Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBE1_LEIDO

TriTrypDb:

LdBPK_364310.1 , LdCL_360050200 , LDHU3_36.5830

Length:

1021

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XBE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBE1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	593	597	PF00656	0.674
CLV_C14_Caspase3-7	788	792	PF00656	0.605
CLV_C14_Caspase3-7	839	843	PF00656	0.627
CLV_MEL_PAP_1	858	864	PF00089	0.529
CLV_NRD_NRD_1	1015	1017	PF00675	0.537
CLV_NRD_NRD_1	251	253	PF00675	0.661
CLV_NRD_NRD_1	334	336	PF00675	0.609
CLV_NRD_NRD_1	384	386	PF00675	0.800
CLV_NRD_NRD_1	695	697	PF00675	0.529
CLV_NRD_NRD_1	8	10	PF00675	0.699
CLV_NRD_NRD_1	805	807	PF00675	0.665
CLV_NRD_NRD_1	85	87	PF00675	0.689
CLV_NRD_NRD_1	950	952	PF00675	0.504
CLV_PCSK_FUR_1	1013	1017	PF00082	0.540
CLV_PCSK_KEX2_1	1015	1017	PF00082	0.537
CLV_PCSK_KEX2_1	185	187	PF00082	0.651
CLV_PCSK_KEX2_1	251	253	PF00082	0.661
CLV_PCSK_KEX2_1	334	336	PF00082	0.609
CLV_PCSK_KEX2_1	384	386	PF00082	0.741
CLV_PCSK_KEX2_1	565	567	PF00082	0.716
CLV_PCSK_KEX2_1	695	697	PF00082	0.529
CLV_PCSK_KEX2_1	8	10	PF00082	0.766
CLV_PCSK_KEX2_1	805	807	PF00082	0.665
CLV_PCSK_KEX2_1	85	87	PF00082	0.689
CLV_PCSK_KEX2_1	950	952	PF00082	0.504
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.651
CLV_PCSK_PC1ET2_1	565	567	PF00082	0.732
CLV_PCSK_PC7_1	4	10	PF00082	0.757
CLV_PCSK_SKI1_1	252	256	PF00082	0.577
CLV_PCSK_SKI1_1	356	360	PF00082	0.524
CLV_PCSK_SKI1_1	421	425	PF00082	0.482
CLV_PCSK_SKI1_1	444	448	PF00082	0.578
CLV_PCSK_SKI1_1	600	604	PF00082	0.599
CLV_PCSK_SKI1_1	696	700	PF00082	0.607
DEG_APCC_DBOX_1	355	363	PF00400	0.514
DEG_SCF_FBW7_1	360	367	PF00400	0.569
DEG_SPOP_SBC_1	23	27	PF00917	0.721
DEG_SPOP_SBC_1	877	881	PF00917	0.692
DEG_SPOP_SBC_1	930	934	PF00917	0.648
DEG_SPOP_SBC_1	976	980	PF00917	0.693
DOC_CKS1_1	124	129	PF01111	0.567
DOC_CYCLIN_RxL_1	248	257	PF00134	0.519
DOC_CYCLIN_RxL_1	418	426	PF00134	0.481
DOC_CYCLIN_RxL_1	438	449	PF00134	0.266
DOC_CYCLIN_yCln2_LP_2	10	16	PF00134	0.763
DOC_CYCLIN_yCln2_LP_2	455	461	PF00134	0.467
DOC_CYCLIN_yCln2_LP_2	884	890	PF00134	0.634
DOC_MAPK_DCC_7	185	194	PF00069	0.523
DOC_MAPK_gen_1	1013	1021	PF00069	0.574
DOC_MAPK_gen_1	577	586	PF00069	0.671
DOC_MAPK_gen_1	803	811	PF00069	0.697
DOC_MAPK_gen_1	907	916	PF00069	0.578
DOC_PP2B_LxvP_1	601	604	PF13499	0.596
DOC_PP4_FxxP_1	1011	1014	PF00568	0.510
