Serine/threonine kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBF4_LEIDO

TriTrypDb:

LdBPK_364460.1 , LdCL_360051800 , LDHU3_36.6050

Length:

807

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XBF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBF4

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018107	peptidyl-threonine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0018210	peptidyl-threonine modification	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004713	protein tyrosine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.798
CLV_C14_Caspase3-7	363	367	PF00656	0.389
CLV_C14_Caspase3-7	494	498	PF00656	0.411
CLV_NRD_NRD_1	146	148	PF00675	0.436
CLV_NRD_NRD_1	335	337	PF00675	0.460
CLV_NRD_NRD_1	429	431	PF00675	0.411
CLV_NRD_NRD_1	448	450	PF00675	0.411
CLV_NRD_NRD_1	54	56	PF00675	0.411
CLV_PCSK_KEX2_1	146	148	PF00082	0.436
CLV_PCSK_KEX2_1	335	337	PF00082	0.460
CLV_PCSK_KEX2_1	429	431	PF00082	0.411
CLV_PCSK_KEX2_1	54	56	PF00082	0.411
CLV_PCSK_SKI1_1	381	385	PF00082	0.411
CLV_PCSK_SKI1_1	55	59	PF00082	0.411
CLV_PCSK_SKI1_1	726	730	PF00082	0.577
CLV_PCSK_SKI1_1	95	99	PF00082	0.400
CLV_Separin_Metazoa	99	103	PF03568	0.411
DEG_APCC_DBOX_1	54	62	PF00400	0.411
DEG_APCC_KENBOX_2	67	71	PF00400	0.513
DEG_SCF_FBW7_2	486	493	PF00400	0.436
DEG_SIAH_1	751	759	PF03145	0.703
DEG_SPOP_SBC_1	570	574	PF00917	0.697
DOC_CYCLIN_RxL_1	378	388	PF00134	0.416
DOC_CYCLIN_yClb5_NLxxxL_5	92	101	PF00134	0.411
DOC_MAPK_gen_1	102	111	PF00069	0.411
DOC_MAPK_gen_1	112	121	PF00069	0.411
DOC_MAPK_HePTP_8	109	121	PF00069	0.436
DOC_MAPK_MEF2A_6	112	121	PF00069	0.436
DOC_PP2B_LxvP_1	585	588	PF13499	0.781
DOC_PP4_FxxP_1	276	279	PF00568	0.678
DOC_PP4_FxxP_1	417	420	PF00568	0.513
DOC_PP4_FxxP_1	795	798	PF00568	0.539
DOC_USP7_MATH_1	124	128	PF00917	0.513
DOC_USP7_MATH_1	150	154	PF00917	0.788
DOC_USP7_MATH_1	162	166	PF00917	0.633
DOC_USP7_MATH_1	257	261	PF00917	0.776
DOC_USP7_MATH_1	364	368	PF00917	0.411
DOC_USP7_MATH_1	385	389	PF00917	0.436
DOC_USP7_MATH_1	516	520	PF00917	0.513
DOC_USP7_MATH_1	556	560	PF00917	0.693
DOC_USP7_MATH_1	601	605	PF00917	0.690
DOC_USP7_MATH_1	616	620	PF00917	0.670
DOC_USP7_MATH_1	752	756	PF00917	0.703
DOC_WW_Pin1_4	146	151	PF00397	0.642
DOC_WW_Pin1_4	154	159	PF00397	0.673
DOC_WW_Pin1_4	231	236	PF00397	0.697
DOC_WW_Pin1_4	486	491	PF00397	0.513
DOC_WW_Pin1_4	547	552	PF00397	0.691
DOC_WW_Pin1_4	580	585	PF00397	0.693
DOC_WW_Pin1_4	589	594	PF00397	0.678
