Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBB6_LEIDO

TriTrypDb:

LdBPK_363980.1 , LdCL_360046800 , LDHU3_36.5330

Length:

967

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XBB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBB6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.338
CLV_C14_Caspase3-7	448	452	PF00656	0.619
CLV_C14_Caspase3-7	514	518	PF00656	0.512
CLV_C14_Caspase3-7	576	580	PF00656	0.504
CLV_C14_Caspase3-7	855	859	PF00656	0.588
CLV_NRD_NRD_1	147	149	PF00675	0.509
CLV_NRD_NRD_1	476	478	PF00675	0.486
CLV_NRD_NRD_1	590	592	PF00675	0.477
CLV_NRD_NRD_1	593	595	PF00675	0.503
CLV_NRD_NRD_1	61	63	PF00675	0.474
CLV_NRD_NRD_1	719	721	PF00675	0.656
CLV_NRD_NRD_1	738	740	PF00675	0.441
CLV_NRD_NRD_1	743	745	PF00675	0.470
CLV_NRD_NRD_1	79	81	PF00675	0.498
CLV_NRD_NRD_1	863	865	PF00675	0.628
CLV_NRD_NRD_1	955	957	PF00675	0.457
CLV_NRD_NRD_1	961	963	PF00675	0.502
CLV_PCSK_FUR_1	591	595	PF00082	0.557
CLV_PCSK_KEX2_1	147	149	PF00082	0.509
CLV_PCSK_KEX2_1	590	592	PF00082	0.481
CLV_PCSK_KEX2_1	593	595	PF00082	0.508
CLV_PCSK_KEX2_1	61	63	PF00082	0.440
CLV_PCSK_KEX2_1	719	721	PF00082	0.656
CLV_PCSK_KEX2_1	737	739	PF00082	0.455
CLV_PCSK_KEX2_1	79	81	PF00082	0.526
CLV_PCSK_KEX2_1	863	865	PF00082	0.628
CLV_PCSK_KEX2_1	955	957	PF00082	0.457
CLV_PCSK_PC7_1	715	721	PF00082	0.441
CLV_PCSK_SKI1_1	181	185	PF00082	0.647
CLV_PCSK_SKI1_1	429	433	PF00082	0.491
CLV_PCSK_SKI1_1	45	49	PF00082	0.341
CLV_PCSK_SKI1_1	478	482	PF00082	0.488
CLV_PCSK_SKI1_1	486	490	PF00082	0.406
CLV_PCSK_SKI1_1	739	743	PF00082	0.543
CLV_PCSK_SKI1_1	754	758	PF00082	0.403
CLV_PCSK_SKI1_1	776	780	PF00082	0.559
DEG_APCC_DBOX_1	319	327	PF00400	0.459
DEG_APCC_DBOX_1	485	493	PF00400	0.417
DEG_Nend_UBRbox_1	1	4	PF02207	0.536
DEG_SCF_TRCP1_1	176	182	PF00400	0.689
DEG_SCF_TRCP1_1	514	519	PF00400	0.515
DEG_SPOP_SBC_1	216	220	PF00917	0.624
DEG_SPOP_SBC_1	626	630	PF00917	0.467
DOC_CKS1_1	850	855	PF01111	0.571
DOC_CYCLIN_RxL_1	42	51	PF00134	0.352
DOC_CYCLIN_RxL_1	483	494	PF00134	0.427
DOC_CYCLIN_RxL_1	770	783	PF00134	0.557
DOC_CYCLIN_yCln2_LP_2	847	853	PF00134	0.572
DOC_MAPK_gen_1	147	153	PF00069	0.536
DOC_MAPK_MEF2A_6	35	43	PF00069	0.323
DOC_MAPK_MEF2A_6	99	108	PF00069	0.416