DOC_PP4_FxxP_1	368	371	PF00568	0.813
DOC_USP7_MATH_1	218	222	PF00917	0.592
DOC_USP7_MATH_1	23	27	PF00917	0.726
DOC_USP7_MATH_1	354	358	PF00917	0.523
DOC_USP7_MATH_1	587	591	PF00917	0.620
DOC_USP7_MATH_1	606	610	PF00917	0.500
DOC_USP7_MATH_1	837	841	PF00917	0.649
DOC_USP7_MATH_1	843	847	PF00917	0.596
DOC_USP7_MATH_1	875	879	PF00917	0.655
DOC_USP7_MATH_1	90	94	PF00917	0.592
DOC_USP7_MATH_1	930	934	PF00917	0.649
DOC_USP7_MATH_1	976	980	PF00917	0.693
DOC_WW_Pin1_4	108	113	PF00397	0.711
DOC_WW_Pin1_4	123	128	PF00397	0.601
DOC_WW_Pin1_4	283	288	PF00397	0.327
DOC_WW_Pin1_4	360	365	PF00397	0.540
DOC_WW_Pin1_4	846	851	PF00397	0.513
DOC_WW_Pin1_4	920	925	PF00397	0.623
LIG_14-3-3_CanoR_1	203	207	PF00244	0.644
LIG_14-3-3_CanoR_1	569	578	PF00244	0.731
LIG_14-3-3_CanoR_1	580	586	PF00244	0.577
LIG_14-3-3_CanoR_1	917	924	PF00244	0.640
LIG_14-3-3_CanoR_1	95	104	PF00244	0.647
LIG_14-3-3_CanoR_1	950	960	PF00244	0.527
LIG_Actin_WH2_2	187	205	PF00022	0.609
LIG_Actin_WH2_2	901	919	PF00022	0.595
LIG_APCC_ABBA_1	862	867	PF00400	0.506
LIG_APCC_ABBAyCdc20_2	861	867	PF00400	0.505
LIG_BIR_II_1	1	5	PF00653	0.801
LIG_BRCT_BRCA1_1	235	239	PF00533	0.735
LIG_Clathr_ClatBox_1	192	196	PF01394	0.501
LIG_CSL_BTD_1	343	346	PF09270	0.646
LIG_CtBP_PxDLS_1	850	854	PF00389	0.531
LIG_deltaCOP1_diTrp_1	714	721	PF00928	0.722
LIG_FHA_1	135	141	PF00498	0.613
LIG_FHA_1	150	156	PF00498	0.361
LIG_FHA_1	265	271	PF00498	0.710
LIG_FHA_1	275	281	PF00498	0.539
LIG_FHA_1	350	356	PF00498	0.515
LIG_FHA_1	411	417	PF00498	0.588
LIG_FHA_1	424	430	PF00498	0.398
LIG_FHA_1	447	453	PF00498	0.447
LIG_FHA_1	543	549	PF00498	0.527
LIG_FHA_1	720	726	PF00498	0.662
LIG_FHA_1	753	759	PF00498	0.537
LIG_FHA_1	853	859	PF00498	0.545
LIG_FHA_1	930	936	PF00498	0.598
LIG_FHA_1	95	101	PF00498	0.736
LIG_FHA_1	952	958	PF00498	0.466
LIG_FHA_2	296	302	PF00498	0.569
LIG_FHA_2	460	466	PF00498	0.755
LIG_FHA_2	489	495	PF00498	0.667
LIG_FHA_2	658	664	PF00498	0.646
LIG_FHA_2	701	707	PF00498	0.621
LIG_FHA_2	786	792	PF00498	0.674
LIG_FHA_2	877	883	PF00498	0.772
LIG_FHA_2	984	990	PF00498	0.604
LIG_GBD_Chelix_1	198	206	PF00786	0.508
LIG_Integrin_RGD_1	69	71	PF01839	0.524
LIG_IRF3_LxIS_1	893	900	PF10401	0.597
LIG_LIR_Apic_2	367	371	PF02991	0.805
LIG_LIR_Gen_1	286	297	PF02991	0.439
LIG_LIR_Gen_1	298	307	PF02991	0.651
LIG_LIR_Gen_1	425	435	PF02991	0.482
LIG_LIR_Gen_1	52	62	PF02991	0.616