DOC_WW_Pin1_4	699	704	PF00397	0.706
DOC_WW_Pin1_4	717	722	PF00397	0.700
DOC_WW_Pin1_4	736	741	PF00397	0.544
DOC_WW_Pin1_4	785	790	PF00397	0.621
LIG_14-3-3_CanoR_1	120	128	PF00244	0.430
LIG_14-3-3_CanoR_1	146	150	PF00244	0.697
LIG_14-3-3_CanoR_1	207	216	PF00244	0.593
LIG_14-3-3_CanoR_1	300	304	PF00244	0.623
LIG_14-3-3_CanoR_1	521	531	PF00244	0.513
LIG_14-3-3_CanoR_1	54	61	PF00244	0.411
LIG_14-3-3_CanoR_1	6	12	PF00244	0.484
LIG_Actin_WH2_2	131	148	PF00022	0.411
LIG_BIR_III_2	319	323	PF00653	0.572
LIG_BRCT_BRCA1_1	220	224	PF00533	0.691
LIG_BRCT_BRCA1_1	719	723	PF00533	0.694
LIG_CtBP_PxDLS_1	108	112	PF00389	0.411
LIG_deltaCOP1_diTrp_1	366	375	PF00928	0.411
LIG_eIF4E_1	323	329	PF01652	0.461
LIG_EVH1_2	638	642	PF00568	0.614
LIG_EVH1_2	7	11	PF00568	0.533
LIG_FHA_1	207	213	PF00498	0.738
LIG_FHA_1	256	262	PF00498	0.836
LIG_FHA_1	324	330	PF00498	0.463
LIG_FHA_1	360	366	PF00498	0.411
LIG_FHA_1	470	476	PF00498	0.436
LIG_FHA_1	523	529	PF00498	0.418
LIG_FHA_1	570	576	PF00498	0.622
LIG_FHA_1	627	633	PF00498	0.738
LIG_FHA_1	657	663	PF00498	0.728
LIG_FHA_1	664	670	PF00498	0.641
LIG_FHA_1	672	678	PF00498	0.536
LIG_FHA_2	290	296	PF00498	0.713
LIG_FHA_2	339	345	PF00498	0.411
LIG_FHA_2	361	367	PF00498	0.389
LIG_FHA_2	476	482	PF00498	0.380
LIG_IBAR_NPY_1	321	323	PF08397	0.598
LIG_LIR_Apic_2	273	279	PF02991	0.681
LIG_LIR_Apic_2	347	353	PF02991	0.411
LIG_LIR_Apic_2	4	8	PF02991	0.545
LIG_LIR_Apic_2	415	420	PF02991	0.436
LIG_LIR_Apic_2	699	703	PF02991	0.700
LIG_LIR_Nem_3	24	30	PF02991	0.411
LIG_LIR_Nem_3	330	334	PF02991	0.411
LIG_LIR_Nem_3	339	345	PF02991	0.411
LIG_LIR_Nem_3	643	648	PF02991	0.782
LIG_LYPXL_yS_3	645	648	PF13949	0.788
LIG_MYND_1	158	162	PF01753	0.678
LIG_PTB_Apo_2	100	107	PF02174	0.367
LIG_PTB_Apo_2	127	134	PF02174	0.513
LIG_PTB_Phospho_1	127	133	PF10480	0.513
LIG_SH2_CRK	27	31	PF00017	0.411
LIG_SH2_CRK	34	38	PF00017	0.411
LIG_SH2_CRK	5	9	PF00017	0.534
LIG_SH2_CRK	700	704	PF00017	0.714
LIG_SH2_STAP1	34	38	PF00017	0.299
LIG_SH2_STAP1	361	365	PF00017	0.411
LIG_SH2_STAT3	244	247	PF00017	0.854
LIG_SH2_STAT3	343	346	PF00017	0.411
LIG_SH2_STAT5	133	136	PF00017	0.436
LIG_SH2_STAT5	16	19	PF00017	0.494
LIG_SH2_STAT5	323	326	PF00017	0.445
LIG_SH2_STAT5	361	364	PF00017	0.411
LIG_SH2_STAT5	654	657	PF00017	0.727
LIG_SH2_STAT5	700	703	PF00017	0.815
LIG_SH2_STAT5	764	767	PF00017	0.726
LIG_SH2_STAT5	790	793	PF00017	0.745
LIG_SH3_3	379	385	PF00018	0.411
LIG_SH3_3	397	403	PF00018	0.411
