Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP119

Species:

Leishmania donovani

UniProt:

A0A3S7XBA5_LEIDO

TriTrypDb:

LdBPK_363880.1 , LdCL_360045800 , LDHU3_36.5210

Length:

1075

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:0044611	nuclear pore inner ring	3	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3S7XBA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XBA5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.387
CLV_C14_Caspase3-7	357	361	PF00656	0.406
CLV_C14_Caspase3-7	384	388	PF00656	0.414
CLV_C14_Caspase3-7	425	429	PF00656	0.490
CLV_C14_Caspase3-7	559	563	PF00656	0.532
CLV_C14_Caspase3-7	994	998	PF00656	0.510
CLV_NRD_NRD_1	1064	1066	PF00675	0.454
CLV_NRD_NRD_1	143	145	PF00675	0.486
CLV_NRD_NRD_1	33	35	PF00675	0.509
CLV_NRD_NRD_1	667	669	PF00675	0.414
CLV_NRD_NRD_1	74	76	PF00675	0.547
CLV_NRD_NRD_1	89	91	PF00675	0.357
CLV_PCSK_KEX2_1	219	221	PF00082	0.455
CLV_PCSK_KEX2_1	302	304	PF00082	0.611
CLV_PCSK_KEX2_1	33	35	PF00082	0.509
CLV_PCSK_KEX2_1	667	669	PF00082	0.414
CLV_PCSK_KEX2_1	74	76	PF00082	0.547
CLV_PCSK_KEX2_1	89	91	PF00082	0.406
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.494
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.591
CLV_PCSK_SKI1_1	1037	1041	PF00082	0.467
CLV_PCSK_SKI1_1	45	49	PF00082	0.555
CLV_PCSK_SKI1_1	576	580	PF00082	0.503
CLV_PCSK_SKI1_1	627	631	PF00082	0.385
CLV_PCSK_SKI1_1	668	672	PF00082	0.469
CLV_PCSK_SKI1_1	761	765	PF00082	0.439
CLV_PCSK_SKI1_1	90	94	PF00082	0.442
DEG_APCC_DBOX_1	229	237	PF00400	0.450
DEG_APCC_DBOX_1	667	675	PF00400	0.400
DEG_APCC_DBOX_1	999	1007	PF00400	0.451
DEG_SPOP_SBC_1	359	363	PF00917	0.488
DEG_SPOP_SBC_1	720	724	PF00917	0.408
DOC_CYCLIN_RxL_1	83	96	PF00134	0.370
DOC_CYCLIN_yClb5_NLxxxL_5	808	817	PF00134	0.357
DOC_CYCLIN_yCln2_LP_2	462	468	PF00134	0.385
DOC_MAPK_gen_1	117	126	PF00069	0.519
DOC_MAPK_gen_1	228	236	PF00069	0.369
DOC_MAPK_gen_1	667	673	PF00069	0.395
DOC_MAPK_MEF2A_6	607	615	PF00069	0.510
DOC_MAPK_MEF2A_6	767	776	PF00069	0.373
DOC_MAPK_MEF2A_6	810	817	PF00069	0.374
DOC_PP1_RVXF_1	538	544	PF00149	0.454
DOC_PP1_RVXF_1	759	766	PF00149	0.378
DOC_PP1_RVXF_1	835	842	PF00149	0.350
DOC_PP1_RVXF_1	859	866	PF00149	0.505
DOC_PP1_RVXF_1	97	104	PF00149	0.511
DOC_PP2B_LxvP_1	813	816	PF13499	0.425
DOC_PP2B_LxvP_1	934	937	PF13499	0.390
DOC_PP4_FxxP_1	951	954	PF00568	0.475
DOC_USP7_MATH_1	128	132	PF00917	0.455
DOC_USP7_MATH_1	155	159	PF00917	0.509
DOC_USP7_MATH_1	3	7	PF00917	0.589
DOC_USP7_MATH_1	331	335	PF00917	0.514
DOC_USP7_MATH_1	359	363	PF00917	0.677
DOC_USP7_MATH_1	720	724	PF00917	0.503
DOC_USP7_MATH_1	739	743	PF00917	0.567