LIG_LIR_Gen_1	544	554	PF02991	0.579
LIG_LIR_Gen_1	63	73	PF02991	0.542
LIG_LIR_Gen_1	810	821	PF02991	0.616
LIG_LIR_Gen_1	991	1001	PF02991	0.622
LIG_LIR_Nem_3	154	160	PF02991	0.488
LIG_LIR_Nem_3	2	6	PF02991	0.697
LIG_LIR_Nem_3	286	292	PF02991	0.406
LIG_LIR_Nem_3	298	302	PF02991	0.611
LIG_LIR_Nem_3	425	430	PF02991	0.474
LIG_LIR_Nem_3	484	490	PF02991	0.520
LIG_LIR_Nem_3	52	57	PF02991	0.635
LIG_LIR_Nem_3	544	549	PF02991	0.569
LIG_LIR_Nem_3	63	68	PF02991	0.556
LIG_LIR_Nem_3	810	816	PF02991	0.632
LIG_LIR_Nem_3	991	996	PF02991	0.620
LIG_LYPXL_SIV_4	693	701	PF13949	0.575
LIG_NRBOX	442	448	PF00104	0.579
LIG_OCRL_FandH_1	248	260	PF00620	0.568
LIG_PCNA_yPIPBox_3	170	179	PF02747	0.518
LIG_PCNA_yPIPBox_3	941	951	PF02747	0.486
LIG_PDZ_Class_2	1016	1021	PF00595	0.597
LIG_Pex14_1	813	817	PF04695	0.637
LIG_RPA_C_Fungi	575	587	PF08784	0.761
LIG_RPA_C_Fungi	755	767	PF08784	0.600
LIG_SH2_CRK	528	532	PF00017	0.510
LIG_SH2_CRK	65	69	PF00017	0.544
LIG_SH2_NCK_1	490	494	PF00017	0.564
LIG_SH2_NCK_1	649	653	PF00017	0.642
LIG_SH2_PTP2	655	658	PF00017	0.503
LIG_SH2_SRC	649	652	PF00017	0.647
LIG_SH2_STAP1	341	345	PF00017	0.547
LIG_SH2_STAP1	366	370	PF00017	0.791
LIG_SH2_STAP1	997	1001	PF00017	0.625
LIG_SH2_STAT5	490	493	PF00017	0.613
LIG_SH2_STAT5	65	68	PF00017	0.547
LIG_SH2_STAT5	655	658	PF00017	0.503
LIG_SH2_STAT5	769	772	PF00017	0.537
LIG_SH3_1	185	191	PF00018	0.629
LIG_SH3_3	118	124	PF00018	0.665
LIG_SH3_3	185	191	PF00018	0.529
LIG_SH3_3	205	211	PF00018	0.322
LIG_SH3_3	404	410	PF00018	0.669
LIG_SH3_3	472	478	PF00018	0.636
LIG_SH3_3	887	893	PF00018	0.704
LIG_SH3_3	97	103	PF00018	0.660
LIG_Sin3_3	681	688	PF02671	0.584
LIG_SUMO_SIM_anti_2	131	137	PF11976	0.524
LIG_SUMO_SIM_anti_2	522	527	PF11976	0.478
LIG_SUMO_SIM_anti_2	748	755	PF11976	0.593
LIG_SUMO_SIM_anti_2	854	860	PF11976	0.477
LIG_SUMO_SIM_anti_2	954	961	PF11976	0.587
LIG_SUMO_SIM_par_1	131	137	PF11976	0.524
LIG_SUMO_SIM_par_1	351	357	PF11976	0.515
LIG_SUMO_SIM_par_1	849	855	PF11976	0.577
LIG_SUMO_SIM_par_1	895	900	PF11976	0.573
LIG_TRAF2_1	533	536	PF00917	0.493
LIG_TRAF2_1	591	594	PF00917	0.732
LIG_TRAF2_1	781	784	PF00917	0.688
LIG_TRAF2_1	866	869	PF00917	0.590
LIG_TRFH_1	123	127	PF08558	0.480
LIG_TYR_ITIM	526	531	PF00017	0.503
LIG_UBA3_1	133	139	PF00899	0.522
LIG_WRC_WIRS_1	365	370	PF05994	0.676
LIG_WW_2	893	896	PF00397	0.604
MOD_CK1_1	213	219	PF00069	0.571
MOD_CK1_1	227	233	PF00069	0.673
