CLV_PCSK_PC1ET2_1	589	591	PF00082	0.725
CLV_PCSK_PC1ET2_1	687	689	PF00082	0.662
CLV_PCSK_PC1ET2_1	750	752	PF00082	0.681
CLV_PCSK_PC7_1	754	760	PF00082	0.664
CLV_PCSK_SKI1_1	373	377	PF00082	0.813
CLV_PCSK_SKI1_1	428	432	PF00082	0.734
CLV_PCSK_SKI1_1	590	594	PF00082	0.720
DEG_APCC_DBOX_1	758	766	PF00400	0.786
DEG_SCF_FBW7_1	873	879	PF00400	0.800
DEG_SCF_FBW7_1	881	886	PF00400	0.721
DEG_SPOP_SBC_1	219	223	PF00917	0.665
DEG_SPOP_SBC_1	564	568	PF00917	0.739
DOC_ANK_TNKS_1	614	621	PF00023	0.695
DOC_CKS1_1	24	29	PF01111	0.795
DOC_CKS1_1	730	735	PF01111	0.715
DOC_CKS1_1	835	840	PF01111	0.702
DOC_CKS1_1	873	878	PF01111	0.818
DOC_CKS1_1	94	99	PF01111	0.720
DOC_CYCLIN_RxL_1	583	597	PF00134	0.719
DOC_CYCLIN_yClb1_LxF_4	588	593	PF00134	0.817
DOC_CYCLIN_yCln2_LP_2	610	616	PF00134	0.659
DOC_PP1_RVXF_1	33	40	PF00149	0.803
DOC_PP1_RVXF_1	587	594	PF00149	0.713
DOC_PP4_FxxP_1	21	24	PF00568	0.814
DOC_USP7_MATH_1	124	128	PF00917	0.739
DOC_USP7_MATH_1	159	163	PF00917	0.735
DOC_USP7_MATH_1	166	170	PF00917	0.768
DOC_USP7_MATH_1	209	213	PF00917	0.732
DOC_USP7_MATH_1	215	219	PF00917	0.777
DOC_USP7_MATH_1	22	26	PF00917	0.649
DOC_USP7_MATH_1	246	250	PF00917	0.786
DOC_USP7_MATH_1	415	419	PF00917	0.822
DOC_USP7_MATH_1	444	448	PF00917	0.725
DOC_USP7_MATH_1	504	508	PF00917	0.813
DOC_USP7_MATH_1	74	78	PF00917	0.716
DOC_USP7_MATH_1	839	843	PF00917	0.793
DOC_USP7_MATH_1	883	887	PF00917	0.838
DOC_WW_Pin1_4	131	136	PF00397	0.706
DOC_WW_Pin1_4	200	205	PF00397	0.679
DOC_WW_Pin1_4	23	28	PF00397	0.806
DOC_WW_Pin1_4	280	285	PF00397	0.724
DOC_WW_Pin1_4	376	381	PF00397	0.770
DOC_WW_Pin1_4	42	47	PF00397	0.481
DOC_WW_Pin1_4	466	471	PF00397	0.745
DOC_WW_Pin1_4	474	479	PF00397	0.739
DOC_WW_Pin1_4	541	546	PF00397	0.707
DOC_WW_Pin1_4	582	587	PF00397	0.679
DOC_WW_Pin1_4	604	609	PF00397	0.702
DOC_WW_Pin1_4	729	734	PF00397	0.822
DOC_WW_Pin1_4	776	781	PF00397	0.657
DOC_WW_Pin1_4	834	839	PF00397	0.806
DOC_WW_Pin1_4	872	877	PF00397	0.813
DOC_WW_Pin1_4	879	884	PF00397	0.723
DOC_WW_Pin1_4	90	95	PF00397	0.741
LIG_14-3-3_CanoR_1	149	155	PF00244	0.728
LIG_14-3-3_CanoR_1	167	171	PF00244	0.623
LIG_14-3-3_CanoR_1	185	190	PF00244	0.491
LIG_14-3-3_CanoR_1	274	284	PF00244	0.821
LIG_14-3-3_CanoR_1	294	299	PF00244	0.489
LIG_14-3-3_CanoR_1	334	342	PF00244	0.671
LIG_14-3-3_CanoR_1	798	806	PF00244	0.681
LIG_BRCT_BRCA1_1	17	21	PF00533	0.812
LIG_BRCT_BRCA1_1	510	514	PF00533	0.719
LIG_CtBP_PxDLS_1	497	503	PF00389	0.725
LIG_CtBP_PxDLS_1	727	731	PF00389	0.587
LIG_FHA_1	149	155	PF00498	0.693
LIG_FHA_1	185	191	PF00498	0.706
