Tetratricopeptide repeat-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBE8_LEIDO

TriTrypDb:

LdBPK_364240.1 , LdCL_360049500 , LDHU3_36.5670

Length:

430

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XBE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBE8

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	1
GO:0006335	DNA replication-dependent chromatin assembly	5	1
GO:0006338	chromatin remodeling	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0031055	chromatin remodeling at centromere	6	1
GO:0034080	CENP-A containing chromatin assembly	7	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042393	histone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	401	403	PF00675	0.760
CLV_PCSK_KEX2_1	406	408	PF00082	0.786
CLV_PCSK_KEX2_1	421	423	PF00082	0.793
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.841
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.793
CLV_PCSK_PC7_1	402	408	PF00082	0.841
CLV_PCSK_SKI1_1	127	131	PF00082	0.580
DEG_APCC_DBOX_1	266	274	PF00400	0.662
DEG_SPOP_SBC_1	50	54	PF00917	0.915
DOC_CKS1_1	322	327	PF01111	0.759
DOC_CYCLIN_yCln2_LP_2	357	363	PF00134	0.793
DOC_PP1_RVXF_1	167	173	PF00149	0.463
DOC_PP2B_LxvP_1	357	360	PF13499	0.701
DOC_PP2B_LxvP_1	381	384	PF13499	0.765
DOC_USP7_MATH_1	10	14	PF00917	0.875
DOC_USP7_MATH_1	352	356	PF00917	0.794
DOC_USP7_MATH_1	384	388	PF00917	0.807
DOC_USP7_MATH_2	27	33	PF00917	0.668
DOC_USP7_MATH_2	325	331	PF00917	0.735
DOC_WW_Pin1_4	321	326	PF00397	0.762
DOC_WW_Pin1_4	388	393	PF00397	0.835
LIG_14-3-3_CanoR_1	265	271	PF00244	0.593
LIG_Actin_WH2_2	239	257	PF00022	0.549
LIG_BIR_II_1	1	5	PF00653	0.871
LIG_BIR_III_2	226	230	PF00653	0.703
LIG_FHA_1	158	164	PF00498	0.554
LIG_FHA_1	391	397	PF00498	0.869
LIG_FHA_2	1	7	PF00498	0.818
LIG_FHA_2	142	148	PF00498	0.746
LIG_FHA_2	267	273	PF00498	0.605
LIG_FHA_2	322	328	PF00498	0.653
LIG_FHA_2	406	412	PF00498	0.842
LIG_FHA_2	51	57	PF00498	0.927
LIG_FHA_2	78	84	PF00498	0.646
LIG_GBD_Chelix_1	281	289	PF00786	0.639
LIG_LIR_Gen_1	160	170	PF02991	0.470
LIG_LIR_Gen_1	353	363	PF02991	0.755
LIG_LIR_Nem_3	105	111	PF02991	0.511
LIG_LIR_Nem_3	160	165	PF02991	0.478
LIG_LIR_Nem_3	327	331	PF02991	0.705
LIG_NRBOX	288	294	PF00104	0.666
LIG_PCNA_PIPBox_1	107	116	PF02747	0.507
LIG_PCNA_yPIPBox_3	138	150	PF02747	0.709
LIG_SH2_CRK	108	112	PF00017	0.513
LIG_SH2_CRK	221	225	PF00017	0.533
LIG_SH2_GRB2like	162	165	PF00017	0.602
LIG_SH2_PTP2	162	165	PF00017	0.602
LIG_SH2_SRC	100	103	PF00017	0.572
LIG_SH2_STAP1	100	104	PF00017	0.548
LIG_SH2_STAP1	207	211	PF00017	0.517
LIG_SH2_STAP1	214	218	PF00017	0.450
LIG_SH2_STAT5	128	131	PF00017	0.493
LIG_SH2_STAT5	162	165	PF00017	0.602
LIG_SH2_STAT5	356	359	PF00017	0.779
LIG_SH3_3	146	152	PF00018	0.752
LIG_SH3_3	389	395	PF00018	0.866
LIG_SUMO_SIM_anti_2	230	238	PF11976	0.702
LIG_TRAF2_1	228	231	PF00917	0.711
LIG_TRAF2_1	27	30	PF00917	0.904
LIG_TRAF2_1	324	327	PF00917	0.636
LIG_TRAF2_1	45	48	PF00917	0.797
LIG_TRAF2_1	80	83	PF00917	0.644
LIG_TYR_ITIM	106	111	PF00017	0.504
LIG_TYR_ITIM	219	224	PF00017	0.539
MOD_CK1_1	355	361	PF00069	0.710
MOD_CK1_1	42	48	PF00069	0.863
MOD_CK1_1	51	57	PF00069	0.796
MOD_CK2_1	254	260	PF00069	0.661
MOD_CK2_1	266	272	PF00069	0.580
MOD_CK2_1	321	327	PF00069	0.653
MOD_CK2_1	42	48	PF00069	0.827
MOD_CK2_1	51	57	PF00069	0.779
MOD_CK2_1	77	83	PF00069	0.680
MOD_DYRK1A_RPxSP_1	388	392	PF00069	0.866
MOD_GlcNHglycan	121	124	PF01048	0.599
MOD_GlcNHglycan	340	343	PF01048	0.723
MOD_GlcNHglycan	361	364	PF01048	0.775
MOD_GlcNHglycan	388	391	PF01048	0.889
MOD_GlcNHglycan	426	429	PF01048	0.907
MOD_GSK3_1	1	8	PF00069	0.843
MOD_GSK3_1	277	284	PF00069	0.697
MOD_GSK3_1	355	362	PF00069	0.703
MOD_GSK3_1	367	374	PF00069	0.678
MOD_GSK3_1	384	391	PF00069	0.632
MOD_GSK3_1	39	46	PF00069	0.866
MOD_GSK3_1	405	412	PF00069	0.875
MOD_GSK3_1	48	55	PF00069	0.768
MOD_NEK2_1	377	382	PF00069	0.727
MOD_NEK2_2	157	162	PF00069	0.539
MOD_PIKK_1	132	138	PF00454	0.472
MOD_PIKK_1	43	49	PF00454	0.913
MOD_PKA_2	266	272	PF00069	0.604
MOD_PKB_1	422	430	PF00069	0.869
MOD_Plk_1	29	35	PF00069	0.706
MOD_Plk_1	352	358	PF00069	0.740
MOD_Plk_1	409	415	PF00069	0.879
MOD_Plk_1	72	78	PF00069	0.805
MOD_Plk_2-3	327	333	PF00069	0.708
MOD_Plk_4	232	238	PF00069	0.686
MOD_Plk_4	281	287	PF00069	0.671
MOD_Plk_4	352	358	PF00069	0.821
MOD_Plk_4	377	383	PF00069	0.736
MOD_ProDKin_1	321	327	PF00069	0.761
MOD_ProDKin_1	388	394	PF00069	0.835
MOD_SUMO_for_1	35	38	PF00179	0.827
MOD_SUMO_rev_2	226	235	PF00179	0.709
MOD_SUMO_rev_2	271	275	PF00179	0.634
MOD_SUMO_rev_2	330	338	PF00179	0.762
MOD_SUMO_rev_2	414	423	PF00179	0.794
TRG_DiLeu_BaEn_1	21	26	PF01217	0.910
TRG_DiLeu_BaEn_1	288	293	PF01217	0.663
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.574
TRG_ENDOCYTIC_2	108	111	PF00928	0.507
TRG_ENDOCYTIC_2	162	165	PF00928	0.602
TRG_ENDOCYTIC_2	221	224	PF00928	0.503
TRG_ENDOCYTIC_2	356	359	PF00928	0.736
TRG_NLS_Bipartite_1	403	425	PF00514	0.843
TRG_NLS_MonoExtC_3	401	406	PF00514	0.774
TRG_NLS_MonoExtC_3	420	426	PF00514	0.752
TRG_NLS_MonoExtN_4	402	407	PF00514	0.756
TRG_NLS_MonoExtN_4	418	425	PF00514	0.808
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.660
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXN4	Leptomonas seymouri	83%	100%
A0A0S4IPT5	Bodo saltans	46%	100%
A0A1X0P488	Trypanosomatidae	49%	89%
A0A3R7NPK3	Trypanosoma rangeli	49%	95%
A4HPS2	Leishmania braziliensis	87%	100%
A4ICZ1	Leishmania infantum	100%	100%
D0A8N7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ATI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q111	Leishmania major	97%	100%
V5BS19	Trypanosoma cruzi	52%	94%