Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBE2_LEIDO

TriTrypDb:

LdBPK_364360.1 , LdCL_360050700 , LDHU3_36.5900

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	5
GO:0031514	motile cilium	5	5
GO:0042995	cell projection	2	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0110165	cellular anatomical entity	1	5
GO:0120025	plasma membrane bounded cell projection	3	5

Expansion

Sequence features

A0A3S7XBE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBE2

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0030030	cell projection organization	4	1
GO:0044782	cilium organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	504	508	PF00656	0.538
CLV_C14_Caspase3-7	575	579	PF00656	0.603
CLV_C14_Caspase3-7	77	81	PF00656	0.619
CLV_NRD_NRD_1	172	174	PF00675	0.489
CLV_NRD_NRD_1	249	251	PF00675	0.512
CLV_NRD_NRD_1	438	440	PF00675	0.539
CLV_NRD_NRD_1	474	476	PF00675	0.594
CLV_NRD_NRD_1	571	573	PF00675	0.608
CLV_PCSK_KEX2_1	172	174	PF00082	0.489
CLV_PCSK_KEX2_1	249	251	PF00082	0.512
CLV_PCSK_KEX2_1	570	572	PF00082	0.623
CLV_PCSK_PC7_1	168	174	PF00082	0.552
CLV_PCSK_SKI1_1	207	211	PF00082	0.546
CLV_PCSK_SKI1_1	250	254	PF00082	0.529
CLV_PCSK_SKI1_1	261	265	PF00082	0.440
CLV_PCSK_SKI1_1	268	272	PF00082	0.405
CLV_PCSK_SKI1_1	3	7	PF00082	0.686
CLV_PCSK_SKI1_1	417	421	PF00082	0.501
CLV_PCSK_SKI1_1	439	443	PF00082	0.481
DEG_APCC_DBOX_1	248	256	PF00400	0.467
DEG_APCC_DBOX_1	71	79	PF00400	0.499
DEG_SCF_FBW7_2	84	89	PF00400	0.720
DEG_SPOP_SBC_1	370	374	PF00917	0.657
DOC_CYCLIN_RxL_1	207	218	PF00134	0.537
DOC_MAPK_gen_1	427	436	PF00069	0.449
DOC_MAPK_MEF2A_6	430	438	PF00069	0.448
DOC_MAPK_RevD_3	158	173	PF00069	0.554
DOC_USP7_MATH_1	108	112	PF00917	0.708
DOC_USP7_MATH_1	117	121	PF00917	0.687
DOC_USP7_MATH_1	215	219	PF00917	0.557
DOC_USP7_MATH_1	357	361	PF00917	0.687
DOC_USP7_MATH_1	370	374	PF00917	0.486
DOC_USP7_MATH_1	505	509	PF00917	0.491
DOC_USP7_MATH_1	531	535	PF00917	0.611
DOC_USP7_MATH_1	582	586	PF00917	0.623
DOC_USP7_MATH_1	62	66	PF00917	0.610
DOC_USP7_UBL2_3	257	261	PF12436	0.528
DOC_USP7_UBL2_3	524	528	PF12436	0.588
DOC_USP7_UBL2_3	605	609	PF12436	0.629
DOC_WW_Pin1_4	10	15	PF00397	0.637
DOC_WW_Pin1_4	82	87	PF00397	0.663
LIG_14-3-3_CanoR_1	157	161	PF00244	0.574
LIG_14-3-3_CanoR_1	226	236	PF00244	0.578
LIG_14-3-3_CanoR_1	325	335	PF00244	0.761
LIG_14-3-3_CanoR_1	342	346	PF00244	0.623
LIG_14-3-3_CanoR_1	368	378	PF00244	0.629
LIG_14-3-3_CanoR_1	430	438	PF00244	0.502
LIG_14-3-3_CanoR_1	502	509	PF00244	0.515
