14-3-3 protein 1, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

14-3-3 protein 1, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XB66_LEIDO

TriTrypDb:

LdBPK_363360.1 , LdCL_360040400 , LDHU3_36.4620

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 1
Silverman et al.	no	yes: 1
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 3

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 3

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016281	eukaryotic translation initiation factor 4F complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0097542	ciliary tip	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7XB66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XB66

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0007088	regulation of mitotic nuclear division	6	1
GO:0007165	signal transduction	2	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010639	negative regulation of organelle organization	6	1
GO:0010948	negative regulation of cell cycle process	6	1
GO:0016192	vesicle-mediated transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0033043	regulation of organelle organization	5	1
GO:0045786	negative regulation of cell cycle	5	1
GO:0045839	negative regulation of mitotic nuclear division	7	1
GO:0045930	negative regulation of mitotic cell cycle	6	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051129	negative regulation of cellular component organization	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051726	regulation of cell cycle	4	1
GO:0051783	regulation of nuclear division	6	1
GO:0051784	negative regulation of nuclear division	7	1
GO:0065007	biological regulation	1	1
GO:0070727	cellular macromolecule localization	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.504
CLV_NRD_NRD_1	111	113	PF00675	0.389
CLV_NRD_NRD_1	52	54	PF00675	0.401
CLV_NRD_NRD_1	81	83	PF00675	0.387
CLV_PCSK_KEX2_1	111	113	PF00082	0.428
CLV_PCSK_KEX2_1	81	83	PF00082	0.387
CLV_PCSK_SKI1_1	67	71	PF00082	0.470
CLV_PCSK_SKI1_1	8	12	PF00082	0.678
CLV_PCSK_SKI1_1	86	90	PF00082	0.387
DEG_APCC_KENBOX_2	97	101	PF00400	0.504
DEG_ODPH_VHL_1	185	197	PF01847	0.434
DOC_CKS1_1	77	82	PF01111	0.515
DOC_MAPK_gen_1	244	252	PF00069	0.416
DOC_MAPK_MEF2A_6	192	199	PF00069	0.391
DOC_MAPK_MEF2A_6	44	52	PF00069	0.401
DOC_MAPK_NFAT4_5	192	200	PF00069	0.387
DOC_USP7_MATH_1	18	22	PF00917	0.661
DOC_USP7_MATH_1	181	185	PF00917	0.391
DOC_USP7_UBL2_3	208	212	PF12436	0.387
DOC_WW_Pin1_4	116	121	PF00397	0.509
DOC_WW_Pin1_4	76	81	PF00397	0.515
LIG_14-3-3_CanoR_1	67	73	PF00244	0.391
LIG_FHA_1	129	135	PF00498	0.416
LIG_FHA_1	186	192	PF00498	0.387
LIG_FHA_2	224	230	PF00498	0.404
LIG_FHA_2	87	93	PF00498	0.416
LIG_FHA_2	9	15	PF00498	0.664
LIG_GBD_Chelix_1	242	250	PF00786	0.401
LIG_LIR_Apic_2	130	135	PF02991	0.387
LIG_LIR_Gen_1	43	52	PF02991	0.401
LIG_LIR_Nem_3	152	156	PF02991	0.387
LIG_LIR_Nem_3	200	206	PF02991	0.387
LIG_LIR_Nem_3	4	10	PF02991	0.766
LIG_LIR_Nem_3	71	77	PF02991	0.384
LIG_LYPXL_SIV_4	220	228	PF13949	0.401
LIG_NRBOX	124	130	PF00104	0.401
LIG_PDZ_Class_3	253	258	PF00595	0.652
LIG_SH2_CRK	74	78	PF00017	0.387
LIG_SH2_NCK_1	157	161	PF00017	0.399
LIG_SH2_PTP2	55	58	PF00017	0.515
LIG_SH2_SRC	132	135	PF00017	0.387
LIG_SH2_SRC	157	160	PF00017	0.401
LIG_SH2_SRC	221	224	PF00017	0.401
LIG_SH2_STAP1	221	225	PF00017	0.401
LIG_SH2_STAT5	132	135	PF00017	0.378
LIG_SH2_STAT5	146	149	PF00017	0.363
LIG_SH2_STAT5	55	58	PF00017	0.513
LIG_SH3_2	187	192	PF14604	0.416
LIG_SH3_3	14	20	PF00018	0.671
LIG_SH3_3	184	190	PF00018	0.416
LIG_SH3_3	74	80	PF00018	0.515
LIG_SUMO_SIM_anti_2	123	131	PF11976	0.401
LIG_SUMO_SIM_par_1	123	131	PF11976	0.391
LIG_TYR_ITIM	201	206	PF00017	0.364
LIG_TYR_ITIM	72	77	PF00017	0.456
LIG_UBA3_1	32	37	PF00899	0.567
LIG_UBA3_1	48	54	PF00899	0.348
MOD_CDK_SPK_2	76	81	PF00069	0.515
MOD_CDK_SPxK_1	76	82	PF00069	0.515
MOD_CK1_1	90	96	PF00069	0.377
MOD_CK2_1	223	229	PF00069	0.399
MOD_CK2_1	86	92	PF00069	0.401
MOD_GlcNHglycan	161	164	PF01048	0.496
MOD_GlcNHglycan	99	103	PF01048	0.483
MOD_GSK3_1	124	131	PF00069	0.478
MOD_GSK3_1	181	188	PF00069	0.382
MOD_GSK3_1	223	230	PF00069	0.401
MOD_GSK3_1	57	64	PF00069	0.416
MOD_GSK3_1	86	93	PF00069	0.361
MOD_N-GLC_1	181	186	PF02516	0.392
MOD_N-GLC_1	197	202	PF02516	0.324
MOD_N-GLC_1	8	13	PF02516	0.636
MOD_NEK2_1	1	6	PF00069	0.693
MOD_NEK2_1	128	133	PF00069	0.407
MOD_NEK2_1	197	202	PF00069	0.404
MOD_Plk_1	181	187	PF00069	0.398
MOD_Plk_1	197	203	PF00069	0.348
MOD_Plk_1	8	14	PF00069	0.649
MOD_Plk_2-3	124	130	PF00069	0.482
MOD_Plk_2-3	223	229	PF00069	0.401
MOD_Plk_2-3	61	67	PF00069	0.401
MOD_Plk_4	124	130	PF00069	0.427
MOD_Plk_4	238	244	PF00069	0.515
MOD_ProDKin_1	116	122	PF00069	0.509
MOD_ProDKin_1	76	82	PF00069	0.515
MOD_SUMO_rev_2	21	26	PF00179	0.554
TRG_DiLeu_BaEn_1	65	70	PF01217	0.387
TRG_DiLeu_BaEn_4	65	71	PF01217	0.387
TRG_DiLeu_BaLyEn_6	241	246	PF01217	0.410
TRG_ENDOCYTIC_2	146	149	PF00928	0.394
TRG_ENDOCYTIC_2	157	160	PF00928	0.373
TRG_ENDOCYTIC_2	203	206	PF00928	0.386
TRG_ENDOCYTIC_2	55	58	PF00928	0.484
TRG_ENDOCYTIC_2	74	77	PF00928	0.225
TRG_ER_diArg_1	110	112	PF00400	0.436
TRG_ER_diArg_1	80	82	PF00400	0.515
TRG_NES_CRM1_1	46	61	PF08389	0.401
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P443	Leptomonas seymouri	51%	100%
A0A0N1IJ96	Leptomonas seymouri	96%	100%
A0A0S4IUJ3	Bodo saltans	57%	93%
A0A0S4JJB7	Bodo saltans	72%	99%
A0A1X0NVF8	Trypanosomatidae	53%	100%
A0A1X0P3Q3	Trypanosomatidae	80%	98%
A0A3R7KVM5	Trypanosoma rangeli	52%	100%
A0A3S7WRH0	Leishmania donovani	52%	100%
A0A422NKL2	Trypanosoma rangeli	78%	98%
A4H6F2	Leishmania braziliensis	52%	100%
A4HPI7	Leishmania braziliensis	96%	100%