DOC_MAPK_RevD_3	944	957	PF00069	0.561
DOC_PP2B_LxvP_1	205	208	PF13499	0.625
DOC_PP2B_LxvP_1	293	296	PF13499	0.574
DOC_PP2B_LxvP_1	920	923	PF13499	0.684
DOC_PP4_FxxP_1	124	127	PF00568	0.405
DOC_USP7_MATH_1	208	212	PF00917	0.787
DOC_USP7_MATH_1	216	220	PF00917	0.676
DOC_USP7_MATH_1	268	272	PF00917	0.676
DOC_USP7_MATH_1	281	285	PF00917	0.702
DOC_USP7_MATH_1	302	306	PF00917	0.572
DOC_USP7_MATH_1	447	451	PF00917	0.699
DOC_USP7_MATH_1	531	535	PF00917	0.593
DOC_USP7_MATH_1	789	793	PF00917	0.647
DOC_USP7_MATH_1	796	800	PF00917	0.682
DOC_USP7_MATH_1	829	833	PF00917	0.615
DOC_USP7_MATH_1	887	891	PF00917	0.611
DOC_USP7_MATH_1	927	931	PF00917	0.677
DOC_USP7_MATH_1	939	943	PF00917	0.558
DOC_USP7_MATH_2	536	542	PF00917	0.517
DOC_WW_Pin1_4	135	140	PF00397	0.390
DOC_WW_Pin1_4	185	190	PF00397	0.594
DOC_WW_Pin1_4	197	202	PF00397	0.584
DOC_WW_Pin1_4	23	28	PF00397	0.370
DOC_WW_Pin1_4	261	266	PF00397	0.682
DOC_WW_Pin1_4	300	305	PF00397	0.611
DOC_WW_Pin1_4	386	391	PF00397	0.579
DOC_WW_Pin1_4	507	512	PF00397	0.514
DOC_WW_Pin1_4	790	795	PF00397	0.627
DOC_WW_Pin1_4	825	830	PF00397	0.640
DOC_WW_Pin1_4	837	842	PF00397	0.567
DOC_WW_Pin1_4	846	851	PF00397	0.734
DOC_WW_Pin1_4	879	884	PF00397	0.625
DOC_WW_Pin1_4	923	928	PF00397	0.615
LIG_14-3-3_CanoR_1	185	189	PF00244	0.616
LIG_14-3-3_CanoR_1	2	10	PF00244	0.459
LIG_14-3-3_CanoR_1	279	289	PF00244	0.623
LIG_14-3-3_CanoR_1	347	353	PF00244	0.441
LIG_14-3-3_CanoR_1	831	838	PF00244	0.656
LIG_14-3-3_CanoR_1	897	906	PF00244	0.649
LIG_14-3-3_CanoR_1	907	914	PF00244	0.552
LIG_14-3-3_CanoR_1	929	938	PF00244	0.683
LIG_Actin_WH2_2	286	303	PF00022	0.566
LIG_Actin_WH2_2	481	498	PF00022	0.413
LIG_APCC_ABBA_1	408	413	PF00400	0.477
LIG_APCC_ABBA_1	509	514	PF00400	0.520
LIG_eIF4E_1	100	106	PF01652	0.336
LIG_eIF4E_1	313	319	PF01652	0.527
LIG_FHA_1	198	204	PF00498	0.566
LIG_FHA_1	42	48	PF00498	0.368
LIG_FHA_1	566	572	PF00498	0.480
LIG_FHA_1	671	677	PF00498	0.490
LIG_FHA_1	73	79	PF00498	0.405
LIG_FHA_1	755	761	PF00498	0.551
LIG_FHA_1	842	848	PF00498	0.607
LIG_FHA_1	909	915	PF00498	0.692
LIG_FHA_2	628	634	PF00498	0.435
LIG_FHA_2	850	856	PF00498	0.693
LIG_FHA_2	897	903	PF00498	0.604
LIG_GBD_Chelix_1	570	578	PF00786	0.465