LIG_14-3-3_CanoR_1	61	67	PF00244	0.493
LIG_14-3-3_CanoR_1	99	107	PF00244	0.687
LIG_Actin_WH2_2	207	224	PF00022	0.536
LIG_BIR_III_4	530	534	PF00653	0.611
LIG_BIR_III_4	80	84	PF00653	0.669
LIG_CaM_IQ_9	600	615	PF13499	0.701
LIG_FHA_1	182	188	PF00498	0.679
LIG_FHA_1	222	228	PF00498	0.573
LIG_FHA_1	251	257	PF00498	0.518
LIG_FHA_1	271	277	PF00498	0.401
LIG_FHA_1	34	40	PF00498	0.669
LIG_FHA_1	458	464	PF00498	0.564
LIG_FHA_1	489	495	PF00498	0.545
LIG_FHA_2	26	32	PF00498	0.686
LIG_FHA_2	488	494	PF00498	0.598
LIG_FHA_2	50	56	PF00498	0.647
LIG_FHA_2	502	508	PF00498	0.527
LIG_FHA_2	515	521	PF00498	0.576
LIG_FHA_2	541	547	PF00498	0.641
LIG_Integrin_isoDGR_2	247	249	PF01839	0.538
LIG_LIR_Gen_1	372	383	PF02991	0.485
LIG_LIR_Gen_1	55	64	PF02991	0.637
LIG_LIR_Nem_3	171	177	PF02991	0.442
LIG_LIR_Nem_3	240	245	PF02991	0.492
LIG_LIR_Nem_3	303	309	PF02991	0.714
LIG_LIR_Nem_3	372	378	PF02991	0.506
LIG_LIR_Nem_3	493	498	PF02991	0.572
LIG_LIR_Nem_3	55	59	PF02991	0.654
LIG_MYND_1	192	196	PF01753	0.580
LIG_NRBOX	251	257	PF00104	0.469
LIG_NRBOX	74	80	PF00104	0.516
LIG_Pex14_2	346	350	PF04695	0.717
LIG_SH2_NCK_1	581	585	PF00017	0.513
LIG_SH2_STAT5	498	501	PF00017	0.611
LIG_SH3_3	186	192	PF00018	0.585
LIG_SH3_3	199	205	PF00018	0.525
LIG_SH3_3	364	370	PF00018	0.630
LIG_SUMO_SIM_anti_2	159	166	PF11976	0.546
LIG_SUMO_SIM_anti_2	213	218	PF11976	0.579
LIG_SUMO_SIM_anti_2	71	77	PF11976	0.511
LIG_SUMO_SIM_par_1	144	149	PF11976	0.611
LIG_SUMO_SIM_par_1	74	80	PF11976	0.559
LIG_TRAF2_1	551	554	PF00917	0.647
LIG_TRAF2_1	565	568	PF00917	0.557
MOD_CK1_1	10	16	PF00069	0.715
MOD_CK1_1	111	117	PF00069	0.696
MOD_CK1_1	135	141	PF00069	0.510
MOD_CK1_1	324	330	PF00069	0.617
MOD_CK1_1	336	342	PF00069	0.622
MOD_CK1_1	49	55	PF00069	0.607
MOD_CK2_1	156	162	PF00069	0.522
MOD_CK2_1	18	24	PF00069	0.743
MOD_CK2_1	487	493	PF00069	0.518
MOD_CK2_1	514	520	PF00069	0.521
MOD_CK2_1	540	546	PF00069	0.633
MOD_CK2_1	582	588	PF00069	0.571
MOD_Cter_Amidation	247	250	PF01082	0.506
MOD_GlcNHglycan	102	105	PF01048	0.679
MOD_GlcNHglycan	20	23	PF01048	0.726
MOD_GlcNHglycan	3	6	PF01048	0.759
MOD_GlcNHglycan	338	341	PF01048	0.671
MOD_GlcNHglycan	431	434	PF01048	0.519
MOD_GlcNHglycan	495	498	PF01048	0.572
MOD_GlcNHglycan	560	563	PF01048	0.631
MOD_GSK3_1	291	298	PF00069	0.712
MOD_GSK3_1	3	10	PF00069	0.650
MOD_GSK3_1	321	328	PF00069	0.629
MOD_GSK3_1	334	341	PF00069	0.546
MOD_GSK3_1	483	490	PF00069	0.585
MOD_GSK3_1	501	508	PF00069	0.324
MOD_GSK3_1	95	102	PF00069	0.663