LIG_SH3_3	590	596	PF00018	0.677
LIG_SH3_3	746	752	PF00018	0.705
LIG_SH3_3	801	807	PF00018	0.667
LIG_SUMO_SIM_anti_2	500	508	PF11976	0.397
LIG_SUMO_SIM_par_1	107	113	PF11976	0.411
LIG_TRAF2_1	188	191	PF00917	0.653
LIG_TRAF2_1	499	502	PF00917	0.411
LIG_UBA3_1	374	381	PF00899	0.411
LIG_UBA3_1	64	68	PF00899	0.411
LIG_WRC_WIRS_1	77	82	PF05994	0.411
MOD_CDK_SPK_2	231	236	PF00069	0.697
MOD_CDK_SPK_2	721	726	PF00069	0.572
MOD_CK1_1	152	158	PF00069	0.718
MOD_CK1_1	169	175	PF00069	0.564
MOD_CK1_1	211	217	PF00069	0.809
MOD_CK1_1	218	224	PF00069	0.699
MOD_CK1_1	234	240	PF00069	0.696
MOD_CK1_1	469	475	PF00069	0.383
MOD_CK1_1	477	483	PF00069	0.383
MOD_CK1_1	583	589	PF00069	0.681
MOD_CK1_1	592	598	PF00069	0.679
MOD_CK1_1	702	708	PF00069	0.745
MOD_CK1_1	715	721	PF00069	0.684
MOD_CK1_1	768	774	PF00069	0.754
MOD_CK2_1	107	113	PF00069	0.411
MOD_CK2_1	436	442	PF00069	0.465
MOD_CK2_1	475	481	PF00069	0.397
MOD_GlcNHglycan	122	125	PF01048	0.399
MOD_GlcNHglycan	130	133	PF01048	0.428
MOD_GlcNHglycan	175	178	PF01048	0.718
MOD_GlcNHglycan	220	223	PF01048	0.691
MOD_GlcNHglycan	253	256	PF01048	0.834
MOD_GlcNHglycan	261	264	PF01048	0.695
MOD_GlcNHglycan	268	271	PF01048	0.737
MOD_GlcNHglycan	285	288	PF01048	0.669
MOD_GlcNHglycan	540	543	PF01048	0.686
MOD_GlcNHglycan	55	58	PF01048	0.411
MOD_GlcNHglycan	558	561	PF01048	0.570
MOD_GlcNHglycan	60	64	PF01048	0.411
MOD_GlcNHglycan	603	606	PF01048	0.701
MOD_GlcNHglycan	714	717	PF01048	0.775
MOD_GlcNHglycan	767	770	PF01048	0.753
MOD_GlcNHglycan	783	786	PF01048	0.489
MOD_GSK3_1	120	127	PF00069	0.490
MOD_GSK3_1	145	152	PF00069	0.603
MOD_GSK3_1	162	169	PF00069	0.730
MOD_GSK3_1	207	214	PF00069	0.618
MOD_GSK3_1	251	258	PF00069	0.795
MOD_GSK3_1	285	292	PF00069	0.749
MOD_GSK3_1	307	314	PF00069	0.743
MOD_GSK3_1	360	367	PF00069	0.389
MOD_GSK3_1	516	523	PF00069	0.411
MOD_GSK3_1	534	541	PF00069	0.621
MOD_GSK3_1	606	613	PF00069	0.685
MOD_GSK3_1	626	633	PF00069	0.782
MOD_GSK3_1	648	655	PF00069	0.759
MOD_GSK3_1	699	706	PF00069	0.794
MOD_GSK3_1	715	722	PF00069	0.705
MOD_GSK3_1	777	784	PF00069	0.778
MOD_N-GLC_1	166	171	PF02516	0.736
MOD_N-GLC_1	173	178	PF02516	0.721
MOD_N-GLC_1	207	212	PF02516	0.589
MOD_N-GLC_1	289	294	PF02516	0.745
MOD_N-GLC_1	534	539	PF02516	0.613
MOD_N-GLC_1	656	661	PF02516	0.745
MOD_NEK2_1	1	6	PF00069	0.698
MOD_NEK2_1	128	133	PF00069	0.513
MOD_NEK2_1	145	150	PF00069	0.396
MOD_NEK2_1	215	220	PF00069	0.703
MOD_NEK2_1	266	271	PF00069	0.699
