LeishMANIAdb
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Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Calponin-homology (CH) domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7XBB6_LEIDO
TriTrypDb:
LdBPK_363980.1 , LdCL_360046800 , LDHU3_36.5330
Length:
967

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XBB6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBB6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 33 37 PF00656 0.338
CLV_C14_Caspase3-7 448 452 PF00656 0.619
CLV_C14_Caspase3-7 514 518 PF00656 0.512
CLV_C14_Caspase3-7 576 580 PF00656 0.504
CLV_C14_Caspase3-7 855 859 PF00656 0.588
CLV_NRD_NRD_1 147 149 PF00675 0.509
CLV_NRD_NRD_1 476 478 PF00675 0.486
CLV_NRD_NRD_1 590 592 PF00675 0.477
CLV_NRD_NRD_1 593 595 PF00675 0.503
CLV_NRD_NRD_1 61 63 PF00675 0.474
CLV_NRD_NRD_1 719 721 PF00675 0.656
CLV_NRD_NRD_1 738 740 PF00675 0.441
CLV_NRD_NRD_1 743 745 PF00675 0.470
CLV_NRD_NRD_1 79 81 PF00675 0.498
CLV_NRD_NRD_1 863 865 PF00675 0.628
CLV_NRD_NRD_1 955 957 PF00675 0.457
CLV_NRD_NRD_1 961 963 PF00675 0.502
CLV_PCSK_FUR_1 591 595 PF00082 0.557
CLV_PCSK_KEX2_1 147 149 PF00082 0.509
CLV_PCSK_KEX2_1 590 592 PF00082 0.481
CLV_PCSK_KEX2_1 593 595 PF00082 0.508
CLV_PCSK_KEX2_1 61 63 PF00082 0.440
CLV_PCSK_KEX2_1 719 721 PF00082 0.656
CLV_PCSK_KEX2_1 737 739 PF00082 0.455
CLV_PCSK_KEX2_1 79 81 PF00082 0.526
CLV_PCSK_KEX2_1 863 865 PF00082 0.628
CLV_PCSK_KEX2_1 955 957 PF00082 0.457
CLV_PCSK_PC7_1 715 721 PF00082 0.441
CLV_PCSK_SKI1_1 181 185 PF00082 0.647
CLV_PCSK_SKI1_1 429 433 PF00082 0.491
CLV_PCSK_SKI1_1 45 49 PF00082 0.341
CLV_PCSK_SKI1_1 478 482 PF00082 0.488
CLV_PCSK_SKI1_1 486 490 PF00082 0.406
CLV_PCSK_SKI1_1 739 743 PF00082 0.543
CLV_PCSK_SKI1_1 754 758 PF00082 0.403
CLV_PCSK_SKI1_1 776 780 PF00082 0.559
DEG_APCC_DBOX_1 319 327 PF00400 0.459
DEG_APCC_DBOX_1 485 493 PF00400 0.417
DEG_Nend_UBRbox_1 1 4 PF02207 0.536
DEG_SCF_TRCP1_1 176 182 PF00400 0.689
DEG_SCF_TRCP1_1 514 519 PF00400 0.515
DEG_SPOP_SBC_1 216 220 PF00917 0.624
DEG_SPOP_SBC_1 626 630 PF00917 0.467
DOC_CKS1_1 850 855 PF01111 0.571
DOC_CYCLIN_RxL_1 42 51 PF00134 0.352
DOC_CYCLIN_RxL_1 483 494 PF00134 0.427
DOC_CYCLIN_RxL_1 770 783 PF00134 0.557
DOC_CYCLIN_yCln2_LP_2 847 853 PF00134 0.572