LIG_FHA_1	211	217	PF00498	0.726
LIG_FHA_1	437	443	PF00498	0.717
LIG_FHA_1	706	712	PF00498	0.704
LIG_FHA_2	301	307	PF00498	0.733
LIG_FHA_2	436	442	PF00498	0.646
LIG_FHA_2	566	572	PF00498	0.781
LIG_FHA_2	730	736	PF00498	0.760
LIG_FHA_2	770	776	PF00498	0.746
LIG_FHA_2	817	823	PF00498	0.787
LIG_Integrin_isoDGR_2	371	373	PF01839	0.755
LIG_LIR_Apic_2	18	24	PF02991	0.813
LIG_LIR_Apic_2	716	722	PF02991	0.699
LIG_LIR_Apic_2	832	838	PF02991	0.750
LIG_LIR_Gen_1	251	262	PF02991	0.474
LIG_LIR_Gen_1	732	740	PF02991	0.817
LIG_LIR_Gen_1	826	835	PF02991	0.718
LIG_LIR_Nem_3	310	314	PF02991	0.709
LIG_LIR_Nem_3	450	454	PF02991	0.716
LIG_LIR_Nem_3	732	737	PF02991	0.815
LIG_MYND_1	608	612	PF01753	0.799
LIG_Pex14_1	659	663	PF04695	0.805
LIG_SH2_PTP2	835	838	PF00017	0.706
LIG_SH2_STAT3	258	261	PF00017	0.792
LIG_SH2_STAT5	258	261	PF00017	0.736
LIG_SH2_STAT5	368	371	PF00017	0.612
LIG_SH2_STAT5	719	722	PF00017	0.707
LIG_SH2_STAT5	835	838	PF00017	0.706
LIG_SH3_3	21	27	PF00018	0.810
LIG_SH3_3	239	245	PF00018	0.746
LIG_SH3_3	281	287	PF00018	0.728
LIG_SH3_3	336	342	PF00018	0.726
LIG_SH3_3	549	555	PF00018	0.816
LIG_SH3_3	870	876	PF00018	0.683
LIG_SH3_3	91	97	PF00018	0.727
LIG_SxIP_EBH_1	604	615	PF03271	0.700
LIG_TRAF2_1	351	354	PF00917	0.726
LIG_TRAF2_1	418	421	PF00917	0.749
LIG_TRAF2_1	57	60	PF00917	0.726
LIG_TRAF2_1	592	595	PF00917	0.718
LIG_TRAF2_1	66	69	PF00917	0.644
LIG_WW_3	469	473	PF00397	0.743
MOD_CDC14_SPxK_1	779	782	PF00782	0.608
MOD_CDK_SPK_2	584	589	PF00069	0.792
MOD_CDK_SPK_2	93	98	PF00069	0.824
MOD_CDK_SPxK_1	466	472	PF00069	0.744
MOD_CDK_SPxK_1	584	590	PF00069	0.797
MOD_CDK_SPxK_1	776	782	PF00069	0.606
MOD_CDK_SPxxK_3	541	548	PF00069	0.809
MOD_CDK_SPxxK_3	582	589	PF00069	0.688
MOD_CK1_1	120	126	PF00069	0.779
MOD_CK1_1	134	140	PF00069	0.600
MOD_CK1_1	15	21	PF00069	0.723
MOD_CK1_1	155	161	PF00069	0.804
MOD_CK1_1	205	211	PF00069	0.618
MOD_CK1_1	218	224	PF00069	0.714
MOD_CK1_1	276	282	PF00069	0.718
MOD_CK1_1	346	352	PF00069	0.758
MOD_CK1_1	447	453	PF00069	0.754
MOD_CK1_1	524	530	PF00069	0.670
MOD_CK1_1	566	572	PF00069	0.668
MOD_CK1_1	581	587	PF00069	0.690
MOD_CK1_1	729	735	PF00069	0.763
MOD_CK1_1	769	775	PF00069	0.762
MOD_CK1_1	828	834	PF00069	0.713
MOD_CK1_1	840	846	PF00069	0.706
MOD_CK1_1	852	858	PF00069	0.649
MOD_CK1_1	866	872	PF00069	0.689
MOD_CK1_1	93	99	PF00069	0.754
MOD_CK2_1	22	28	PF00069	0.705
MOD_CK2_1	415	421	PF00069	0.785
MOD_CK2_1	565	571	PF00069	0.788
MOD_CK2_1	729	735	PF00069	0.828
MOD_GlcNHglycan	112	115	PF01048	0.701
MOD_GlcNHglycan	117	120	PF01048	0.718
