NUDIX_hydrolase_3_putative/GeneDB:LmjF.36.3660

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NUDIX hydrolase 3, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBB4_LEIDO

TriTrypDb:

LdBPK_363840.1 , LdCL_360045400 , LDHU3_36.5170

Length:

222

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3S7XBB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBB4

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016462	pyrophosphatase activity	5	6
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	6
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	6
GO:0047631	ADP-ribose diphosphatase activity	6	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	73	75	PF00675	0.309
CLV_PCSK_KEX2_1	73	75	PF00082	0.335
CLV_PCSK_SKI1_1	185	189	PF00082	0.392
DEG_APCC_DBOX_1	6	14	PF00400	0.416
DEG_Nend_UBRbox_1	1	4	PF02207	0.435
DOC_ANK_TNKS_1	150	157	PF00023	0.342
DOC_CYCLIN_yCln2_LP_2	95	101	PF00134	0.309
DOC_PP2B_LxvP_1	177	180	PF13499	0.389
DOC_SPAK_OSR1_1	78	82	PF12202	0.286
DOC_USP7_MATH_1	89	93	PF00917	0.286

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P576	Leptomonas seymouri	64%	97%
A0A0S4JQK4	Bodo saltans	39%	91%
A0A1X0P4G7	Trypanosomatidae	43%	92%
A0A422N1K2	Trypanosoma rangeli	45%	92%
A4HPN3	Leishmania braziliensis	85%	100%
A4ID31	Leishmania infantum	99%	100%
D0A8I0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	90%
E9ATE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q01976	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	96%
Q4Q150	Leishmania major	94%	100%

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