LeishMANIAdb
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TSPc domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
TSPc domain-containing protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania donovani
UniProt:
A0A3S7XB55_LEIDO
TriTrypDb:
LdBPK_363400.1 * , LdCL_360040800 , LDHU3_36.4660
Length:
853

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Cellular components
Term Name Level Count
GO:0016020 membrane 2 4
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

A0A3S7XB55
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7XB55

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 811 815 PF00656 0.412
CLV_NRD_NRD_1 243 245 PF00675 0.585
CLV_NRD_NRD_1 31 33 PF00675 0.682
CLV_NRD_NRD_1 721 723 PF00675 0.575
CLV_PCSK_FUR_1 29 33 PF00082 0.690
CLV_PCSK_KEX2_1 243 245 PF00082 0.585
CLV_PCSK_KEX2_1 29 31 PF00082 0.813
CLV_PCSK_KEX2_1 721 723 PF00082 0.575
CLV_PCSK_SKI1_1 639 643 PF00082 0.510
DEG_APCC_KENBOX_2 705 709 PF00400 0.331
DEG_Nend_UBRbox_2 1 3 PF02207 0.511
DEG_SCF_FBW7_1 537 543 PF00400 0.491
DEG_SCF_FBW7_1 804 810 PF00400 0.450
DEG_SCF_FBW7_2 744 750 PF00400 0.385
DEG_SPOP_SBC_1 541 545 PF00917 0.471
DOC_ANK_TNKS_1 149 156 PF00023 0.410
DOC_ANK_TNKS_1 816 823 PF00023 0.410
DOC_CKS1_1 358 363 PF01111 0.355
DOC_CKS1_1 537 542 PF01111 0.492
DOC_CKS1_1 744 749 PF01111 0.385
DOC_CKS1_1 804 809 PF01111 0.446
DOC_CYCLIN_yCln2_LP_2 818 821 PF00134 0.406
DOC_MAPK_DCC_7 289 299 PF00069 0.353
DOC_PP2B_LxvP_1 365 368 PF13499 0.378
DOC_PP2B_LxvP_1 818 821 PF13499 0.406
DOC_USP7_MATH_1 126 130 PF00917 0.386
DOC_USP7_MATH_1 191 195 PF00917 0.411
DOC_USP7_MATH_1 196 200 PF00917 0.356
DOC_USP7_MATH_1 518 522 PF00917 0.486
DOC_USP7_MATH_1 524 528 PF00917 0.486
DOC_USP7_MATH_1 540 544 PF00917 0.442
DOC_USP7_MATH_1 808 812 PF00917 0.423
DOC_USP7_MATH_2 679 685 PF00917 0.345
DOC_WW_Pin1_4 324 329 PF00397 0.535
DOC_WW_Pin1_4 357 362 PF00397 0.381
DOC_WW_Pin1_4 412 417 PF00397 0.461
DOC_WW_Pin1_4 536 541 PF00397 0.491
DOC_WW_Pin1_4 743 748 PF00397 0.406
DOC_WW_Pin1_4 803 808 PF00397 0.442
LIG_14-3-3_CanoR_1 124 134 PF00244 0.350
LIG_14-3-3_CanoR_1 289 294 PF00244 0.322
LIG_14-3-3_CanoR_1 492 498 PF00244 0.571
LIG_14-3-3_CanoR_1 639 647 PF00244 0.342
LIG_14-3-3_CanoR_1 768 773 PF00244 0.394
