Short chain dehydrogenase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

short chain dehydrogenase-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7XB64_LEIDO

TriTrypDb:

LdBPK_363570.1 , LdCL_360042700 , LDHU3_36.4850

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	3

Expansion

Sequence features

A0A3S7XB64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XB64

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016491	oxidoreductase activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	23	25	PF00675	0.303
CLV_NRD_NRD_1	248	250	PF00675	0.576
CLV_NRD_NRD_1	296	298	PF00675	0.603
CLV_PCSK_KEX2_1	23	25	PF00082	0.337
CLV_PCSK_KEX2_1	248	250	PF00082	0.576
CLV_PCSK_KEX2_1	296	298	PF00082	0.596
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.596
CLV_PCSK_PC7_1	19	25	PF00082	0.327
CLV_PCSK_PC7_1	244	250	PF00082	0.515
CLV_PCSK_SKI1_1	234	238	PF00082	0.627
CLV_PCSK_SKI1_1	284	288	PF00082	0.486
CLV_PCSK_SKI1_1	3	7	PF00082	0.298
DEG_APCC_DBOX_1	283	291	PF00400	0.367
DEG_APCC_DBOX_1	296	304	PF00400	0.300
DOC_CYCLIN_yCln2_LP_2	116	122	PF00134	0.225
DOC_MAPK_MEF2A_6	212	221	PF00069	0.256
DOC_PP1_RVXF_1	1	7	PF00149	0.209
DOC_PP1_SILK_1	190	195	PF00149	0.256
DOC_PP2B_LxvP_1	116	119	PF13499	0.225
DOC_USP7_MATH_1	147	151	PF00917	0.170
DOC_WW_Pin1_4	172	177	PF00397	0.314
DOC_WW_Pin1_4	249	254	PF00397	0.402
LIG_14-3-3_CanoR_1	100	109	PF00244	0.314
LIG_14-3-3_CanoR_1	194	204	PF00244	0.210
LIG_14-3-3_CanoR_1	218	222	PF00244	0.273
LIG_14-3-3_CanoR_1	297	301	PF00244	0.392
LIG_Actin_WH2_1	178	196	PF00022	0.277
LIG_Actin_WH2_2	181	196	PF00022	0.252
LIG_Actin_WH2_2	56	73	PF00022	0.261
LIG_BIR_II_1	1	5	PF00653	0.233
LIG_CtBP_PxDLS_1	46	51	PF00389	0.390
LIG_FHA_1	286	292	PF00498	0.320
LIG_FHA_1	96	102	PF00498	0.245
LIG_LIR_Gen_1	103	113	PF02991	0.314
LIG_LIR_Gen_1	138	149	PF02991	0.298
LIG_LIR_Nem_3	103	108	PF02991	0.314
LIG_MAD2	234	242	PF02301	0.338
LIG_SH2_CRK	105	109	PF00017	0.301
LIG_SH2_CRK	22	26	PF00017	0.576
LIG_SH2_STAP1	105	109	PF00017	0.314
LIG_SH2_STAT5	122	125	PF00017	0.254
LIG_SH2_STAT5	153	156	PF00017	0.210
LIG_SH2_STAT5	197	200	PF00017	0.210
LIG_SH2_STAT5	226	229	PF00017	0.210
LIG_SH2_STAT5	87	90	PF00017	0.299
LIG_Sin3_3	6	13	PF02671	0.243
LIG_SUMO_SIM_anti_2	177	184	PF11976	0.221
LIG_SUMO_SIM_anti_2	59	64	PF11976	0.253
LIG_TRFH_1	281	285	PF08558	0.274
LIG_TYR_ITIM	120	125	PF00017	0.277
LIG_UBA3_1	290	298	PF00899	0.358
MOD_CDC14_SPxK_1	175	178	PF00782	0.314
MOD_CDK_SPxK_1	172	178	PF00069	0.314
MOD_CK1_1	172	178	PF00069	0.281
MOD_CK1_1	195	201	PF00069	0.210
MOD_CK1_1	299	305	PF00069	0.319
MOD_CK2_1	53	59	PF00069	0.225
MOD_CK2_1	90	96	PF00069	0.314
MOD_GlcNHglycan	194	197	PF01048	0.442
MOD_GlcNHglycan	42	45	PF01048	0.260
MOD_GSK3_1	165	172	PF00069	0.239
MOD_GSK3_1	188	195	PF00069	0.210
MOD_GSK3_1	226	233	PF00069	0.280
MOD_GSK3_1	36	43	PF00069	0.309
MOD_LATS_1	232	238	PF00433	0.371
MOD_N-GLC_1	169	174	PF02516	0.523
MOD_NEK2_1	53	58	PF00069	0.225
MOD_PIKK_1	165	171	PF00454	0.256
MOD_PKA_1	296	302	PF00069	0.318
MOD_PKA_2	217	223	PF00069	0.273
MOD_PKA_2	296	302	PF00069	0.360
MOD_Plk_4	188	194	PF00069	0.252
MOD_ProDKin_1	172	178	PF00069	0.314
MOD_ProDKin_1	249	255	PF00069	0.397
MOD_SUMO_rev_2	233	243	PF00179	0.433
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.210
TRG_ENDOCYTIC_2	105	108	PF00928	0.324
TRG_ENDOCYTIC_2	122	125	PF00928	0.245
TRG_ENDOCYTIC_2	22	25	PF00928	0.521
TRG_ER_diArg_1	22	24	PF00400	0.501
TRG_ER_diArg_1	27	30	PF00400	0.482
TRG_ER_diArg_1	281	284	PF00400	0.286
