Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XB97_LEIDO

TriTrypDb:

LdBPK_363420.1 , LdCL_360041000 , LDHU3_36.4680

Length:

194

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	8
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	8
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7XB97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XB97

PDB structure(s): 7aih_K , 7am2_K , 7ane_K

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0000027	ribosomal large subunit assembly	7	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11
GO:0005488	binding	1	11
GO:0019843	rRNA binding	5	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.618
CLV_NRD_NRD_1	31	33	PF00675	0.575
CLV_NRD_NRD_1	62	64	PF00675	0.608
CLV_PCSK_KEX2_1	149	151	PF00082	0.618
CLV_PCSK_KEX2_1	37	39	PF00082	0.592
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.599
CLV_PCSK_SKI1_1	150	154	PF00082	0.607
CLV_PCSK_SKI1_1	21	25	PF00082	0.599
CLV_PCSK_SKI1_1	37	41	PF00082	0.623
DEG_APCC_DBOX_1	85	93	PF00400	0.747
DEG_Nend_Nbox_1	1	3	PF02207	0.594
DOC_MAPK_gen_1	27	36	PF00069	0.582
DOC_PP1_RVXF_1	35	42	PF00149	0.594
DOC_USP7_UBL2_3	33	37	PF12436	0.586
LIG_14-3-3_CanoR_1	12	20	PF00244	0.571
LIG_14-3-3_CanoR_1	174	180	PF00244	0.723
LIG_14-3-3_CanoR_1	38	42	PF00244	0.689
LIG_FHA_1	12	18	PF00498	0.573
LIG_FHA_1	124	130	PF00498	0.731
LIG_FHA_2	134	140	PF00498	0.742
LIG_LIR_Gen_1	75	85	PF02991	0.672
LIG_LIR_Nem_3	181	186	PF02991	0.581
LIG_LIR_Nem_3	75	80	PF02991	0.600
LIG_SH3_1	117	123	PF00018	0.600
LIG_SH3_3	115	121	PF00018	0.608
LIG_SH3_3	135	141	PF00018	0.431
MOD_CK2_1	133	139	PF00069	0.711
MOD_GlcNHglycan	189	192	PF01048	0.664
MOD_GlcNHglycan	67	70	PF01048	0.609
MOD_GlcNHglycan	74	77	PF01048	0.600
MOD_GSK3_1	1	8	PF00069	0.632
MOD_NEK2_1	1	6	PF00069	0.598
MOD_NEK2_1	113	118	PF00069	0.603
MOD_NEK2_1	159	164	PF00069	0.671
MOD_NEK2_1	42	47	PF00069	0.585
MOD_PIKK_1	173	179	PF00454	0.648
MOD_PIKK_1	42	48	PF00454	0.585
MOD_PIKK_1	92	98	PF00454	0.638
MOD_PKA_1	37	43	PF00069	0.689
MOD_PKA_2	11	17	PF00069	0.519
MOD_PKA_2	173	179	PF00069	0.725
MOD_PKA_2	2	8	PF00069	0.570
MOD_PKA_2	37	43	PF00069	0.689
MOD_Plk_4	5	11	PF00069	0.690
MOD_SUMO_rev_2	139	144	PF00179	0.707
TRG_ENDOCYTIC_2	102	105	PF00928	0.590
TRG_ER_diArg_1	24	27	PF00400	0.562
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P460	Leptomonas seymouri	84%	100%
A0A0S4JQ85	Bodo saltans	55%	100%
A0A1X0P3D5	Trypanosomatidae	61%	94%
A0A422NVN0	Trypanosoma rangeli	64%	100%
A4HPJ3	Leishmania braziliensis	92%	100%
A4ID70	Leishmania infantum	99%	100%
D0A8M2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	91%
E9ATA5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q192	Leishmania major	97%	100%