LIG_LIR_Apic_2	123	127	PF02991	0.393
LIG_LIR_Apic_2	836	841	PF02991	0.568
LIG_LIR_Gen_1	524	531	PF02991	0.599
LIG_LIR_Nem_3	29	34	PF02991	0.361
LIG_LIR_Nem_3	524	529	PF02991	0.600
LIG_NRBOX	682	688	PF00104	0.426
LIG_PDZ_Class_3	962	967	PF00595	0.557
LIG_Pex14_2	120	124	PF04695	0.394
LIG_SH2_CRK	838	842	PF00017	0.670
LIG_SH2_STAP1	421	425	PF00017	0.417
LIG_SH2_STAP1	458	462	PF00017	0.553
LIG_SH2_STAT5	100	103	PF00017	0.368
LIG_SH2_STAT5	109	112	PF00017	0.291
LIG_SH2_STAT5	313	316	PF00017	0.553
LIG_SH2_STAT5	40	43	PF00017	0.294
LIG_SH3_2	201	206	PF14604	0.599
LIG_SH3_3	124	130	PF00018	0.395
LIG_SH3_3	198	204	PF00018	0.599
LIG_SH3_3	220	226	PF00018	0.525
LIG_SH3_3	847	853	PF00018	0.654
LIG_SUMO_SIM_anti_2	680	688	PF11976	0.491
LIG_SUMO_SIM_par_1	140	146	PF11976	0.446
LIG_SUMO_SIM_par_1	488	494	PF11976	0.441
LIG_SUMO_SIM_par_1	568	576	PF11976	0.464
LIG_SUMO_SIM_par_1	944	949	PF11976	0.490
LIG_TRAF2_1	457	460	PF00917	0.495
LIG_TRAF2_1	649	652	PF00917	0.460
LIG_TRAF2_1	699	702	PF00917	0.528
LIG_TYR_ITIM	107	112	PF00017	0.317
LIG_TYR_ITIM	38	43	PF00017	0.314
MOD_CDC14_SPxK_1	510	513	PF00782	0.524
MOD_CDC14_SPxK_1	926	929	PF00782	0.651
MOD_CDK_SPK_2	261	266	PF00069	0.625
MOD_CDK_SPxK_1	507	513	PF00069	0.516
MOD_CDK_SPxK_1	825	831	PF00069	0.673
MOD_CDK_SPxK_1	923	929	PF00069	0.646
MOD_CDK_SPxxK_3	23	30	PF00069	0.355
MOD_CDK_SPxxK_3	790	797	PF00069	0.569
MOD_CK1_1	138	144	PF00069	0.383
MOD_CK1_1	154	160	PF00069	0.583
MOD_CK1_1	188	194	PF00069	0.613
MOD_CK1_1	215	221	PF00069	0.600
MOD_CK1_1	261	267	PF00069	0.628
MOD_CK1_1	303	309	PF00069	0.532
MOD_CK1_1	445	451	PF00069	0.576
MOD_CK1_1	494	500	PF00069	0.525
MOD_CK1_1	524	530	PF00069	0.559
MOD_CK1_1	636	642	PF00069	0.474
MOD_CK1_1	655	661	PF00069	0.326
MOD_CK1_1	72	78	PF00069	0.359
MOD_CK1_1	783	789	PF00069	0.587
MOD_CK1_1	836	842	PF00069	0.707
MOD_CK1_1	849	855	PF00069	0.584
MOD_CK1_1	892	898	PF00069	0.646
MOD_CK1_1	930	936	PF00069	0.625
MOD_CK2_1	281	287	PF00069	0.624
MOD_CK2_1	730	736	PF00069	0.550
MOD_CK2_1	752	758	PF00069	0.547
MOD_CK2_1	896	902	PF00069	0.606
MOD_CK2_1	946	952	PF00069	0.529
MOD_GlcNHglycan	163	166	PF01048	0.609
MOD_GlcNHglycan	176	179	PF01048	0.742
MOD_GlcNHglycan	214	217	PF01048	0.608
MOD_GlcNHglycan	236	239	PF01048	0.611
MOD_GlcNHglycan	283	286	PF01048	0.634
MOD_GlcNHglycan	348	351	PF01048	0.529
MOD_GlcNHglycan	451	454	PF01048	0.564
MOD_GlcNHglycan	514	517	PF01048	0.666
MOD_GlcNHglycan	526	529	PF01048	0.506
MOD_GlcNHglycan	575	578	PF01048	0.452
MOD_GlcNHglycan	754	757	PF01048	0.543
MOD_GlcNHglycan	798	801	PF01048	0.709
MOD_GlcNHglycan	812	815	PF01048	0.718
MOD_GlcNHglycan	873	876	PF01048	0.644
MOD_GlcNHglycan	889	892	PF01048	0.585
MOD_GlcNHglycan	941	944	PF01048	0.640
MOD_GlcNHglycan	948	951	PF01048	0.478
MOD_GSK3_1	151	158	PF00069	0.577
MOD_GSK3_1	181	188	PF00069	0.618
MOD_GSK3_1	191	198	PF00069	0.619
MOD_GSK3_1	208	215	PF00069	0.514
MOD_GSK3_1	441	448	PF00069	0.513
MOD_GSK3_1	490	497	PF00069	0.453
MOD_GSK3_1	512	519	PF00069	0.576
MOD_GSK3_1	622	629	PF00069	0.474
MOD_GSK3_1	666	673	PF00069	0.465
MOD_GSK3_1	69	76	PF00069	0.364
MOD_GSK3_1	779	786	PF00069	0.703
MOD_GSK3_1	796	803	PF00069	0.516
MOD_GSK3_1	82	89	PF00069	0.371
MOD_GSK3_1	825	832	PF00069	0.786
MOD_GSK3_1	833	840	PF00069	0.645
MOD_GSK3_1	879	886	PF00069	0.676
MOD_GSK3_1	889	896	PF00069	0.595
MOD_GSK3_1	923	930	PF00069	0.654
MOD_LATS_1	325	331	PF00433	0.485
MOD_LATS_1	869	875	PF00433	0.642
MOD_N-GLC_1	69	74	PF02516	0.366
MOD_N-GLC_1	764	769	PF02516	0.622
MOD_N-GLC_2	551	553	PF02516	0.405
MOD_NEK2_1	209	214	PF00069	0.622
MOD_NEK2_1	332	337	PF00069	0.482
MOD_NEK2_1	346	351	PF00069	0.430
MOD_NEK2_1	370	375	PF00069	0.448
MOD_NEK2_1	4	9	PF00069	0.469
MOD_NEK2_1	41	46	PF00069	0.438
MOD_NEK2_1	488	493	PF00069	0.429
MOD_NEK2_1	495	500	PF00069	0.465
MOD_NEK2_1	529	534	PF00069	0.639
MOD_NEK2_1	666	671	PF00069	0.459
MOD_NEK2_1	73	78	PF00069	0.390
MOD_NEK2_1	779	784	PF00069	0.567
MOD_NEK2_1	946	951	PF00069	0.610
MOD_NEK2_2	348	353	PF00069	0.457
MOD_PIKK_1	311	317	PF00454	0.630
MOD_PIKK_1	327	333	PF00454	0.400
MOD_PIKK_1	414	420	PF00454	0.505
MOD_PIKK_1	603	609	PF00454	0.564
MOD_PIKK_1	650	656	PF00454	0.493
MOD_PIKK_1	759	765	PF00454	0.530
MOD_PIKK_1	803	809	PF00454	0.643
MOD_PIKK_1	86	92	PF00454	0.409
MOD_PKA_1	61	67	PF00069	0.517
MOD_PKA_2	184	190	PF00069	0.615
MOD_PKA_2	209	215	PF00069	0.623
MOD_PKA_2	255	261	PF00069	0.667
MOD_PKA_2	337	343	PF00069	0.499
MOD_PKA_2	346	352	PF00069	0.463
