Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2870), putative

Species:

Leishmania donovani

UniProt:

A0A3S7XB90_LEIDO

TriTrypDb:

LdBPK_363650.1 , LdCL_360043500 , LDHU3_36.4940

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XB90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XB90

Function

Biological processes
Term	Name	Level	Count
GO:0003352	regulation of cilium movement	6	16
GO:0032886	regulation of microtubule-based process	4	16
GO:0050789	regulation of biological process	2	16
GO:0050794	regulation of cellular process	3	16
GO:0060632	regulation of microtubule-based movement	5	16
GO:0065007	biological regulation	1	16

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.494
CLV_NRD_NRD_1	235	237	PF00675	0.369
CLV_NRD_NRD_1	262	264	PF00675	0.276
CLV_NRD_NRD_1	286	288	PF00675	0.216
CLV_NRD_NRD_1	329	331	PF00675	0.719
CLV_PCSK_KEX2_1	262	264	PF00082	0.282
CLV_PCSK_KEX2_1	286	288	PF00082	0.216
CLV_PCSK_KEX2_1	64	66	PF00082	0.510
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.510
CLV_PCSK_SKI1_1	122	126	PF00082	0.502
CLV_PCSK_SKI1_1	141	145	PF00082	0.400
CLV_PCSK_SKI1_1	186	190	PF00082	0.436
CLV_PCSK_SKI1_1	19	23	PF00082	0.599
CLV_PCSK_SKI1_1	286	290	PF00082	0.307
CLV_PCSK_SKI1_1	325	329	PF00082	0.719
CLV_PCSK_SKI1_1	69	73	PF00082	0.480
DEG_SCF_FBW7_1	304	311	PF00400	0.542
DEG_SPOP_SBC_1	24	28	PF00917	0.544
DEG_SPOP_SBC_1	49	53	PF00917	0.463
DOC_CYCLIN_RxL_1	183	192	PF00134	0.532
DOC_MAPK_gen_1	223	233	PF00069	0.462
DOC_MAPK_gen_1	330	338	PF00069	0.694
DOC_MAPK_gen_1	64	72	PF00069	0.438
DOC_MAPK_MEF2A_6	226	233	PF00069	0.460
DOC_MAPK_MEF2A_6	64	72	PF00069	0.397
DOC_USP7_MATH_1	239	243	PF00917	0.505
DOC_USP7_MATH_1	24	28	PF00917	0.609
DOC_USP7_MATH_1	295	299	PF00917	0.692
DOC_USP7_MATH_1	308	312	PF00917	0.468
DOC_USP7_MATH_1	44	48	PF00917	0.687
DOC_USP7_MATH_1	49	53	PF00917	0.653
DOC_USP7_UBL2_3	228	232	PF12436	0.482
DOC_WW_Pin1_4	123	128	PF00397	0.499
DOC_WW_Pin1_4	28	33	PF00397	0.700
DOC_WW_Pin1_4	304	309	PF00397	0.769
DOC_WW_Pin1_4	312	317	PF00397	0.654
DOC_WW_Pin1_4	37	42	PF00397	0.706
LIG_14-3-3_CanoR_1	141	148	PF00244	0.501
LIG_EH1_1	65	73	PF00400	0.518
LIG_eIF4E_1	183	189	PF01652	0.518
LIG_FHA_1	124	130	PF00498	0.487
LIG_FHA_1	142	148	PF00498	0.403
LIG_FHA_1	176	182	PF00498	0.537
LIG_FHA_1	20	26	PF00498	0.567
LIG_FHA_1	283	289	PF00498	0.513
LIG_FHA_1	319	325	PF00498	0.675
LIG_FHA_1	49	55	PF00498	0.543
LIG_FHA_2	151	157	PF00498	0.500
LIG_FHA_2	165	171	PF00498	0.265
LIG_LIR_Gen_1	115	124	PF02991	0.449
LIG_LIR_Gen_1	146	155	PF02991	0.555
LIG_LIR_LC3C_4	177	182	PF02991	0.516
LIG_LIR_Nem_3	115	121	PF02991	0.426
LIG_LIR_Nem_3	146	151	PF02991	0.514
LIG_LIR_Nem_3	264	269	PF02991	0.496
LIG_PCNA_PIPBox_1	111	120	PF02747	0.462
LIG_PCNA_yPIPBox_3	109	118	PF02747	0.550
LIG_SH2_CRK	110	114	PF00017	0.479
LIG_SH2_CRK	118	122	PF00017	0.502
LIG_SH2_CRK	148	152	PF00017	0.477
LIG_SH2_CRK	256	260	PF00017	0.570
LIG_SH2_STAT3	249	252	PF00017	0.482
LIG_SH2_STAT5	166	169	PF00017	0.580
LIG_SH2_STAT5	220	223	PF00017	0.515
LIG_SH3_2	326	331	PF14604	0.627
LIG_SH3_3	323	329	PF00018	0.622
LIG_SH3_3	35	41	PF00018	0.754
LIG_TRAF2_1	27	30	PF00917	0.641
LIG_TRAF2_1	74	77	PF00917	0.533
MOD_CDK_SPK_2	28	33	PF00069	0.573
MOD_CK1_1	150	156	PF00069	0.582
MOD_CK1_1	28	34	PF00069	0.730
MOD_CK1_1	282	288	PF00069	0.513
MOD_CK1_1	311	317	PF00069	0.754
MOD_CK1_1	47	53	PF00069	0.475
MOD_CK1_1	89	95	PF00069	0.646
MOD_CK2_1	164	170	PF00069	0.566
MOD_CK2_1	23	29	PF00069	0.646
MOD_CK2_1	295	301	PF00069	0.652
MOD_CK2_1	71	77	PF00069	0.430
MOD_GlcNHglycan	310	313	PF01048	0.747
MOD_GlcNHglycan	73	76	PF01048	0.446
MOD_GSK3_1	143	150	PF00069	0.520
MOD_GSK3_1	19	26	PF00069	0.495
MOD_GSK3_1	304	311	PF00069	0.727
MOD_GSK3_1	43	50	PF00069	0.701
MOD_N-GLC_1	213	218	PF02516	0.216
MOD_NEK2_1	143	148	PF00069	0.470
MOD_NEK2_1	213	218	PF00069	0.498
MOD_NEK2_1	71	76	PF00069	0.486
MOD_PIKK_1	97	103	PF00454	0.698
MOD_PKA_2	282	288	PF00069	0.557
MOD_PKA_2	97	103	PF00069	0.683
MOD_Plk_1	13	19	PF00069	0.497
MOD_Plk_1	175	181	PF00069	0.541
MOD_Plk_1	213	219	PF00069	0.540
MOD_Plk_2-3	13	19	PF00069	0.519
MOD_Plk_4	143	149	PF00069	0.522
MOD_Plk_4	50	56	PF00069	0.572
MOD_Plk_4	77	83	PF00069	0.470
MOD_ProDKin_1	123	129	PF00069	0.506
MOD_ProDKin_1	28	34	PF00069	0.700
MOD_ProDKin_1	304	310	PF00069	0.769
MOD_ProDKin_1	312	318	PF00069	0.654
MOD_ProDKin_1	37	43	PF00069	0.707
MOD_SUMO_rev_2	190	195	PF00179	0.543
TRG_DiLeu_BaEn_1	176	181	PF01217	0.493
TRG_DiLeu_BaLyEn_6	284	289	PF01217	0.499
TRG_ENDOCYTIC_2	110	113	PF00928	0.410
TRG_ENDOCYTIC_2	118	121	PF00928	0.408
TRG_ENDOCYTIC_2	148	151	PF00928	0.548
TRG_ENDOCYTIC_2	256	259	PF00928	0.539
TRG_ENDOCYTIC_2	266	269	PF00928	0.496
TRG_ER_diArg_1	245	248	PF00400	0.539
TRG_ER_diArg_1	286	288	PF00400	0.504
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.252

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4K9	Leptomonas seymouri	60%	100%
A0A0S4JE13	Bodo saltans	40%	100%
A0A0S4JHQ4	Bodo saltans	40%	100%
A0A0S4JRV9	Bodo saltans	25%	100%
A0A1X0P4D1	Trypanosomatidae	41%	100%
A0A3R7NWF2	Trypanosoma rangeli	25%	100%
A0A422MZF7	Trypanosoma rangeli	44%	100%
A4HPL6	Leishmania braziliensis	77%	100%
A4ID48	Leishmania infantum	100%	100%
D0A4B5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A8J8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ATC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q169	Leishmania major	92%	100%
V5B6Z0	Trypanosoma cruzi	42%	100%