WD domain, G-beta repeat, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBC0_LEIDO

TriTrypDb:

LdBPK_363810.1 , LdCL_360045100 , LDHU3_36.5140

Length:

393

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0005840	ribosome	5	1
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S7XBC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBC0

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	317	319	PF00675	0.558
CLV_NRD_NRD_1	38	40	PF00675	0.593
CLV_PCSK_KEX2_1	316	318	PF00082	0.568
CLV_PCSK_SKI1_1	174	178	PF00082	0.287
CLV_PCSK_SKI1_1	29	33	PF00082	0.562
DEG_APCC_DBOX_1	28	36	PF00400	0.543
DEG_Nend_UBRbox_3	1	3	PF02207	0.533
DEG_SCF_FBW7_1	94	101	PF00400	0.522
DOC_CYCLIN_RxL_1	363	376	PF00134	0.560
DOC_MAPK_gen_1	180	188	PF00069	0.562
DOC_MAPK_gen_1	316	325	PF00069	0.512
DOC_MAPK_gen_1	368	374	PF00069	0.458
DOC_MAPK_gen_1	39	46	PF00069	0.587
DOC_MAPK_MEF2A_6	180	188	PF00069	0.537
DOC_MAPK_MEF2A_6	45	53	PF00069	0.376
DOC_PP1_RVXF_1	172	179	PF00149	0.487
DOC_PP2B_LxvP_1	332	335	PF13499	0.516
DOC_USP7_MATH_1	124	128	PF00917	0.557
DOC_USP7_MATH_1	232	236	PF00917	0.473
DOC_USP7_MATH_1	288	292	PF00917	0.412
DOC_USP7_MATH_1	336	340	PF00917	0.452
DOC_USP7_MATH_1	344	348	PF00917	0.365
DOC_USP7_MATH_1	79	83	PF00917	0.380
DOC_WW_Pin1_4	135	140	PF00397	0.413
DOC_WW_Pin1_4	180	185	PF00397	0.576
DOC_WW_Pin1_4	20	25	PF00397	0.580
DOC_WW_Pin1_4	271	276	PF00397	0.499
DOC_WW_Pin1_4	94	99	PF00397	0.498
LIG_14-3-3_CanoR_1	10	14	PF00244	0.574
LIG_14-3-3_CanoR_1	317	323	PF00244	0.579
LIG_14-3-3_CanoR_1	363	367	PF00244	0.508
LIG_14-3-3_CanoR_1	45	53	PF00244	0.564
LIG_Actin_WH2_2	1	16	PF00022	0.548
LIG_Actin_WH2_2	105	120	PF00022	0.529
LIG_BRCT_BRCA1_1	14	18	PF00533	0.637
LIG_deltaCOP1_diTrp_1	171	178	PF00928	0.487
LIG_FHA_1	148	154	PF00498	0.445
LIG_FHA_1	155	161	PF00498	0.425
LIG_FHA_1	168	174	PF00498	0.441
LIG_FHA_1	21	27	PF00498	0.588
LIG_FHA_1	235	241	PF00498	0.492
LIG_FHA_1	249	255	PF00498	0.622
LIG_FHA_1	293	299	PF00498	0.372
LIG_FHA_1	304	310	PF00498	0.397
LIG_FHA_1	365	371	PF00498	0.442
LIG_FHA_1	54	60	PF00498	0.498
LIG_FHA_1	86	92	PF00498	0.472
LIG_FHA_2	189	195	PF00498	0.487
LIG_LIR_Gen_1	170	179	PF02991	0.487
LIG_LIR_Gen_1	321	329	PF02991	0.473
LIG_LIR_Nem_3	170	175	PF02991	0.474
LIG_LIR_Nem_3	225	230	PF02991	0.460
LIG_LIR_Nem_3	321	325	PF02991	0.514
LIG_NRBOX	31	37	PF00104	0.561
LIG_NRBOX	387	393	PF00104	0.530
LIG_Pex14_2	322	326	PF04695	0.437
LIG_SH2_CRK	227	231	PF00017	0.532
LIG_SH2_SRC	111	114	PF00017	0.539
LIG_SH2_STAP1	128	132	PF00017	0.448
LIG_SH2_STAP1	366	370	PF00017	0.445
LIG_SH2_STAT5	11	14	PF00017	0.575
LIG_SH2_STAT5	111	114	PF00017	0.539
LIG_SH2_STAT5	143	146	PF00017	0.487
LIG_SH2_STAT5	243	246	PF00017	0.547
LIG_SH2_STAT5	273	276	PF00017	0.525
LIG_SH2_STAT5	300	303	PF00017	0.534
LIG_SH2_STAT5	366	369	PF00017	0.453
LIG_SH3_3	298	304	PF00018	0.444
LIG_SH3_3	353	359	PF00018	0.418
LIG_SUMO_SIM_anti_2	338	344	PF11976	0.410
LIG_SUMO_SIM_par_1	150	159	PF11976	0.418
LIG_SUMO_SIM_par_1	228	235	PF11976	0.406
LIG_SUMO_SIM_par_1	291	299	PF11976	0.382
LIG_SUMO_SIM_par_1	55	63	PF11976	0.403
LIG_TRFH_1	300	304	PF08558	0.425
LIG_WRC_WIRS_1	374	379	PF05994	0.518
MOD_CDK_SPxxK_3	135	142	PF00069	0.503
MOD_CK1_1	206	212	PF00069	0.514
MOD_CK1_1	225	231	PF00069	0.216
MOD_CK1_1	234	240	PF00069	0.428
MOD_CK1_1	247	253	PF00069	0.461
MOD_CK1_1	348	354	PF00069	0.427
MOD_CK1_1	89	95	PF00069	0.483
MOD_CK2_1	211	217	PF00069	0.467
MOD_CK2_1	286	292	PF00069	0.386
MOD_GlcNHglycan	14	17	PF01048	0.608
MOD_GlcNHglycan	227	230	PF01048	0.481
MOD_GlcNHglycan	234	237	PF01048	0.475
MOD_GlcNHglycan	288	291	PF01048	0.380
MOD_GlcNHglycan	90	94	PF01048	0.466
MOD_GSK3_1	143	150	PF00069	0.403
MOD_GSK3_1	151	158	PF00069	0.418
MOD_GSK3_1	211	218	PF00069	0.468
MOD_GSK3_1	231	238	PF00069	0.189
MOD_GSK3_1	244	251	PF00069	0.495
MOD_GSK3_1	288	295	PF00069	0.413
MOD_GSK3_1	344	351	PF00069	0.443
MOD_GSK3_1	358	365	PF00069	0.401
MOD_GSK3_1	40	47	PF00069	0.582
MOD_GSK3_1	85	92	PF00069	0.459
MOD_GSK3_1	94	101	PF00069	0.450
MOD_LATS_1	38	44	PF00433	0.566
MOD_N-GLC_1	248	253	PF02516	0.680
MOD_NEK2_1	102	107	PF00069	0.502
MOD_NEK2_1	133	138	PF00069	0.468
MOD_NEK2_1	203	208	PF00069	0.446
MOD_NEK2_1	215	220	PF00069	0.399
MOD_NEK2_1	222	227	PF00069	0.257
MOD_NEK2_1	31	36	PF00069	0.489
MOD_PIKK_1	281	287	PF00454	0.429
MOD_PK_1	40	46	PF00069	0.491
MOD_PKA_2	117	123	PF00069	0.530
MOD_PKA_2	362	368	PF00069	0.500
MOD_PKA_2	44	50	PF00069	0.573
MOD_PKA_2	9	15	PF00069	0.580
MOD_PKB_1	316	324	PF00069	0.660
MOD_Plk_1	211	217	PF00069	0.500
MOD_Plk_1	222	228	PF00069	0.348
MOD_Plk_1	281	287	PF00069	0.440
MOD_Plk_1	292	298	PF00069	0.340
MOD_Plk_4	151	157	PF00069	0.397
MOD_Plk_4	203	209	PF00069	0.476
MOD_Plk_4	222	228	PF00069	0.250
MOD_Plk_4	235	241	PF00069	0.509
MOD_Plk_4	296	302	PF00069	0.424
MOD_Plk_4	31	37	PF00069	0.458
MOD_Plk_4	336	342	PF00069	0.497
MOD_Plk_4	348	354	PF00069	0.354
MOD_Plk_4	373	379	PF00069	0.532
MOD_Plk_4	73	79	PF00069	0.503
MOD_Plk_4	98	104	PF00069	0.514
MOD_ProDKin_1	135	141	PF00069	0.411
MOD_ProDKin_1	180	186	PF00069	0.576
MOD_ProDKin_1	20	26	PF00069	0.578
MOD_ProDKin_1	271	277	PF00069	0.496
MOD_ProDKin_1	94	100	PF00069	0.496
MOD_SUMO_rev_2	136	144	PF00179	0.487
MOD_SUMO_rev_2	158	163	PF00179	0.547
TRG_ENDOCYTIC_2	227	230	PF00928	0.541
TRG_ER_diArg_1	316	318	PF00400	0.629
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAQ1	Leptomonas seymouri	80%	100%
A0A0S4JA64	Bodo saltans	23%	66%
A0A1X0P3H5	Trypanosomatidae	49%	100%
A0A422MYE0	Trypanosoma rangeli	47%	100%
A4HPN2	Leishmania braziliensis	93%	100%
A4ID34	Leishmania infantum	100%	100%
D0A8I7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9ATE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q153	Leishmania major	97%	100%
V5B728	Trypanosoma cruzi	49%	100%