TRG_Pf-PMV_PEXEL_1	234	239	PF00026	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0B4FP77	Metarhizium brunneum (strain ARSEF 3297)	32%	100%
A0A0B4GT47	Metarhizium anisopliae (strain ARSEF 549)	30%	100%
A0A0B4GU97	Metarhizium guizhouense (strain ARSEF 977)	29%	100%
A0A0B4HVU2	Metarhizium majus (strain ARSEF 297)	30%	100%
A0A0N1I1P8	Leptomonas seymouri	29%	89%
A0A0N1I7L3	Leptomonas seymouri	72%	100%
A0A0S4JBE7	Bodo saltans	26%	94%
A0A0S4JCK7	Bodo saltans	28%	100%
A0A0S4JL82	Bodo saltans	42%	100%
A0A0S4JMY7	Bodo saltans	32%	89%
A0A0S4JXD8	Bodo saltans	26%	100%
A0A140FAN3	Pinus massoniana	31%	86%
A0A1L5BU05	Sphingobium indicum (strain DSM 16412 / CCM 7286 / MTCC 6364 / B90A)	28%	100%
A0A1X0P3I1	Trypanosomatidae	58%	100%
A0A2U8U2K8	Sarocladium schorii	26%	100%
A0A3Q8IHN8	Leishmania donovani	30%	91%
A0A3R7KI53	Trypanosoma rangeli	27%	100%
A0A3S5IS03	Trypanosoma rangeli	58%	100%
A0A422NCL5	Trypanosoma rangeli	28%	100%
A0A422NNE9	Trypanosoma rangeli	30%	90%
A4HM71	Leishmania braziliensis	30%	90%
A4HPK8	Leishmania braziliensis	86%	100%
A4IAT4	Leishmania infantum	30%	91%
A4ID56	Leishmania infantum	100%	100%
A5JYX5	Caenorhabditis elegans	27%	99%
A5PJJ7	Bos taurus	28%	97%
A6NNS2	Homo sapiens	26%	98%
A6SG70	Botryotinia fuckeliana (strain B05.10)	30%	92%
A7DY56	Cochlearia officinalis	27%	100%
A7F8T1	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	29%	92%
A7LB59	Arachis hypogaea	26%	87%
A9UM79	Xenopus tropicalis	26%	98%
B8M9L2	Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)	22%	93%
C0KTJ6	Cereibacter sphaeroides	30%	100%
D0A2C4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	88%
D0A8K5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	98%
D3U1D9	Klebsiella oxytoca	29%	100%
D4Z260	Sphingobium japonicum (strain DSM 16413 / CCM 7287 / MTCC 6362 / UT26 / NBRC 101211 / UT26S)	28%	100%
E3VWI6	Streptomyces arenae	28%	100%
E9AEL0	Leishmania major	30%	91%
E9ATC0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9B5S1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9EHG1	Metarhizium acridum (strain CQMa 102)	32%	100%
E9ET40	Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075)	30%	100%
H9BFQ2	Erythroxylum coca	25%	100%
I6Y778	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	24%	67%
M2ZIX7	Pseudocercospora fijiensis (strain CIRAD86)	28%	99%
O05730	Helicobacter pylori (strain ATCC 700392 / 26695)	27%	100%
O16881	Caenorhabditis elegans	24%	79%
O31680	Bacillus subtilis (strain 168)	28%	100%
O31767	Bacillus subtilis (strain 168)	25%	100%
O32291	Bacillus subtilis (strain 168)	27%	86%
O74628	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
O93868	Agaricus bisporus	27%	100%
P00335	Klebsiella aerogenes	31%	100%
P0DKC5	Arabidopsis thaliana	30%	88%
P0DKC6	Arabidopsis thaliana	30%	88%
P14061	Homo sapiens	30%	93%
P14802	Bacillus subtilis (strain 168)	23%	100%
P16232	Rattus norvegicus	30%	100%
P16542	Streptomyces violaceoruber	27%	100%
P16544	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	28%	100%
P28845	Homo sapiens	30%	100%
P31808	Escherichia coli (strain K12)	28%	100%
P35320	Streptomyces lividans	30%	100%
P37059	Homo sapiens	26%	79%
P38004	Chlamydia trachomatis (strain D/UW-3/Cx)	26%	100%
P39577	Bacillus subtilis (strain 168)	29%	100%
P40580	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
P41177	Streptomyces virginiae	27%	100%
P42317	Bacillus subtilis (strain 168)	27%	100%
P50172	Mus musculus	29%	100%
P50199	Gluconobacter oxydans (strain 621H)	28%	100%
P50206	Pseudomonas sp. (strain KKS102)	28%	100%
P50842	Bacillus subtilis (strain 168)	28%	100%
