CRAL/TRIO domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBD6_LEIDO

TriTrypDb:

LdBPK_363590.1 , LdCL_360042900 , LDHU3_36.4870

Length:

792

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XBD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBD6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	298	304	PF00089	0.640
CLV_NRD_NRD_1	176	178	PF00675	0.497
CLV_NRD_NRD_1	219	221	PF00675	0.376
CLV_NRD_NRD_1	292	294	PF00675	0.519
CLV_NRD_NRD_1	295	297	PF00675	0.556
CLV_NRD_NRD_1	41	43	PF00675	0.586
CLV_NRD_NRD_1	410	412	PF00675	0.497
CLV_NRD_NRD_1	516	518	PF00675	0.681
CLV_NRD_NRD_1	564	566	PF00675	0.502
CLV_NRD_NRD_1	575	577	PF00675	0.625
CLV_NRD_NRD_1	692	694	PF00675	0.694
CLV_NRD_NRD_1	93	95	PF00675	0.457
CLV_PCSK_FUR_1	293	297	PF00082	0.500
CLV_PCSK_KEX2_1	176	178	PF00082	0.497
CLV_PCSK_KEX2_1	219	221	PF00082	0.350
CLV_PCSK_KEX2_1	292	294	PF00082	0.519
CLV_PCSK_KEX2_1	295	297	PF00082	0.556
CLV_PCSK_KEX2_1	41	43	PF00082	0.586
CLV_PCSK_KEX2_1	425	427	PF00082	0.716
CLV_PCSK_KEX2_1	516	518	PF00082	0.681
CLV_PCSK_KEX2_1	564	566	PF00082	0.547
CLV_PCSK_KEX2_1	577	579	PF00082	0.465
CLV_PCSK_KEX2_1	634	636	PF00082	0.768
CLV_PCSK_KEX2_1	652	654	PF00082	0.492
CLV_PCSK_KEX2_1	692	694	PF00082	0.694
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.716
CLV_PCSK_PC1ET2_1	577	579	PF00082	0.539
CLV_PCSK_PC1ET2_1	634	636	PF00082	0.778
CLV_PCSK_PC1ET2_1	652	654	PF00082	0.577
CLV_PCSK_PC1ET2_1	692	694	PF00082	0.694
CLV_PCSK_SKI1_1	151	155	PF00082	0.430
CLV_PCSK_SKI1_1	219	223	PF00082	0.342
CLV_PCSK_SKI1_1	330	334	PF00082	0.706
CLV_PCSK_SKI1_1	52	56	PF00082	0.498
CLV_PCSK_SKI1_1	577	581	PF00082	0.525
CLV_PCSK_SKI1_1	653	657	PF00082	0.728
CLV_Separin_Metazoa	216	220	PF03568	0.376
DEG_APCC_DBOX_1	159	167	PF00400	0.501
DEG_APCC_DBOX_1	603	611	PF00400	0.545
DEG_SPOP_SBC_1	338	342	PF00917	0.709
DEG_SPOP_SBC_1	382	386	PF00917	0.788
DEG_SPOP_SBC_1	400	404	PF00917	0.500
DOC_ANK_TNKS_1	294	301	PF00023	0.581
DOC_ANK_TNKS_1	596	603	PF00023	0.592
DOC_CYCLIN_RxL_1	216	226	PF00134	0.371
DOC_MAPK_DCC_7	131	139	PF00069	0.430
DOC_MAPK_DCC_7	250	260	PF00069	0.287
DOC_MAPK_gen_1	176	187	PF00069	0.429
DOC_MAPK_gen_1	235	245	PF00069	0.399
DOC_MAPK_gen_1	50	57	PF00069	0.514
DOC_MAPK_gen_1	516	524	PF00069	0.566
