Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBE3_LEIDO

TriTrypDb:

LdBPK_364060.1 , LdCL_360047600 , LDHU3_36.5450

Length:

841

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	6
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A0A3S7XBE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBE3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.669
CLV_C14_Caspase3-7	528	532	PF00656	0.690
CLV_C14_Caspase3-7	78	82	PF00656	0.647
CLV_NRD_NRD_1	140	142	PF00675	0.476
CLV_NRD_NRD_1	603	605	PF00675	0.618
CLV_NRD_NRD_1	680	682	PF00675	0.659
CLV_NRD_NRD_1	731	733	PF00675	0.484
CLV_NRD_NRD_1	79	81	PF00675	0.660
CLV_PCSK_KEX2_1	140	142	PF00082	0.476
CLV_PCSK_KEX2_1	603	605	PF00082	0.618
CLV_PCSK_KEX2_1	79	81	PF00082	0.668
CLV_PCSK_SKI1_1	306	310	PF00082	0.509
CLV_PCSK_SKI1_1	356	360	PF00082	0.447
CLV_PCSK_SKI1_1	681	685	PF00082	0.538
DEG_APCC_DBOX_1	680	688	PF00400	0.532
DEG_APCC_DBOX_1	720	728	PF00400	0.446
DEG_SCF_FBW7_1	126	133	PF00400	0.516
DOC_CKS1_1	219	224	PF01111	0.467
DOC_CKS1_1	605	610	PF01111	0.701
DOC_MAPK_DCC_7	544	553	PF00069	0.659
DOC_MAPK_gen_1	681	687	PF00069	0.550
DOC_MAPK_MEF2A_6	30	38	PF00069	0.486
DOC_MAPK_MEF2A_6	544	553	PF00069	0.659
DOC_PP1_RVXF_1	102	108	PF00149	0.382
DOC_USP7_MATH_1	166	170	PF00917	0.451
DOC_USP7_MATH_1	227	231	PF00917	0.640
DOC_USP7_MATH_1	267	271	PF00917	0.572
DOC_USP7_MATH_1	419	423	PF00917	0.764
DOC_USP7_MATH_1	477	481	PF00917	0.663
DOC_USP7_MATH_1	526	530	PF00917	0.738
DOC_USP7_MATH_1	534	538	PF00917	0.646
DOC_USP7_MATH_1	594	598	PF00917	0.670
DOC_USP7_MATH_1	618	622	PF00917	0.671
DOC_USP7_MATH_1	627	631	PF00917	0.652
DOC_USP7_MATH_1	664	668	PF00917	0.554
DOC_USP7_MATH_1	67	71	PF00917	0.651
DOC_USP7_MATH_1	693	697	PF00917	0.570
DOC_USP7_MATH_1	800	804	PF00917	0.548
DOC_USP7_MATH_1	92	96	PF00917	0.603
DOC_WW_Pin1_4	121	126	PF00397	0.671
DOC_WW_Pin1_4	17	22	PF00397	0.503
DOC_WW_Pin1_4	218	223	PF00397	0.578
DOC_WW_Pin1_4	415	420	PF00397	0.739
DOC_WW_Pin1_4	433	438	PF00397	0.527
DOC_WW_Pin1_4	445	450	PF00397	0.619
DOC_WW_Pin1_4	502	507	PF00397	0.616
DOC_WW_Pin1_4	54	59	PF00397	0.508
DOC_WW_Pin1_4	583	588	PF00397	0.669
DOC_WW_Pin1_4	595	600	PF00397	0.557
DOC_WW_Pin1_4	604	609	PF00397	0.632
DOC_WW_Pin1_4	62	67	PF00397	0.573
DOC_WW_Pin1_4	623	628	PF00397	0.691
DOC_WW_Pin1_4	803	808	PF00397	0.606
DOC_WW_Pin1_4	84	89	PF00397	0.662