LIG_APCC_ABBAyCdc20_2 41 47 PF00400 0.470
LIG_BRCT_BRCA1_1 193 197 PF00533 0.414
LIG_BRCT_BRCA1_1 214 218 PF00533 0.383
LIG_BRCT_BRCA1_1 69 73 PF00533 0.420
LIG_BRCT_BRCA1_1 832 836 PF00533 0.303
LIG_Clathr_ClatBox_1 332 336 PF01394 0.350
LIG_DLG_GKlike_1 768 776 PF00625 0.342
LIG_eIF4E_1 830 836 PF01652 0.355
LIG_FHA_1 118 124 PF00498 0.386
LIG_FHA_1 129 135 PF00498 0.347
LIG_FHA_1 163 169 PF00498 0.325
LIG_FHA_1 181 187 PF00498 0.339
LIG_FHA_1 325 331 PF00498 0.484
LIG_FHA_1 384 390 PF00498 0.394
LIG_FHA_1 558 564 PF00498 0.601
LIG_FHA_1 610 616 PF00498 0.340
LIG_FHA_1 629 635 PF00498 0.342
LIG_FHA_1 711 717 PF00498 0.473
LIG_FHA_1 735 741 PF00498 0.432
LIG_FHA_1 774 780 PF00498 0.338
LIG_FHA_1 804 810 PF00498 0.450
LIG_FHA_1 811 817 PF00498 0.414
LIG_FHA_1 822 828 PF00498 0.330
LIG_FHA_1 86 92 PF00498 0.424
LIG_FHA_2 55 61 PF00498 0.424
LIG_FHA_2 702 708 PF00498 0.354
LIG_LIR_Apic_2 290 296 PF02991 0.326
LIG_LIR_Apic_2 355 361 PF02991 0.368
LIG_LIR_Apic_2 654 660 PF02991 0.469
LIG_LIR_Apic_2 675 679 PF02991 0.406
LIG_LIR_Gen_1 143 153 PF02991 0.406
LIG_LIR_Gen_1 164 173 PF02991 0.399
LIG_LIR_Gen_1 407 417 PF02991 0.366
LIG_LIR_Gen_1 595 600 PF02991 0.357
LIG_LIR_Gen_1 70 80 PF02991 0.394
LIG_LIR_Gen_1 738 747 PF02991 0.370
LIG_LIR_Gen_1 748 759 PF02991 0.354
LIG_LIR_LC3C_4 49 54 PF02991 0.381
LIG_LIR_Nem_3 164 169 PF02991 0.400
LIG_LIR_Nem_3 183 187 PF02991 0.245
LIG_LIR_Nem_3 199 205 PF02991 0.296
LIG_LIR_Nem_3 360 365 PF02991 0.490
LIG_LIR_Nem_3 407 412 PF02991 0.356
LIG_LIR_Nem_3 463 468 PF02991 0.399
LIG_LIR_Nem_3 478 483 PF02991 0.271
LIG_LIR_Nem_3 595 599 PF02991 0.367
LIG_LIR_Nem_3 70 76 PF02991 0.417
LIG_LIR_Nem_3 738 744 PF02991 0.421
LIG_LIR_Nem_3 748 754 PF02991 0.441
LIG_LIR_Nem_3 785 791 PF02991 0.357
LIG_LIR_Nem_3 833 839 PF02991 0.303
LIG_LYPXL_S_1 36 40 PF13949 0.671
LIG_LYPXL_yS_3 37 40 PF13949 0.473
LIG_MYND_1 115 119 PF01753 0.433
LIG_Pex14_1 273 277 PF04695 0.319
LIG_Pex14_1 358 362 PF04695 0.525
LIG_Pex14_1 657 661 PF04695 0.375
LIG_Pex14_2 173 177 PF04695 0.408
LIG_PTB_Apo_2 39 46 PF02174 0.472
LIG_PTB_Phospho_1 39 45 PF10480 0.474
LIG_REV1ctd_RIR_1 93 101 PF16727 0.433
LIG_SH2_CRK 187 191 PF00017 0.503
LIG_SH2_CRK 400 404 PF00017 0.350
LIG_SH2_CRK 596 600 PF00017 0.367