A4HUU6	Leishmania infantum	52%	100%
A4IDA9	Leishmania infantum	100%	100%
A4K2U9	Pongo abelii	52%	100%
B8NLM9	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	54%	100%
C0H4V6	Plasmodium falciparum (isolate 3D7)	47%	98%
D0A7L0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
D0A8F0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	98%
E2RU97	Giardia intestinalis (strain ATCC 50803 / WB clone C6)	50%	100%
E9ANI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9AT99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
O42766	Candida albicans (strain SC5314 / ATCC MYA-2876)	53%	98%
O49995	Nicotiana tabacum	55%	100%
O49996	Nicotiana tabacum	52%	100%
O49997	Nicotiana tabacum	55%	95%
O49998	Nicotiana tabacum	54%	100%
O65352	Helianthus annuus	54%	100%
O70456	Mus musculus	50%	100%
O77642	Ovis aries	50%	100%
O96436	Eimeria tenella	45%	93%
P27348	Homo sapiens	53%	100%
P29305	Hordeum vulgare	54%	98%
P29307	Oenothera elata subsp. hookeri	53%	99%
P29308	Spinacia oleracea	56%	100%
P29309	Xenopus laevis	51%	100%
P29310	Drosophila melanogaster	51%	100%
P29311	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	54%	97%
P29361	Ovis aries	51%	100%
P31946	Homo sapiens	52%	100%
P31947	Homo sapiens	50%	100%
P34730	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	54%	95%
P35213	Rattus norvegicus	52%	100%
P41932	Caenorhabditis elegans	52%	100%
P42643	Arabidopsis thaliana	57%	97%
P42644	Arabidopsis thaliana	54%	100%
P42645	Arabidopsis thaliana	53%	96%
P42648	Entamoeba histolytica	49%	100%
P42649	Entamoeba histolytica	49%	100%
P42650	Entamoeba histolytica	51%	100%
P42652	Solanum lycopersicum	54%	99%
P42653	Vicia faba	54%	99%
P42654	Vicia faba	51%	99%
P42656	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	51%	96%
P42657	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	52%	96%
P46077	Arabidopsis thaliana	55%	97%
P46266	Pisum sativum	56%	99%
P48347	Arabidopsis thaliana	51%	100%
P48348	Arabidopsis thaliana	55%	100%
P48349	Arabidopsis thaliana	54%	100%
P49106	Zea mays	53%	99%
P52908	Chlamydomonas reinhardtii	56%	100%
P54632	Dictyostelium discoideum	51%	100%
P61981	Homo sapiens	49%	100%
P61982	Mus musculus	49%	100%
P61983	Rattus norvegicus	49%	100%
P62258	Homo sapiens	54%	100%
P62259	Mus musculus	54%	100%
P62260	Rattus norvegicus	54%	100%
P62261	Bos taurus	54%	100%
P62262	Ovis aries	54%	100%
P63101	Mus musculus	51%	100%
P63102	Rattus norvegicus	51%	100%
P63103	Bos taurus	51%	100%
P63104	Homo sapiens	51%	100%
P68250	Bos taurus	52%	100%
P68251	Ovis aries	41%	100%
P68252	Bos taurus	49%	100%
P68254	Mus musculus	53%	100%
P68255	Rattus norvegicus	53%	100%
P68509	Bos taurus	50%	100%
P68510	Mus musculus	50%	100%
P68511	Rattus norvegicus	50%	100%
P92177	Drosophila melanogaster	54%	98%
P93206	Solanum lycopersicum	53%	100%
P93207	Solanum lycopersicum	51%	100%
