Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XB99_LEIDO

TriTrypDb:

LdBPK_363660.1 , LdCL_360043600 , LDHU3_36.4950

Length:

820

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XB99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XB99

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	388	392	PF00656	0.544
CLV_C14_Caspase3-7	493	497	PF00656	0.709
CLV_C14_Caspase3-7	529	533	PF00656	0.664
CLV_C14_Caspase3-7	756	760	PF00656	0.709
CLV_NRD_NRD_1	386	388	PF00675	0.700
CLV_NRD_NRD_1	519	521	PF00675	0.675
CLV_NRD_NRD_1	58	60	PF00675	0.723
CLV_PCSK_FUR_1	309	313	PF00082	0.744
CLV_PCSK_KEX2_1	242	244	PF00082	0.693
CLV_PCSK_KEX2_1	311	313	PF00082	0.692
CLV_PCSK_KEX2_1	386	388	PF00082	0.700
CLV_PCSK_KEX2_1	519	521	PF00082	0.675
CLV_PCSK_KEX2_1	58	60	PF00082	0.723
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.697
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.692
CLV_PCSK_PC7_1	54	60	PF00082	0.688
CLV_PCSK_SKI1_1	239	243	PF00082	0.795
CLV_PCSK_SKI1_1	248	252	PF00082	0.666
CLV_PCSK_SKI1_1	781	785	PF00082	0.590
CLV_PCSK_SKI1_1	797	801	PF00082	0.595
DEG_SCF_FBW7_1	39	46	PF00400	0.784
DEG_SPOP_SBC_1	231	235	PF00917	0.804
DEG_SPOP_SBC_1	363	367	PF00917	0.727
DEG_SPOP_SBC_1	92	96	PF00917	0.654
DOC_CDC14_PxL_1	726	734	PF14671	0.608
DOC_CYCLIN_yCln2_LP_2	340	346	PF00134	0.745
DOC_CYCLIN_yCln2_LP_2	439	445	PF00134	0.688
DOC_CYCLIN_yCln2_LP_2	449	455	PF00134	0.553
DOC_MAPK_gen_1	311	321	PF00069	0.787
DOC_MAPK_gen_1	32	39	PF00069	0.718
DOC_MAPK_MEF2A_6	425	433	PF00069	0.534
DOC_MAPK_NFAT4_5	430	438	PF00069	0.626
DOC_MIT_MIM_1	642	652	PF04212	0.488
DOC_PP2B_LxvP_1	340	343	PF13499	0.792
DOC_PP2B_LxvP_1	449	452	PF13499	0.720
DOC_PP2B_LxvP_1	666	669	PF13499	0.654
DOC_USP7_MATH_1	207	211	PF00917	0.659
DOC_USP7_MATH_1	223	227	PF00917	0.739
DOC_USP7_MATH_1	230	234	PF00917	0.755
DOC_USP7_MATH_1	313	317	PF00917	0.755
DOC_USP7_MATH_1	324	328	PF00917	0.676
DOC_USP7_MATH_1	349	353	PF00917	0.685
DOC_USP7_MATH_1	363	367	PF00917	0.705
DOC_USP7_MATH_1	377	381	PF00917	0.738
DOC_USP7_MATH_1	41	45	PF00917	0.788
DOC_USP7_MATH_1	490	494	PF00917	0.745
DOC_USP7_MATH_1	92	96	PF00917	0.722
DOC_USP7_MATH_2	43	49	PF00917	0.594
DOC_USP7_UBL2_3	75	79	PF12436	0.808
DOC_WW_Pin1_4	216	221	PF00397	0.708
DOC_WW_Pin1_4	283	288	PF00397	0.804
DOC_WW_Pin1_4	342	347	PF00397	0.699
DOC_WW_Pin1_4	380	385	PF00397	0.747
DOC_WW_Pin1_4	39	44	PF00397	0.776
DOC_WW_Pin1_4	605	610	PF00397	0.717
DOC_WW_Pin1_4	68	73	PF00397	0.742
DOC_WW_Pin1_4	713	718	PF00397	0.613
DOC_WW_Pin1_4	93	98	PF00397	0.734
LIG_14-3-3_CanoR_1	18	26	PF00244	0.695
LIG_14-3-3_CanoR_1	196	200	PF00244	0.514
LIG_14-3-3_CanoR_1	312	321	PF00244	0.748
LIG_14-3-3_CanoR_1	329	337	PF00244	0.582
LIG_14-3-3_CanoR_1	34	40	PF00244	0.525
LIG_14-3-3_CanoR_1	386	396	PF00244	0.658
LIG_14-3-3_CanoR_1	402	410	PF00244	0.505
LIG_14-3-3_CanoR_1	54	58	PF00244	0.770
LIG_14-3-3_CanoR_1	719	727	PF00244	0.557
LIG_14-3-3_CanoR_1	731	739	PF00244	0.530
LIG_14-3-3_CanoR_1	754	762	PF00244	0.594
LIG_14-3-3_CanoR_1	770	777	PF00244	0.610
LIG_Actin_WH2_2	798	814	PF00022	0.569
LIG_AP2alpha_2	3	5	PF02296	0.655
LIG_APCC_ABBA_1	165	170	PF00400	0.557
LIG_BIR_II_1	1	5	PF00653	0.682
LIG_BIR_III_1	1	5	PF00653	0.720
LIG_BIR_III_3	1	5	PF00653	0.720
LIG_BIR_III_4	391	395	PF00653	0.625
LIG_BRCT_BRCA1_1	344	348	PF00533	0.728
LIG_BRCT_BRCA1_1	502	506	PF00533	0.559
LIG_BRCT_BRCA1_1	84	88	PF00533	0.599
LIG_Clathr_ClatBox_1	741	745	PF01394	0.624
LIG_FHA_1	105	111	PF00498	0.702
LIG_FHA_1	305	311	PF00498	0.603
LIG_FHA_1	444	450	PF00498	0.656
LIG_FHA_1	534	540	PF00498	0.581
LIG_FHA_1	61	67	PF00498	0.727
LIG_FHA_1	675	681	PF00498	0.505
LIG_FHA_1	696	702	PF00498	0.422
LIG_FHA_2	150	156	PF00498	0.548
LIG_FHA_2	249	255	PF00498	0.727
LIG_FHA_2	264	270	PF00498	0.813
LIG_FHA_2	386	392	PF00498	0.561
LIG_FHA_2	40	46	PF00498	0.574
LIG_FHA_2	719	725	PF00498	0.569
LIG_FHA_2	754	760	PF00498	0.728
LIG_LIR_Gen_1	157	168	PF02991	0.593
LIG_LIR_Gen_1	3	12	PF02991	0.528
LIG_LIR_Gen_1	395	401	PF02991	0.692
LIG_LIR_Gen_1	503	513	PF02991	0.528
LIG_LIR_Gen_1	679	689	PF02991	0.457
LIG_LIR_Gen_1	724	732	PF02991	0.625
LIG_LIR_LC3C_4	646	651	PF02991	0.608
LIG_LIR_Nem_3	157	163	PF02991	0.630
LIG_LIR_Nem_3	3	8	PF02991	0.526
LIG_LIR_Nem_3	395	400	PF02991	0.621
LIG_LIR_Nem_3	407	413	PF02991	0.623
LIG_LIR_Nem_3	503	509	PF02991	0.499
LIG_LIR_Nem_3	569	573	PF02991	0.586
LIG_LIR_Nem_3	679	684	PF02991	0.450
LIG_LIR_Nem_3	724	729	PF02991	0.624
LIG_NRBOX	395	401	PF00104	0.692
LIG_NRBOX	435	441	PF00104	0.523
LIG_NRBOX	731	737	PF00104	0.600
LIG_Pex14_2	410	414	PF04695	0.613
LIG_Pex14_2	506	510	PF04695	0.532
LIG_PTB_Apo_2	504	511	PF02174	0.319
LIG_RPA_C_Fungi	618	630	PF08784	0.462
LIG_SH2_CRK	164	168	PF00017	0.539
LIG_SH2_GRB2like	554	557	PF00017	0.556
LIG_SH2_NCK_1	160	164	PF00017	0.562
LIG_SH2_STAP1	160	164	PF00017	0.562
LIG_SH2_STAP1	573	577	PF00017	0.579
LIG_SH2_STAP1	681	685	PF00017	0.501
LIG_SH2_STAT3	542	545	PF00017	0.580
LIG_SH2_STAT3	573	576	PF00017	0.582
LIG_SH2_STAT5	554	557	PF00017	0.607
LIG_SH2_STAT5	573	576	PF00017	0.324
LIG_SH2_STAT5	711	714	PF00017	0.459
LIG_SH3_2	220	225	PF14604	0.763
LIG_SH3_3	217	223	PF00018	0.657
LIG_SH3_3	340	346	PF00018	0.712
LIG_SH3_3	456	462	PF00018	0.651
LIG_SH3_3	5	11	PF00018	0.608
LIG_SH3_3	724	730	PF00018	0.548
LIG_SH3_4	75	82	PF00018	0.729
LIG_SUMO_SIM_anti_2	464	471	PF11976	0.590
LIG_SUMO_SIM_anti_2	686	691	PF11976	0.535
LIG_SUMO_SIM_par_1	10	15	PF11976	0.734
LIG_SUMO_SIM_par_1	213	219	PF11976	0.577
LIG_TRAF2_1	266	269	PF00917	0.722
LIG_TRAF2_1	765	768	PF00917	0.489
LIG_TYR_ITIM	162	167	PF00017	0.548
LIG_WRC_WIRS_1	632	637	PF05994	0.544
MOD_CDC14_SPxK_1	383	386	PF00782	0.711
MOD_CDC14_SPxK_1	716	719	PF00782	0.635
MOD_CDK_SPK_2	93	98	PF00069	0.718
MOD_CDK_SPxK_1	380	386	PF00069	0.715
MOD_CDK_SPxK_1	713	719	PF00069	0.619
MOD_CDK_SPxxK_3	218	225	PF00069	0.708
MOD_CDK_SPxxK_3	283	290	PF00069	0.801
MOD_CDK_SPxxK_3	380	387	PF00069	0.615
MOD_CDK_SPxxK_3	68	75	PF00069	0.737
MOD_CK1_1	210	216	PF00069	0.691
MOD_CK1_1	221	227	PF00069	0.709
MOD_CK1_1	233	239	PF00069	0.785
MOD_CK1_1	259	265	PF00069	0.753
MOD_CK1_1	305	311	PF00069	0.745
MOD_CK1_1	317	323	PF00069	0.681
MOD_CK1_1	327	333	PF00069	0.662
MOD_CK1_1	367	373	PF00069	0.768
MOD_CK1_1	380	386	PF00069	0.603
MOD_CK1_1	52	58	PF00069	0.763
MOD_CK1_1	569	575	PF00069	0.571
MOD_CK1_1	585	591	PF00069	0.548
MOD_CK1_1	608	614	PF00069	0.708
MOD_CK1_1	746	752	PF00069	0.729
MOD_CK1_1	755	761	PF00069	0.613
MOD_CK2_1	134	140	PF00069	0.598
MOD_CK2_1	149	155	PF00069	0.416
MOD_CK2_1	221	227	PF00069	0.674
MOD_CK2_1	263	269	PF00069	0.739
MOD_CK2_1	39	45	PF00069	0.566
MOD_CK2_1	586	592	PF00069	0.703
MOD_CK2_1	718	724	PF00069	0.521
MOD_GlcNHglycan	235	238	PF01048	0.766
MOD_GlcNHglycan	316	319	PF01048	0.774
MOD_GlcNHglycan	322	325	PF01048	0.709
MOD_GlcNHglycan	332	335	PF01048	0.577
MOD_GlcNHglycan	353	356	PF01048	0.696
MOD_GlcNHglycan	367	370	PF01048	0.755
MOD_GlcNHglycan	379	382	PF01048	0.714
MOD_GlcNHglycan	455	458	PF01048	0.564
MOD_GlcNHglycan	502	505	PF01048	0.593
MOD_GlcNHglycan	589	592	PF01048	0.620
MOD_GlcNHglycan	721	724	PF01048	0.543
MOD_GlcNHglycan	759	762	PF01048	0.554
MOD_GlcNHglycan	789	792	PF01048	0.604
MOD_GSK3_1	207	214	PF00069	0.713
MOD_GSK3_1	259	266	PF00069	0.775
MOD_GSK3_1	313	320	PF00069	0.806
MOD_GSK3_1	35	42	PF00069	0.669
MOD_GSK3_1	363	370	PF00069	0.727
MOD_GSK3_1	45	52	PF00069	0.740
MOD_GSK3_1	464	471	PF00069	0.629
MOD_GSK3_1	581	588	PF00069	0.639
MOD_GSK3_1	601	608	PF00069	0.623
MOD_GSK3_1	749	756	PF00069	0.740
MOD_GSK3_1	82	89	PF00069	0.788
MOD_N-GLC_1	259	264	PF02516	0.745
MOD_N-GLC_1	283	288	PF02516	0.726
MOD_N-GLC_1	555	560	PF02516	0.612
MOD_NEK2_1	14	19	PF00069	0.695
MOD_NEK2_1	148	153	PF00069	0.510
MOD_NEK2_1	195	200	PF00069	0.664
MOD_NEK2_1	319	324	PF00069	0.828
MOD_NEK2_1	455	460	PF00069	0.706
MOD_NEK2_1	505	510	PF00069	0.505
MOD_NEK2_1	566	571	PF00069	0.662
MOD_NEK2_1	583	588	PF00069	0.622
MOD_NEK2_1	601	606	PF00069	0.575
MOD_NEK2_1	801	806	PF00069	0.678
MOD_NEK2_2	514	519	PF00069	0.600
MOD_NEK2_2	643	648	PF00069	0.485
MOD_NEK2_2	814	819	PF00069	0.735
MOD_PIKK_1	134	140	PF00454	0.649
MOD_PIKK_1	17	23	PF00454	0.705
MOD_PIKK_1	264	270	PF00454	0.811
MOD_PKA_2	17	23	PF00069	0.713
MOD_PKA_2	195	201	PF00069	0.493
MOD_PKA_2	313	319	PF00069	0.816
MOD_PKA_2	325	331	PF00069	0.711
MOD_PKA_2	35	41	PF00069	0.453
MOD_PKA_2	385	391	PF00069	0.612
MOD_PKA_2	401	407	PF00069	0.723
MOD_PKA_2	420	426	PF00069	0.353
MOD_PKA_2	53	59	PF00069	0.770
MOD_PKA_2	695	701	PF00069	0.429
MOD_PKA_2	718	724	PF00069	0.572
MOD_PKA_2	730	736	PF00069	0.531
MOD_PKA_2	753	759	PF00069	0.739
MOD_PKA_2	769	775	PF00069	0.593
MOD_PKA_2	787	793	PF00069	0.373
MOD_PKA_2	801	807	PF00069	0.593
MOD_PKA_2	86	92	PF00069	0.728
MOD_PKB_1	312	320	PF00069	0.822
MOD_Plk_1	14	20	PF00069	0.716
MOD_Plk_1	356	362	PF00069	0.612
MOD_Plk_1	443	449	PF00069	0.646
MOD_Plk_1	52	58	PF00069	0.732
MOD_Plk_1	555	561	PF00069	0.641
MOD_Plk_4	211	217	PF00069	0.704
MOD_Plk_4	505	511	PF00069	0.479
MOD_Plk_4	566	572	PF00069	0.589
MOD_Plk_4	801	807	PF00069	0.631
MOD_ProDKin_1	216	222	PF00069	0.706
MOD_ProDKin_1	283	289	PF00069	0.798
MOD_ProDKin_1	342	348	PF00069	0.699
MOD_ProDKin_1	380	386	PF00069	0.746
MOD_ProDKin_1	39	45	PF00069	0.780
MOD_ProDKin_1	605	611	PF00069	0.720
MOD_ProDKin_1	68	74	PF00069	0.742
MOD_ProDKin_1	713	719	PF00069	0.619
MOD_ProDKin_1	93	99	PF00069	0.733
MOD_SUMO_for_1	117	120	PF00179	0.585
TRG_DiLeu_BaEn_4	172	178	PF01217	0.542
TRG_DiLeu_BaLyEn_6	471	476	PF01217	0.570
TRG_DiLeu_BaLyEn_6	703	708	PF01217	0.490
TRG_DiLeu_BaLyEn_6	806	811	PF01217	0.682
TRG_ENDOCYTIC_2	160	163	PF00928	0.588
TRG_ENDOCYTIC_2	164	167	PF00928	0.309
TRG_ENDOCYTIC_2	653	656	PF00928	0.556
TRG_ENDOCYTIC_2	681	684	PF00928	0.503
TRG_ER_diArg_1	33	36	PF00400	0.698
TRG_ER_diArg_1	518	520	PF00400	0.663
TRG_ER_diArg_1	57	59	PF00400	0.730
TRG_ER_diArg_1	627	630	PF00400	0.635
TRG_NES_CRM1_1	679	691	PF08389	0.469
TRG_NLS_MonoCore_2	310	315	PF00514	0.819
TRG_NLS_MonoExtN_4	239	246	PF00514	0.804
TRG_NLS_MonoExtN_4	309	315	PF00514	0.746
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	474	479	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	599	603	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	706	710	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	775	780	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	809	813	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P691	Leptomonas seymouri	49%	93%
A4HPL7	Leishmania braziliensis	81%	100%
A4ID47	Leishmania infantum	100%	100%
E9ATC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q168	Leishmania major	93%	100%
V5DNK6	Trypanosoma cruzi	26%	100%