LIG_SH2_CRK 741 745 PF00017 0.380
LIG_SH2_NCK_1 187 191 PF00017 0.327
LIG_SH2_NCK_1 483 487 PF00017 0.476
LIG_SH2_NCK_1 596 600 PF00017 0.367
LIG_SH2_NCK_1 759 763 PF00017 0.377
LIG_SH2_PTP2 676 679 PF00017 0.374
LIG_SH2_SRC 646 649 PF00017 0.361
LIG_SH2_SRC 676 679 PF00017 0.374
LIG_SH2_STAP1 304 308 PF00017 0.357
LIG_SH2_STAP1 519 523 PF00017 0.462
LIG_SH2_STAP1 596 600 PF00017 0.367
LIG_SH2_STAP1 98 102 PF00017 0.426
LIG_SH2_STAT3 246 249 PF00017 0.353
LIG_SH2_STAT3 98 101 PF00017 0.432
LIG_SH2_STAT5 184 187 PF00017 0.454
LIG_SH2_STAT5 219 222 PF00017 0.383
LIG_SH2_STAT5 246 249 PF00017 0.390
LIG_SH2_STAT5 293 296 PF00017 0.343
LIG_SH2_STAT5 480 483 PF00017 0.466
LIG_SH2_STAT5 596 599 PF00017 0.377
LIG_SH2_STAT5 646 649 PF00017 0.414
LIG_SH2_STAT5 661 664 PF00017 0.427
LIG_SH2_STAT5 676 679 PF00017 0.303
LIG_SH2_STAT5 68 71 PF00017 0.437
LIG_SH2_STAT5 687 690 PF00017 0.482
LIG_SH2_STAT5 703 706 PF00017 0.318
LIG_SH2_STAT5 717 720 PF00017 0.274
LIG_SH2_STAT5 75 78 PF00017 0.391
LIG_SH2_STAT5 803 806 PF00017 0.433
LIG_SH2_STAT5 830 833 PF00017 0.355
LIG_SH3_3 562 568 PF00018 0.475
LIG_SUMO_SIM_anti_2 314 320 PF11976 0.343
LIG_SUMO_SIM_anti_2 331 336 PF11976 0.353
LIG_SUMO_SIM_anti_2 51 58 PF11976 0.564
LIG_SUMO_SIM_anti_2 88 95 PF11976 0.425
LIG_SUMO_SIM_par_1 253 260 PF11976 0.369
LIG_SUMO_SIM_par_1 331 336 PF11976 0.353
LIG_SUMO_SIM_par_1 414 420 PF11976 0.387
LIG_SUMO_SIM_par_1 51 58 PF11976 0.473
LIG_SUMO_SIM_par_1 563 569 PF11976 0.463
LIG_TRAF2_1 46 49 PF00917 0.472
LIG_TYR_ITIM 398 403 PF00017 0.359
LIG_TYR_ITIM 779 784 PF00017 0.349
LIG_UBA3_1 91 97 PF00899 0.429
LIG_WRC_WIRS_1 127 132 PF05994 0.385
LIG_WRC_WIRS_1 349 354 PF05994 0.391
MOD_CK1_1 125 131 PF00069 0.349
MOD_CK1_1 221 227 PF00069 0.315
MOD_CK1_1 256 262 PF00069 0.373
MOD_CK1_1 378 384 PF00069 0.349
MOD_CK1_1 407 413 PF00069 0.354
MOD_CK1_1 478 484 PF00069 0.489
MOD_CK1_1 491 497 PF00069 0.492
MOD_CK1_1 500 506 PF00069 0.481
MOD_CK1_1 527 533 PF00069 0.474
MOD_CK1_1 573 579 PF00069 0.511
MOD_CK1_1 598 604 PF00069 0.388
MOD_CK1_1 609 615 PF00069 0.328
MOD_CK1_1 632 638 PF00069 0.373
MOD_CK1_1 664 670 PF00069 0.382
MOD_CK1_1 680 686 PF00069 0.309
MOD_CK2_1 126 132 PF00069 0.383
MOD_CK2_1 348 354 PF00069 0.348
MOD_CK2_1 417 423 PF00069 0.455
