F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7XB84_LEIDO

TriTrypDb:

LdBPK_363770.1 , LdCL_360044700 , LDHU3_36.5080

Length:

537

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XB84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XB84

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	429	433	PF00656	0.462
CLV_C14_Caspase3-7	473	477	PF00656	0.513
CLV_NRD_NRD_1	29	31	PF00675	0.594
CLV_PCSK_KEX2_1	200	202	PF00082	0.647
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.647
CLV_PCSK_SKI1_1	131	135	PF00082	0.530
CLV_PCSK_SKI1_1	177	181	PF00082	0.593
CLV_PCSK_SKI1_1	394	398	PF00082	0.549
DEG_Nend_UBRbox_2	1	3	PF02207	0.443
DEG_ODPH_VHL_1	58	69	PF01847	0.404
DEG_SPOP_SBC_1	507	511	PF00917	0.313
DOC_CKS1_1	321	326	PF01111	0.413
DOC_CYCLIN_RxL_1	483	493	PF00134	0.465
DOC_MAPK_FxFP_2	118	121	PF00069	0.358
DOC_MAPK_gen_1	136	144	PF00069	0.362
DOC_MAPK_gen_1	16	22	PF00069	0.427
DOC_MAPK_gen_1	72	80	PF00069	0.389
DOC_MAPK_MEF2A_6	72	80	PF00069	0.389
DOC_PP1_RVXF_1	175	182	PF00149	0.337
DOC_PP1_RVXF_1	42	49	PF00149	0.396
DOC_PP2B_LxvP_1	488	491	PF13499	0.480
DOC_PP2B_LxvP_1	58	61	PF13499	0.410
DOC_PP4_FxxP_1	118	121	PF00568	0.358
DOC_USP7_MATH_1	119	123	PF00917	0.373
DOC_USP7_MATH_1	232	236	PF00917	0.459
DOC_USP7_MATH_1	460	464	PF00917	0.465
DOC_WW_Pin1_4	162	167	PF00397	0.364
DOC_WW_Pin1_4	192	197	PF00397	0.486
DOC_WW_Pin1_4	320	325	PF00397	0.435
LIG_14-3-3_CanoR_1	30	40	PF00244	0.363
LIG_14-3-3_CanoR_1	301	306	PF00244	0.436
LIG_14-3-3_CanoR_1	340	345	PF00244	0.342
LIG_14-3-3_CanoR_1	350	359	PF00244	0.320
LIG_14-3-3_CanoR_1	380	384	PF00244	0.381
LIG_14-3-3_CanoR_1	420	426	PF00244	0.452
LIG_AP2alpha_2	231	233	PF02296	0.436
LIG_AP2alpha_2	469	471	PF02296	0.492
LIG_BRCT_BRCA1_1	229	233	PF00533	0.330
LIG_BRCT_BRCA1_1	33	37	PF00533	0.371
LIG_eIF4E_1	95	101	PF01652	0.375
LIG_EVH1_2	255	259	PF00568	0.358
LIG_FHA_1	181	187	PF00498	0.307
LIG_FHA_1	351	357	PF00498	0.391
LIG_FHA_1	380	386	PF00498	0.372
LIG_FHA_1	4	10	PF00498	0.416
LIG_FHA_1	403	409	PF00498	0.413
LIG_FHA_1	425	431	PF00498	0.436
LIG_FHA_1	452	458	PF00498	0.397
LIG_FHA_1	84	90	PF00498	0.410
LIG_FHA_1	96	102	PF00498	0.313
LIG_FHA_2	13	19	PF00498	0.381
LIG_FHA_2	149	155	PF00498	0.421
LIG_FHA_2	193	199	PF00498	0.452
LIG_FHA_2	321	327	PF00498	0.387
