Serine/threonine kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBF4_LEIDO

TriTrypDb:

LdBPK_364460.1 , LdCL_360051800 , LDHU3_36.6050

Length:

807

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3S7XBF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBF4

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018107	peptidyl-threonine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0004674	protein serine/threonine kinase activity	4	1
GO:0004713	protein tyrosine kinase activity	4	1
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.798
CLV_C14_Caspase3-7	363	367	PF00656	0.389
CLV_C14_Caspase3-7	494	498	PF00656	0.411
CLV_NRD_NRD_1	146	148	PF00675	0.436
CLV_NRD_NRD_1	335	337	PF00675	0.460
CLV_NRD_NRD_1	429	431	PF00675	0.411
CLV_NRD_NRD_1	448	450	PF00675	0.411
CLV_NRD_NRD_1	54	56	PF00675	0.411
CLV_PCSK_KEX2_1	146	148	PF00082	0.436
CLV_PCSK_KEX2_1	335	337	PF00082	0.460

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCR0	Leptomonas seymouri	57%	100%
A4HPU4	Leishmania braziliensis	79%	100%
A4IE49	Leishmania infantum	100%	100%
E9ATK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q0Y9	Leishmania major	94%	100%

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