LIG_14-3-3_CanoR_1	603	608	PF00244	0.686
LIG_14-3-3_CanoR_1	69	77	PF00244	0.641
LIG_14-3-3_CanoR_1	708	716	PF00244	0.448
LIG_14-3-3_CanoR_1	741	749	PF00244	0.428
LIG_Actin_WH2_2	399	415	PF00022	0.431
LIG_BRCT_BRCA1_1	374	378	PF00533	0.501
LIG_BRCT_BRCA1_1	596	600	PF00533	0.584
LIG_CSL_BTD_1	509	512	PF09270	0.548
LIG_FHA_1	190	196	PF00498	0.373
LIG_FHA_1	295	301	PF00498	0.595
LIG_FHA_1	303	309	PF00498	0.481
LIG_FHA_1	426	432	PF00498	0.740
LIG_FHA_1	588	594	PF00498	0.579
LIG_FHA_1	641	647	PF00498	0.713
LIG_FHA_1	697	703	PF00498	0.507
LIG_FHA_1	708	714	PF00498	0.407
LIG_FHA_1	741	747	PF00498	0.429
LIG_FHA_1	765	771	PF00498	0.454
LIG_FHA_2	131	137	PF00498	0.543
LIG_FHA_2	266	272	PF00498	0.552
LIG_FHA_2	360	366	PF00498	0.501
LIG_FHA_2	675	681	PF00498	0.481
LIG_FHA_2	712	718	PF00498	0.485
LIG_FHA_2	820	826	PF00498	0.538
LIG_LIR_Gen_1	100	109	PF02991	0.471
LIG_LIR_Gen_1	35	46	PF02991	0.418
LIG_LIR_Nem_3	100	105	PF02991	0.483
LIG_LIR_Nem_3	236	240	PF02991	0.390
LIG_LIR_Nem_3	35	41	PF02991	0.424
LIG_MYND_1	554	558	PF01753	0.568
LIG_OCRL_FandH_1	101	113	PF00620	0.424
LIG_PCNA_yPIPBox_3	175	188	PF02747	0.520
LIG_Pex14_1	510	514	PF04695	0.572
LIG_SH2_CRK	563	567	PF00017	0.640
LIG_SH2_GRB2like	282	285	PF00017	0.569
LIG_SH2_GRB2like	337	340	PF00017	0.447
LIG_SH2_PTP2	546	549	PF00017	0.663
LIG_SH2_SRC	546	549	PF00017	0.663
LIG_SH2_STAT3	10	13	PF00017	0.418
LIG_SH2_STAT5	10	13	PF00017	0.418
LIG_SH2_STAT5	337	340	PF00017	0.447
LIG_SH2_STAT5	546	549	PF00017	0.663
LIG_SH2_STAT5	563	566	PF00017	0.637
LIG_SH3_1	464	470	PF00018	0.623
LIG_SH3_3	221	227	PF00018	0.550
LIG_SH3_3	232	238	PF00018	0.473
LIG_SH3_3	438	444	PF00018	0.723
LIG_SH3_3	446	452	PF00018	0.786
LIG_SH3_3	462	468	PF00018	0.694
LIG_SH3_3	470	476	PF00018	0.625
LIG_SH3_3	503	509	PF00018	0.594
LIG_SH3_3	546	552	PF00018	0.586
LIG_SH3_3	602	608	PF00018	0.712
LIG_SH3_3	619	625	PF00018	0.643
LIG_SUMO_SIM_par_1	408	416	PF11976	0.447
LIG_SUMO_SIM_par_1	52	57	PF11976	0.420
LIG_SUMO_SIM_par_1	683	689	PF11976	0.476
LIG_SUMO_SIM_par_1	755	760	PF11976	0.478
LIG_TRAF2_1	239	242	PF00917	0.389
LIG_WRC_WIRS_1	157	162	PF05994	0.367
LIG_WW_2	476	479	PF00397	0.574
MOD_CDK_SPxxK_3	218	225	PF00069	0.477
MOD_CDK_SPxxK_3	54	61	PF00069	0.527
MOD_CDK_SPxxK_3	62	69	PF00069	0.578
MOD_CDK_SPxxK_3	803	810	PF00069	0.665
MOD_CDK_SPxxK_3	84	91	PF00069	0.663