DOC_MAPK_gen_1 147 153 PF00069 0.536
DOC_MAPK_MEF2A_6 35 43 PF00069 0.323
DOC_MAPK_MEF2A_6 99 108 PF00069 0.416
DOC_MAPK_RevD_3 944 957 PF00069 0.561
DOC_PP2B_LxvP_1 205 208 PF13499 0.625
DOC_PP2B_LxvP_1 293 296 PF13499 0.574
DOC_PP2B_LxvP_1 920 923 PF13499 0.684
DOC_PP4_FxxP_1 124 127 PF00568 0.405
DOC_USP7_MATH_1 208 212 PF00917 0.787
DOC_USP7_MATH_1 216 220 PF00917 0.676
DOC_USP7_MATH_1 268 272 PF00917 0.676
DOC_USP7_MATH_1 281 285 PF00917 0.702
DOC_USP7_MATH_1 302 306 PF00917 0.572
DOC_USP7_MATH_1 447 451 PF00917 0.699
DOC_USP7_MATH_1 531 535 PF00917 0.593
DOC_USP7_MATH_1 789 793 PF00917 0.647
DOC_USP7_MATH_1 796 800 PF00917 0.682
DOC_USP7_MATH_1 829 833 PF00917 0.615
DOC_USP7_MATH_1 887 891 PF00917 0.611
DOC_USP7_MATH_1 927 931 PF00917 0.677
DOC_USP7_MATH_1 939 943 PF00917 0.558
DOC_USP7_MATH_2 536 542 PF00917 0.517
DOC_WW_Pin1_4 135 140 PF00397 0.390
DOC_WW_Pin1_4 185 190 PF00397 0.594
DOC_WW_Pin1_4 197 202 PF00397 0.584
DOC_WW_Pin1_4 23 28 PF00397 0.370
DOC_WW_Pin1_4 261 266 PF00397 0.682
DOC_WW_Pin1_4 300 305 PF00397 0.611
DOC_WW_Pin1_4 386 391 PF00397 0.579
DOC_WW_Pin1_4 507 512 PF00397 0.514
DOC_WW_Pin1_4 790 795 PF00397 0.627
DOC_WW_Pin1_4 825 830 PF00397 0.640
DOC_WW_Pin1_4 837 842 PF00397 0.567
DOC_WW_Pin1_4 846 851 PF00397 0.734
DOC_WW_Pin1_4 879 884 PF00397 0.625
DOC_WW_Pin1_4 923 928 PF00397 0.615
LIG_14-3-3_CanoR_1 185 189 PF00244 0.616
LIG_14-3-3_CanoR_1 2 10 PF00244 0.459
LIG_14-3-3_CanoR_1 279 289 PF00244 0.623
LIG_14-3-3_CanoR_1 347 353 PF00244 0.441
LIG_14-3-3_CanoR_1 831 838 PF00244 0.656
LIG_14-3-3_CanoR_1 897 906 PF00244 0.649
LIG_14-3-3_CanoR_1 907 914 PF00244 0.552
LIG_14-3-3_CanoR_1 929 938 PF00244 0.683
LIG_Actin_WH2_2 286 303 PF00022 0.566
LIG_Actin_WH2_2 481 498 PF00022 0.413
LIG_APCC_ABBA_1 408 413 PF00400 0.477
LIG_APCC_ABBA_1 509 514 PF00400 0.520
LIG_eIF4E_1 100 106 PF01652 0.336
LIG_eIF4E_1 313 319 PF01652 0.527
LIG_FHA_1 198 204 PF00498 0.566
LIG_FHA_1 42 48 PF00498 0.368
LIG_FHA_1 566 572 PF00498 0.480
LIG_FHA_1 671 677 PF00498 0.490
LIG_FHA_1 73 79 PF00498 0.405
LIG_FHA_1 755 761 PF00498 0.551
LIG_FHA_1 842 848 PF00498 0.607
LIG_FHA_1 909 915 PF00498 0.692
LIG_FHA_2 628 634 PF00498 0.435
LIG_FHA_2 850 856 PF00498 0.693
