BSD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XB77_LEIDO

TriTrypDb:

LdBPK_363260.1 , LdCL_360039300 , LDHU3_36.4500

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7XB77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XB77

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.462
CLV_NRD_NRD_1	313	315	PF00675	0.639
CLV_NRD_NRD_1	343	345	PF00675	0.481
CLV_NRD_NRD_1	45	47	PF00675	0.482
CLV_PCSK_KEX2_1	313	315	PF00082	0.645
CLV_PCSK_KEX2_1	343	345	PF00082	0.522
CLV_PCSK_PC7_1	309	315	PF00082	0.496
CLV_PCSK_SKI1_1	191	195	PF00082	0.518
CLV_PCSK_SKI1_1	313	317	PF00082	0.672
CLV_PCSK_SKI1_1	326	330	PF00082	0.438
CLV_PCSK_SKI1_1	344	348	PF00082	0.335
CLV_PCSK_SKI1_1	37	41	PF00082	0.549
DEG_APCC_DBOX_1	312	320	PF00400	0.596
DEG_SPOP_SBC_1	220	224	PF00917	0.652
DOC_MAPK_gen_1	5	15	PF00069	0.359
DOC_USP7_MATH_1	115	119	PF00917	0.540
DOC_USP7_MATH_1	220	224	PF00917	0.652
DOC_USP7_MATH_1	279	283	PF00917	0.635
DOC_USP7_UBL2_3	172	176	PF12436	0.591
DOC_WW_Pin1_4	155	160	PF00397	0.504
DOC_WW_Pin1_4	300	305	PF00397	0.746
LIG_14-3-3_CanoR_1	205	215	PF00244	0.657
LIG_14-3-3_CanoR_1	337	341	PF00244	0.498
LIG_Actin_WH2_2	143	158	PF00022	0.564
LIG_BRCT_BRCA1_1	189	193	PF00533	0.493
LIG_Clathr_ClatBox_1	254	258	PF01394	0.657
LIG_FHA_1	138	144	PF00498	0.509
LIG_FHA_1	156	162	PF00498	0.528
LIG_FHA_1	220	226	PF00498	0.669
LIG_FHA_1	240	246	PF00498	0.484
LIG_FHA_1	38	44	PF00498	0.482
LIG_FHA_2	132	138	PF00498	0.591
LIG_FHA_2	190	196	PF00498	0.500
LIG_LIR_Gen_1	126	136	PF02991	0.583
LIG_LIR_Gen_1	139	146	PF02991	0.615
LIG_LIR_Gen_1	177	187	PF02991	0.535
LIG_LIR_Gen_1	21	32	PF02991	0.529
LIG_LIR_Nem_3	126	132	PF02991	0.595
LIG_LIR_Nem_3	139	144	PF02991	0.521
LIG_LIR_Nem_3	177	182	PF02991	0.591
LIG_LIR_Nem_3	21	27	PF02991	0.515
LIG_LIR_Nem_3	267	271	PF02991	0.619
LIG_Pex14_2	189	193	PF04695	0.493
LIG_Pex14_2	268	272	PF04695	0.677
LIG_SH2_CRK	24	28	PF00017	0.552
LIG_SH2_STAP1	24	28	PF00017	0.552
LIG_SH2_STAT5	186	189	PF00017	0.446
LIG_SH2_STAT5	350	353	PF00017	0.601
LIG_SH2_STAT5	61	64	PF00017	0.501
LIG_SH3_2	304	309	PF14604	0.471
LIG_SH3_3	209	215	PF00018	0.747
LIG_SH3_3	25	31	PF00018	0.448
LIG_SH3_3	301	307	PF00018	0.623
LIG_SUMO_SIM_anti_2	222	229	PF11976	0.631
LIG_TRFH_1	141	145	PF08558	0.543
LIG_WRC_WIRS_1	19	24	PF05994	0.540
LIG_WRC_WIRS_1	265	270	PF05994	0.504
LIG_WRC_WIRS_1	332	337	PF05994	0.491
LIG_WW_3	306	310	PF00397	0.468
MOD_CK1_1	219	225	PF00069	0.686
MOD_CK2_1	174	180	PF00069	0.474
MOD_CK2_1	189	195	PF00069	0.495
MOD_CK2_1	86	92	PF00069	0.637
MOD_Cter_Amidation	311	314	PF01082	0.499
MOD_GlcNHglycan	117	120	PF01048	0.587
MOD_GlcNHglycan	216	219	PF01048	0.710
MOD_GlcNHglycan	281	284	PF01048	0.694
MOD_GSK3_1	216	223	PF00069	0.748
MOD_GSK3_1	296	303	PF00069	0.710
MOD_GSK3_1	331	338	PF00069	0.497
MOD_N-GLC_1	228	233	PF02516	0.622
MOD_N-GLC_1	37	42	PF02516	0.540
MOD_NEK2_1	187	192	PF00069	0.473
MOD_NEK2_1	216	221	PF00069	0.729
MOD_NEK2_1	23	28	PF00069	0.523
MOD_NEK2_1	264	269	PF00069	0.617
MOD_NEK2_1	335	340	PF00069	0.503
MOD_NEK2_1	42	47	PF00069	0.449
MOD_NEK2_1	74	79	PF00069	0.515
MOD_NEK2_2	328	333	PF00069	0.554
MOD_NEK2_2	336	341	PF00069	0.454
MOD_PIKK_1	37	43	PF00454	0.435
MOD_PKA_2	137	143	PF00069	0.623
MOD_PKA_2	336	342	PF00069	0.531
MOD_PKA_2	351	357	PF00069	0.582
MOD_Plk_1	228	234	PF00069	0.606
MOD_Plk_1	37	43	PF00069	0.435
MOD_Plk_1	9	15	PF00069	0.496
MOD_Plk_4	131	137	PF00069	0.472
MOD_Plk_4	174	180	PF00069	0.571
MOD_Plk_4	223	229	PF00069	0.665
MOD_Plk_4	23	29	PF00069	0.471
MOD_Plk_4	281	287	PF00069	0.617
MOD_Plk_4	57	63	PF00069	0.448
MOD_Plk_4	74	80	PF00069	0.441
MOD_ProDKin_1	155	161	PF00069	0.498
MOD_ProDKin_1	300	306	PF00069	0.744
MOD_SUMO_for_1	63	66	PF00179	0.494
MOD_SUMO_rev_2	171	177	PF00179	0.590
TRG_DiLeu_BaEn_1	139	144	PF01217	0.627
TRG_DiLeu_BaEn_3	111	117	PF01217	0.578
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.497
TRG_ENDOCYTIC_2	186	189	PF00928	0.446
TRG_ENDOCYTIC_2	24	27	PF00928	0.533
TRG_ER_diArg_1	3	6	PF00400	0.349
TRG_ER_diArg_1	313	315	PF00400	0.693
TRG_ER_diArg_1	43	46	PF00400	0.446
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2M7	Leptomonas seymouri	63%	100%
A0A1X0P3J0	Trypanosomatidae	36%	98%
A0A3S5IRD4	Trypanosoma rangeli	39%	100%
A4HPH7	Leishmania braziliensis	84%	100%
A4ID99	Leishmania infantum	99%	100%
D0A8D9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AT89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q1A8	Leishmania major	93%	100%
V5B9K7	Trypanosoma cruzi	40%	87%