P93208	Solanum lycopersicum	56%	100%
P93209	Solanum lycopersicum	54%	99%
P93210	Solanum lycopersicum	54%	100%
P93211	Solanum lycopersicum	54%	100%
P93212	Solanum lycopersicum	51%	100%
P93213	Solanum lycopersicum	50%	99%
P93214	Solanum lycopersicum	50%	99%
P93259	Mesembryanthemum crystallinum	55%	98%
P93342	Nicotiana tabacum	53%	100%
P93343	Nicotiana tabacum	55%	99%
P93784	Solanum tuberosum	54%	100%
Q01525	Arabidopsis thaliana	56%	100%
Q01526	Zea mays	52%	99%
Q04917	Homo sapiens	50%	100%
Q06967	Oryza sativa subsp. japonica	54%	99%
Q0VC36	Bos taurus	50%	100%
Q1HR36	Aedes aegypti	50%	100%
Q20655	Caenorhabditis elegans	51%	100%
Q24902	Echinococcus multilocularis	46%	100%
Q25538	Neospora caninum	46%	97%
Q26537	Schistosoma mansoni	52%	100%
Q26540	Schistosoma mansoni	48%	100%
Q2F637	Bombyx mori	50%	100%
Q2R1D5	Oryza sativa subsp. japonica	35%	100%
Q2R2W2	Oryza sativa subsp. japonica	54%	97%
Q39757	Fucus vesiculosus	53%	100%
Q3SZI4	Bos taurus	53%	100%
Q41246	Nicotiana tabacum	49%	100%
Q41418	Solanum tuberosum	53%	100%
Q43470	Hordeum vulgare	52%	98%
Q43643	Solanum tuberosum	53%	100%
Q4Q198	Leishmania major	99%	100%
Q4QH45	Leishmania major	52%	100%
Q4R572	Macaca fascicularis	52%	100%
Q52M98	Xenopus laevis	53%	100%
Q5F3W6	Gallus gallus	49%	100%
Q5PRD0	Danio rerio	51%	100%
Q5QNB8	Oryza sativa subsp. japonica	50%	100%
Q5R651	Pongo abelii	51%	100%
Q5RC20	Pongo abelii	49%	100%
Q5RFJ2	Pongo abelii	53%	100%
Q5XGC8	Xenopus tropicalis	51%	100%
Q5XHK2	Xenopus laevis	51%	100%
Q5ZKC9	Gallus gallus	51%	100%
Q5ZLQ6	Gallus gallus	52%	100%
Q5ZMD1	Gallus gallus	52%	100%
Q5ZMT0	Gallus gallus	54%	100%
Q6EUP4	Oryza sativa subsp. japonica	53%	98%
Q6NRY9	Xenopus laevis	48%	100%
Q6P4Z5	Xenopus tropicalis	52%	100%
Q6PC29	Danio rerio	48%	100%
Q6PCG0	Xenopus laevis	49%	100%
Q6Q6X0	Oryctolagus cuniculus	53%	100%
Q6UFZ2	Oncorhynchus mykiss	49%	100%
Q6UFZ3	Oncorhynchus mykiss	48%	100%
Q6UFZ8	Oncorhynchus mykiss	49%	100%
Q6UFZ9	Oncorhynchus mykiss	51%	100%
Q6ZKC0	Oryza sativa subsp. japonica	54%	100%
Q7T356	Danio rerio	50%	100%
Q7XTE8	Oryza sativa subsp. japonica	52%	98%
Q84J55	Oryza sativa subsp. japonica	54%	98%
Q8AVQ3	Xenopus laevis	51%	100%
Q8MM75	Echinococcus multilocularis	49%	100%
Q8MUA4	Echinococcus granulosus	49%	100%
Q8SW28	Encephalitozoon cuniculi (strain GB-M1)	42%	100%
Q91896	Xenopus laevis	51%	100%
Q96299	Arabidopsis thaliana	53%	98%
Q96300	Arabidopsis thaliana	54%	97%
Q96450	Glycine max	53%	100%
Q96451	Glycine max	51%	100%
Q96452	Glycine max	53%	100%
Q96453	Glycine max	52%	99%
Q99002	Trichoderma harzianum	53%	98%
Q9C5W6	Arabidopsis thaliana	54%	96%
Q9CQV8	Mus musculus	51%	100%
Q9S9Z8	Arabidopsis thaliana	50%	100%
Q9SP07	Lilium longiflorum	55%	100%
Q9U408	Echinococcus granulosus	45%	100%
V5B9L7	Trypanosoma cruzi	78%	98%
V5C116	Trypanosoma cruzi	53%	100%