MOD_GlcNHglycan	126	129	PF01048	0.619
MOD_GlcNHglycan	157	160	PF01048	0.801
MOD_GlcNHglycan	17	20	PF01048	0.628
MOD_GlcNHglycan	175	178	PF01048	0.558
MOD_GlcNHglycan	190	193	PF01048	0.686
MOD_GlcNHglycan	204	207	PF01048	0.636
MOD_GlcNHglycan	217	220	PF01048	0.767
MOD_GlcNHglycan	265	268	PF01048	0.668
MOD_GlcNHglycan	279	282	PF01048	0.767
MOD_GlcNHglycan	335	338	PF01048	0.673
MOD_GlcNHglycan	399	403	PF01048	0.733
MOD_GlcNHglycan	411	414	PF01048	0.518
MOD_GlcNHglycan	417	420	PF01048	0.569
MOD_GlcNHglycan	466	469	PF01048	0.786
MOD_GlcNHglycan	494	497	PF01048	0.751
MOD_GlcNHglycan	523	526	PF01048	0.721
MOD_GlcNHglycan	6	9	PF01048	0.779
MOD_GlcNHglycan	602	605	PF01048	0.726
MOD_GlcNHglycan	629	633	PF01048	0.819
MOD_GlcNHglycan	654	657	PF01048	0.788
MOD_GlcNHglycan	660	663	PF01048	0.718
MOD_GlcNHglycan	665	668	PF01048	0.640
MOD_GlcNHglycan	677	680	PF01048	0.516
MOD_GlcNHglycan	800	803	PF01048	0.700
MOD_GlcNHglycan	807	810	PF01048	0.823
MOD_GlcNHglycan	868	871	PF01048	0.692
MOD_GlcNHglycan	89	93	PF01048	0.719
MOD_GSK3_1	120	127	PF00069	0.805
MOD_GSK3_1	134	141	PF00069	0.574
MOD_GSK3_1	148	155	PF00069	0.782
MOD_GSK3_1	184	191	PF00069	0.803
MOD_GSK3_1	205	212	PF00069	0.640
MOD_GSK3_1	215	222	PF00069	0.774
MOD_GSK3_1	273	280	PF00069	0.719
MOD_GSK3_1	389	396	PF00069	0.791
MOD_GSK3_1	424	431	PF00069	0.692
MOD_GSK3_1	462	469	PF00069	0.761
MOD_GSK3_1	470	477	PF00069	0.771
MOD_GSK3_1	504	511	PF00069	0.776
MOD_GSK3_1	578	585	PF00069	0.782
MOD_GSK3_1	600	607	PF00069	0.715
MOD_GSK3_1	671	678	PF00069	0.795
MOD_GSK3_1	789	796	PF00069	0.765
MOD_GSK3_1	825	832	PF00069	0.715
MOD_GSK3_1	837	844	PF00069	0.700
MOD_GSK3_1	848	855	PF00069	0.756
MOD_GSK3_1	868	875	PF00069	0.663
MOD_GSK3_1	879	886	PF00069	0.787
MOD_N-GLC_1	288	293	PF02516	0.816
MOD_N-GLC_1	424	429	PF02516	0.630
MOD_N-GLC_1	447	452	PF02516	0.640
MOD_N-GLC_1	50	55	PF02516	0.598
MOD_N-GLC_1	879	884	PF02516	0.706
MOD_N-GLC_2	199	201	PF02516	0.746
MOD_NEK2_1	117	122	PF00069	0.800
MOD_NEK2_1	12	17	PF00069	0.756
MOD_NEK2_1	220	225	PF00069	0.681
MOD_NEK2_1	257	262	PF00069	0.679
MOD_NEK2_1	275	280	PF00069	0.805
MOD_NEK2_1	343	348	PF00069	0.702
MOD_NEK2_1	393	398	PF00069	0.640
MOD_NEK2_1	514	519	PF00069	0.796
MOD_NEK2_1	652	657	PF00069	0.705
MOD_NEK2_1	663	668	PF00069	0.678
MOD_NEK2_1	671	676	PF00069	0.521
MOD_NEK2_1	682	687	PF00069	0.455
MOD_NEK2_1	793	798	PF00069	0.668
MOD_NEK2_1	82	87	PF00069	0.667
MOD_NEK2_1	850	855	PF00069	0.674
MOD_NEK2_2	578	583	PF00069	0.772
MOD_PIKK_1	257	263	PF00454	0.783
MOD_PIKK_1	327	333	PF00454	0.686
