Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7XB75_LEIDO

TriTrypDb:

LdBPK_363670.1 , LdCL_360043700 , LDHU3_36.4960

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7XB75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XB75

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	87	89	PF00675	0.571
CLV_PCSK_KEX2_1	108	110	PF00082	0.663
CLV_PCSK_KEX2_1	135	137	PF00082	0.548
CLV_PCSK_KEX2_1	47	49	PF00082	0.531
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.663
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.548
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.531
DEG_Nend_Nbox_1	1	3	PF02207	0.748
DOC_MAPK_gen_1	135	143	PF00069	0.619
DOC_MAPK_MEF2A_6	135	143	PF00069	0.553
DOC_MAPK_NFAT4_5	136	144	PF00069	0.552
DOC_PIKK_1	68	76	PF02985	0.599
DOC_PP2B_LxvP_1	164	167	PF13499	0.719
DOC_PP2B_PxIxI_1	37	43	PF00149	0.573
DOC_USP7_MATH_1	149	153	PF00917	0.711
DOC_USP7_MATH_1	18	22	PF00917	0.698
DOC_USP7_UBL2_3	47	51	PF12436	0.621
DOC_WW_Pin1_4	155	160	PF00397	0.623
LIG_14-3-3_CanoR_1	136	140	PF00244	0.556
LIG_14-3-3_CanoR_1	54	60	PF00244	0.568
LIG_14-3-3_CanoR_1	98	104	PF00244	0.683
LIG_Actin_WH2_2	126	142	PF00022	0.549
LIG_EVH1_1	164	168	PF00568	0.696
LIG_FHA_1	159	165	PF00498	0.717
LIG_FHA_1	29	35	PF00498	0.693
LIG_FHA_1	54	60	PF00498	0.508
LIG_FHA_1	92	98	PF00498	0.651
LIG_FHA_2	31	37	PF00498	0.637
LIG_LIR_Nem_3	120	126	PF02991	0.647
LIG_PCNA_yPIPBox_3	109	123	PF02747	0.611
LIG_SH2_SRC	79	82	PF00017	0.523
LIG_SH2_STAT5	79	82	PF00017	0.499
LIG_SH3_1	162	168	PF00018	0.702
LIG_SH3_3	153	159	PF00018	0.783
LIG_SH3_3	160	166	PF00018	0.673
LIG_SUMO_SIM_par_1	30	37	PF11976	0.639
LIG_SUMO_SIM_par_1	79	86	PF11976	0.516
MOD_CDK_SPxxK_3	155	162	PF00069	0.622
MOD_CK1_1	158	164	PF00069	0.582
MOD_CK1_1	3	9	PF00069	0.703
MOD_CK1_1	82	88	PF00069	0.544
MOD_CK1_1	99	105	PF00069	0.532
MOD_CK2_1	30	36	PF00069	0.646
MOD_Cter_Amidation	106	109	PF01082	0.665
MOD_GlcNHglycan	118	122	PF01048	0.566
MOD_GlcNHglycan	20	23	PF01048	0.684
MOD_GSK3_1	1	8	PF00069	0.561
MOD_NEK2_1	1	6	PF00069	0.676
MOD_NEK2_1	43	48	PF00069	0.628
MOD_PIKK_1	180	186	PF00454	0.694
MOD_PKA_1	135	141	PF00069	0.556
MOD_PKA_2	135	141	PF00069	0.556
MOD_PKA_2	53	59	PF00069	0.559
MOD_PKA_2	99	105	PF00069	0.693
MOD_Plk_1	117	123	PF00069	0.659
MOD_Plk_2-3	91	97	PF00069	0.648
MOD_Plk_4	99	105	PF00069	0.693
MOD_ProDKin_1	155	161	PF00069	0.622
TRG_DiLeu_BaEn_4	68	74	PF01217	0.597
TRG_ER_diArg_1	97	100	PF00400	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P3J1	Trypanosomatidae	38%	100%
A4HPL8	Leishmania braziliensis	70%	100%
A4ID46	Leishmania infantum	100%	100%
E9ATD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q167	Leishmania major	94%	100%