MOD_CK2_1 43 49 PF00069 0.470
MOD_CK2_1 578 584 PF00069 0.453
MOD_CK2_1 701 707 PF00069 0.336
MOD_Cter_Amidation 241 244 PF01082 0.593
MOD_GlcNHglycan 124 127 PF01048 0.601
MOD_GlcNHglycan 159 162 PF01048 0.604
MOD_GlcNHglycan 264 267 PF01048 0.605
MOD_GlcNHglycan 269 272 PF01048 0.569
MOD_GlcNHglycan 442 445 PF01048 0.597
MOD_GlcNHglycan 494 497 PF01048 0.735
MOD_GlcNHglycan 5 8 PF01048 0.652
MOD_GlcNHglycan 520 523 PF01048 0.678
MOD_GlcNHglycan 526 529 PF01048 0.674
MOD_GlcNHglycan 530 533 PF01048 0.682
MOD_GlcNHglycan 578 581 PF01048 0.704
MOD_GlcNHglycan 623 626 PF01048 0.652
MOD_GlcNHglycan 634 637 PF01048 0.531
MOD_GlcNHglycan 664 667 PF01048 0.601
MOD_GlcNHglycan 69 72 PF01048 0.642
MOD_GlcNHglycan 755 758 PF01048 0.560
MOD_GlcNHglycan 759 762 PF01048 0.516
MOD_GlcNHglycan 810 813 PF01048 0.625
MOD_GSK3_1 122 129 PF00069 0.397
MOD_GSK3_1 157 164 PF00069 0.421
MOD_GSK3_1 191 198 PF00069 0.434
MOD_GSK3_1 218 225 PF00069 0.361
MOD_GSK3_1 228 235 PF00069 0.378
MOD_GSK3_1 253 260 PF00069 0.361
MOD_GSK3_1 267 274 PF00069 0.307
MOD_GSK3_1 348 355 PF00069 0.464
MOD_GSK3_1 407 414 PF00069 0.354
MOD_GSK3_1 471 478 PF00069 0.458
MOD_GSK3_1 481 488 PF00069 0.396
MOD_GSK3_1 490 497 PF00069 0.486
MOD_GSK3_1 499 506 PF00069 0.444
MOD_GSK3_1 523 530 PF00069 0.459
MOD_GSK3_1 536 543 PF00069 0.452
MOD_GSK3_1 570 577 PF00069 0.477
MOD_GSK3_1 594 601 PF00069 0.384
MOD_GSK3_1 628 635 PF00069 0.402
MOD_GSK3_1 647 654 PF00069 0.308
MOD_GSK3_1 664 671 PF00069 0.362
MOD_GSK3_1 677 684 PF00069 0.318
MOD_GSK3_1 723 730 PF00069 0.447
MOD_GSK3_1 753 760 PF00069 0.325
MOD_GSK3_1 762 769 PF00069 0.414
MOD_GSK3_1 803 810 PF00069 0.484
MOD_N-GLC_1 209 214 PF02516 0.613
MOD_N-GLC_1 322 327 PF02516 0.537
MOD_N-GLC_1 339 344 PF02516 0.561
MOD_N-GLC_1 389 394 PF02516 0.593
MOD_N-GLC_1 570 575 PF02516 0.664
MOD_N-GLC_1 609 614 PF02516 0.537
MOD_N-GLC_1 621 626 PF02516 0.573
MOD_N-GLC_1 668 673 PF02516 0.601
MOD_N-GLC_1 710 715 PF02516 0.558
MOD_NEK2_1 173 178 PF00069 0.404
MOD_NEK2_1 267 272 PF00069 0.388
MOD_NEK2_1 352 357 PF00069 0.478
MOD_NEK2_1 375 380 PF00069 0.364
MOD_NEK2_1 389 394 PF00069 0.304
MOD_NEK2_1 40 45 PF00069 0.494
MOD_NEK2_1 411 416 PF00069 0.357
MOD_NEK2_1 417 422 PF00069 0.364
MOD_NEK2_1 479 484 PF00069 0.356