MOD_CK1_1	153	159	PF00069	0.460
MOD_CK1_1	270	276	PF00069	0.682
MOD_CK1_1	341	347	PF00069	0.552
MOD_CK1_1	415	421	PF00069	0.649
MOD_CK1_1	436	442	PF00069	0.575
MOD_CK1_1	480	486	PF00069	0.674
MOD_CK1_1	626	632	PF00069	0.681
MOD_CK1_1	654	660	PF00069	0.623
MOD_CK1_1	696	702	PF00069	0.650
MOD_CK1_1	70	76	PF00069	0.672
MOD_CK1_1	803	809	PF00069	0.546
MOD_CK1_1	84	90	PF00069	0.591
MOD_CK1_1	95	101	PF00069	0.498
MOD_CK2_1	130	136	PF00069	0.548
MOD_CK2_1	2	8	PF00069	0.438
MOD_CK2_1	359	365	PF00069	0.443
MOD_CK2_1	436	442	PF00069	0.642
MOD_CK2_1	455	461	PF00069	0.629
MOD_CK2_1	583	589	PF00069	0.561
MOD_CK2_1	626	632	PF00069	0.692
MOD_CK2_1	686	692	PF00069	0.465
MOD_CK2_1	711	717	PF00069	0.485
MOD_DYRK1A_RPxSP_1	604	608	PF00069	0.668
MOD_GlcNHglycan	152	155	PF01048	0.451
MOD_GlcNHglycan	228	232	PF01048	0.599
MOD_GlcNHglycan	302	305	PF01048	0.590
MOD_GlcNHglycan	332	335	PF01048	0.429
MOD_GlcNHglycan	392	396	PF01048	0.578
MOD_GlcNHglycan	438	441	PF01048	0.677
MOD_GlcNHglycan	487	490	PF01048	0.743
MOD_GlcNHglycan	495	498	PF01048	0.578
MOD_GlcNHglycan	528	531	PF01048	0.760
MOD_GlcNHglycan	537	540	PF01048	0.620
MOD_GlcNHglycan	629	632	PF01048	0.715
MOD_GlcNHglycan	664	667	PF01048	0.611
MOD_GlcNHglycan	73	76	PF01048	0.664
MOD_GlcNHglycan	759	762	PF01048	0.532
MOD_GlcNHglycan	796	799	PF01048	0.598
MOD_GlcNHglycan	94	97	PF01048	0.551
MOD_GSK3_1	105	112	PF00069	0.577
MOD_GSK3_1	121	128	PF00069	0.655
MOD_GSK3_1	152	159	PF00069	0.548
MOD_GSK3_1	223	230	PF00069	0.591
MOD_GSK3_1	265	272	PF00069	0.577
MOD_GSK3_1	339	346	PF00069	0.453
MOD_GSK3_1	348	355	PF00069	0.383
MOD_GSK3_1	372	379	PF00069	0.561
MOD_GSK3_1	415	422	PF00069	0.736
MOD_GSK3_1	485	492	PF00069	0.725
MOD_GSK3_1	520	527	PF00069	0.660
MOD_GSK3_1	583	590	PF00069	0.585
MOD_GSK3_1	623	630	PF00069	0.613
MOD_GSK3_1	640	647	PF00069	0.610
MOD_GSK3_1	67	74	PF00069	0.664
MOD_GSK3_1	707	714	PF00069	0.450
MOD_GSK3_1	83	90	PF00069	0.574
MOD_GSK3_1	91	98	PF00069	0.567
MOD_N-GLC_1	109	114	PF02516	0.459
MOD_N-GLC_1	338	343	PF02516	0.480
MOD_N-GLC_1	71	76	PF02516	0.655
MOD_NEK2_1	105	110	PF00069	0.380
MOD_NEK2_1	217	222	PF00069	0.444
MOD_NEK2_1	300	305	PF00069	0.602
MOD_NEK2_1	311	316	PF00069	0.551
MOD_NEK2_1	338	343	PF00069	0.378
MOD_NEK2_1	348	353	PF00069	0.381
MOD_NEK2_1	359	364	PF00069	0.595
MOD_NEK2_1	367	372	PF00069	0.343