DOC_MAPK_gen_1	571	581	PF00069	0.494
DOC_MAPK_gen_1	604	611	PF00069	0.538
DOC_MAPK_gen_1	634	644	PF00069	0.707
DOC_MAPK_gen_1	692	700	PF00069	0.675
DOC_MAPK_HePTP_8	632	644	PF00069	0.703
DOC_MAPK_MEF2A_6	131	139	PF00069	0.430
DOC_MAPK_MEF2A_6	235	243	PF00069	0.430
DOC_MAPK_MEF2A_6	366	373	PF00069	0.728
DOC_MAPK_MEF2A_6	604	611	PF00069	0.538
DOC_MAPK_MEF2A_6	635	644	PF00069	0.708
DOC_PP1_RVXF_1	218	225	PF00149	0.344
DOC_PP1_RVXF_1	246	252	PF00149	0.430
DOC_PP1_RVXF_1	694	701	PF00149	0.677
DOC_PP2B_LxvP_1	502	505	PF13499	0.513
DOC_SPAK_OSR1_1	71	75	PF12202	0.416
DOC_USP7_MATH_1	27	31	PF00917	0.545
DOC_USP7_MATH_1	309	313	PF00917	0.666
DOC_USP7_MATH_1	401	405	PF00917	0.709
DOC_USP7_MATH_1	445	449	PF00917	0.718
DOC_USP7_MATH_1	456	460	PF00917	0.619
DOC_USP7_MATH_1	481	485	PF00917	0.536
DOC_USP7_MATH_1	534	538	PF00917	0.745
DOC_USP7_MATH_1	658	662	PF00917	0.782
DOC_USP7_MATH_1	702	706	PF00917	0.724
DOC_USP7_MATH_1	714	718	PF00917	0.675
DOC_USP7_MATH_1	776	780	PF00917	0.693
DOC_USP7_UBL2_3	692	696	PF12436	0.709
DOC_USP7_UBL2_3	744	748	PF12436	0.597
DOC_WW_Pin1_4	10	15	PF00397	0.555
DOC_WW_Pin1_4	113	118	PF00397	0.570
DOC_WW_Pin1_4	137	142	PF00397	0.423
DOC_WW_Pin1_4	300	305	PF00397	0.614
DOC_WW_Pin1_4	339	344	PF00397	0.658
DOC_WW_Pin1_4	347	352	PF00397	0.662
DOC_WW_Pin1_4	412	417	PF00397	0.706
DOC_WW_Pin1_4	430	435	PF00397	0.696
DOC_WW_Pin1_4	686	691	PF00397	0.748
LIG_14-3-3_CanoR_1	180	184	PF00244	0.395
LIG_14-3-3_CanoR_1	322	328	PF00244	0.712
LIG_14-3-3_CanoR_1	576	582	PF00244	0.392
LIG_14-3-3_CanoR_1	92	102	PF00244	0.575
LIG_Actin_WH2_2	188	206	PF00022	0.430
LIG_APCC_ABBA_1	54	59	PF00400	0.497
LIG_BRCT_BRCA1_1	32	36	PF00533	0.558
LIG_BRCT_BRCA1_1	696	700	PF00533	0.681
LIG_CaM_NSCaTE_8	675	682	PF13499	0.691
LIG_FHA_1	180	186	PF00498	0.376
LIG_FHA_1	197	203	PF00498	0.376
LIG_FHA_1	255	261	PF00498	0.346
LIG_FHA_1	323	329	PF00498	0.693
LIG_FHA_1	339	345	PF00498	0.698
LIG_FHA_1	376	382	PF00498	0.787
LIG_FHA_1	455	461	PF00498	0.843
LIG_FHA_1	639	645	PF00498	0.757
LIG_FHA_1	727	733	PF00498	0.619
LIG_FHA_2	11	17	PF00498	0.696
LIG_FHA_2	456	462	PF00498	0.621
LIG_FHA_2	505	511	PF00498	0.719
LIG_Integrin_isoDGR_2	672	674	PF01839	0.641
LIG_LIR_Gen_1	169	178	PF02991	0.401
LIG_LIR_Gen_1	580	590	PF02991	0.606
LIG_LIR_Gen_1	678	688	PF02991	0.637
LIG_LIR_Gen_1	89	97	PF02991	0.500
LIG_LIR_Nem_3	169	174	PF02991	0.401
LIG_LIR_Nem_3	231	237	PF02991	0.426
LIG_LIR_Nem_3	427	431	PF02991	0.697
LIG_LIR_Nem_3	580	585	PF02991	0.591
LIG_LIR_Nem_3	623	628	PF02991	0.528
LIG_LIR_Nem_3	67	73	PF02991	0.404
LIG_LIR_Nem_3	678	683	PF02991	0.667
LIG_LIR_Nem_3	739	745	PF02991	0.507
LIG_LIR_Nem_3	89	93	PF02991	0.496
LIG_LYPXL_yS_3	214	217	PF13949	0.376
LIG_MYND_1	519	523	PF01753	0.696
LIG_Pex14_1	17	21	PF04695	0.551
LIG_Pex14_2	224	228	PF04695	0.341
LIG_Pex14_2	514	518	PF04695	0.616
LIG_SH2_CRK	428	432	PF00017	0.741
LIG_SH2_CRK	582	586	PF00017	0.532
LIG_SH2_CRK	70	74	PF00017	0.406
LIG_SH2_CRK	90	94	PF00017	0.250
LIG_SH2_NCK_1	503	507	PF00017	0.521
LIG_SH2_NCK_1	582	586	PF00017	0.532
LIG_SH2_PTP2	171	174	PF00017	0.462
LIG_SH2_SRC	503	506	PF00017	0.520
LIG_SH2_SRC	599	602	PF00017	0.583
LIG_SH2_STAP1	21	25	PF00017	0.534
LIG_SH2_STAT5	171	174	PF00017	0.475
LIG_SH2_STAT5	183	186	PF00017	0.371
LIG_SH2_STAT5	264	267	PF00017	0.447
LIG_SH2_STAT5	488	491	PF00017	0.539
LIG_SH2_STAT5	568	571	PF00017	0.496
LIG_SH2_STAT5	599	602	PF00017	0.583
LIG_SH3_3	111	117	PF00018	0.570
LIG_SH3_3	209	215	PF00018	0.501
LIG_SH3_3	233	239	PF00018	0.376
LIG_SH3_3	279	285	PF00018	0.533
LIG_SH3_3	311	317	PF00018	0.697
LIG_SH3_3	428	434	PF00018	0.718
LIG_SH3_3	535	541	PF00018	0.620
LIG_SH3_3	606	612	PF00018	0.537
LIG_SH3_3	637	643	PF00018	0.711
LIG_SH3_3	684	690	PF00018	0.538
LIG_SH3_3	705	711	PF00018	0.715
LIG_SUMO_SIM_anti_2	199	204	PF11976	0.462
LIG_SUMO_SIM_anti_2	257	262	PF11976	0.346
LIG_SUMO_SIM_par_1	256	262	PF11976	0.287
LIG_SUMO_SIM_par_1	471	476	PF11976	0.553
LIG_SUMO_SIM_par_1	8	13	PF11976	0.632
LIG_TRAF2_1	37	40	PF00917	0.533
LIG_TYR_ITIM	212	217	PF00017	0.430
LIG_TYR_ITIM	68	73	PF00017	0.401
LIG_TYR_ITSM	578	585	PF00017	0.534
LIG_UBA3_1	146	151	PF00899	0.385
MOD_CDC14_SPxK_1	689	692	PF00782	0.688
MOD_CDK_SPxK_1	686	692	PF00069	0.685
MOD_CDK_SPxxK_3	113	120	PF00069	0.543
MOD_CDK_SPxxK_3	430	437	PF00069	0.713
MOD_CDK_SPxxK_3	686	693	PF00069	0.688
MOD_CK1_1	113	119	PF00069	0.566
MOD_CK1_1	193	199	PF00069	0.210
MOD_CK1_1	30	36	PF00069	0.650
MOD_CK1_1	318	324	PF00069	0.780
MOD_CK1_1	337	343	PF00069	0.619
MOD_CK1_1	375	381	PF00069	0.787
MOD_CK1_1	385	391	PF00069	0.695
MOD_CK1_1	399	405	PF00069	0.585
MOD_CK1_1	433	439	PF00069	0.681
MOD_CK1_1	525	531	PF00069	0.746
MOD_CK1_1	614	620	PF00069	0.670
MOD_CK1_1	663	669	PF00069	0.737
MOD_CK1_1	717	723	PF00069	0.626
MOD_CK1_1	779	785	PF00069	0.711
MOD_CK2_1	12	18	PF00069	0.627
MOD_CK2_1	34	40	PF00069	0.576
MOD_CK2_1	400	406	PF00069	0.771
MOD_CK2_1	455	461	PF00069	0.769
MOD_DYRK1A_RPxSP_1	686	690	PF00069	0.639
MOD_GlcNHglycan	230	233	PF01048	0.430
MOD_GlcNHglycan	252	255	PF01048	0.376
MOD_GlcNHglycan	278	281	PF01048	0.547
MOD_GlcNHglycan	30	33	PF01048	0.594
MOD_GlcNHglycan	374	377	PF01048	0.699
MOD_GlcNHglycan	387	390	PF01048	0.670
MOD_GlcNHglycan	403	406	PF01048	0.693
MOD_GlcNHglycan	438	442	PF01048	0.729
MOD_GlcNHglycan	485	488	PF01048	0.553
MOD_GlcNHglycan	5	8	PF01048	0.765
MOD_GlcNHglycan	508	514	PF01048	0.693
MOD_GlcNHglycan	702	705	PF01048	0.670
MOD_GlcNHglycan	715	719	PF01048	0.651
MOD_GSK3_1	162	169	PF00069	0.424
MOD_GSK3_1	250	257	PF00069	0.376
MOD_GSK3_1	270	277	PF00069	0.171
MOD_GSK3_1	30	37	PF00069	0.566
MOD_GSK3_1	318	325	PF00069	0.784
MOD_GSK3_1	334	341	PF00069	0.606
MOD_GSK3_1	343	350	PF00069	0.649
MOD_GSK3_1	381	388	PF00069	0.689
MOD_GSK3_1	396	403	PF00069	0.568
MOD_GSK3_1	433	440	PF00069	0.752
MOD_GSK3_1	441	448	PF00069	0.720
MOD_GSK3_1	456	463	PF00069	0.757
MOD_GSK3_1	611	618	PF00069	0.578
MOD_GSK3_1	630	637	PF00069	0.544
MOD_GSK3_1	654	661	PF00069	0.780
MOD_GSK3_1	663	670	PF00069	0.687
MOD_GSK3_1	696	703	PF00069	0.800
MOD_GSK3_1	722	729	PF00069	0.613
MOD_GSK3_1	743	750	PF00069	0.627
MOD_GSK3_1	759	766	PF00069	0.464
MOD_GSK3_1	779	786	PF00069	0.546
MOD_N-GLC_1	614	619	PF02516	0.709
MOD_NEK2_1	166	171	PF00069	0.424
MOD_NEK2_1	274	279	PF00069	0.539
MOD_NEK2_1	381	386	PF00069	0.764
MOD_NEK2_1	394	399	PF00069	0.627
MOD_NEK2_1	524	529	PF00069	0.556
MOD_NEK2_1	648	653	PF00069	0.781
MOD_NEK2_1	667	672	PF00069	0.492
MOD_NEK2_1	700	705	PF00069	0.686
MOD_NEK2_2	675	680	PF00069	0.698
MOD_PIKK_1	461	467	PF00454	0.587
MOD_PIKK_1	522	528	PF00454	0.718
MOD_PIKK_1	667	673	PF00454	0.676
MOD_PIKK_1	726	732	PF00454	0.647
MOD_PIKK_1	759	765	PF00454	0.520
MOD_PK_1	694	700	PF00069	0.676
MOD_PKA_1	577	583	PF00069	0.517