MOD_PIKK_1	393	399	PF00454	0.812
MOD_PIKK_1	695	701	PF00454	0.682
MOD_PIKK_1	82	88	PF00454	0.635
MOD_PIKK_1	825	831	PF00454	0.668
MOD_PIKK_1	837	843	PF00454	0.697
MOD_PIKK_1	852	858	PF00454	0.614
MOD_PIKK_1	868	874	PF00454	0.563
MOD_PK_1	50	56	PF00069	0.598
MOD_PKA_2	148	154	PF00069	0.713
MOD_PKA_2	15	21	PF00069	0.772
MOD_PKA_2	166	172	PF00069	0.710
MOD_PKA_2	184	190	PF00069	0.489
MOD_PKA_2	270	276	PF00069	0.725
MOD_PKA_2	293	299	PF00069	0.713
MOD_PKA_2	300	306	PF00069	0.693
MOD_PKA_2	333	339	PF00069	0.684
MOD_PKA_2	558	564	PF00069	0.723
MOD_PKA_2	600	606	PF00069	0.770
MOD_PKA_2	757	763	PF00069	0.637
MOD_PKB_1	150	158	PF00069	0.815
MOD_Plk_1	159	165	PF00069	0.663
MOD_Plk_1	288	294	PF00069	0.783
MOD_Plk_1	353	359	PF00069	0.800
MOD_Plk_1	715	721	PF00069	0.699
MOD_Plk_4	134	140	PF00069	0.700
MOD_Plk_4	185	191	PF00069	0.809
MOD_Plk_4	321	327	PF00069	0.686
MOD_Plk_4	353	359	PF00069	0.738
MOD_Plk_4	606	612	PF00069	0.759
MOD_Plk_4	702	708	PF00069	0.721
MOD_Plk_4	715	721	PF00069	0.593
MOD_Plk_4	789	795	PF00069	0.611
MOD_ProDKin_1	131	137	PF00069	0.705
MOD_ProDKin_1	200	206	PF00069	0.679
MOD_ProDKin_1	23	29	PF00069	0.799
MOD_ProDKin_1	280	286	PF00069	0.725
MOD_ProDKin_1	376	382	PF00069	0.772
MOD_ProDKin_1	42	48	PF00069	0.482
MOD_ProDKin_1	466	472	PF00069	0.746
MOD_ProDKin_1	474	480	PF00069	0.739
MOD_ProDKin_1	541	547	PF00069	0.706
MOD_ProDKin_1	582	588	PF00069	0.682
MOD_ProDKin_1	604	610	PF00069	0.703
MOD_ProDKin_1	729	735	PF00069	0.824
MOD_ProDKin_1	776	782	PF00069	0.658
MOD_ProDKin_1	834	840	PF00069	0.805
MOD_ProDKin_1	872	878	PF00069	0.815
MOD_ProDKin_1	879	885	PF00069	0.718
MOD_ProDKin_1	90	96	PF00069	0.739
MOD_SUMO_for_1	351	354	PF00179	0.623
MOD_SUMO_rev_2	317	325	PF00179	0.710
TRG_DiLeu_BaEn_1	321	326	PF01217	0.588
TRG_DiLeu_BaEn_1	353	358	PF01217	0.779
TRG_DiLeu_BaEn_4	353	359	PF01217	0.779
TRG_ER_diArg_1	103	106	PF00400	0.618
TRG_ER_diArg_1	148	150	PF00400	0.811
TRG_ER_diArg_1	298	301	PF00400	0.813
TRG_ER_diArg_1	623	625	PF00400	0.668
TRG_ER_diArg_1	683	686	PF00400	0.666
TRG_ER_diArg_1	751	754	PF00400	0.781
TRG_ER_diArg_1	758	761	PF00400	0.662
TRG_NLS_MonoExtC_3	749	754	PF00514	0.681
TRG_NLS_MonoExtN_4	684	690	PF00514	0.664
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.725
TRG_Pf-PMV_PEXEL_1	688	692	PF00026	0.661

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P766	Leptomonas seymouri	31%	100%
A4HPV2	Leishmania braziliensis	60%	99%
A4IE39	Leishmania infantum	99%	100%
E9ATL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q0X9	Leishmania major	86%	100%