MOD_NEK2_1	390	395	PF00069	0.426
MOD_NEK2_1	424	429	PF00069	0.648
MOD_NEK2_1	513	518	PF00069	0.600
MOD_NEK2_1	764	769	PF00069	0.516
MOD_NEK2_1	828	833	PF00069	0.553
MOD_NEK2_1	97	102	PF00069	0.578
MOD_NEK2_2	200	205	PF00069	0.307
MOD_NEK2_2	274	279	PF00069	0.619
MOD_PIKK_1	130	136	PF00454	0.548
MOD_PIKK_1	311	317	PF00454	0.415
MOD_PIKK_1	654	660	PF00454	0.648
MOD_PIKK_1	830	836	PF00454	0.529
MOD_PIKK_1	97	103	PF00454	0.478
MOD_PKA_1	603	609	PF00069	0.642
MOD_PKA_2	2	8	PF00069	0.514
MOD_PKA_2	412	418	PF00069	0.521
MOD_PKA_2	520	526	PF00069	0.584
MOD_PKA_2	603	609	PF00069	0.722
MOD_PKA_2	672	678	PF00069	0.600
MOD_PKA_2	70	76	PF00069	0.647
MOD_PKA_2	707	713	PF00069	0.485
MOD_PKA_2	740	746	PF00069	0.466
MOD_PKA_2	92	98	PF00069	0.551
MOD_PKB_1	69	77	PF00069	0.572
MOD_Plk_1	109	115	PF00069	0.450
MOD_Plk_1	241	247	PF00069	0.373
MOD_Plk_1	270	276	PF00069	0.572
MOD_Plk_1	618	624	PF00069	0.584
MOD_Plk_4	2	8	PF00069	0.438
MOD_Plk_4	241	247	PF00069	0.424
MOD_Plk_4	348	354	PF00069	0.449
MOD_Plk_4	419	425	PF00069	0.786
MOD_Plk_4	455	461	PF00069	0.629
MOD_Plk_4	513	519	PF00069	0.551
MOD_Plk_4	764	770	PF00069	0.540
MOD_ProDKin_1	121	127	PF00069	0.668
MOD_ProDKin_1	17	23	PF00069	0.508
MOD_ProDKin_1	218	224	PF00069	0.594
MOD_ProDKin_1	415	421	PF00069	0.743
MOD_ProDKin_1	433	439	PF00069	0.528
MOD_ProDKin_1	445	451	PF00069	0.619
MOD_ProDKin_1	502	508	PF00069	0.609
MOD_ProDKin_1	54	60	PF00069	0.518
MOD_ProDKin_1	583	589	PF00069	0.670
MOD_ProDKin_1	595	601	PF00069	0.554
MOD_ProDKin_1	604	610	PF00069	0.630
MOD_ProDKin_1	62	68	PF00069	0.575
MOD_ProDKin_1	623	629	PF00069	0.693
MOD_ProDKin_1	803	809	PF00069	0.606
MOD_ProDKin_1	84	90	PF00069	0.661
MOD_SUMO_rev_2	675	684	PF00179	0.557
TRG_DiLeu_BaEn_1	386	391	PF01217	0.378
TRG_DiLeu_BaEn_2	240	246	PF01217	0.369
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.550
TRG_DiLeu_BaLyEn_6	804	809	PF01217	0.616
TRG_ENDOCYTIC_2	282	285	PF00928	0.581
TRG_ENDOCYTIC_2	337	340	PF00928	0.447
TRG_ENDOCYTIC_2	546	549	PF00928	0.663
TRG_ER_diArg_1	139	141	PF00400	0.491
TRG_ER_diArg_1	603	605	PF00400	0.654
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL79	Leptomonas seymouri	41%	94%
A4HPQ4	Leishmania braziliensis	66%	99%
A4ID09	Leishmania infantum	99%	100%
E9ATG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q128	Leishmania major	90%	100%