Class-E_vacuolar_protein-sorting_protein_24_(Vps2 4p)_putative/GeneDB:LmjF.36.3440

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Charged multivesicular body protein 3, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBB5_LEIDO

TriTrypDb:

LdBPK_363600.1 , LdCL_360043000 , LDHU3_36.4880

Length:

217

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000815	ESCRT III complex	3	1
GO:0005737	cytoplasm	2	1
GO:0005768	endosome	7	1
GO:0005770	late endosome	8	1
GO:0005771	multivesicular body	9	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0032991	protein-containing complex	1	1
GO:0036452	ESCRT complex	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0098796	membrane protein complex	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	2

Expansion

Sequence features

A0A3S7XBB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBB5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0007034	vacuolar transport	4	12
GO:0009987	cellular process	1	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0008104	protein localization	4	1
GO:0015031	protein transport	4	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0032509	endosome transport via multivesicular body sorting pathway	5	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0045324	late endosome to vacuole transport	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071985	multivesicular body sorting pathway	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.473
CLV_NRD_NRD_1	28	30	PF00675	0.277
CLV_NRD_NRD_1	39	41	PF00675	0.346
CLV_NRD_NRD_1	71	73	PF00675	0.346
CLV_PCSK_KEX2_1	39	41	PF00082	0.398
DOC_MAPK_gen_1	29	35	PF00069	0.340
DOC_MAPK_gen_1	37	47	PF00069	0.290
DOC_MAPK_MEF2A_6	40	49	PF00069	0.387
DOC_USP7_UBL2_3	46	50	PF12436	0.323
DOC_WW_Pin1_4	9	14	PF00397	0.559
LIG_14-3-3_CanoR_1	22	31	PF00244	0.316
LIG_14-3-3_CterR_2	215	217	PF00244	0.564
LIG_Actin_WH2_2	92	108	PF00022	0.315
LIG_FHA_1	19	25	PF00498	0.425
LIG_FHA_2	146	152	PF00498	0.337
LIG_FHA_2	158	164	PF00498	0.316
LIG_FHA_2	9	15	PF00498	0.571
LIG_LIR_Nem_3	209	214	PF02991	0.534
LIG_Pex14_2	4	8	PF04695	0.600
LIG_SH2_STAP1	79	83	PF00017	0.389
LIG_SxIP_EBH_1	182	194	PF03271	0.733
LIG_TRAF2_1	12	15	PF00917	0.492
LIG_TRAF2_1	198	201	PF00917	0.639
LIG_UBA3_1	111	120	PF00899	0.425
LIG_UBA3_1	128	133	PF00899	0.425
MOD_CK1_1	23	29	PF00069	0.416
MOD_CK2_1	145	151	PF00069	0.346
MOD_CK2_1	155	161	PF00069	0.261
MOD_CK2_1	8	14	PF00069	0.586
MOD_GlcNHglycan	101	104	PF01048	0.365
MOD_GSK3_1	101	108	PF00069	0.389
MOD_N-GLC_1	145	150	PF02516	0.304
MOD_NEK2_1	33	38	PF00069	0.416
MOD_NEK2_1	68	73	PF00069	0.461
MOD_NEK2_1	78	83	PF00069	0.320
MOD_NEK2_1	8	13	PF00069	0.671
MOD_NEK2_1	99	104	PF00069	0.347
MOD_NEK2_2	20	25	PF00069	0.417
MOD_PIKK_1	94	100	PF00454	0.350
MOD_PKA_1	106	112	PF00069	0.279
MOD_PKA_1	18	24	PF00069	0.409
MOD_Plk_1	145	151	PF00069	0.310
MOD_Plk_2-3	155	161	PF00069	0.361
MOD_Plk_4	114	120	PF00069	0.414
MOD_Plk_4	124	130	PF00069	0.391
MOD_ProDKin_1	9	15	PF00069	0.554
MOD_SUMO_rev_2	41	45	PF00179	0.320
TRG_DiLeu_BaEn_1	114	119	PF01217	0.389
TRG_DiLeu_BaEn_1	203	208	PF01217	0.587
TRG_ER_diArg_1	38	40	PF00400	0.398
TRG_ER_diArg_1	69	72	PF00400	0.330
TRG_NES_CRM1_1	110	123	PF08389	0.425
TRG_NES_CRM1_1	161	172	PF08389	0.389
TRG_Pf-PMV_PEXEL_1	22	27	PF00026	0.309
TRG_Pf-PMV_PEXEL_1	62	67	PF00026	0.293

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL91	Leptomonas seymouri	81%	100%
A0A0S4JKU7	Bodo saltans	53%	83%
A0A0S4JP11	Bodo saltans	33%	99%
A0A1X0P3A0	Trypanosomatidae	62%	100%
A0A1X0P5N6	Trypanosomatidae	32%	100%
A0A381ML17	Leishmania infantum	31%	100%
A0A3R7RGQ9	Trypanosoma rangeli	57%	100%
A0A3S5H7H9	Leishmania donovani	31%	100%
A4HFS1	Leishmania braziliensis	33%	100%
A4HPL1	Leishmania braziliensis	88%	100%
A4ID53	Leishmania infantum	100%	100%
D0A613	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D0A8K3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	99%
E9ADC5	Leishmania major	31%	100%
E9ATC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9AZ49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
O14296	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	94%
O43633	Homo sapiens	30%	98%
P36095	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	97%
P36108	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	94%
Q0WTY4	Arabidopsis thaliana	26%	98%
Q3SX42	Bos taurus	28%	100%
Q4Q174	Leishmania major	93%	100%
Q4R574	Macaca fascicularis	45%	98%
Q54DB1	Dictyostelium discoideum	26%	100%
Q54GK9	Dictyostelium discoideum	24%	100%
Q54P63	Dictyostelium discoideum	42%	100%
Q58CS7	Bos taurus	45%	98%
Q5BKM3	Xenopus tropicalis	43%	99%
Q5F3A2	Gallus gallus	28%	100%
Q5RAU5	Pongo abelii	46%	98%
Q5RAV2	Pongo abelii	28%	100%
Q5ZHN1	Gallus gallus	30%	99%
Q66IV6	Xenopus laevis	27%	100%
Q6DFS6	Xenopus tropicalis	30%	99%
Q6IP52	Xenopus laevis	30%	99%
Q6NRM7	Xenopus laevis	44%	99%
Q6NVL7	Xenopus tropicalis	28%	100%
Q6NXD2	Danio rerio	29%	100%
Q6NY88	Danio rerio	43%	98%
Q7SYR0	Xenopus laevis	27%	100%
Q7ZW25	Danio rerio	29%	99%
Q8BJF9	Mus musculus	28%	100%
Q8CGS4	Rattus norvegicus	45%	97%
Q941D5	Arabidopsis thaliana	26%	100%
Q9CQ10	Mus musculus	45%	97%
Q9DB34	Mus musculus	30%	98%
Q9FFB3	Arabidopsis thaliana	43%	95%
Q9LXH5	Arabidopsis thaliana	38%	100%
Q9SKI2	Arabidopsis thaliana	27%	96%
Q9UQN3	Homo sapiens	28%	100%
Q9Y3E7	Homo sapiens	46%	98%
V5DNK1	Trypanosoma cruzi	56%	67%