LIG_FHA_2	471	477	PF00498	0.456
LIG_FHA_2	493	499	PF00498	0.447
LIG_LIR_Apic_2	160	166	PF02991	0.355
LIG_LIR_Apic_2	319	324	PF02991	0.413
LIG_LIR_Gen_1	328	339	PF02991	0.336
LIG_LIR_Gen_1	405	413	PF02991	0.403
LIG_LIR_Gen_1	501	508	PF02991	0.313
LIG_LIR_Gen_1	53	61	PF02991	0.452
LIG_LIR_Nem_3	265	271	PF02991	0.328
LIG_LIR_Nem_3	34	40	PF02991	0.433
LIG_LIR_Nem_3	382	386	PF02991	0.306
LIG_LIR_Nem_3	405	410	PF02991	0.410
LIG_LIR_Nem_3	436	441	PF02991	0.539
LIG_LIR_Nem_3	493	497	PF02991	0.395
LIG_LIR_Nem_3	501	505	PF02991	0.328
LIG_LIR_Nem_3	53	58	PF02991	0.553
LIG_LYPXL_yS_3	294	297	PF13949	0.354
LIG_SH2_CRK	321	325	PF00017	0.415
LIG_SH2_CRK	438	442	PF00017	0.376
LIG_SH2_CRK	97	101	PF00017	0.381
LIG_SH2_NCK_1	163	167	PF00017	0.362
LIG_SH2_NCK_1	206	210	PF00017	0.479
LIG_SH2_PTP2	55	58	PF00017	0.447
LIG_SH2_STAP1	97	101	PF00017	0.335
LIG_SH2_STAT5	106	109	PF00017	0.402
LIG_SH2_STAT5	13	16	PF00017	0.420
LIG_SH2_STAT5	132	135	PF00017	0.315
LIG_SH2_STAT5	260	263	PF00017	0.369
LIG_SH2_STAT5	383	386	PF00017	0.377
LIG_SH2_STAT5	416	419	PF00017	0.439
LIG_SH2_STAT5	45	48	PF00017	0.445
LIG_SH2_STAT5	453	456	PF00017	0.478
LIG_SH2_STAT5	55	58	PF00017	0.545
LIG_SH2_STAT5	95	98	PF00017	0.361
LIG_SH3_3	250	256	PF00018	0.460
LIG_SH3_3	454	460	PF00018	0.397
LIG_SUMO_SIM_anti_2	283	290	PF11976	0.368
LIG_SUMO_SIM_anti_2	393	401	PF11976	0.349
LIG_SUMO_SIM_anti_2	5	12	PF11976	0.417
LIG_SUMO_SIM_par_1	393	401	PF11976	0.376
LIG_SUMO_SIM_par_1	5	12	PF11976	0.406
LIG_SUMO_SIM_par_1	76	82	PF11976	0.383
LIG_TRAF2_1	39	42	PF00917	0.412
LIG_UBA3_1	64	72	PF00899	0.389
LIG_WRC_WIRS_1	452	457	PF05994	0.478
MOD_CK1_1	12	18	PF00069	0.421
MOD_CK1_1	23	29	PF00069	0.424
MOD_CK1_1	304	310	PF00069	0.387
MOD_CK1_1	36	42	PF00069	0.408
MOD_CK1_1	367	373	PF00069	0.354
MOD_CK1_1	379	385	PF00069	0.376
MOD_CK1_1	400	406	PF00069	0.409
MOD_CK1_1	424	430	PF00069	0.436
MOD_CK2_1	12	18	PF00069	0.434
MOD_CK2_1	148	154	PF00069	0.313
MOD_CK2_1	320	326	PF00069	0.380
MOD_CK2_1	349	355	PF00069	0.389
MOD_CK2_1	36	42	PF00069	0.366
MOD_CK2_1	492	498	PF00069	0.449
MOD_GlcNHglycan	127	130	PF01048	0.527
MOD_GlcNHglycan	214	217	PF01048	0.672
MOD_GlcNHglycan	22	25	PF01048	0.576
MOD_GlcNHglycan	240	243	PF01048	0.705
MOD_GlcNHglycan	264	267	PF01048	0.647