LIG_FHA_2 897 903 PF00498 0.604
LIG_GBD_Chelix_1 570 578 PF00786 0.465
LIG_LIR_Apic_2 123 127 PF02991 0.393
LIG_LIR_Apic_2 836 841 PF02991 0.568
LIG_LIR_Gen_1 524 531 PF02991 0.599
LIG_LIR_Nem_3 29 34 PF02991 0.361
LIG_LIR_Nem_3 524 529 PF02991 0.600
LIG_NRBOX 682 688 PF00104 0.426
LIG_PDZ_Class_3 962 967 PF00595 0.557
LIG_Pex14_2 120 124 PF04695 0.394
LIG_SH2_CRK 838 842 PF00017 0.670
LIG_SH2_STAP1 421 425 PF00017 0.417
LIG_SH2_STAP1 458 462 PF00017 0.553
LIG_SH2_STAT5 100 103 PF00017 0.368
LIG_SH2_STAT5 109 112 PF00017 0.291
LIG_SH2_STAT5 313 316 PF00017 0.553
LIG_SH2_STAT5 40 43 PF00017 0.294
LIG_SH3_2 201 206 PF14604 0.599
LIG_SH3_3 124 130 PF00018 0.395
LIG_SH3_3 198 204 PF00018 0.599
LIG_SH3_3 220 226 PF00018 0.525
LIG_SH3_3 847 853 PF00018 0.654
LIG_SUMO_SIM_anti_2 680 688 PF11976 0.491
LIG_SUMO_SIM_par_1 140 146 PF11976 0.446
LIG_SUMO_SIM_par_1 488 494 PF11976 0.441
LIG_SUMO_SIM_par_1 568 576 PF11976 0.464
LIG_SUMO_SIM_par_1 944 949 PF11976 0.490
LIG_TRAF2_1 457 460 PF00917 0.495
LIG_TRAF2_1 649 652 PF00917 0.460
LIG_TRAF2_1 699 702 PF00917 0.528
LIG_TYR_ITIM 107 112 PF00017 0.317
LIG_TYR_ITIM 38 43 PF00017 0.314
MOD_CDC14_SPxK_1 510 513 PF00782 0.524
MOD_CDC14_SPxK_1 926 929 PF00782 0.651
MOD_CDK_SPK_2 261 266 PF00069 0.625
MOD_CDK_SPxK_1 507 513 PF00069 0.516
MOD_CDK_SPxK_1 825 831 PF00069 0.673
MOD_CDK_SPxK_1 923 929 PF00069 0.646
MOD_CDK_SPxxK_3 23 30 PF00069 0.355
MOD_CDK_SPxxK_3 790 797 PF00069 0.569
MOD_CK1_1 138 144 PF00069 0.383
MOD_CK1_1 154 160 PF00069 0.583
MOD_CK1_1 188 194 PF00069 0.613
MOD_CK1_1 215 221 PF00069 0.600
MOD_CK1_1 261 267 PF00069 0.628
MOD_CK1_1 303 309 PF00069 0.532
MOD_CK1_1 445 451 PF00069 0.576
MOD_CK1_1 494 500 PF00069 0.525
MOD_CK1_1 524 530 PF00069 0.559
MOD_CK1_1 636 642 PF00069 0.474
MOD_CK1_1 655 661 PF00069 0.326
MOD_CK1_1 72 78 PF00069 0.359
MOD_CK1_1 783 789 PF00069 0.587
MOD_CK1_1 836 842 PF00069 0.707
MOD_CK1_1 849 855 PF00069 0.584
MOD_CK1_1 892 898 PF00069 0.646
MOD_CK1_1 930 936 PF00069 0.625
MOD_CK2_1 281 287 PF00069 0.624
MOD_CK2_1 730 736 PF00069 0.550
MOD_CK2_1 752 758 PF00069 0.547
MOD_CK2_1 896 902 PF00069 0.606
MOD_CK2_1 946 952 PF00069 0.529
MOD_GlcNHglycan 163 166 PF01048 0.609
MOD_GlcNHglycan 176 179 PF01048 0.742
