NUDIX_hydrolase_3_putative/GeneDB:LmjF.36.3660

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NUDIX hydrolase 3, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XBB4_LEIDO

TriTrypDb:

LdBPK_363840.1 , LdCL_360045400 , LDHU3_36.5170

Length:

222

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XBB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBB4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019693	ribose phosphate metabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016462	pyrophosphatase activity	5	6
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	6
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	6
GO:0047631	ADP-ribose diphosphatase activity	6	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	73	75	PF00675	0.309
CLV_PCSK_KEX2_1	73	75	PF00082	0.335
CLV_PCSK_SKI1_1	185	189	PF00082	0.392
DEG_APCC_DBOX_1	6	14	PF00400	0.416
DEG_Nend_UBRbox_1	1	4	PF02207	0.435
DOC_ANK_TNKS_1	150	157	PF00023	0.342
DOC_CYCLIN_yCln2_LP_2	95	101	PF00134	0.309
DOC_PP2B_LxvP_1	177	180	PF13499	0.389
DOC_SPAK_OSR1_1	78	82	PF12202	0.286
DOC_USP7_MATH_1	89	93	PF00917	0.286
DOC_WW_Pin1_4	130	135	PF00397	0.359
DOC_WW_Pin1_4	46	51	PF00397	0.462
DOC_WW_Pin1_4	54	59	PF00397	0.417
LIG_14-3-3_CanoR_1	20	25	PF00244	0.401
LIG_14-3-3_CanoR_1	44	50	PF00244	0.500
LIG_14-3-3_CanoR_1	73	82	PF00244	0.443
LIG_Actin_WH2_2	3	19	PF00022	0.413
LIG_BRCT_BRCA1_1	75	79	PF00533	0.339
LIG_Clathr_ClatBox_1	149	153	PF01394	0.339
LIG_FHA_1	118	124	PF00498	0.284
LIG_FHA_2	211	217	PF00498	0.403
LIG_FHA_2	25	31	PF00498	0.362
LIG_FHA_2	6	12	PF00498	0.439
LIG_LIR_Gen_1	76	86	PF02991	0.284
LIG_LIR_Nem_3	76	82	PF02991	0.284
LIG_SH2_CRK	86	90	PF00017	0.249
LIG_SH2_STAT5	212	215	PF00017	0.423
LIG_SH2_STAT5	26	29	PF00017	0.444
LIG_SH2_STAT5	5	8	PF00017	0.443
LIG_SUMO_SIM_anti_2	172	178	PF11976	0.264
LIG_SUMO_SIM_anti_2	8	14	PF11976	0.416
LIG_SUMO_SIM_par_1	128	133	PF11976	0.312
LIG_TRAF2_2	164	169	PF00917	0.264
LIG_UBA3_1	177	185	PF00899	0.386
LIG_WRC_WIRS_1	211	216	PF05994	0.398
MOD_CK1_1	189	195	PF00069	0.538
MOD_CK2_1	210	216	PF00069	0.465
MOD_CK2_1	5	11	PF00069	0.494
MOD_GlcNHglycan	13	16	PF01048	0.375
MOD_GlcNHglycan	188	191	PF01048	0.358
MOD_GlcNHglycan	51	54	PF01048	0.565
MOD_GSK3_1	1	8	PF00069	0.489
MOD_GSK3_1	130	137	PF00069	0.351
MOD_GSK3_1	16	23	PF00069	0.389
MOD_GSK3_1	42	49	PF00069	0.487
MOD_N-GLC_1	106	111	PF02516	0.213
MOD_NEK2_1	1	6	PF00069	0.505
MOD_NEK2_1	142	147	PF00069	0.249
MOD_NEK2_1	16	21	PF00069	0.499
MOD_NEK2_1	24	29	PF00069	0.499
MOD_PIKK_1	106	112	PF00454	0.174
MOD_PIKK_1	179	185	PF00454	0.487
MOD_PKA_1	73	79	PF00069	0.448
MOD_PKA_2	43	49	PF00069	0.421
MOD_PKA_2	72	78	PF00069	0.443
MOD_Plk_4	1	7	PF00069	0.415
MOD_Plk_4	210	216	PF00069	0.347
MOD_ProDKin_1	130	136	PF00069	0.359
MOD_ProDKin_1	46	52	PF00069	0.463
MOD_ProDKin_1	54	60	PF00069	0.415
TRG_DiLeu_BaEn_2	117	123	PF01217	0.339
TRG_ENDOCYTIC_2	212	215	PF00928	0.328
TRG_ER_diArg_1	72	74	PF00400	0.309
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P576	Leptomonas seymouri	64%	97%
A0A0S4JQK4	Bodo saltans	39%	91%
A0A1X0P4G7	Trypanosomatidae	43%	92%
A0A422N1K2	Trypanosoma rangeli	45%	92%
A4HPN3	Leishmania braziliensis	85%	100%
A4ID31	Leishmania infantum	99%	100%
D0A8I0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	90%
E9ATE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q01976	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	96%
Q4Q150	Leishmania major	94%	100%
Q5RCY2	Pongo abelii	35%	100%
Q6AY63	Rattus norvegicus	36%	100%
Q9JKX6	Mus musculus	34%	100%
Q9P791	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	38%	100%
Q9UKK9	Homo sapiens	36%	100%
V5B9P3	Trypanosoma cruzi	48%	92%