MOD_PKA_2	495	501	PF00069	0.460
MOD_PKA_2	512	518	PF00069	0.575
MOD_PKA_2	538	544	PF00069	0.495
MOD_PKA_2	565	571	PF00069	0.481
MOD_PKA_2	61	67	PF00069	0.411
MOD_PKA_2	636	642	PF00069	0.468
MOD_PKA_2	693	699	PF00069	0.535
MOD_PKA_2	803	809	PF00069	0.643
MOD_PKA_2	830	836	PF00069	0.677
MOD_PKA_2	896	902	PF00069	0.645
MOD_PKA_2	928	934	PF00069	0.685
MOD_Plk_1	269	275	PF00069	0.633
MOD_Plk_1	370	376	PF00069	0.524
MOD_Plk_1	403	409	PF00069	0.607
MOD_Plk_1	421	427	PF00069	0.313
MOD_Plk_1	458	464	PF00069	0.544
MOD_Plk_1	633	639	PF00069	0.478
MOD_Plk_1	69	75	PF00069	0.365
MOD_Plk_4	138	144	PF00069	0.382
MOD_Plk_4	269	275	PF00069	0.633
MOD_Plk_4	295	301	PF00069	0.643
MOD_Plk_4	4	10	PF00069	0.426
MOD_Plk_4	833	839	PF00069	0.635
MOD_ProDKin_1	135	141	PF00069	0.383
MOD_ProDKin_1	185	191	PF00069	0.593
MOD_ProDKin_1	197	203	PF00069	0.585
MOD_ProDKin_1	23	29	PF00069	0.374
MOD_ProDKin_1	261	267	PF00069	0.682
MOD_ProDKin_1	300	306	PF00069	0.605
MOD_ProDKin_1	386	392	PF00069	0.576
MOD_ProDKin_1	507	513	PF00069	0.516
MOD_ProDKin_1	790	796	PF00069	0.628
MOD_ProDKin_1	825	831	PF00069	0.640
MOD_ProDKin_1	837	843	PF00069	0.570
MOD_ProDKin_1	846	852	PF00069	0.735
MOD_ProDKin_1	879	885	PF00069	0.620
MOD_ProDKin_1	923	929	PF00069	0.620
MOD_SUMO_for_1	357	360	PF00179	0.521
TRG_DiLeu_BaEn_1	682	687	PF01217	0.492
TRG_DiLeu_BaEn_1	861	866	PF01217	0.649
TRG_DiLeu_BaLyEn_6	942	947	PF01217	0.499
TRG_DiLeu_LyEn_5	861	866	PF01217	0.649
TRG_ENDOCYTIC_2	109	112	PF00928	0.321
TRG_ENDOCYTIC_2	31	34	PF00928	0.343
TRG_ENDOCYTIC_2	40	43	PF00928	0.314
TRG_ER_diArg_1	147	149	PF00400	0.452
TRG_ER_diArg_1	590	593	PF00400	0.493
TRG_ER_diArg_1	718	720	PF00400	0.424
TRG_ER_diArg_1	737	739	PF00400	0.610
TRG_ER_diArg_1	78	80	PF00400	0.409
TRG_ER_diArg_1	863	865	PF00400	0.696
TRG_NES_CRM1_1	33	46	PF08389	0.331
TRG_Pf-PMV_PEXEL_1	776	780	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	863	867	PF00026	0.649
TRG_Pf-PMV_PEXEL_1	907	912	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3T9	Leptomonas seymouri	39%	99%
A4HPP7	Leishmania braziliensis	67%	99%
A4ID17	Leishmania infantum	100%	100%
E9ATG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q136	Leishmania major	88%	97%