MOD_LATS_1	201	207	PF00433	0.491
MOD_N-GLC_1	118	123	PF02516	0.694
MOD_N-GLC_1	95	100	PF02516	0.753
MOD_NEK2_1	1	6	PF00069	0.711
MOD_NEK2_1	146	151	PF00069	0.601
MOD_NEK2_1	221	226	PF00069	0.482
MOD_NEK2_1	227	232	PF00069	0.528
MOD_NEK2_1	291	296	PF00069	0.704
MOD_NEK2_1	32	37	PF00069	0.567
MOD_NEK2_1	371	376	PF00069	0.586
MOD_NEK2_1	603	608	PF00069	0.684
MOD_NEK2_1	88	93	PF00069	0.644
MOD_PIKK_1	146	152	PF00454	0.582
MOD_PIKK_1	176	182	PF00454	0.586
MOD_PIKK_1	227	233	PF00454	0.603
MOD_PIKK_1	270	276	PF00454	0.585
MOD_PIKK_1	3	9	PF00454	0.550
MOD_PIKK_1	385	391	PF00454	0.594
MOD_PIKK_1	49	55	PF00454	0.652
MOD_PKA_2	156	162	PF00069	0.454
MOD_PKA_2	221	227	PF00069	0.521
MOD_PKA_2	291	297	PF00069	0.644
MOD_PKA_2	324	330	PF00069	0.726
MOD_PKA_2	341	347	PF00069	0.711
MOD_PKA_2	357	363	PF00069	0.603
MOD_PKA_2	429	435	PF00069	0.488
MOD_PKA_2	501	507	PF00069	0.391
MOD_PKA_2	540	546	PF00069	0.577
MOD_PKA_2	558	564	PF00069	0.594
MOD_PKA_2	596	602	PF00069	0.615
MOD_Plk_1	132	138	PF00069	0.628
MOD_Plk_1	250	256	PF00069	0.516
MOD_Plk_1	261	267	PF00069	0.512
MOD_Plk_2-3	514	520	PF00069	0.610
MOD_Plk_2-3	74	80	PF00069	0.559
MOD_Plk_4	111	117	PF00069	0.734
MOD_Plk_4	156	162	PF00069	0.596
MOD_Plk_4	181	187	PF00069	0.672
MOD_Plk_4	341	347	PF00069	0.615
MOD_Plk_4	582	588	PF00069	0.560
MOD_Plk_4	74	80	PF00069	0.559
MOD_ProDKin_1	10	16	PF00069	0.638
MOD_ProDKin_1	82	88	PF00069	0.670
MOD_SUMO_for_1	434	437	PF00179	0.578
MOD_SUMO_rev_2	508	518	PF00179	0.483
TRG_DiLeu_BaEn_1	251	256	PF01217	0.468
TRG_DiLeu_BaEn_1	71	76	PF01217	0.487
TRG_DiLeu_BaLyEn_6	223	228	PF01217	0.559
TRG_ENDOCYTIC_2	174	177	PF00928	0.434
TRG_ENDOCYTIC_2	375	378	PF00928	0.553
TRG_ER_diArg_1	172	174	PF00400	0.501
TRG_ER_diArg_1	356	359	PF00400	0.644
TRG_ER_diArg_1	570	572	PF00400	0.625
TRG_ER_diLys_1	611	616	PF00400	0.720
TRG_NES_CRM1_1	426	437	PF08389	0.522
TRG_NLS_MonoCore_2	607	612	PF00514	0.653
TRG_NLS_MonoExtC_3	607	612	PF00514	0.747
TRG_NLS_MonoExtN_4	605	612	PF00514	0.652
TRG_Pf-PMV_PEXEL_1	226	231	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	516	520	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCM9	Leptomonas seymouri	58%	92%
A0A1X0P338	Trypanosomatidae	37%	100%
A0A3R7NMF4	Trypanosoma rangeli	37%	100%
A4HPT4	Leishmania braziliensis	78%	100%
A4IE58	Leishmania infantum	99%	100%
D0A8P9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ATJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q0Z9	Leishmania major	94%	100%
V5BS07	Trypanosoma cruzi	38%	100%