DOC_USP7_MATH_1	830	834	PF00917	0.413
DOC_USP7_UBL2_3	632	636	PF12436	0.404
DOC_WW_Pin1_4	10	15	PF00397	0.701
DOC_WW_Pin1_4	1018	1023	PF00397	0.437
DOC_WW_Pin1_4	214	219	PF00397	0.479
DOC_WW_Pin1_4	910	915	PF00397	0.372
DOC_WW_Pin1_4	967	972	PF00397	0.484
LIG_14-3-3_CanoR_1	117	126	PF00244	0.564
LIG_14-3-3_CanoR_1	220	226	PF00244	0.435
LIG_14-3-3_CanoR_1	239	244	PF00244	0.450
LIG_14-3-3_CanoR_1	303	308	PF00244	0.582
LIG_14-3-3_CanoR_1	33	41	PF00244	0.693
LIG_14-3-3_CanoR_1	474	482	PF00244	0.496
LIG_14-3-3_CanoR_1	488	496	PF00244	0.346
LIG_14-3-3_CanoR_1	645	651	PF00244	0.433
LIG_14-3-3_CanoR_1	761	766	PF00244	0.410
LIG_14-3-3_CanoR_1	785	791	PF00244	0.434
LIG_14-3-3_CanoR_1	810	816	PF00244	0.394
LIG_Actin_WH2_2	915	932	PF00022	0.404
LIG_APCC_ABBA_1	103	108	PF00400	0.499
LIG_APCC_ABBA_1	243	248	PF00400	0.476
LIG_APCC_ABBA_1	907	912	PF00400	0.357
LIG_APCC_ABBA_1	957	962	PF00400	0.453
LIG_Clathr_ClatBox_1	821	825	PF01394	0.380
LIG_FHA_1	119	125	PF00498	0.424
LIG_FHA_1	320	326	PF00498	0.553
LIG_FHA_1	341	347	PF00498	0.416
LIG_FHA_1	361	367	PF00498	0.311
LIG_FHA_1	391	397	PF00498	0.362
LIG_FHA_1	422	428	PF00498	0.381
LIG_FHA_1	504	510	PF00498	0.574
LIG_FHA_1	628	634	PF00498	0.452
LIG_FHA_1	680	686	PF00498	0.545
LIG_FHA_1	722	728	PF00498	0.476
LIG_FHA_1	921	927	PF00498	0.350
LIG_FHA_2	1048	1054	PF00498	0.420
LIG_FHA_2	107	113	PF00498	0.532
LIG_FHA_2	348	354	PF00498	0.491
LIG_FHA_2	754	760	PF00498	0.531
LIG_FHA_2	985	991	PF00498	0.497
LIG_GBD_Chelix_1	338	346	PF00786	0.364
LIG_GBD_Chelix_1	439	447	PF00786	0.327
LIG_GBD_Chelix_1	849	857	PF00786	0.455
LIG_GBD_Chelix_1	918	926	PF00786	0.449
LIG_IRF3_LxIS_1	446	453	PF10401	0.376
LIG_LIR_Apic_2	214	218	PF02991	0.434
LIG_LIR_Apic_2	593	598	PF02991	0.523
LIG_LIR_Apic_2	950	954	PF02991	0.385
LIG_LIR_Gen_1	390	397	PF02991	0.453
LIG_LIR_Gen_1	726	735	PF02991	0.524
LIG_LIR_Gen_1	764	772	PF02991	0.390
LIG_LIR_Gen_1	81	86	PF02991	0.378
LIG_LIR_Gen_1	962	971	PF02991	0.549
LIG_LIR_Gen_1	987	996	PF02991	0.392
LIG_LIR_Nem_3	22	27	PF02991	0.724
LIG_LIR_Nem_3	390	394	PF02991	0.357
LIG_LIR_Nem_3	499	505	PF02991	0.507
LIG_LIR_Nem_3	656	662	PF02991	0.407
LIG_LIR_Nem_3	726	731	PF02991	0.492
LIG_LIR_Nem_3	764	768	PF02991	0.381
LIG_LIR_Nem_3	81	85	PF02991	0.380
LIG_LIR_Nem_3	962	966	PF02991	0.475
LIG_LIR_Nem_3	987	992	PF02991	0.388
LIG_MYND_1	461	465	PF01753	0.479
LIG_NRBOX	567	573	PF00104	0.349
LIG_NRBOX	600	606	PF00104	0.412
LIG_PCNA_PIPBox_1	941	950	PF02747	0.415
LIG_PCNA_yPIPBox_3	564	576	PF02747	0.468
LIG_PDZ_Class_1	1070	1075	PF00595	0.567
LIG_PTB_Apo_2	47	54	PF02174	0.531
LIG_PTB_Apo_2	998	1005	PF02174	0.539