MOD_GlcNHglycan 214 217 PF01048 0.608
MOD_GlcNHglycan 236 239 PF01048 0.611
MOD_GlcNHglycan 283 286 PF01048 0.634
MOD_GlcNHglycan 348 351 PF01048 0.529
MOD_GlcNHglycan 451 454 PF01048 0.564
MOD_GlcNHglycan 514 517 PF01048 0.666
MOD_GlcNHglycan 526 529 PF01048 0.506
MOD_GlcNHglycan 575 578 PF01048 0.452
MOD_GlcNHglycan 754 757 PF01048 0.543
MOD_GlcNHglycan 798 801 PF01048 0.709
MOD_GlcNHglycan 812 815 PF01048 0.718
MOD_GlcNHglycan 873 876 PF01048 0.644
MOD_GlcNHglycan 889 892 PF01048 0.585
MOD_GlcNHglycan 941 944 PF01048 0.640
MOD_GlcNHglycan 948 951 PF01048 0.478
MOD_GSK3_1 151 158 PF00069 0.577
MOD_GSK3_1 181 188 PF00069 0.618
MOD_GSK3_1 191 198 PF00069 0.619
MOD_GSK3_1 208 215 PF00069 0.514
MOD_GSK3_1 441 448 PF00069 0.513
MOD_GSK3_1 490 497 PF00069 0.453
MOD_GSK3_1 512 519 PF00069 0.576
MOD_GSK3_1 622 629 PF00069 0.474
MOD_GSK3_1 666 673 PF00069 0.465
MOD_GSK3_1 69 76 PF00069 0.364
MOD_GSK3_1 779 786 PF00069 0.703
MOD_GSK3_1 796 803 PF00069 0.516
MOD_GSK3_1 82 89 PF00069 0.371
MOD_GSK3_1 825 832 PF00069 0.786
MOD_GSK3_1 833 840 PF00069 0.645
MOD_GSK3_1 879 886 PF00069 0.676
MOD_GSK3_1 889 896 PF00069 0.595
MOD_GSK3_1 923 930 PF00069 0.654
MOD_LATS_1 325 331 PF00433 0.485
MOD_LATS_1 869 875 PF00433 0.642
MOD_N-GLC_1 69 74 PF02516 0.366
MOD_N-GLC_1 764 769 PF02516 0.622
MOD_N-GLC_2 551 553 PF02516 0.405
MOD_NEK2_1 209 214 PF00069 0.622
MOD_NEK2_1 332 337 PF00069 0.482
MOD_NEK2_1 346 351 PF00069 0.430
MOD_NEK2_1 370 375 PF00069 0.448
MOD_NEK2_1 4 9 PF00069 0.469
MOD_NEK2_1 41 46 PF00069 0.438
MOD_NEK2_1 488 493 PF00069 0.429
MOD_NEK2_1 495 500 PF00069 0.465
MOD_NEK2_1 529 534 PF00069 0.639
MOD_NEK2_1 666 671 PF00069 0.459
MOD_NEK2_1 73 78 PF00069 0.390
MOD_NEK2_1 779 784 PF00069 0.567
MOD_NEK2_1 946 951 PF00069 0.610
MOD_NEK2_2 348 353 PF00069 0.457
MOD_PIKK_1 311 317 PF00454 0.630
MOD_PIKK_1 327 333 PF00454 0.400
MOD_PIKK_1 414 420 PF00454 0.505
MOD_PIKK_1 603 609 PF00454 0.564
MOD_PIKK_1 650 656 PF00454 0.493
MOD_PIKK_1 759 765 PF00454 0.530
MOD_PIKK_1 803 809 PF00454 0.643
MOD_PIKK_1 86 92 PF00454 0.409
MOD_PKA_1 61 67 PF00069 0.517
MOD_PKA_2 184 190 PF00069 0.615
MOD_PKA_2 209 215 PF00069 0.623
MOD_PKA_2 255 261 PF00069 0.667
MOD_PKA_2 337 343 PF00069 0.499
MOD_PKA_2 346 352 PF00069 0.463
MOD_PKA_2 495 501 PF00069 0.460
MOD_PKA_2 512 518 PF00069 0.575
MOD_PKA_2 538 544 PF00069 0.495
MOD_PKA_2 565 571 PF00069 0.481
MOD_PKA_2 61 67 PF00069 0.411
MOD_PKA_2 636 642 PF00069 0.468
MOD_PKA_2 693 699 PF00069 0.535
MOD_PKA_2 803 809 PF00069 0.643
MOD_PKA_2 830 836 PF00069 0.677
MOD_PKA_2 896 902 PF00069 0.645
MOD_PKA_2 928 934 PF00069 0.685
MOD_Plk_1 269 275 PF00069 0.633
MOD_Plk_1 370 376 PF00069 0.524
MOD_Plk_1 403 409 PF00069 0.607
MOD_Plk_1 421 427 PF00069 0.313
MOD_Plk_1 458 464 PF00069 0.544
MOD_Plk_1 633 639 PF00069 0.478
MOD_Plk_1 69 75 PF00069 0.365
MOD_Plk_4 138 144 PF00069 0.382
MOD_Plk_4 269 275 PF00069 0.633
MOD_Plk_4 295 301 PF00069 0.643
MOD_Plk_4 4 10 PF00069 0.426
MOD_Plk_4 833 839 PF00069 0.635
MOD_ProDKin_1 135 141 PF00069 0.383
MOD_ProDKin_1 185 191 PF00069 0.593
MOD_ProDKin_1 197 203 PF00069 0.585
MOD_ProDKin_1 23 29 PF00069 0.374
MOD_ProDKin_1 261 267 PF00069 0.682
MOD_ProDKin_1 300 306 PF00069 0.605
MOD_ProDKin_1 386 392 PF00069 0.576
MOD_ProDKin_1 507 513 PF00069 0.516
MOD_ProDKin_1 790 796 PF00069 0.628
MOD_ProDKin_1 825 831 PF00069 0.640
MOD_ProDKin_1 837 843 PF00069 0.570
MOD_ProDKin_1 846 852 PF00069 0.735
MOD_ProDKin_1 879 885 PF00069 0.620
MOD_ProDKin_1 923 929 PF00069 0.620
MOD_SUMO_for_1 357 360 PF00179 0.521
TRG_DiLeu_BaEn_1 682 687 PF01217 0.492
TRG_DiLeu_BaEn_1 861 866 PF01217 0.649
TRG_DiLeu_BaLyEn_6 942 947 PF01217 0.499
TRG_DiLeu_LyEn_5 861 866 PF01217 0.649
TRG_ENDOCYTIC_2 109 112 PF00928 0.321
TRG_ENDOCYTIC_2 31 34 PF00928 0.343
TRG_ENDOCYTIC_2 40 43 PF00928 0.314
TRG_ER_diArg_1 147 149 PF00400 0.452
TRG_ER_diArg_1 590 593 PF00400 0.493
TRG_ER_diArg_1 718 720 PF00400 0.424
TRG_ER_diArg_1 737 739 PF00400 0.610
TRG_ER_diArg_1 78 80 PF00400 0.409
TRG_ER_diArg_1 863 865 PF00400 0.696
TRG_NES_CRM1_1 33 46 PF08389 0.331
TRG_Pf-PMV_PEXEL_1 776 780 PF00026 0.560
TRG_Pf-PMV_PEXEL_1 863 867 PF00026 0.649
TRG_Pf-PMV_PEXEL_1 907 912 PF00026 0.556

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3T9 Leptomonas seymouri 39% 99%
A4HPP7 Leishmania braziliensis 67% 99%
A4ID17 Leishmania infantum 100% 100%
E9ATG1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4Q136 Leishmania major 88% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS