ATP_synthase_putative/GeneDB:LmjF.36.3100

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP synthase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7XB56_LEIDO

TriTrypDb:

LdBPK_363250.1 , LdCL_360039100 , LDHU3_36.4480

Length:

216

Annotations

Annotations by Jardim et al.

ATP metabolism, ATP synthase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	11
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	11
GO:0098796	membrane protein complex	2	11
GO:0110165	cellular anatomical entity	1	1

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7XB56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XB56

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0005215	transporter activity	1	11
GO:0008324	monoatomic cation transmembrane transporter activity	4	11
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	11
GO:0015075	monoatomic ion transmembrane transporter activity	3	11
GO:0015078	proton transmembrane transporter activity	5	11
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	11
GO:0015399	primary active transmembrane transporter activity	4	11
GO:0016787	hydrolase activity	2	7
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	3	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.315
CLV_NRD_NRD_1	63	65	PF00675	0.296
CLV_PCSK_KEX2_1	63	65	PF00082	0.299
CLV_PCSK_SKI1_1	108	112	PF00082	0.292
CLV_PCSK_SKI1_1	54	58	PF00082	0.440
DOC_MAPK_gen_1	150	159	PF00069	0.362
DOC_MAPK_gen_1	54	61	PF00069	0.302
LIG_14-3-3_CanoR_1	193	202	PF00244	0.392
LIG_14-3-3_CanoR_1	5	11	PF00244	0.424
LIG_14-3-3_CanoR_1	82	87	PF00244	0.321

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I680	Leptomonas seymouri	81%	100%
A0A0S4J7J5	Bodo saltans	61%	100%
A0A1X0P3P2	Trypanosomatidae	63%	100%
A0A422NKP5	Trypanosoma rangeli	61%	100%
A4HPH6	Leishmania braziliensis	82%	100%
A4ID98	Leishmania infantum	100%	100%
D0A8D7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AT88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O00780	Dictyostelium discoideum	29%	93%
O13687	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	95%

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