P51656	Mus musculus	27%	89%
P51657	Rattus norvegicus	28%	89%
P51975	Ovis aries	31%	100%
P54554	Bacillus subtilis (strain 168)	29%	100%
P55434	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	27%	100%
P80365	Homo sapiens	31%	76%
P9WGP8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	25%	100%
P9WGP9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	25%	100%
P9WGR4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	30%	100%
P9WGR5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	30%	100%
P9WGR6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	25%	100%
P9WGR7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	25%	100%
Q05016	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q05A13	Mus musculus	27%	97%
Q06136	Homo sapiens	30%	92%
Q07530	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	99%
Q09851	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q0IH28	Xenopus laevis	32%	95%
Q0VFE7	Xenopus tropicalis	32%	99%
Q13268	Homo sapiens	24%	100%
Q1WNP0	Pan troglodytes	30%	93%
Q29608	Saimiri sciureus	30%	100%
Q2KIJ5	Bos taurus	29%	92%
Q3T0R4	Bos taurus	30%	94%
Q4A054	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	28%	100%
Q4JK73	Macaca fascicularis	27%	100%
Q4Q177	Leishmania major	96%	100%
Q566S6	Danio rerio	29%	99%
Q5BL28	Danio rerio	27%	96%
Q5HLD8	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	28%	100%
Q5M875	Rattus norvegicus	26%	100%
Q5NVG2	Pongo abelii	27%	100%
Q5R6U1	Pongo abelii	30%	94%
Q5RCF8	Pongo abelii	26%	100%
Q5RJY4	Rattus norvegicus	30%	94%
Q62730	Rattus norvegicus	29%	80%
Q6AYS8	Rattus norvegicus	29%	100%
Q6BIG0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	26%	88%
Q6CE86	Yarrowia lipolytica (strain CLIB 122 / E 150)	26%	82%
Q6CHP1	Yarrowia lipolytica (strain CLIB 122 / E 150)	28%	79%
Q6GDV6	Staphylococcus aureus (strain MRSA252)	23%	100%
Q6IAN0	Homo sapiens	30%	94%
Q6P7J1	Xenopus laevis	29%	100%
Q6PUF3	Danio rerio	31%	100%
Q6PUF4	Gallus gallus	35%	100%
Q6QLL4	Cavia porcellus	29%	100%
Q6R0J2	Mesocricetus auratus	30%	100%
Q6WVP7	Lentilactobacillus kefiri	26%	100%
Q7M3I4	Oryctolagus cuniculus	32%	100%
Q7Q732	Anopheles gambiae	28%	97%
Q7SYS6	Xenopus laevis	26%	100%
Q7T2D1	Danio rerio	26%	91%
Q7TQA3	Mus musculus	32%	99%
Q7Z5J1	Homo sapiens	33%	97%
Q7Z5P4	Homo sapiens	24%	100%
Q8CN40	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	28%	100%
Q8HZJ8	Bos taurus	31%	100%
Q8LKV5	Sesamum indicum	26%	85%
Q8N3Y7	Homo sapiens	29%	99%
Q8NBQ5	Homo sapiens	28%	100%
Q8SPU8	Bos taurus	25%	100%
Q8T197	Dictyostelium discoideum	30%	97%
Q8VCH7	Mus musculus	25%	90%
Q8VCR2	Mus musculus	26%	100%
Q8VID1	Rattus norvegicus	25%	100%
Q92RN6	Rhizobium meliloti (strain 1021)	27%	100%
Q93W57	Sesamum indicum	30%	88%
Q99J47	Mus musculus	31%	95%
Q99LB2	Mus musculus	24%	100%
Q9BTZ2	Homo sapiens	26%	100%
Q9CXR1	Mus musculus	24%	91%
Q9EQ06	Mus musculus	29%	100%
Q9LUE4	Arabidopsis thaliana	29%	89%
Q9N126	Bos taurus	28%	98%
Q9NYR8	Homo sapiens	28%	98%
Q9PKF7	Chlamydia muridarum (strain MoPn / Nigg)	26%	100%
Q9RPT1	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	27%	100%
Q9STY7	Arabidopsis thaliana	30%	99%
Q9STY8	Arabidopsis thaliana	27%	99%
Q9T0G0	Arabidopsis thaliana	27%	79%
Q9Y140	Drosophila melanogaster	27%	94%
Q9Y394	Homo sapiens	24%	90%
Q9ZKW1	Helicobacter pylori (strain J99 / ATCC 700824)	27%	100%
Q9ZW03	Arabidopsis thaliana	29%	100%
Q9ZW04	Arabidopsis thaliana	30%	100%
Q9ZW12	Arabidopsis thaliana	27%	95%
Q9ZW13	Arabidopsis thaliana	28%	100%
V5BS47	Trypanosoma cruzi	55%	100%