MOD_NEK2_1	522	527	PF00069	0.389
MOD_NEK2_1	569	574	PF00069	0.688
MOD_NEK2_1	625	630	PF00069	0.732
MOD_NEK2_1	663	668	PF00069	0.651
MOD_NEK2_1	688	693	PF00069	0.798
MOD_NEK2_1	759	764	PF00069	0.689
MOD_NEK2_2	124	129	PF00069	0.513
MOD_NEK2_2	649	654	PF00069	0.648
MOD_PIKK_1	307	313	PF00454	0.759
MOD_PIKK_1	401	407	PF00454	0.389
MOD_PIKK_1	412	418	PF00454	0.389
MOD_PIKK_1	516	522	PF00454	0.411
MOD_PIKK_1	631	637	PF00454	0.754
MOD_PIKK_1	668	674	PF00454	0.782
MOD_PIKK_1	705	711	PF00454	0.746
MOD_PKA_2	145	151	PF00069	0.592
MOD_PKA_2	170	176	PF00069	0.622
MOD_PKA_2	206	212	PF00069	0.676
MOD_PKA_2	251	257	PF00069	0.771
MOD_PKA_2	266	272	PF00069	0.559
MOD_PKA_2	299	305	PF00069	0.761
MOD_PKA_2	520	526	PF00069	0.411
MOD_PKA_2	53	59	PF00069	0.411
MOD_Plk_1	207	213	PF00069	0.591
MOD_Plk_1	311	317	PF00069	0.741
MOD_Plk_1	338	344	PF00069	0.411
MOD_Plk_1	59	65	PF00069	0.411
MOD_Plk_1	625	631	PF00069	0.732
MOD_Plk_1	70	76	PF00069	0.411
MOD_Plk_2-3	497	503	PF00069	0.411
MOD_Plk_4	211	217	PF00069	0.732
MOD_Plk_4	33	39	PF00069	0.299
MOD_Plk_4	338	344	PF00069	0.411
MOD_Plk_4	391	397	PF00069	0.411
MOD_Plk_4	616	622	PF00069	0.778
MOD_Plk_4	649	655	PF00069	0.760
MOD_Plk_4	760	766	PF00069	0.671
MOD_Plk_4	800	806	PF00069	0.682
MOD_ProDKin_1	146	152	PF00069	0.653
MOD_ProDKin_1	154	160	PF00069	0.676
MOD_ProDKin_1	231	237	PF00069	0.697
MOD_ProDKin_1	486	492	PF00069	0.513
MOD_ProDKin_1	547	553	PF00069	0.693
MOD_ProDKin_1	580	586	PF00069	0.691
MOD_ProDKin_1	589	595	PF00069	0.679
MOD_ProDKin_1	699	705	PF00069	0.705
MOD_ProDKin_1	717	723	PF00069	0.701
MOD_ProDKin_1	736	742	PF00069	0.544
MOD_ProDKin_1	785	791	PF00069	0.622
MOD_SUMO_for_1	138	141	PF00179	0.411
MOD_SUMO_rev_2	131	140	PF00179	0.513
TRG_DiLeu_BaEn_1	481	486	PF01217	0.513
TRG_DiLeu_BaEn_1	501	506	PF01217	0.183
TRG_DiLeu_BaEn_1	60	65	PF01217	0.411
TRG_DiLeu_BaEn_4	481	487	PF01217	0.513
TRG_ENDOCYTIC_2	27	30	PF00928	0.465
TRG_ENDOCYTIC_2	34	37	PF00928	0.506
TRG_ENDOCYTIC_2	342	345	PF00928	0.411
TRG_ENDOCYTIC_2	645	648	PF00928	0.788
TRG_ER_diArg_1	101	104	PF00400	0.411
TRG_ER_diArg_1	145	147	PF00400	0.436
TRG_ER_diArg_1	334	336	PF00400	0.397
TRG_ER_diArg_1	53	55	PF00400	0.411
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCR0	Leptomonas seymouri	57%	100%
A4HPU4	Leishmania braziliensis	79%	100%
A4IE49	Leishmania infantum	100%	100%
E9ATK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q0Y9	Leishmania major	94%	100%