Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XBA9_LEIDO

TriTrypDb:

LdBPK_363850.1 , LdCL_360045500 , LDHU3_36.5180

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XBA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBA9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.434
CLV_NRD_NRD_1	179	181	PF00675	0.414
CLV_NRD_NRD_1	186	188	PF00675	0.439
CLV_NRD_NRD_1	219	221	PF00675	0.502
CLV_NRD_NRD_1	338	340	PF00675	0.747
CLV_NRD_NRD_1	51	53	PF00675	0.668
CLV_NRD_NRD_1	59	61	PF00675	0.597
CLV_PCSK_KEX2_1	130	132	PF00082	0.440
CLV_PCSK_KEX2_1	138	140	PF00082	0.445
CLV_PCSK_KEX2_1	219	221	PF00082	0.502
CLV_PCSK_KEX2_1	51	53	PF00082	0.675
CLV_PCSK_KEX2_1	67	69	PF00082	0.700
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.440
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.751
CLV_PCSK_SKI1_1	130	134	PF00082	0.474
CLV_PCSK_SKI1_1	180	184	PF00082	0.425
DEG_APCC_DBOX_1	33	41	PF00400	0.609
DEG_Nend_Nbox_1	1	3	PF02207	0.598
DEG_SPOP_SBC_1	90	94	PF00917	0.697
DOC_MAPK_gen_1	187	193	PF00069	0.455
DOC_MAPK_gen_1	19	27	PF00069	0.710
DOC_PP1_RVXF_1	115	121	PF00149	0.560
DOC_PP1_RVXF_1	65	72	PF00149	0.659
DOC_PP2B_LxvP_1	272	275	PF13499	0.593
DOC_USP7_MATH_1	275	279	PF00917	0.611
DOC_USP7_MATH_1	292	296	PF00917	0.522
DOC_USP7_MATH_1	90	94	PF00917	0.789
DOC_USP7_UBL2_3	188	192	PF12436	0.455
DOC_USP7_UBL2_3	57	61	PF12436	0.680
DOC_WW_Pin1_4	111	116	PF00397	0.572
DOC_WW_Pin1_4	124	129	PF00397	0.487
DOC_WW_Pin1_4	262	267	PF00397	0.634
LIG_14-3-3_CanoR_1	117	121	PF00244	0.539
LIG_14-3-3_CanoR_1	131	135	PF00244	0.463
LIG_14-3-3_CanoR_1	219	227	PF00244	0.513
LIG_14-3-3_CanoR_1	45	53	PF00244	0.620
LIG_APCC_ABBAyCdc20_2	152	158	PF00400	0.429
LIG_BRCT_BRCA1_1	7	11	PF00533	0.600
LIG_FHA_1	131	137	PF00498	0.563
LIG_FHA_2	108	114	PF00498	0.710
LIG_FHA_2	207	213	PF00498	0.504
LIG_FHA_2	331	337	PF00498	0.588
LIG_FHA_2	92	98	PF00498	0.726
LIG_LIR_Gen_1	122	129	PF02991	0.606
LIG_LIR_Gen_1	153	164	PF02991	0.527
LIG_LIR_Gen_1	168	176	PF02991	0.326
LIG_LIR_Gen_1	248	257	PF02991	0.705
LIG_LIR_Gen_1	3	11	PF02991	0.547
LIG_LIR_Nem_3	119	123	PF02991	0.579
LIG_LIR_Nem_3	133	137	PF02991	0.410
LIG_LIR_Nem_3	146	150	PF02991	0.420
LIG_LIR_Nem_3	153	159	PF02991	0.259
LIG_LIR_Nem_3	168	172	PF02991	0.347
LIG_LIR_Nem_3	248	254	PF02991	0.598
LIG_LIR_Nem_3	3	7	PF02991	0.541
LIG_LIR_Nem_3	300	306	PF02991	0.576
LIG_Pex14_1	147	151	PF04695	0.477
LIG_Pex14_2	71	75	PF04695	0.648
LIG_Pex14_2	9	13	PF04695	0.459
LIG_SH2_CRK	137	141	PF00017	0.513
LIG_SH2_CRK	251	255	PF00017	0.638
LIG_SH2_GRB2like	164	167	PF00017	0.499
LIG_SH2_SRC	156	159	PF00017	0.479
LIG_SH2_STAT3	121	124	PF00017	0.694