LIG_Rb_pABgroove_1	220	228	PF01858	0.418
LIG_Rb_pABgroove_1	579	587	PF01858	0.408
LIG_SH2_CRK	585	589	PF00017	0.359
LIG_SH2_CRK	595	599	PF00017	0.394
LIG_SH2_CRK	676	680	PF00017	0.401
LIG_SH2_CRK	702	706	PF00017	0.405
LIG_SH2_CRK	728	732	PF00017	0.386
LIG_SH2_CRK	82	86	PF00017	0.368
LIG_SH2_CRK	894	898	PF00017	0.449
LIG_SH2_GRB2like	52	55	PF00017	0.415
LIG_SH2_GRB2like	78	81	PF00017	0.389
LIG_SH2_GRB2like	881	884	PF00017	0.298
LIG_SH2_NCK_1	246	250	PF00017	0.380
LIG_SH2_SRC	221	224	PF00017	0.416
LIG_SH2_STAP1	585	589	PF00017	0.327
LIG_SH2_STAP1	681	685	PF00017	0.452
LIG_SH2_STAT3	454	457	PF00017	0.410
LIG_SH2_STAT5	100	103	PF00017	0.378
LIG_SH2_STAT5	114	117	PF00017	0.329
LIG_SH2_STAT5	215	218	PF00017	0.563
LIG_SH2_STAT5	221	224	PF00017	0.471
LIG_SH2_STAT5	232	235	PF00017	0.309
LIG_SH2_STAT5	397	400	PF00017	0.463
LIG_SH2_STAT5	454	457	PF00017	0.545
LIG_SH2_STAT5	52	55	PF00017	0.483
LIG_SH2_STAT5	665	668	PF00017	0.422
LIG_SH2_STAT5	681	684	PF00017	0.241
LIG_SH2_STAT5	78	81	PF00017	0.479
LIG_SH2_STAT5	881	884	PF00017	0.332
LIG_SH2_STAT5	947	950	PF00017	0.493
LIG_SH3_3	149	155	PF00018	0.344
LIG_SH3_3	953	959	PF00018	0.334
LIG_SH3_3	978	984	PF00018	0.488
LIG_SH3_3	99	105	PF00018	0.390
LIG_SUMO_SIM_anti_2	343	350	PF11976	0.446
LIG_SUMO_SIM_anti_2	649	656	PF11976	0.448
LIG_SUMO_SIM_anti_2	730	737	PF11976	0.384
LIG_SUMO_SIM_par_1	232	238	PF11976	0.448
LIG_SUMO_SIM_par_1	343	350	PF11976	0.395
LIG_SUMO_SIM_par_1	438	444	PF11976	0.332
LIG_SUMO_SIM_par_1	820	825	PF11976	0.376
LIG_SUMO_SIM_par_1	90	96	PF11976	0.375
LIG_TRAF2_1	19	22	PF00917	0.589
LIG_TRAF2_1	40	43	PF00917	0.551
LIG_TYR_ITIM	674	679	PF00017	0.402
LIG_UBA3_1	887	895	PF00899	0.370
LIG_WRC_WIRS_1	391	396	PF05994	0.447
LIG_WRC_WIRS_1	762	767	PF05994	0.390
LIG_WRC_WIRS_1	925	930	PF05994	0.386
LIG_WRC_WIRS_1	948	953	PF05994	0.545
LIG_WRC_WIRS_1	989	994	PF05994	0.415
MOD_CDC14_SPxK_1	217	220	PF00782	0.459
MOD_CDK_SPK_2	214	219	PF00069	0.479
MOD_CDK_SPxK_1	214	220	PF00069	0.477
MOD_CK1_1	1068	1074	PF00069	0.467
MOD_CK1_1	15	21	PF00069	0.617
MOD_CK1_1	247	253	PF00069	0.481
MOD_CK1_1	319	325	PF00069	0.565
MOD_CK1_1	361	367	PF00069	0.565
MOD_CK1_1	390	396	PF00069	0.463
MOD_CK1_1	422	428	PF00069	0.535
MOD_CK1_1	453	459	PF00069	0.478
MOD_CK1_1	491	497	PF00069	0.419
MOD_CK1_1	6	12	PF00069	0.707
MOD_CK1_1	64	70	PF00069	0.439
MOD_CK1_1	680	686	PF00069	0.388
MOD_CK1_1	689	695	PF00069	0.337
MOD_CK1_1	709	715	PF00069	0.227
MOD_CK1_1	742	748	PF00069	0.353
MOD_CK1_1	811	817	PF00069	0.416
MOD_CK2_1	16	22	PF00069	0.662
MOD_CK2_1	307	313	PF00069	0.546
MOD_CK2_1	347	353	PF00069	0.483
MOD_CK2_1	428	434	PF00069	0.581
MOD_CK2_1	511	517	PF00069	0.468
MOD_CK2_1	65	71	PF00069	0.448
MOD_CK2_1	713	719	PF00069	0.459
MOD_CK2_1	883	889	PF00069	0.474
MOD_Cter_Amidation	300	303	PF01082	0.538
MOD_GlcNHglycan	130	133	PF01048	0.392
MOD_GlcNHglycan	157	160	PF01048	0.384
MOD_GlcNHglycan	255	259	PF01048	0.552
MOD_GlcNHglycan	287	290	PF01048	0.577
MOD_GlcNHglycan	318	321	PF01048	0.501
MOD_GlcNHglycan	34	37	PF01048	0.685
MOD_GlcNHglycan	424	427	PF01048	0.509
MOD_GlcNHglycan	447	450	PF01048	0.440
MOD_GlcNHglycan	5	8	PF01048	0.569
MOD_GlcNHglycan	557	561	PF01048	0.458
MOD_GlcNHglycan	934	937	PF01048	0.404
MOD_GSK3_1	116	123	PF00069	0.429
MOD_GSK3_1	235	242	PF00069	0.478
MOD_GSK3_1	303	310	PF00069	0.491
MOD_GSK3_1	361	368	PF00069	0.646
MOD_GSK3_1	6	13	PF00069	0.683
MOD_GSK3_1	61	68	PF00069	0.525
MOD_GSK3_1	685	692	PF00069	0.422
MOD_GSK3_1	709	716	PF00069	0.486
MOD_GSK3_1	739	746	PF00069	0.430
MOD_GSK3_1	826	833	PF00069	0.460
MOD_GSK3_1	920	927	PF00069	0.504
MOD_GSK3_1	984	991	PF00069	0.441
MOD_LATS_1	625	631	PF00433	0.375
MOD_N-GLC_1	176	181	PF02516	0.463
MOD_N-GLC_1	239	244	PF02516	0.382
MOD_N-GLC_1	811	816	PF02516	0.370
MOD_NEK2_1	1033	1038	PF00069	0.514
MOD_NEK2_1	106	111	PF00069	0.547
MOD_NEK2_1	16	21	PF00069	0.607
MOD_NEK2_1	234	239	PF00069	0.397
MOD_NEK2_1	254	259	PF00069	0.233
MOD_NEK2_1	284	289	PF00069	0.454
MOD_NEK2_1	296	301	PF00069	0.545
MOD_NEK2_1	342	347	PF00069	0.400
MOD_NEK2_1	419	424	PF00069	0.509
MOD_NEK2_1	496	501	PF00069	0.428
MOD_NEK2_1	509	514	PF00069	0.410
MOD_NEK2_1	516	521	PF00069	0.242
MOD_NEK2_1	570	575	PF00069	0.334
MOD_NEK2_1	646	651	PF00069	0.478
MOD_NEK2_1	65	70	PF00069	0.425
MOD_NEK2_1	663	668	PF00069	0.356
MOD_NEK2_1	685	690	PF00069	0.425
MOD_NEK2_1	727	732	PF00069	0.418
MOD_NEK2_1	786	791	PF00069	0.412
MOD_NEK2_1	808	813	PF00069	0.401
MOD_NEK2_1	85	90	PF00069	0.297
MOD_NEK2_1	93	98	PF00069	0.466
MOD_NEK2_2	221	226	PF00069	0.469
MOD_PIKK_1	1065	1071	PF00454	0.502
MOD_PIKK_1	365	371	PF00454	0.606
MOD_PIKK_1	453	459	PF00454	0.405
MOD_PIKK_1	6	12	PF00454	0.625
MOD_PIKK_1	690	696	PF00454	0.490
MOD_PKA_1	1065	1071	PF00069	0.550
MOD_PKA_2	116	122	PF00069	0.529
MOD_PKA_2	138	144	PF00069	0.451
MOD_PKA_2	32	38	PF00069	0.657
MOD_PKA_2	473	479	PF00069	0.497
MOD_PKA_2	503	509	PF00069	0.569
MOD_PKA_2	866	872	PF00069	0.442
MOD_Plk_1	176	182	PF00069	0.423
MOD_Plk_1	239	245	PF00069	0.354
MOD_Plk_1	247	253	PF00069	0.395
MOD_Plk_1	381	387	PF00069	0.532
MOD_Plk_1	399	405	PF00069	0.301
MOD_Plk_1	491	497	PF00069	0.389
MOD_Plk_1	556	562	PF00069	0.526
MOD_Plk_1	686	692	PF00069	0.498
MOD_Plk_1	706	712	PF00069	0.232
MOD_Plk_1	742	748	PF00069	0.465
MOD_Plk_1	811	817	PF00069	0.407
MOD_Plk_1	883	889	PF00069	0.365
MOD_Plk_2-3	176	182	PF00069	0.413
MOD_Plk_2-3	713	719	PF00069	0.507
MOD_Plk_2-3	753	759	PF00069	0.409
MOD_Plk_4	1006	1012	PF00069	0.314
MOD_Plk_4	120	126	PF00069	0.377
MOD_Plk_4	148	154	PF00069	0.348
MOD_Plk_4	221	227	PF00069	0.398
MOD_Plk_4	239	245	PF00069	0.224
MOD_Plk_4	321	327	PF00069	0.527
MOD_Plk_4	332	338	PF00069	0.292
MOD_Plk_4	342	348	PF00069	0.321
MOD_Plk_4	387	393	PF00069	0.390
MOD_Plk_4	399	405	PF00069	0.337
MOD_Plk_4	61	67	PF00069	0.522
MOD_Plk_4	646	652	PF00069	0.422
MOD_Plk_4	713	719	PF00069	0.486
MOD_Plk_4	727	733	PF00069	0.439
MOD_Plk_4	743	749	PF00069	0.467
MOD_Plk_4	848	854	PF00069	0.505
MOD_Plk_4	883	889	PF00069	0.430
MOD_Plk_4	924	930	PF00069	0.462
MOD_Plk_4	984	990	PF00069	0.443
MOD_Plk_4	991	997	PF00069	0.397
MOD_ProDKin_1	10	16	PF00069	0.701
MOD_ProDKin_1	1018	1024	PF00069	0.436
MOD_ProDKin_1	214	220	PF00069	0.477
MOD_ProDKin_1	910	916	PF00069	0.374
MOD_ProDKin_1	967	973	PF00069	0.488
MOD_SUMO_rev_2	546	556	PF00179	0.426
TRG_DiLeu_BaEn_1	566	571	PF01217	0.458
TRG_DiLeu_BaEn_1	81	86	PF01217	0.378
TRG_DiLeu_BaEn_3	1051	1057	PF01217	0.326
TRG_DiLeu_BaEn_3	42	48	PF01217	0.625
TRG_DiLeu_BaLyEn_6	458	463	PF01217	0.393
TRG_DiLeu_BaLyEn_6	695	700	PF01217	0.349
TRG_DiLeu_BaLyEn_6	817	822	PF01217	0.447
TRG_DiLeu_BaLyEn_6	834	839	PF01217	0.479
TRG_ENDOCYTIC_2	100	103	PF00928	0.251
TRG_ENDOCYTIC_2	232	235	PF00928	0.365
TRG_ENDOCYTIC_2	246	249	PF00928	0.525
TRG_ENDOCYTIC_2	502	505	PF00928	0.510
TRG_ENDOCYTIC_2	52	55	PF00928	0.483
TRG_ENDOCYTIC_2	585	588	PF00928	0.340
TRG_ENDOCYTIC_2	676	679	PF00928	0.395
TRG_ENDOCYTIC_2	728	731	PF00928	0.507
TRG_ENDOCYTIC_2	82	85	PF00928	0.368
TRG_ENDOCYTIC_2	894	897	PF00928	0.492
TRG_ER_diArg_1	513	516	PF00400	0.393
TRG_ER_diArg_1	538	541	PF00400	0.461
TRG_ER_diArg_1	643	646	PF00400	0.365
TRG_ER_diArg_1	695	698	PF00400	0.502
TRG_ER_diArg_1	89	91	PF00400	0.474
TRG_NES_CRM1_1	847	862	PF08389	0.373
TRG_Pf-PMV_PEXEL_1	1065	1069	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	668	672	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	820	825	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	875	879	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	942	946	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Q1	Leptomonas seymouri	60%	100%
A0A1X0P467	Trypanosomatidae	29%	99%
A0A3R7KQG4	Trypanosoma rangeli	28%	100%
A4HPN7	Leishmania braziliensis	86%	100%
A4ID27	Leishmania infantum	100%	100%
D0A8H7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9ATF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q146	Leishmania major	95%	100%
V5BEA1	Trypanosoma cruzi	29%	100%