MOD_GlcNHglycan	276	279	PF01048	0.483
MOD_GlcNHglycan	516	519	PF01048	0.302
MOD_GlcNHglycan	81	84	PF01048	0.598
MOD_GSK3_1	227	234	PF00069	0.460
MOD_GSK3_1	236	243	PF00069	0.523
MOD_GSK3_1	300	307	PF00069	0.379
MOD_GSK3_1	360	367	PF00069	0.393
MOD_GSK3_1	396	403	PF00069	0.346
MOD_GSK3_1	424	431	PF00069	0.374
MOD_GSK3_1	508	515	PF00069	0.292
MOD_GSK3_1	79	86	PF00069	0.365
MOD_N-GLC_1	237	242	PF02516	0.645
MOD_NEK2_1	148	153	PF00069	0.342
MOD_NEK2_1	180	185	PF00069	0.341
MOD_NEK2_1	20	25	PF00069	0.382
MOD_NEK2_1	217	222	PF00069	0.362
MOD_NEK2_1	261	266	PF00069	0.359
MOD_NEK2_1	273	278	PF00069	0.300
MOD_NEK2_1	305	310	PF00069	0.451
MOD_NEK2_1	349	354	PF00069	0.386
MOD_NEK2_1	402	407	PF00069	0.411
MOD_NEK2_1	512	517	PF00069	0.292
MOD_NEK2_1	79	84	PF00069	0.420
MOD_NEK2_1	9	14	PF00069	0.528
MOD_NEK2_2	182	187	PF00069	0.310
MOD_PIKK_1	59	65	PF00454	0.429
MOD_PIKK_1	95	101	PF00454	0.375
MOD_PK_1	406	412	PF00069	0.421
MOD_PKA_2	300	306	PF00069	0.397
MOD_PKA_2	349	355	PF00069	0.396
MOD_PKA_2	379	385	PF00069	0.398
MOD_PKA_2	411	417	PF00069	0.425
MOD_Plk_1	400	406	PF00069	0.371
MOD_Plk_4	120	126	PF00069	0.481
MOD_Plk_4	148	154	PF00069	0.386
MOD_Plk_4	284	290	PF00069	0.394
MOD_Plk_4	3	9	PF00069	0.415
MOD_Plk_4	33	39	PF00069	0.386
MOD_Plk_4	342	348	PF00069	0.344
MOD_Plk_4	360	366	PF00069	0.256
MOD_Plk_4	379	385	PF00069	0.390
MOD_Plk_4	421	427	PF00069	0.421
MOD_Plk_4	498	504	PF00069	0.257
MOD_Plk_4	508	514	PF00069	0.292
MOD_ProDKin_1	162	168	PF00069	0.362
MOD_ProDKin_1	192	198	PF00069	0.491
MOD_ProDKin_1	320	326	PF00069	0.440
MOD_SUMO_rev_2	36	46	PF00179	0.368
TRG_DiLeu_BaEn_1	42	47	PF01217	0.373
TRG_DiLeu_BaEn_1	73	78	PF01217	0.382
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.387
TRG_ENDOCYTIC_2	294	297	PF00928	0.426
TRG_ENDOCYTIC_2	331	334	PF00928	0.326
TRG_ENDOCYTIC_2	346	349	PF00928	0.363
TRG_ENDOCYTIC_2	438	441	PF00928	0.380
TRG_ENDOCYTIC_2	55	58	PF00928	0.465
TRG_ENDOCYTIC_2	97	100	PF00928	0.362
TRG_NES_CRM1_1	146	160	PF08389	0.350

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJZ9	Leptomonas seymouri	60%	97%
A0A1X0P3D8	Trypanosomatidae	30%	100%
A4HPM8	Leishmania braziliensis	81%	100%
A4ID38	Leishmania infantum	100%	100%
E9ATE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q157	Leishmania major	92%	100%