LIG_SH2_STAT3	164	167	PF00017	0.499
LIG_SH2_STAT5	164	167	PF00017	0.499
LIG_SH2_STAT5	251	254	PF00017	0.753
LIG_SH3_3	96	102	PF00018	0.718
LIG_TRAF2_1	110	113	PF00917	0.599
LIG_TRAF2_1	210	213	PF00917	0.519
LIG_TYR_ITIM	249	254	PF00017	0.625
LIG_UBA3_1	293	301	PF00899	0.584
LIG_ULM_U2AF65_1	180	185	PF00076	0.418
MOD_CDC14_SPxK_1	127	130	PF00782	0.477
MOD_CDK_SPxK_1	111	117	PF00069	0.571
MOD_CDK_SPxK_1	124	130	PF00069	0.484
MOD_CDK_SPxxK_3	124	131	PF00069	0.503
MOD_CK1_1	250	256	PF00069	0.636
MOD_CK1_1	92	98	PF00069	0.652
MOD_CK2_1	107	113	PF00069	0.562
MOD_CK2_1	206	212	PF00069	0.498
MOD_CK2_1	292	298	PF00069	0.605
MOD_CK2_1	330	336	PF00069	0.774
MOD_CK2_1	92	98	PF00069	0.718
MOD_GlcNHglycan	158	162	PF01048	0.552
MOD_GlcNHglycan	290	293	PF01048	0.597
MOD_GlcNHglycan	31	34	PF01048	0.722
MOD_GlcNHglycan	85	88	PF01048	0.778
MOD_GSK3_1	107	114	PF00069	0.571
MOD_GSK3_1	288	295	PF00069	0.614
MOD_GSK3_1	3	10	PF00069	0.515
MOD_GSK3_1	306	313	PF00069	0.576
MOD_GSK3_1	85	92	PF00069	0.715
MOD_N-GLC_1	165	170	PF02516	0.472
MOD_NEK2_1	239	244	PF00069	0.719
MOD_NEK2_1	28	33	PF00069	0.697
MOD_NEK2_1	280	285	PF00069	0.715
MOD_NEK2_1	7	12	PF00069	0.547
MOD_OFUCOSY	44	49	PF10250	0.658
MOD_PIKK_1	310	316	PF00454	0.629
MOD_PKA_1	130	136	PF00069	0.485
MOD_PKA_2	116	122	PF00069	0.544
MOD_PKA_2	130	136	PF00069	0.465
MOD_PKA_2	218	224	PF00069	0.507
MOD_PKA_2	280	286	PF00069	0.751
MOD_PKB_1	308	316	PF00069	0.632
MOD_Plk_1	165	171	PF00069	0.470
MOD_Plk_1	193	199	PF00069	0.512
MOD_Plk_1	247	253	PF00069	0.580
MOD_Plk_4	116	122	PF00069	0.537
MOD_Plk_4	193	199	PF00069	0.512
MOD_Plk_4	239	245	PF00069	0.745
MOD_ProDKin_1	111	117	PF00069	0.571
MOD_ProDKin_1	124	130	PF00069	0.484
MOD_ProDKin_1	262	268	PF00069	0.633
MOD_SUMO_rev_2	295	302	PF00179	0.662
MOD_SUMO_rev_2	59	69	PF00179	0.733
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.662
TRG_ENDOCYTIC_2	137	140	PF00928	0.473
TRG_ENDOCYTIC_2	151	154	PF00928	0.455
TRG_ENDOCYTIC_2	156	159	PF00928	0.338
TRG_ENDOCYTIC_2	202	205	PF00928	0.448
TRG_ENDOCYTIC_2	251	254	PF00928	0.636
TRG_ER_diArg_1	137	139	PF00400	0.442
TRG_ER_diArg_1	307	310	PF00400	0.606
TRG_ER_diArg_1	51	53	PF00400	0.717
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	45	50	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4T7	Leptomonas seymouri	76%	100%
A0A1X0P4T0	Trypanosomatidae	78%	98%
A4HPN4	Leishmania braziliensis	85%	100%
A4ID30	Leishmania infantum	99%	100%
D0A8H9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9ATE8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q149	Leishmania major	93%	100%
V5BIQ3	Trypanosoma cruzi	78%	96%