MOD_CK1_1	387	393	PF00069	0.797
MOD_CK1_1	56	62	PF00069	0.696
MOD_CK1_1	570	576	PF00069	0.674
MOD_CK1_1	730	736	PF00069	0.726
MOD_CK1_1	846	852	PF00069	0.533
MOD_CK1_1	876	882	PF00069	0.720
MOD_CK1_1	920	926	PF00069	0.699
MOD_CK1_1	968	974	PF00069	0.669
MOD_CK2_1	376	382	PF00069	0.839
MOD_CK2_1	459	465	PF00069	0.732
MOD_CK2_1	587	593	PF00069	0.646
MOD_CK2_1	657	663	PF00069	0.610
MOD_CK2_1	700	706	PF00069	0.703
MOD_CK2_1	777	783	PF00069	0.612
MOD_CK2_1	876	882	PF00069	0.693
MOD_CMANNOS	718	721	PF00535	0.687
MOD_CMANNOS	939	942	PF00535	0.485
MOD_Cter_Amidation	382	385	PF01082	0.747
MOD_GlcNHglycan	116	119	PF01048	0.662
MOD_GlcNHglycan	212	215	PF01048	0.577
MOD_GlcNHglycan	220	223	PF01048	0.594
MOD_GlcNHglycan	226	229	PF01048	0.642
MOD_GlcNHglycan	256	259	PF01048	0.732
MOD_GlcNHglycan	26	29	PF01048	0.621
MOD_GlcNHglycan	356	359	PF01048	0.622
MOD_GlcNHglycan	373	376	PF01048	0.679
MOD_GlcNHglycan	389	392	PF01048	0.694
MOD_GlcNHglycan	549	552	PF01048	0.641
MOD_GlcNHglycan	569	572	PF01048	0.515
MOD_GlcNHglycan	581	584	PF01048	0.724
MOD_GlcNHglycan	590	593	PF01048	0.587
MOD_GlcNHglycan	624	627	PF01048	0.590
MOD_GlcNHglycan	678	681	PF01048	0.481
MOD_GlcNHglycan	733	736	PF01048	0.748
MOD_GlcNHglycan	779	782	PF01048	0.716
MOD_GlcNHglycan	839	842	PF01048	0.652
MOD_GlcNHglycan	875	878	PF01048	0.699
MOD_GlcNHglycan	919	922	PF01048	0.650
MOD_GlcNHglycan	92	95	PF01048	0.665
MOD_GlcNHglycan	966	970	PF01048	0.749
MOD_GSK3_1	198	205	PF00069	0.587
MOD_GSK3_1	213	220	PF00069	0.464
MOD_GSK3_1	223	230	PF00069	0.615
MOD_GSK3_1	254	261	PF00069	0.714
MOD_GSK3_1	354	361	PF00069	0.552
MOD_GSK3_1	453	460	PF00069	0.377
MOD_GSK3_1	488	495	PF00069	0.537
MOD_GSK3_1	696	703	PF00069	0.667
MOD_GSK3_1	727	734	PF00069	0.702
MOD_GSK3_1	817	824	PF00069	0.439
MOD_GSK3_1	837	844	PF00069	0.675
MOD_GSK3_1	871	878	PF00069	0.597
MOD_GSK3_1	90	97	PF00069	0.756
MOD_GSK3_1	978	985	PF00069	0.635
MOD_N-GLC_1	233	238	PF02516	0.691
MOD_N-GLC_1	295	300	PF02516	0.614
MOD_N-GLC_1	519	524	PF02516	0.593
MOD_N-GLC_1	676	681	PF02516	0.615
MOD_NEK2_1	134	139	PF00069	0.627
MOD_NEK2_1	198	203	PF00069	0.605
MOD_NEK2_1	217	222	PF00069	0.391
MOD_NEK2_1	24	29	PF00069	0.622
MOD_NEK2_1	254	259	PF00069	0.608
MOD_NEK2_1	295	300	PF00069	0.614
MOD_NEK2_1	423	428	PF00069	0.571
MOD_NEK2_1	446	451	PF00069	0.502
MOD_NEK2_1	542	547	PF00069	0.523
MOD_NEK2_1	607	612	PF00069	0.605
MOD_NEK2_1	676	681	PF00069	0.594
MOD_NEK2_1	746	751	PF00069	0.500
MOD_NEK2_1	776	781	PF00069	0.562
MOD_NEK2_1	835	840	PF00069	0.593
MOD_NEK2_1	851	856	PF00069	0.305
MOD_NEK2_1	982	987	PF00069	0.550
MOD_NEK2_2	364	369	PF00069	0.654
MOD_NEK2_2	721	726	PF00069	0.656
MOD_OFUCOSY	605	611	PF10250	0.468
MOD_PIKK_1	727	733	PF00454	0.697
MOD_PIKK_1	785	791	PF00454	0.816
MOD_PIKK_1	821	827	PF00454	0.452
MOD_PK_1	53	59	PF00069	0.624
MOD_PKA_1	384	390	PF00069	0.787
MOD_PKA_1	565	571	PF00069	0.795
MOD_PKA_2	202	208	PF00069	0.642
MOD_PKA_2	327	333	PF00069	0.763
MOD_PKA_2	384	390	PF00069	0.766
MOD_PKA_2	565	571	PF00069	0.684
MOD_PKA_2	579	585	PF00069	0.693
MOD_PKA_2	909	915	PF00069	0.478
MOD_PKA_2	94	100	PF00069	0.750
MOD_PKB_1	915	923	PF00069	0.562
MOD_Plk_1	233	239	PF00069	0.684
MOD_Plk_1	295	301	PF00069	0.626
MOD_Plk_1	841	847	PF00069	0.500
MOD_Plk_4	202	208	PF00069	0.563
MOD_Plk_4	423	429	PF00069	0.571
MOD_Plk_4	521	527	PF00069	0.478
MOD_Plk_4	749	755	PF00069	0.492
MOD_Plk_4	931	937	PF00069	0.575
MOD_Plk_4	943	949	PF00069	0.476
MOD_Plk_4	978	984	PF00069	0.594
MOD_Plk_4	988	994	PF00069	0.534
MOD_ProDKin_1	108	114	PF00069	0.709
MOD_ProDKin_1	123	129	PF00069	0.590
MOD_ProDKin_1	283	289	PF00069	0.323
MOD_ProDKin_1	360	366	PF00069	0.555
MOD_ProDKin_1	846	852	PF00069	0.506
MOD_ProDKin_1	920	926	PF00069	0.630
TRG_DiLeu_BaEn_1	131	136	PF01217	0.530
TRG_DiLeu_BaEn_1	594	599	PF01217	0.696
TRG_DiLeu_BaEn_4	131	137	PF01217	0.524
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.670
TRG_DiLeu_BaLyEn_6	438	443	PF01217	0.514
TRG_ENDOCYTIC_2	146	149	PF00928	0.553
TRG_ENDOCYTIC_2	528	531	PF00928	0.512
TRG_ENDOCYTIC_2	65	68	PF00928	0.547
TRG_ENDOCYTIC_2	655	658	PF00928	0.514
TRG_ER_diArg_1	1012	1015	PF00400	0.515
TRG_ER_diArg_1	250	252	PF00400	0.659
TRG_ER_diArg_1	333	335	PF00400	0.620
TRG_ER_diArg_1	694	696	PF00400	0.521
TRG_ER_diArg_1	7	9	PF00400	0.745
TRG_ER_diArg_1	914	917	PF00400	0.515
TRG_NES_CRM1_1	153	165	PF08389	0.493
TRG_NLS_MonoExtN_4	562	568	PF00514	0.731
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	557	561	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	961	966	PF00026	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHV3	Leptomonas seymouri	44%	99%
A4HPS9	Leishmania braziliensis	76%	100%
A4IE63	Leishmania infantum	99%	100%
E9ATJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q104	Leishmania major	91%	100%