MOD_PKA_1	634	640	PF00069	0.784
MOD_PKA_2	179	185	PF00069	0.417
MOD_PKA_2	315	321	PF00069	0.779
MOD_PKA_2	570	576	PF00069	0.568
MOD_PKA_2	577	583	PF00069	0.518
MOD_PKA_2	634	640	PF00069	0.782
MOD_PKA_2	663	669	PF00069	0.654
MOD_PKA_2	93	99	PF00069	0.587
MOD_Plk_1	166	172	PF00069	0.385
MOD_Plk_1	394	400	PF00069	0.657
MOD_Plk_1	509	515	PF00069	0.659
MOD_Plk_1	726	732	PF00069	0.599
MOD_Plk_2-3	722	728	PF00069	0.702
MOD_Plk_4	110	116	PF00069	0.516
MOD_Plk_4	179	185	PF00069	0.430
MOD_Plk_4	30	36	PF00069	0.497
MOD_Plk_4	309	315	PF00069	0.757
MOD_Plk_4	323	329	PF00069	0.694
MOD_Plk_4	331	337	PF00069	0.673
MOD_Plk_4	517	523	PF00069	0.781
MOD_Plk_4	525	531	PF00069	0.607
MOD_Plk_4	577	583	PF00069	0.608
MOD_Plk_4	675	681	PF00069	0.625
MOD_ProDKin_1	10	16	PF00069	0.543
MOD_ProDKin_1	113	119	PF00069	0.566
MOD_ProDKin_1	137	143	PF00069	0.423
MOD_ProDKin_1	300	306	PF00069	0.617
MOD_ProDKin_1	339	345	PF00069	0.659
MOD_ProDKin_1	347	353	PF00069	0.663
MOD_ProDKin_1	412	418	PF00069	0.702
MOD_ProDKin_1	430	436	PF00069	0.696
MOD_ProDKin_1	686	692	PF00069	0.751
MOD_SUMO_for_1	249	252	PF00179	0.430
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.430
TRG_ENDOCYTIC_2	171	174	PF00928	0.462
TRG_ENDOCYTIC_2	214	217	PF00928	0.376
TRG_ENDOCYTIC_2	428	431	PF00928	0.740
TRG_ENDOCYTIC_2	582	585	PF00928	0.535
TRG_ENDOCYTIC_2	70	73	PF00928	0.402
TRG_ENDOCYTIC_2	90	93	PF00928	0.256
TRG_ER_diArg_1	176	178	PF00400	0.494
TRG_ER_diArg_1	218	220	PF00400	0.376
TRG_ER_diArg_1	291	293	PF00400	0.518
TRG_ER_diArg_1	294	296	PF00400	0.527
TRG_ER_diArg_1	515	517	PF00400	0.676
TRG_ER_diArg_1	564	567	PF00400	0.506
TRG_ER_diArg_1	575	578	PF00400	0.482
TRG_NLS_Bipartite_1	564	580	PF00514	0.528
TRG_NLS_MonoCore_2	692	697	PF00514	0.573
TRG_NLS_MonoExtC_3	691	696	PF00514	0.694
TRG_NLS_MonoExtN_4	574	580	PF00514	0.565
TRG_NLS_MonoExtN_4	690	697	PF00514	0.690
TRG_Pf-PMV_PEXEL_1	238	242	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	567	572	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P689	Leptomonas seymouri	50%	97%
A0A1X0P424	Trypanosomatidae	35%	100%
A4HPL0	Leishmania braziliensis	67%	97%
A4ID54	Leishmania infantum	99%	100%
E9ATC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q175	Leishmania major	92%	100%