MOD_NEK2_1 485 490 PF00069 0.453
MOD_NEK2_1 606 611 PF00069 0.364
MOD_NEK2_1 616 621 PF00069 0.374
MOD_NEK2_1 634 639 PF00069 0.287
MOD_NEK2_1 641 646 PF00069 0.349
MOD_NEK2_1 662 667 PF00069 0.385
MOD_NEK2_1 701 706 PF00069 0.379
MOD_NEK2_1 727 732 PF00069 0.385
MOD_NEK2_1 845 850 PF00069 0.580
MOD_NEK2_1 85 90 PF00069 0.510
MOD_NEK2_2 119 124 PF00069 0.400
MOD_NEK2_2 284 289 PF00069 0.371
MOD_NEK2_2 600 605 PF00069 0.337
MOD_PIKK_1 471 477 PF00454 0.356
MOD_PIKK_1 629 635 PF00454 0.364
MOD_PIKK_1 641 647 PF00454 0.307
MOD_PKA_2 149 155 PF00069 0.428
MOD_PKA_2 491 497 PF00069 0.558
MOD_PKA_2 574 580 PF00069 0.486
MOD_PKA_2 662 668 PF00069 0.388
MOD_Plk_1 212 218 PF00069 0.396
MOD_Plk_1 222 228 PF00069 0.336
MOD_Plk_1 311 317 PF00069 0.367
MOD_Plk_1 352 358 PF00069 0.416
MOD_Plk_1 570 576 PF00069 0.464
MOD_Plk_1 629 635 PF00069 0.357
MOD_Plk_1 668 674 PF00069 0.396
MOD_Plk_1 766 772 PF00069 0.406
MOD_Plk_4 173 179 PF00069 0.373
MOD_Plk_4 180 186 PF00069 0.330
MOD_Plk_4 352 358 PF00069 0.489
MOD_Plk_4 375 381 PF00069 0.343
MOD_Plk_4 389 395 PF00069 0.344
MOD_Plk_4 40 46 PF00069 0.554
MOD_Plk_4 401 407 PF00069 0.289
MOD_Plk_4 475 481 PF00069 0.375
MOD_Plk_4 509 515 PF00069 0.566
MOD_Plk_4 616 622 PF00069 0.407
MOD_Plk_4 668 674 PF00069 0.392
MOD_Plk_4 723 729 PF00069 0.364
MOD_Plk_4 774 780 PF00069 0.376
MOD_Plk_4 830 836 PF00069 0.355
MOD_Plk_4 86 92 PF00069 0.369
MOD_ProDKin_1 324 330 PF00069 0.529
MOD_ProDKin_1 357 363 PF00069 0.370
MOD_ProDKin_1 412 418 PF00069 0.463
MOD_ProDKin_1 536 542 PF00069 0.491
MOD_ProDKin_1 743 749 PF00069 0.410
MOD_ProDKin_1 803 809 PF00069 0.442
TRG_DiLeu_BaEn_1 48 53 PF01217 0.382
TRG_DiLeu_BaEn_4 132 138 PF01217 0.390
TRG_DiLeu_BaLyEn_6 814 819 PF01217 0.445
TRG_ENDOCYTIC_2 349 352 PF00928 0.384
TRG_ENDOCYTIC_2 362 365 PF00928 0.307
TRG_ENDOCYTIC_2 37 40 PF00928 0.545
TRG_ENDOCYTIC_2 400 403 PF00928 0.348
TRG_ENDOCYTIC_2 596 599 PF00928 0.358
TRG_ENDOCYTIC_2 741 744 PF00928 0.378
TRG_ENDOCYTIC_2 781 784 PF00928 0.352
TRG_ER_diArg_1 28 31 PF00400 0.500
TRG_Pf-PMV_PEXEL_1 373 377 PF00026 0.576

Homologs

Protein Taxonomy Sequence identity Coverage
A4HPJ1 Leishmania braziliensis 68% 100%
A4ID72 Leishmania infantum 100% 100%
E9ATA3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS