Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2870), putative

Species:

Leishmania donovani

UniProt:

A0A3S7XB90_LEIDO

TriTrypDb:

LdBPK_363650.1 , LdCL_360043500 , LDHU3_36.4940

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XB90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XB90

Function

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Biological processes
Term	Name	Level	Count
GO:0003352	regulation of cilium movement	6	16
GO:0032886	regulation of microtubule-based process	4	16
GO:0050789	regulation of biological process	2	16
GO:0050794	regulation of cellular process	3	16
GO:0060632	regulation of microtubule-based movement	5	16
GO:0065007	biological regulation	1	16

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.494
CLV_NRD_NRD_1	235	237	PF00675	0.369
CLV_NRD_NRD_1	262	264	PF00675	0.276
CLV_NRD_NRD_1	286	288	PF00675	0.216
CLV_NRD_NRD_1	329	331	PF00675	0.719
CLV_PCSK_KEX2_1	262	264	PF00082	0.282
CLV_PCSK_KEX2_1	286	288	PF00082	0.216
CLV_PCSK_KEX2_1	64	66	PF00082	0.510
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.510
CLV_PCSK_SKI1_1	122	126	PF00082	0.502

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4K9	Leptomonas seymouri	60%	100%
A0A0S4JE13	Bodo saltans	40%	100%
A0A0S4JHQ4	Bodo saltans	40%	100%
A0A0S4JRV9	Bodo saltans	25%	100%
A0A1X0P4D1	Trypanosomatidae	41%	100%
A0A3R7NWF2	Trypanosoma rangeli	25%	100%
A0A422MZF7	Trypanosoma rangeli	44%	100%
A4HPL6	Leishmania braziliensis	77%	100%
A4ID48	Leishmania infantum	100%	100%
D0A4B5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%

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